11-Ketoetiocholanolone (BioDeep_00000002625)

 

Secondary id: BioDeep_00001875263

human metabolite Endogenous blood metabolite


代谢物信息卡片


(1S,2S,5R,7R,10S,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-14,17-dione

化学式: C19H28O3 (304.2038)
中文名称: 11-氧噻吩乙醇酮
谱图信息: 最多检出来源 Mus musculus(blood) 21.88%

分子结构信息

SMILES: CC12CC(=O)C3C(CCC4CC(O)CCC43C)C1CCC2=O
InChI: InChI=1S/C19H28O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h11-14,17,20H,3-10H2,1-2H3/t11-,12-,13+,14+,17-,18+,19+/m1/s1

描述信息

11-Ketoetiocholanolone is an endogenous anabolic androgenic steroid. The concentration ratio of 11-hydroxyetiocholanolone/11-hydroxyandrosterone is increased in patients with uterine leiomyomas, and it appears to be caused by a decrease in patients metabolite of steroids. The concentration of 11-Ketoetiocholanolone is significantly higher in these patients. There is a relationship between urinary endogenous steroid metabolites and lower urinary tract function related to the residual vol. in uroflowmetry in postmenopausal women. (PMID: 15808004, 14698830, 12728469) [HMDB]
11-Ketoetiocholanolone is an endogenous anabolic androgenic steroid. The concentration ratio of 11-hydroxyetiocholanolone/11-hydroxyandrosterone is increased in patients with uterine leiomyomas, and it appears to be caused by a decrease in patients metabolite of steroids. The concentration of 11-Ketoetiocholanolone is significantly higher in these patients. There is a relationship between urinary endogenous steroid metabolites and lower urinary tract function related to the residual volume in uroflowmetry in postmenopausal women. (PMID: 15808004, 14698830, 12728469).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

14 个代谢物同义名

(1S,2S,5R,7R,10S,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-14,17-dione; (3alpha,5beta)-3-Hydroxy-androstane-11,17-dione; 3alpha-hydroxy-5beta-androstane-11,17-dione; 3alpha-Hydroxy-11,17-dioxo-5beta-androstane; 5beta-Androstan-3alpha-ol-11,17-dione; 3Α-hydroxy-5β-androstane-11,17-dione; 3a-Hydroxy-5b-androstane-11,17-dione; 3-Hydroxyandrostane-11,17-dione; 11-Oxo etiocholanolone; 11-Ketoetiocholanolone; 11-Oxoaetiocholanolone; 11-Oxoetiocholanolone; 11-O-ETIO; 11-Ketoetiocholanolone



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1D1, ALB, CST3, EGFR, ERC1, NOL3, POMC, SAMD4A
Peripheral membrane protein 1 ERC1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 EGFR, GUCY2C, SRD5A1, SRD5A2
Nucleus 3 ACR, ALB, EGFR
cytosol 4 AKR1D1, ALB, NOL3, SAMD4A
dendrite 1 SAMD4A
centrosome 2 ALB, ERC1
Cell membrane 2 EGFR, GUCY2C
Lipid-anchor 1 NOL3
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 SRD5A1, SRD5A2
Golgi apparatus membrane 1 ERC1
Synapse 2 ERC1, SAMD4A
cell junction 2 EGFR, SAMD4A
cell surface 1 EGFR
glutamatergic synapse 1 EGFR
Golgi apparatus 2 ALB, CST3
Golgi membrane 2 EGFR, ERC1
neuronal cell body 2 SRD5A1, SRD5A2
presynaptic membrane 1 ERC1
Presynapse 1 ERC1
endosome 1 EGFR
plasma membrane 3 CST3, EGFR, GUCY2C
Membrane 4 EGFR, ERC1, NOL3, SRD5A1
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 2 ALB, CST3
endoplasmic reticulum 2 ALB, CST3
extracellular space 4 ALB, CST3, EGFR, POMC
perinuclear region of cytoplasm 2 EGFR, SRD5A1
mitochondrion 2 BCO2, NOL3
protein-containing complex 3 ACR, ALB, EGFR
Single-pass type I membrane protein 2 EGFR, GUCY2C
Secreted 3 ALB, CST3, POMC
extracellular region 4 ACR, ALB, CST3, POMC
mitochondrial matrix 1 BCO2
anchoring junction 2 ALB, ERC1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 ERC1
nuclear membrane 1 EGFR
nucleolus 1 NOL3
sarcoplasm 1 NOL3
P-body 1 SAMD4A
Golgi-associated vesicle 1 ACR
vesicle 1 CST3
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton 1 ERC1
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 NOL3
secretory granule 1 POMC
receptor complex 1 EGFR
ciliary basal body 2 ALB, ERC1
cytoskeleton 1 ERC1
Cell projection, podosome 1 ERC1
podosome 1 ERC1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
fibrillar center 1 SAMD4A
Endomembrane system 1 ERC1
cell body fiber 2 SRD5A1, SRD5A2
Cell projection, dendrite 1 SAMD4A
Presynaptic cell membrane 1 ERC1
basal plasma membrane 1 EGFR
[Isoform 3]: Cytoplasm 1 NOL3
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CST3
secretory granule lumen 1 POMC
endoplasmic reticulum lumen 2 ALB, CST3
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 CST3
[Isoform 2]: Cytoplasm 1 NOL3
IkappaB kinase complex 1 ERC1
clathrin-coated endocytic vesicle membrane 1 EGFR
cytoskeleton of presynaptic active zone 1 ERC1
Synapse, synaptosome 1 SAMD4A
[Isoform 1]: Nucleus, nucleolus 1 NOL3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
acrosomal matrix 1 ACR
ciliary transition fiber 1 ALB


文献列表

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  • Lance Brooker, Maria Kristina Parr, Adam Cawley, Ulrich Flenker, Christopher Howe, Rymantas Kazlauskas, Wilhelm Schänzer, Adrian George. Development of criteria for the detection of adrenosterone administration by gas chromatography-mass spectrometry and gas chromatography-combustion-isotope ratio mass spectrometry for doping control. Drug testing and analysis. 2009 Nov; 1(11-12):587-95. doi: 10.1002/dta.108. [PMID: 20355175]
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