Metoprolol (BioDeep_00000002568)

 

Secondary id: BioDeep_00000229728, BioDeep_00000397476

human metabolite blood metabolite


代谢物信息卡片


1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol

化学式: C15H25NO3 (267.1834)
中文名称: 1-[4-(2-甲氧基乙基)苯氧基]-3-丙-2-基氨基丙-2-醇, 美托洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 9.55%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=C(C=C1)CCOC)O
InChI: InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3

描述信息

Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); A selective adrenergic beta-1-blocking agent with no stimulatory action. Its binding to plasma albumin is weaker than alprenolol and it may be useful in the treatment of several diseases of the cardiovascular system; Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA); Seleken or Selokeen (elsewhere); as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG; A selective adrenergic beta-1-blocking agent with no stimulatory action. Its binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias; as Minax by Alphapharm (in Australia), as Betaloc by AstraZeneca and as Corvitol by Berlin-Chemie AG.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties[1][2][3].

同义名列表

40 个代谢物同义名

1-[4-(2-methoxyethyl)phenoxy]-3-[(propan-2-yl)amino]propan-2-ol; 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol; Succinate, metoprolol; Tartrate, metoprolol; Metoprolol succinate; Metoprolol Tartrate; CR-XL, Metoprolol; Metoprolol CR XL; Metoprolol CR-XL; (+/-)-metoprolol; (RS)-Metoprolol; DL-Metoprolol; Betaloc-astra; Betaloc astra; Beloc-duriles; Beloc duriles; Metoprololum; Lopresoretic; BetalocAstra; BelocDuriles; Meijoprolol; metoprolol; Metohexal; Lopressor; Beatrolol; Toprol XL; Toprol-XL; Presolol; Lopresor; ToprolXL; Spesicor; Spesikor; Betaloc; Betalok; Seroken; Seloken; Preblok; Toprol; Metoprolol; Metoprolol



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, AKT1, ALB, AXIN2, CASP3, CYP3A4, PTGS2
Peripheral membrane protein 2 CYP1B1, PTGS2
Endosome membrane 1 ADRB2
Endoplasmic reticulum membrane 3 CYP1B1, CYP3A4, PTGS2
Nucleus 5 ADRB2, AKT1, ALB, AXIN2, CASP3
cytosol 4 AKT1, ALB, AXIN2, CASP3
centrosome 2 ALB, AXIN2
nucleoplasm 2 AKT1, CASP3
Cell membrane 6 ACE, ADRB1, ADRB2, ADRB3, AGTR2, AKT1
lamellipodium 1 AKT1
Multi-pass membrane protein 5 ADRB1, ADRB2, ADRB3, AGTR2, RYR2
cell cortex 1 AKT1
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ADRB2, ALB
Golgi membrane 1 INS
neuronal cell body 1 CASP3
postsynapse 1 AKT1
sarcolemma 1 RYR2
smooth endoplasmic reticulum 1 RYR2
Lysosome 2 ACE, ADRB2
endosome 2 ACE, ADRB2
plasma membrane 11 ACE, ADRB1, ADRB2, ADRB3, AGTR2, AKT1, AXIN2, EDNRA, GCG, REN, RYR2
Membrane 7 ACE, ADRB2, AKT1, CYP1B1, CYP3A4, REN, RYR2
apical plasma membrane 1 ADRB2
caveola 1 PTGS2
extracellular exosome 2 ACE, ALB
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 8 ACE, ALB, CRP, GCG, IL10, IL6, INS, REN
Schaffer collateral - CA1 synapse 1 ADRB1
mitochondrion 1 CYP1B1
protein-containing complex 4 AKT1, ALB, PTGS2, RYR2
intracellular membrane-bounded organelle 2 CYP1B1, CYP3A4
Microsome membrane 3 CYP1B1, CYP3A4, PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE
Secreted 8 ACE, ALB, CRP, GCG, IL10, IL6, INS, REN
extracellular region 8 ACE, ALB, CRP, GCG, IL10, IL6, INS, REN
anchoring junction 1 ALB
external side of plasma membrane 1 ACE
Z disc 1 RYR2
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
Early endosome 2 ADRB1, ADRB2
apical part of cell 1 REN
cell-cell junction 1 AKT1
vesicle 1 AKT1
spindle 1 AKT1
sarcoplasmic reticulum 1 RYR2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 ADRB2, ADRB3
neuron projection 1 PTGS2
ciliary basal body 2 AKT1, ALB
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
endosome lumen 1 INS
basal plasma membrane 1 ACE
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 5 ALB, GCG, IL6, INS, PTGS2
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Sarcoplasmic reticulum membrane 1 RYR2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 ADRB1, ADRB2
clathrin-coated endocytic vesicle membrane 1 ADRB2
calcium channel complex 1 RYR2
junctional sarcoplasmic reticulum membrane 1 RYR2
death-inducing signaling complex 1 CASP3
[Glucagon-like peptide 1]: Secreted 1 GCG
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB


文献列表

  • Florence Nantaba, John Wasswa, Henrik Kylin, Hindrik Bouwman, Wolf-Ulrich Palm, Klaus Kümmerer. Spatial trends and ecotoxic risk assessment of selected pharmaceuticals in sediments from Lake Victoria, Uganda, East Africa. The Science of the total environment. 2023 Sep; 906(?):167348. doi: 10.1016/j.scitotenv.2023.167348. [PMID: 37769731]
  • Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis. The Cochrane database of systematic reviews. 2023 Aug; 8(?):CD013573. doi: 10.1002/14651858.cd013573.pub2. [PMID: 37565307]
  • Pradeep Kumkar, Chandani R Verma, Štěpán Hýsek, Manoj Pise, Sonia Źółtowska, Sachin M Gosavi, Filip Mercl, Matěj Božik, Lukáš Praus, Kateřina Hanková, Radek Rinn, Pavel Klouček, Miloslav Petrtýl, Lukáš Kalous. Contaminants and their ecological risk assessment in beach sediments and water along the Maharashtra coast of India: A comprehensive approach using microplastics, heavy metal(loid)s, pharmaceuticals, personal care products and plasticizers. The Science of the total environment. 2023 Jun; ?(?):164712. doi: 10.1016/j.scitotenv.2023.164712. [PMID: 37301381]
  • Hasan Karkoosh, Meththika Vithanage, Ajit K Sarmah. The role of anthocyanin and kaolinite in modifying cabbage leaves biochar for removal of potentially toxic elements and pharmaceutical from aqueous solution. Environmental pollution (Barking, Essex : 1987). 2023 May; 325(?):121435. doi: 10.1016/j.envpol.2023.121435. [PMID: 36924915]
  • Ming Yi, Jinxiu Lou, Wanlu Zhu, Dan Li, Pingfeng Yu, Huijie Lu. Mechanism of β-blocker biodegradation by wastewater microorganisms. Journal of hazardous materials. 2023 02; 444(Pt A):130338. doi: 10.1016/j.jhazmat.2022.130338. [PMID: 36417780]
  • Yang-Yang Shi, Bo Wei, Jing Zhou, Zhi-Li Yin, Fei Zhao, Ya-Jie Peng, Qing-Wen Yu, Xin-Lu Wang, Ya-Jing Chen. Discovery of 5-(3,4-dihydroxybenzylidene)-1,3-dimethylpyrimidine- 2,4,6(1H,3H,5H)-trione as a novel and effective cardioprotective agent via dual anti-inflammatory and anti-oxidative activities. European journal of medicinal chemistry. 2022 Dec; 244(?):114848. doi: 10.1016/j.ejmech.2022.114848. [PMID: 36274277]
  • Hui-Lin Yang, Ying Li, Yi Chen, Si-Ying Chen, Yue-Ting Li, Yong Huang, Lin Zheng, Jing Huang, Yong-Lin Wang, Zi-Peng Gong. [Effect of Laportea bulbifera extract on CYP450 enzyme activities in rats by Cocktail probe drug method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Dec; 47(23):6320-6332. doi: 10.19540/j.cnki.cjcmm.20220623.204. [PMID: 36604876]
  • Urs Duthaler, Fabio Bachmann, Claudia Suenderhauf, Tanja Grandinetti, Florian Pfefferkorn, Manuel Haschke, Petr Hruz, Jamal Bouitbir, Stephan Krähenbühl. Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently. Clinical pharmacokinetics. 2022 07; 61(7):1039-1055. doi: 10.1007/s40262-022-01119-0. [PMID: 35570253]
  • M Mukkanti Eswarudu, A Lakshmana Rao, K Vijay. Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma. Journal of pharmacological and toxicological methods. 2022 Jul; 116(?):107186. doi: 10.1016/j.vascn.2022.107186. [PMID: 35644433]
  • Elnaz Marzi Khosrowshahi, Behnaz Limuie Khosrowshahi, Mir Ali Farajzadeh, Abolghasem Jouyban, Mustafa Tuzen, Mohammad Reza Afshar Mogaddam, Mahboob Nemati. Application of microcrystalline cellulose as an efficient and cheap sorbent for the extraction of metoprolol from plasma and wastewater before HPLC-MS/MS determination. Biomedical chromatography : BMC. 2022 Jul; 36(7):e5371. doi: 10.1002/bmc.5371. [PMID: 35305038]
  • Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury. Drug and chemical toxicology. 2022 Jul; 45(4):1558-1564. doi: 10.1080/01480545.2020.1846551. [PMID: 33198524]
  • Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Masashi Inagaki, Keita Saku, Masaru Sugimachi. Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction. The journal of physiological sciences : JPS. 2022 Jun; 72(1):12. doi: 10.1186/s12576-022-00836-2. [PMID: 35725377]
  • Xiaonan Li, Gang Xing, Xinxin Guo, Yang Wang, Zixia Hu, Maosheng Cheng, Ying Peng, Jiang Zheng. Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity. Chemical research in toxicology. 2022 Jun; 35(6):1059-1069. doi: 10.1021/acs.chemrestox.2c00052. [PMID: 35575346]
  • Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity. Journal of hazardous materials. 2022 05; 430(?):128499. doi: 10.1016/j.jhazmat.2022.128499. [PMID: 35739679]
  • Maxime Meloche, Grégoire Leclair, Martin Jutras, Essaïd Oussaïd, Marie-Josée Gaulin, Ian Mongrain, David Busseuil, Jean-Claude Tardif, Marie-Pierre Dubé, Simon de Denus. Leveraging large observational studies to discover genetic determinants of drug concentrations: A proof-of-concept study. Clinical and translational science. 2022 04; 15(4):1063-1073. doi: 10.1111/cts.13230. [PMID: 35122397]
  • Rabiha Salam, Syeda Nayyab Batool Rizvi, Naqi Hussain, Shama Firdous, Muhammad Zaheer, Muhammad Naeem. Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model. Xenobiotica; the fate of foreign compounds in biological systems. 2022 Mar; 52(3):295-300. doi: 10.1080/00498254.2022.2067507. [PMID: 35443873]
  • Daniela Luethy, Mary A Robinson, Darko Stefanovski, Joanne Haughan, Catherine Torcivia, Alycia Kowalski, Matthew Ford, Youwen You, Jaclyn Missanelli, Joann Slack. Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses. Journal of veterinary pharmacology and therapeutics. 2022 Mar; 45(2):177-187. doi: 10.1111/jvp.13037. [PMID: 34913168]
  • Jing Wang, Chong Li, Peng Li. A Small Footprint and Robust Interface for Solid Phase Microextraction and Mass Spectrometry Based on Vibrating Sharp-Edge Spray Ionization. Journal of the American Society for Mass Spectrometry. 2022 Feb; 33(2):304-314. doi: 10.1021/jasms.1c00305. [PMID: 35040644]
  • Xinping Chen, Shengmiao Fu, Weihua Xu. Association Between Metoprolol and Prognosis of COVID-19 Patients. Journal of the American College of Cardiology. 2022 01; 79(1):e7. doi: 10.1016/j.jacc.2021.09.1383. [PMID: 34991794]
  • Arnoldo Santos, Juan Martínez-Milla, César Pérez-Calvo, Borja Ibáñez. Reply: Biological Plausibility Behind the Benefits of Intravenous Metoprolol in Severe COVID-19. Journal of the American College of Cardiology. 2022 01; 79(1):e13-e14. doi: 10.1016/j.jacc.2021.10.030. [PMID: 34991793]
  • Zhongbo Shi, Junhao Jiang, Dezhang Zhao, Baogang Xie, Yan Li, Chao Yu. Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism. Current drug metabolism. 2022; 23(2):131-136. doi: 10.2174/1389200223666220128143133. [PMID: 35088663]
  • Yingyi Lu, Fenglian Wang, Haoxuan Ni, Ying Sun, Hailing Shi. Observation of Curative Effect of Trimetazidine Combined with Metoprolol in Elderly Patients with Coronary Heart Disease Complicated with Heart Failure and the Effect of Myocardial Remodeling by Integrated Traditional Chinese and Western Medicine. BioMed research international. 2022; 2022(?):6098799. doi: 10.1155/2022/6098799. [PMID: 36246960]
  • Li Ye, Guofen Hu, Huamin Yu, Jindong Sun, Hong Yuan. Metoprolol Improves Myocardial Remodeling and Cardiac Function in Patients with Permanent Pacemaker Implantation. Journal of healthcare engineering. 2022; 2022(?):7340992. doi: 10.1155/2022/7340992. [PMID: 35449861]
  • Chunyu Liu, Jing Xu, Ran Liu, Miye Wang, Yixuan Zhuo, Lan Su, Hongmei Yan, Qing Zhang. Identifying drug-related attributes to personalise antihypertensive agents: the outcome report of patients receiving metoprolol therapy. BMC medical informatics and decision making. 2021 12; 21(1):370. doi: 10.1186/s12911-021-01739-9. [PMID: 34969399]
  • Cheng Chen, Jiao Tian, Zhicheng He, Wenyong Xiong, Yingying He, Shubai Liu. Identified Three Interferon Induced Proteins as Novel Biomarkers of Human Ischemic Cardiomyopathy. International journal of molecular sciences. 2021 Dec; 22(23):. doi: 10.3390/ijms222313116. [PMID: 34884921]
  • Cristina Almengló, Marinela Couselo-Seijas, Rosa M Agra, Alfonso Varela-Román, José M García-Acuña, Mercedes González-Peteiro, José R González-Juanatey, Sonia Eiras, Ezequiel Álvarez. Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value. Journal of molecular medicine (Berlin, Germany). 2021 12; 99(12):1741-1753. doi: 10.1007/s00109-021-02129-4. [PMID: 34529122]
  • Fabio Bachmann, Urs Duthaler, Stephan Krähenbühl. Effect of deglucuronidation on the results of the Basel phenotyping cocktail. British journal of clinical pharmacology. 2021 12; 87(12):4608-4618. doi: 10.1111/bcp.14874. [PMID: 33890704]
  • Maxime Meloche, Martin Jutras, Isabelle St-Jean, Simon de Denus, Grégoire Leclair. Isocyanate derivatization coupled with phospholipid removal microelution-solid phase extraction for the simultaneous quantification of (S)-metoprolol and (S)-α-hydroxymetoprolol in human plasma with LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 204(?):114263. doi: 10.1016/j.jpba.2021.114263. [PMID: 34274593]
  • Agustín Clemente-Moragón, Juan Martínez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernández, Lorena Rodríguez-González, Cristina Serrano Del Castillo, Ana-María Ioan, María López-Álvarez, Sandra Gómez-Talavera, Carlos Galán-Arriola, Valentín Fuster, César Pérez-Calvo, Borja Ibáñez. Metoprolol in Critically Ill Patients With COVID-19. Journal of the American College of Cardiology. 2021 09; 78(10):1001-1011. doi: 10.1016/j.jacc.2021.07.003. [PMID: 34474731]
  • Liqun Zhang, Jimusi Wuri, Lulu An, Xiaoxuan Liu, Ye Wu, Haotian Hu, Ruixia Wu, Yue Su, Quan Yuan, Tao Yan. Metoprolol attenuates intracerebral hemorrhage-induced cardiac damage by suppression of sympathetic overactivity in mice. Autonomic neuroscience : basic & clinical. 2021 09; 234(?):102832. doi: 10.1016/j.autneu.2021.102832. [PMID: 34126326]
  • Yuan-Yuan Wang, Zhen-Hui Han, Yu-Li Wang, Ying Liao, Chun-Yu Zhang, Ping Liu, Chao-Shu Tang, Jun-Bao Du, Hong-Fang Jin, Ya-Qian Huang. Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy. Chinese medical journal. 2021 08; 134(16):1977-1982. doi: 10.1097/cm9.0000000000001698. [PMID: 34387611]
  • Ravindra Babu Pingili, Sridhar Vemulapalli, Vijaya R Dirisala, Surya Sandeep Mullapudi, Yamini Gullapalli, Naveen Babu Kilaru. Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Aug; 51(8):926-932. doi: 10.1080/00498254.2021.1942311. [PMID: 34138683]
  • Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis. Bioanalysis. 2021 Jul; 13(14):1101-1111. doi: 10.4155/bio-2021-0109. [PMID: 34275331]
  • Shameen Salam, Brandon Nornhold, Jihad Mallat. Massive metoprolol overdose requiring ECMO: brief review of the evidence behind recommended treatments. BMJ case reports. 2021 May; 14(5):. doi: 10.1136/bcr-2019-232130. [PMID: 33952561]
  • Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):704-712. doi: 10.1053/j.ajkd.2020.07.023. [PMID: 33010357]
  • Ning Li, Shujuan He, Chunlan Li, Fatang Yang, Yuming Dong. Sensitive Analysis of Metoprolol Tartrate and Diltiazem Hydrochloride in Human Serum by Capillary Zone Electrophoresis Combining on Column Field-Amplified Sample Injection. Journal of chromatographic science. 2021 Apr; 59(5):465-472. doi: 10.1093/chromsci/bmab025. [PMID: 33675354]
  • Martin Nicol, Malha Sadoune, Evelyne Polidano, Jean Marie Launay, Jane Lise Samuel, Feriel Azibani, Alain Cohen-Solal. Doxorubicin-induced and trastuzumab-induced cardiotoxicity in mice is not prevented by metoprolol. ESC heart failure. 2021 04; 8(2):928-937. doi: 10.1002/ehf2.13198. [PMID: 33529501]
  • Shanjun Tan, Feng Zhou, Zhige Zhang, Junjie Wang, Jiahao Xu, Qiulin Zhuang, Qingyang Meng, Qiulei Xi, Yi Jiang, Guohao Wu. Beta-1 blocker reduces inflammation and preserves intestinal barrier function after open abdominal surgery. Surgery. 2021 04; 169(4):885-893. doi: 10.1016/j.surg.2020.11.004. [PMID: 33303271]
  • John Mach, XiaoSuo Wang, Sarah N Hilmer. Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy. Fundamental & clinical pharmacology. 2021 Apr; 35(2):410-422. doi: 10.1111/fcp.12602. [PMID: 32813878]
  • Katarzyna Markiewicz, Anna Białk-Bielińska, Paulina Łukaszewicz, Piotr Stepnowski, Joanna Dołżonek. Insight into the Sorption of 5-Fluorouracil and Methotrexate onto Soil-pH, Ionic Strength, and Co-Contaminant Influence. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061674. [PMID: 33802784]
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