Amiodarone (BioDeep_00000002390)

 

Secondary id: BioDeep_00000405755

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


{2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine

化学式: C25H29I2NO3 (645.0236864)
中文名称: 胺碘酮
谱图信息: 最多检出来源 Homo sapiens(blood) 64.63%

分子结构信息

SMILES: CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=CC=CC=C2O1
InChI: InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3

描述信息

Amiodarone is only found in individuals that have used or taken this drug. It is an antianginal and antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting Na,K-activated myocardial adenosine triphosphatase. There is a resulting decrease in heart rate and in vascular resistance. [PubChem]The antiarrhythmic effect of amiodarone may be due to at least two major actions. It prolongs the myocardial cell-action potential (phase 3) duration and refractory period and acts as a noncompetitive a- and b-adrenergic inhibitor.
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9504; ORIGINAL_PRECURSOR_SCAN_NO 9502
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9437; ORIGINAL_PRECURSOR_SCAN_NO 9432
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9523; ORIGINAL_PRECURSOR_SCAN_NO 9522
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9470; ORIGINAL_PRECURSOR_SCAN_NO 9468
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9458; ORIGINAL_PRECURSOR_SCAN_NO 9457
CONFIDENCE standard compound; INTERNAL_ID 378; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9497; ORIGINAL_PRECURSOR_SCAN_NO 9495
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065688 - Cytochrome P-450 CYP2C9 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065690 - Cytochrome P-450 CYP2D6 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3067
CONFIDENCE standard compound; INTERNAL_ID 2733
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

37 个代谢物同义名

{2-[4-(2-butyl-1-benzofuran-3-carbonyl)-2,6-diiodophenoxy]ethyl}diethylamine; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-N-Butyl-3,5-diiodo-4-N-diethylaminoethoxy-3-benzoylbenzofuran; Berenguer infale brand OF amiodarone hydrochloride; Sanofi winthrop brand OF amiodarone hydrochloride; Pharma investi brand OF amiodarone hydrochloride; ASTA medica brand OF amiodarone hydrochloride; Alphapharm brand OF amiodarone hydrochloride; Armstrong brand OF amiodarone hydrochloride; Betapharm brand OF amiodarone hydrochloride; Leurquin brand OF amiodarone hydrochloride; Hexal brand OF amiodarone hydrochloride; g Gam brand OF amiodarone hydrochloride; Wyeth brand OF amiodarone hydrochloride; Hydrochloride, amiodarone; Amiodarone hydrochloride; Amiodarone base; SKF 33134 a; SKF 33134-a; Amiodaronum; Tachydaron; Amiodarona; amiodarone; Rytmarone; Corbionax; Amiohexal; Ortacrone; Trangorex; Cordarone; Amiodarex; Kordaron; Amiobeta; Cordarex; Braxan; Aratac; Amiodarone



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Asia Saorin, Gloria Saorin, Fahriye Duzagac, Pietro Parisse, Ni Cao, Giuseppe Corona, Enrico Cavarzerani, Flavio Rizzolio. Microfluidic production of amiodarone loaded nanoparticles and application in drug repositioning in ovarian cancer. Scientific reports. 2024 03; 14(1):6280. doi: 10.1038/s41598-024-55801-3. [PMID: 38491077]
  • Dejan Petrović, Marina Deljanin Ilić, Dejan Simonović, Milovan Stojanović, Milica Stanković, Slaviša Stanišić, Sanja Stojanović, Nebojša Arsić, Dušan T Sokolović. The role of melatonin in preventing amiodarone-induced rat liver damage. Canadian journal of physiology and pharmacology. 2023 Dec; ?(?):. doi: 10.1139/cjpp-2023-0253. [PMID: 38079620]
  • Ismet Burcu Turkyilmaz. Oxidative Brain Injury Induced by Amiodarone in Rats: Protective Effect of S-methyl Methionine Sulfonium Chloride. Acta chimica Slovenica. 2023 Mar; 70(1):131-138. doi: 10.17344/acsi.2022.7899. [PMID: 37005613]
  • Jessica Venugopal, Jintao Wang, Chiao Guo, Daniel T Eitzman. Amiodarone improves anemia in a murine model of sickle cell disease and is associated with increased erythrocyte bis(monoacylglycerol) phosphate. Scientific reports. 2022 09; 12(1):16437. doi: 10.1038/s41598-022-20955-5. [PMID: 36180774]
  • Shunta Akutsu, Yasuaki Mino, Takafumi Naito, Kohei Hoshikawa, Masao Saotome, Yuichiro Maekawa, Junichi Kawakami. Stereoselective interaction of tolvaptan with amiodarone under racemic metabolic impact by CYP3A5 genotypes in heart failure patients. European journal of clinical pharmacology. 2022 Aug; 78(8):1311-1320. doi: 10.1007/s00228-022-03341-y. [PMID: 35604424]
  • Mohamed Samir Ahmed Zaki, Attalla F El-Kott, Hussah I M AlGwaiz, Shehata F Shehata, Muhammad Alaa Eldeen, Mohamed Andarawi, Refaat A Eid, Eman M Abd-Ella. The possible effects of α-tocopherol against amiodarone-treated lungs in rats: vimentin detection, lipid peroxidation assay, and histological and ultrastructural evaluations. Environmental science and pollution research international. 2022 Aug; 29(38):58231-58239. doi: 10.1007/s11356-022-19883-8. [PMID: 35366726]
  • Pin-Hsu Liao, Yu-Cheng Cheng, Po-Yu Liu, I-Te Lee. Primary hypothyroidism with an episode of ventricular tachycardia in a patient with COVID-19: A case report. Medicine. 2022 Jun; 101(25):e29243. doi: 10.1097/md.0000000000029243. [PMID: 35758352]
  • Mate Vamos, Jonas Oldgren, Gi-Byoung Nam, Gregory Y H Lip, Hugh Calkins, Jun Zhu, Kwo-Chang Ueng, Ulf Ludwigs, Mattias Wieloch, John Stewart, Stefan H Hohnloser. Dronedarone vs. placebo in patients with atrial fibrillation or atrial flutter across a range of renal function: a post hoc analysis of the ATHENA trial. European heart journal. Cardiovascular pharmacotherapy. 2022 Jun; 8(4):363-371. doi: 10.1093/ehjcvp/pvab090. [PMID: 34958366]
  • Daniele Cappellani, Liborio Torregrossa, Piermarco Papini, Anello Marcello Poma, Enrico Ambrosini, Luigi De Napoli, Gabriele Materazzi, Fulvio Basolo, Fausto Bogazzi. Salvage total thyroidectomy for amiodarone-induced thyrotoxicosis in a SARS-CoV-2 positive patient: results of the viral genome research on the pathology sample of this destructive thyroiditis. Endocrine. 2022 05; 76(2):495-498. doi: 10.1007/s12020-022-03028-5. [PMID: 35278173]
  • Beata Ceynowa-Sielawko, Maciej T Wybraniec, Aleksandra Topp-Zielińska, Aleksander Maciąg, Dawid Miśkowiec, Paweł Balsam, Maciej Wójcik, Wojciech Wróbel, Michał M Farkowski, Edyta Ćwiek-Rębowska, Krzysztof Ozierański, Robert Błaszczyk, Karolina Bula, Tomasz Dembowski, Michał Peller, Bartosz Krzowski, Wojciech Wańha, Marek Koziński, Jarosław D Kasprzak, Hanna Szwed, Katarzyna Mizia-Stec, Marek Szołkiewicz. Pharmacological Cardioversion in Patients with Recent-Onset Atrial Fibrillation and Chronic Kidney Disease Subanalysis of the CANT II Study. International journal of environmental research and public health. 2022 04; 19(8):. doi: 10.3390/ijerph19084880. [PMID: 35457747]
  • Kamran Banan, Fatemeh Ghorbani-Bidkorbeh, Hanif Afsharara, Dara Hatamabadi, Behnaz Landi, Rüstem Keçili, Börje Sellergren. Nano-sized magnetic core-shell and bulk molecularly imprinted polymers for selective extraction of amiodarone from human plasma. Analytica chimica acta. 2022 Mar; 1198(?):339548. doi: 10.1016/j.aca.2022.339548. [PMID: 35190133]
  • Naoaki Hashimoto, Kosuke Doki, Satoru Kawano, Kazutaka Aonuma, Masaki Ieda, Masato Homma. Increased serum amiodarone concentration in hypertriglyceridemic patients: Effects of drug distribution to serum lipoproteins. Clinical and translational science. 2022 03; 15(3):771-781. doi: 10.1111/cts.13199. [PMID: 34786846]
  • Ashit Trivedi, Winnie Sohn, Cheng-Pang Hsu, Pegah Jafarinasabian, Hanze Zhang, Shauna Hutton, Stephen Flach, Siddique Abbasi, Sandeep Dutta, Edward Lee. Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Amiodarone and Digoxin in Healthy Subjects. Clinical pharmacology in drug development. 2022 03; 11(3):388-396. doi: 10.1002/cpdd.1028. [PMID: 34634185]
  • Inas A Harb, Hend Ashour, Abeer Mostafa, Hala M El Hanbuli, Eman Hassan Nadwa. Cardioprotective effects of amiodarone in a rat model of epilepsy-induced cardiac dysfunction. Clinical and experimental pharmacology & physiology. 2022 03; 49(3):406-418. doi: 10.1111/1440-1681.13615. [PMID: 34796981]
  • Toshinori Hirai, Hidefumi Kasai, Miyoko Naganuma, Nobuhisa Hagiwara, Tsuyoshi Shiga. Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data. BMC pharmacology & toxicology. 2022 02; 23(1):14. doi: 10.1186/s40360-022-00552-y. [PMID: 35144695]
  • Chia Siang Kow, Syed Shahzad Hasan. Amiodarone in COVID-19: let's not forget its potential for pulmonary toxicity. European journal of preventive cardiology. 2022 02; 28(18):e52. doi: 10.1093/eurjpc/zwaa086. [PMID: 33624070]
  • Hong Wei, Albert P Li. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone. Drug metabolism and disposition: the biological fate of chemicals. 2022 02; 50(2):140-149. doi: 10.1124/dmd.121.000645. [PMID: 34750194]
  • Takuto Torimitsu, Tadashi Yoshida, Satomi Nishi, Hiroshi Itoh, Mototsugu Oya. Amiodarone-induced multiple organ damage in an Alström syndrome patient with end-stage renal disease and hepatic cirrhosis. CEN case reports. 2022 02; 11(1):11-16. doi: 10.1007/s13730-021-00621-x. [PMID: 34227055]
  • Munveer Thind, Wojciech Zareba, Dan Atar, Harry J G M Crijns, Jun Zhu, Hui-Nam Pak, James Reiffel, Ulf Ludwigs, Mattias Wieloch, John Stewart, Peter Kowey. Efficacy and safety of dronedarone versus placebo in patients with atrial fibrillation stratified according to renal function: Post hoc analyses of the EURIDIS-ADONIS trials. Clinical cardiology. 2022 Jan; 45(1):101-109. doi: 10.1002/clc.23765. [PMID: 35019175]
  • Munveer Thind, David S McKindley, James A Reiffel, Gerald V Naccarelli, John Stewart, Peter R Kowey. Predictors of dronedarone plasma drug concentrations and effect on atrial fibrillation/atrial flutter recurrence: Analyses from the EURIDIS and ADONIS studies. Clinical cardiology. 2022 Jan; 45(1):119-128. doi: 10.1002/clc.23768. [PMID: 35032136]
  • Abhishek Chaturvedi, Fadi Khoury, Kirtivardhan Vashistha, Kinjalben Patel, Patricia Mareda, Tara Veasey, Christopher Link, Amresh Raina. Incidence of Post-Heart Transplant Chronic Thyroiditis and Its Association With Pretransplant Amiodarone Use. Transplantation proceedings. 2021 Dec; 53(10):3045-3050. doi: 10.1016/j.transproceed.2021.09.014. [PMID: 34728077]
  • Kenji Yahata, Hajime Mizuno, Eiji Sugiyama, Kenichiro Todoroki. Analysis of the intracellular localization of amiodarone using live single-cell mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 Oct; 205(?):114318. doi: 10.1016/j.jpba.2021.114318. [PMID: 34418674]
  • Alberto Aimo, Aldo Baritussio, Michele Emdin, Carlo Tascini. Amiodarone as a possible therapy for coronavirus infection. European journal of preventive cardiology. 2021 10; 28(12):e16-e18. doi: NULL. [PMID: 32295404]
  • Daniele Cappellani, Giuseppina De Marco, Eleonora Ferrarini, Liborio Torregrossa, Agostino Maria Di Certo, Giada Cosentino, Claudio Urbani, Giulia Marconcini, Alessandro Mattiello, Luca Manetti, Patrizia Agretti, Fulvio Basolo, Massimo Tonacchera, Luigi Bartalena, Fausto Bogazzi. Identification of Two Different Phenotypes of Patients with Amiodarone-Induced Thyrotoxicosis and Positive Thyrotropin Receptor Antibody Tests. Thyroid : official journal of the American Thyroid Association. 2021 10; 31(10):1463-1471. doi: 10.1089/thy.2021.0118. [PMID: 34271828]
  • Einav Hubel, Sigal Fishman, Minna Holopainen, Reijo Käkelä, Ortal Shaffer, Inbal Houri, Isabel Zvibel, Oren Shibolet. Repetitive amiodarone administration causes liver damage via adipose tissue ER stress-dependent lipolysis, leading to hepatotoxic free fatty acid accumulation. American journal of physiology. Gastrointestinal and liver physiology. 2021 09; 321(3):G298-G307. doi: 10.1152/ajpgi.00458.2020. [PMID: 34259586]
  • Ghadha Ibrahim Fouad, Mohamed R Mousa. The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats. Molecular and cellular biochemistry. 2021 Sep; 476(9):3433-3448. doi: 10.1007/s11010-021-04173-7. [PMID: 33973131]
  • Luigi Cappannoli, Alessandro Telesca, Roberto Scacciavillani, Edoardo Petrolati, Andrea Smargiassi, Alessia Rabini, Massimo Massetti, Filippo Crea, Nadia Aspromonte. A nontrivial differential diagnosis in COVID-19 pandemic: a case report and literary review of amiodarone-induced interstitial pneumonia. Future cardiology. 2021 09; 17(6):991-997. doi: 10.2217/fca-2020-0168. [PMID: 33331164]
  • Alyaa S Abdel Halim, Hanaa H Ahmed, Hadeer A Aglan, Fatma F Abdel Hamid, Mohamed R Mohamed. Role of bone marrow-derived mesenchymal stem cells in alleviating pulmonary epithelium damage and extracellular matrix remodeling in a rat model of lung fibrosis induced by amiodarone. Biotechnic & histochemistry : official publication of the Biological Stain Commission. 2021 Aug; 96(6):418-430. doi: 10.1080/10520295.2020.1814966. [PMID: 32909452]
  • Mélanie Vasseur, Marine Tambon, Mireille Gony, Nicolas Lebrun, Haleh Bagheri. [Amiodarone or COVID induced-pneumopathy: One train can hide another one!]. Therapie. 2021 Jul; 76(4):374-377. doi: 10.1016/j.therap.2021.03.001. [PMID: 33722418]
  • Natália Kronbauer Oliveira, Luiza Abrahão Frank, Eamim Daidrê Squizani, Julia Catarina Vieira Reuwsaat, Bárbara Machado Marques, Heryk Motta, Ane Wichine Acosta Garcia, Uriel Perin Kinskovski, Vanessa Abreu Barcellos, Augusto Schrank, Adriana Raffin Pohlmann, Charley Christian Staats, Sílvia Stanisçuaski Guterres, Marilene Henning Vainstein, Lívia Kmetzsch. New nanotechnological formulation based on amiodarone-loaded lipid core nanocapsules displays anticryptococcal effect. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Jul; 162(?):105816. doi: 10.1016/j.ejps.2021.105816. [PMID: 33757827]
  • Gaetano Zizzo, Stefano Caruso, Elisabetta Ricchiuti, Roberto Turato, Ilario Stefani, Antonino Mazzone. Amiodarone-induced organizing pneumonia mimicking COVID-19: a case report. European journal of medical research. 2021 Jun; 26(1):62. doi: 10.1186/s40001-021-00522-w. [PMID: 34176493]
  • Amira Motawea, Dalia Alsaied Moustafa Ahmed, Amira Sobhy Eladl, Ahmed Abd El-Rahman El-Mansy, Noha Mohamed Saleh. Appraisal of amiodarone-loaded PLGA nanoparticles for prospective safety and toxicity in a rat model. Life sciences. 2021 Jun; 274(?):119344. doi: 10.1016/j.lfs.2021.119344. [PMID: 33716062]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Shuhei Kanagaki, Takahiro Suezawa, Keita Moriguchi, Kazuhisa Nakao, Masayasu Toyomoto, Yuki Yamamoto, Koji Murakami, Masatoshi Hagiwara, Shimpei Gotoh. Hydroxypropyl Cyclodextrin Improves Amiodarone-induced Aberrant Lipid Homeostasis of Alveolar Cells. American journal of respiratory cell and molecular biology. 2021 04; 64(4):504-514. doi: 10.1165/rcmb.2020-0119oc. [PMID: 33493427]
  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Meor Azraai, Marcus McMahon, Ronald Dick. Case report of amiodarone-associated allergic pneumonitis amidst the COVID-19 pandemic. Reviews in cardiovascular medicine. 2021 03; 22(1):181-184. doi: 10.31083/j.rcm.2021.01.267. [PMID: 33792260]
  • Huishan Wang, Yuji Zhang, Fangran Xin, Hui Jiang, Dengshun Tao, Yan Jin, Yuanchen He, Qiang Wang, Sunny S Po. Calcium-Induced Autonomic Denervation in Patients With Post-Operative Atrial Fibrillation. Journal of the American College of Cardiology. 2021 01; 77(1):57-67. doi: 10.1016/j.jacc.2020.10.049. [PMID: 33413942]
  • Refaat A Eid, Mohamed Samir Ahmed Zaki, Mubarak Al-Shraim, Muhammad Alaa Eldeen, Mohamed A Haidara. Grape seed extract protects against amiodarone - induced nephrotoxicity and ultrastructural alterations associated with the inhibition of biomarkers of inflammation and oxidative stress in rats. Ultrastructural pathology. 2021 Jan; 45(1):49-58. doi: 10.1080/01913123.2020.1864076. [PMID: 33423596]
  • Amira Motawea, Dalia Alsaied Moustafa Ahmed, Ahmed A El-Mansy, Noha Mohamed Saleh. Crucial Role of PLGA Nanoparticles in Mitigating the Amiodarone-Induced Pulmonary Toxicity. International journal of nanomedicine. 2021; 16(?):4713-4737. doi: 10.2147/ijn.s314074. [PMID: 34267519]
  • Yunes Panahi, Mojtaba Mojtahedzadeh, Atabak Najafi, Mohammadreza Gheini, Mohammad Abdollahi, Mohammad Sharifzadeh, Arezoo Ahmadi, Shiva Ganjali, Seyyed Mahdi Rajaee, George E Barreto, Amirhossein Sahebkar. Protective Effects of Intravenous Magnesium Sulfate in Stroke Patients Receiving Amiodarone: A Randomized Controlled Trial. Advances in experimental medicine and biology. 2021; 1308(?):579-588. doi: 10.1007/978-3-030-64872-5_28. [PMID: 33861459]
  • Yanhong Wang, Juanjuan Wang, Jia Yang, Jing Kang, Fuping Xue, Sijia Chang, He Ji, Haojing Zang, Xiaoshuang Zhou, Guiqin Wang, Weiping Fan, Xianyan Yan, Jinli Guo, Xiaojun Ren, Jihua Tian. Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway. Oxidative medicine and cellular longevity. 2021; 2021(?):8889408. doi: 10.1155/2021/8889408. [PMID: 34434487]
  • J Politei, J Frabasil, C Durand, S Di Pietrantonio, A Fernandez, V Albertón, D Velasquez Rivas, R Barriales-Villa, J Larrañaga-Moreira, A B Schenone. Incidental finding of cornea verticillata or lamellar inclusions in kidney biopsy: measurement of lyso-Gb3 in plasma defines between Fabry disease and drug-induced phospholipidosis. Biochimica et biophysica acta. Molecular basis of disease. 2021 01; 1867(1):165985. doi: 10.1016/j.bbadis.2020.165985. [PMID: 33022387]
  • David J Halsall, Susan Oddy. Clinical and laboratory aspects of 3,3',5'-triiodothyronine (reverse T3). Annals of clinical biochemistry. 2021 01; 58(1):29-37. doi: 10.1177/0004563220969150. [PMID: 33040575]
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