Tripelennamine (BioDeep_00000002300)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine

化学式: C16H21N3 (255.1735)
中文名称: 曲吡那敏
谱图信息: 最多检出来源 Homo sapiens(blood) 23.41%

分子结构信息

SMILES: CN(C)CCN(CC1=CC=CC=C1)C1=CC=CC=N1
InChI: InChI=1S/C16H21N3/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3

描述信息

Tripelennamine is only found in individuals that have used or taken this drug. It is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. [PubChem]Tripelennamine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents

同义名列表

18 个代谢物同义名

N-benzyl-N-[2-(dimethylamino)ethyl]pyridin-2-amine; Asid bonz brand OF tripelennamine hydrochloride; Parnell brand OF tripelennamine hydrochloride; Tripelennamine monohydrochloride; Chefaro brand OF tripelennamine; Tripelennamine hydrochloride; Tripelennamine maleate (1:1); Tripelennamine citrate (1:1); Tripelennamine maleate; Tripelennamine citrate; tripelennamine; Pyribenzamine; Vetibenzamin; Histantin; PBZ-SR; Azaron; PBZ; Tripelennamine

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:9741
KEGG: C07180
KEGGdrug: D08645
PubChem: 5587
HMDB: HMDB0014930
Metlin: METLIN44153
DrugBank: DB00792
ChEMBL: CHEMBL1241
Wikipedia: Tripelennamine
MeSH: Tripelennamine
chemspider: 5385
CAS: 6138-56-3
CAS: 91-81-6
PMhub: MS000002309
PubChem: 9389
NIKKAJI: J4.349D
RefMet: Tripelennamine
KNApSAcK: 9741

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	5	AHR, CYP2D6, PTGS1, PTGS2, TNK1
Peripheral membrane protein	4	AOC1, PTGS1, PTGS2, TNK1
Endoplasmic reticulum membrane	4	CYP2D6, DRD1, PTGS1, PTGS2
Nucleus	4	AHR, DRD1, LMNA, MPO
cytosol	2	AHR, LMNA
dendrite	1	DRD2
nucleoplasm	4	AHR, LMNA, MPO, NEO1
Cell membrane	4	AOC1, DRD1, DRD2, PTAFR
Multi-pass membrane protein	4	CACNA1I, DRD1, DRD2, PTAFR
Golgi apparatus membrane	1	DRD2
Synapse	2	DRD2, TAC1
cell surface	1	NEO1
glutamatergic synapse	3	DRD1, DRD2, NEO1
Golgi apparatus	2	NEO1, PTGS1
Golgi membrane	1	DRD2
neuronal cell body	1	TAC1
presynaptic membrane	2	DRD1, DRD2
Lysosome	1	MPO
acrosomal vesicle	1	DRD2
plasma membrane	10	AOC1, BCHE, CACNA1I, DRD1, DRD2, KNG1, NEO1, PTAFR, REN, TNK1
synaptic vesicle membrane	1	DRD2
Membrane	6	CACNA1I, CYP2D6, NEO1, PTAFR, REN, TNK1
axon	3	CCK, DRD2, TAC1
caveola	1	PTGS2
extracellular exosome	4	AOC1, KNG1, MPO, PTGS1
endoplasmic reticulum	2	CYP2D6, PTGS2
extracellular space	8	AOC1, BCHE, CCK, GAST, KNG1, MPO, REN, TAC1
perinuclear region of cytoplasm	1	LMNA
bicellular tight junction	1	AOC1
mitochondrion	1	CYP2D6
protein-containing complex	2	AHR, PTGS2
intracellular membrane-bounded organelle	3	CYP2D6, MPO, PTGS1
Microsome membrane	3	CYP2D6, PTGS1, PTGS2
Single-pass type I membrane protein	1	NEO1
Secreted	4	BCHE, CCK, GAST, REN
extracellular region	8	AOC1, BCHE, CCK, GAST, KNG1, MPO, REN, TAC1
Single-pass membrane protein	1	CYP2D6
Extracellular side	1	AOC1
transcription regulator complex	1	AHR
ciliary membrane	2	DRD1, DRD2
photoreceptor outer segment	1	PTGS1
nuclear membrane	1	LMNA
dendritic spine	2	DRD1, DRD2
perikaryon	1	DRD2
apical part of cell	1	REN
postsynaptic membrane	2	DRD1, DRD2
GABA-ergic synapse	2	DRD1, DRD2
Peroxisome	1	AOC1
intracellular vesicle	1	NEO1
Cell projection, dendritic spine	1	DRD1
collagen-containing extracellular matrix	1	KNG1
secretory granule	1	MPO
intermediate filament	1	LMNA
lateral plasma membrane	1	DRD2
nuclear speck	1	LMNA
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
neuron projection	2	PTGS1, PTGS2
cilium	2	DRD1, DRD2
chromatin	1	AHR
axonal growth cone	1	NEO1
Secreted, extracellular space	2	AOC1, KNG1
plasma membrane protein complex	1	NEO1
blood microparticle	2	BCHE, KNG1
non-motile cilium	2	DRD1, DRD2
site of double-strand break	1	LMNA
sperm flagellum	1	DRD2
nuclear envelope	1	LMNA
Nucleus envelope	1	LMNA
Endomembrane system	1	PTGS1
aryl hydrocarbon receptor complex	1	AHR
Nucleus, nucleoplasm	1	LMNA
Cell projection, dendrite	1	DRD1
tertiary granule membrane	1	PTAFR
azurophil granule	1	MPO
secretory granule membrane	1	PTAFR
endoplasmic reticulum lumen	3	BCHE, KNG1, PTGS2
nuclear matrix	1	LMNA
platelet alpha granule lumen	1	KNG1
axon terminus	1	DRD2
voltage-gated calcium channel complex	1	CACNA1I
specific granule lumen	1	AOC1
endocytic vesicle	1	DRD2
azurophil granule lumen	1	MPO
postsynaptic density membrane	1	NEO1
Nucleus matrix	1	LMNA
nuclear envelope lumen	1	BCHE
nuclear lamina	1	LMNA
phagocytic vesicle lumen	1	MPO
dopaminergic synapse	1	DRD2
Cell projection, cilium membrane	1	DRD1
Nucleus lamina	1	LMNA
[Isoform C]: Nucleus speckle	1	LMNA
lamin filament	1	LMNA
G protein-coupled receptor complex	2	DRD1, DRD2
nuclear aryl hydrocarbon receptor complex	1	AHR
cytosolic aryl hydrocarbon receptor complex	1	AHR

文献列表

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