Cholylglycine (BioDeep_00000229687)
Main id: BioDeep_00000000126
human metabolite PANOMIX_OTCML-2023 Bile acids Antitumor activity BioNovoGene_Lab2019
代谢物信息卡片
N-(3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholan-24-oyl)-glycine
化学式: C26H43NO6 (465.309)
中文名称: 甘氨胆酸, 甘氨胆酸水合物, 甘胆酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C([H])(C4(C)1)CCC1([H])C(C(O)3)(C(CC(O)4)([H])C(C)(C([H])2C3)CCC(C2)O)[H])C)CC(=O)NCC(O)=O
InChI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways[1].
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:17687
- KEGG: C01921
- PubChem: 10140
- HMDB: HMDB00138
- ChEMBL: CHEMBL411070
- LipidMAPS: LMST05030001
- MeSH: Glycocholic Acid
- CAS: 475-31-0
- MoNA: MT000026
- PubChem: 5027
- KNApSAcK: C00030410
- PDB-CCD: GCH
- 3DMET: B04823
- NIKKAJI: J12.411G
- medchemexpress: HY-N1423
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-420
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-969
- KNApSAcK: 17687
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hamid Alghurabi, Huda Jassim Muhammad, Tatsuaki Tagami, Koki Ogawa, Tetsuya Ozeki. Optimization, cellular uptake, and in vivo evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of 5-aminosalicylic acid.
International journal of pharmaceutics.
2023 Dec; 648(?):123597. doi:
10.1016/j.ijpharm.2023.123597. [PMID: 37952559] - Yu Tang, Zhu Han, Han Zhang, Li Che, Genjie Liao, Jun Peng, Yu Lin, Yi Wang. Characterization of Calculus bovis by principal component analysis assisted qHNMR profiling to distinguish nefarious frauds.
Journal of pharmaceutical and biomedical analysis.
2023 Mar; 228(?):115320. doi:
10.1016/j.jpba.2023.115320. [PMID: 36871364] - Shibin Yao, Shengjie Ren, Chunfang Cai, Xiamin Cao, Ye Shi, Ping Wu, Yuantu Ye. Glycocholic acid supplementation improved growth performance and alleviated tissue damage in the liver and intestine in Pelteobagrus fulvidraco fed a high-pectin diet.
Fish physiology and biochemistry.
2022 Dec; ?(?):. doi:
10.1007/s10695-022-01148-3. [PMID: 36454392] - Xiaolu Zhou, Yaling Li, Ren Mu, Chuanming Wang, Yuyan Song, Caibi Zhou, Xin Mei. Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet.
The British journal of nutrition.
2022 Oct; ?(?):1-9. doi:
10.1017/s0007114522003166. [PMID: 36210537] - Jian Wu, Yanping Xu, Yubao Cui, Mariza Bortolanza, Minjie Wang, Bin Jiang, Meina Yan, Wei Liang, Yiwen Yao, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Dawei Wang, Hongcui Cao, Lanjuan Li. Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Journal of medical virology.
2022 06; 94(6):2714-2726. doi:
10.1002/jmv.27669. [PMID: 35199373] - Feiyang Deng, You Han Bae. Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3.
International journal of pharmaceutics.
2022 Apr; 617(?):121589. doi:
10.1016/j.ijpharm.2022.121589. [PMID: 35176336] - Hongxue Liu, Haidong Wang, Muling Zhang. Deep Learning Algorithm-Based Magnetic Resonance Imaging Feature-Guided Serum Bile Acid Profile and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy.
Computational and mathematical methods in medicine.
2022; 2022(?):8081673. doi:
10.1155/2022/8081673. [PMID: 35707042] - Michelle L Manni, Victoria A Heinrich, Gregory J Buchan, James P O'Brien, Crystal Uvalle, Veronika Cechova, Adolf Koudelka, Dharti Ukani, Mohamad Rawas-Qalaji, Tim D Oury, Renee Hart, Madeline Ellgass, Steven J Mullett, Merritt L Fajt, Sally E Wenzel, Fernando Holguin, Bruce A Freeman, Stacy G Wendell. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.
Scientific reports.
2021 09; 11(1):17788. doi:
10.1038/s41598-021-96471-9. [PMID: 34493738] - Xiping Cui, Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Sergei A Eremin, Yunping Mu, Suqing Zhao. Development of enzyme-free single-step immunoassays for glycocholic acid based on palladium nanoparticle-mediated signal generation.
Analytical and bioanalytical chemistry.
2021 Sep; 413(23):5733-5742. doi:
10.1007/s00216-021-03548-5. [PMID: 34476526] - Ying Han, Wei Liu, Liqing Chen, Xin Xin, Qiming Wang, Xintong Zhang, Mingji Jin, Zhonggao Gao, Wei Huang. Effective oral delivery of Exenatide-Zn2+ complex through distal ileum-targeted double layers nanocarriers modified with deoxycholic acid and glycocholic acid in diabetes therapy.
Biomaterials.
2021 08; 275(?):120944. doi:
10.1016/j.biomaterials.2021.120944. [PMID: 34153783] - Hui Li, Yan Wang, Shizhao Ma, Chaoqun Zhang, Hua Liu, Dianxing Sun. Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury.
Scientific reports.
2021 06; 11(1):11642. doi:
10.1038/s41598-021-91164-9. [PMID: 34079030] - Rong Wang, Hongmin Jiang, Yongjun Wang, Yuanqing Yang. Serum TBA and GCA Levels Across Pregnancy and the Gestational Age-Specific Reference Intervals for Pregnant Chinese.
Clinical laboratory.
2021 Jun; 67(6):. doi:
10.7754/clin.lab.2020.201043. [PMID: 34107618] - Qiyi He, Yanxiong Fang, Huiyi Yang, Ding Shen, Yingshan Chen, Yingying Zhong, Xiangguang Li, Sergei A Eremin, Xiping Cui, Suqing Zhao. Enhanced performance of a surface plasmon resonance-based immunosensor for the detection of glycocholic acid.
Analytical methods : advancing methods and applications.
2021 04; 13(16):1919-1924. doi:
10.1039/d1ay00357g. [PMID: 33913980] - Guangzheng Zhang, Zhenyuan Lang, Qifan Yang, You Nie, Zhihan Wang, Ming Gao, Nan Zhang, Xia Xu. UPLC-Q-TOF/MS-based plasma metabolome to identify biomarkers and time of injury in traumatic brain injured rats.
Neuroreport.
2021 04; 32(6):415-422. doi:
10.1097/wnr.0000000000001576. [PMID: 33788810] - Chong Fu, Yali Xu. Value of Serum Glycocholic Acid and Total Bile Acids in Predicting Maternal and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy.
Journal of healthcare engineering.
2021; 2021(?):3911998. doi:
10.1155/2021/3911998. [PMID: 34540186] - Ruirui Dong, Ningzhen Ye, Shaojie Zhao, Gaoying Wang, Yan Zhang, Tiejun Wang, Ping Zou, Jing Wang, Tingting Yao, Minjian Chen, Conghua Zhou, Ting Zhang, Liang Luo. Studies on Novel Diagnostic and Predictive Biomarkers of Intrahepatic Cholestasis of Pregnancy Through Metabolomics and Proteomics.
Frontiers in immunology.
2021; 12(?):733225. doi:
10.3389/fimmu.2021.733225. [PMID: 34721396] - José Tadeu Stefano, Laura Vilar Guedes, Arthur Alencar Arrais de Souza, Denise Siqueira Vanni, Venâncio Avancini Ferreira Alves, Flair José Carrilho, Alvaro Largura, Marco Arrese, Claudia P Oliveira. Usefulness of collagen type IV in the detection of significant liver fibrosis in nonalcoholic fatty liver disease.
Annals of hepatology.
2021 Jan; 20(?):100253. doi:
10.1016/j.aohep.2020.08.070. [PMID: 32949785] - Qiyi He, Huiyi Yang, Yingshan Chen, Ding Shen, Xiping Cui, Chunguo Zhang, Huanxin Xiao, Sergei A Eremin, Yanxiong Fang, Suqing Zhao. Prussian blue nanoparticles with peroxidase-mimicking properties in a dual immunoassays for glycocholic acid.
Journal of pharmaceutical and biomedical analysis.
2020 Aug; 187(?):113317. doi:
10.1016/j.jpba.2020.113317. [PMID: 32416340] - Jiayao Liu, Wenjuan Xu, Anna Zhu, Haoxiang Kang, Yu Cao, Feng Long. Reusable optofluidic point-of-care testing platform with lyophilized specific antibody for fluorescence detection of cholylglycine in serum.
Mikrochimica acta.
2020 07; 187(8):439. doi:
10.1007/s00604-020-04424-2. [PMID: 32653962] - Weiguo Sui, Qing Gan, Fuhua Liu, Minglin Ou, Bingguo Wang, Songbai Liao, Liusheng Lai, Huaizhou Chen, Ming Yang, Yong Dai. Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation.
Annals of transplantation.
2020 Jun; 25(?):e921844. doi:
10.12659/aot.921844. [PMID: 32572018] - Erikka Loftfield, Joseph A Rothwell, Rashmi Sinha, Pekka Keski-Rahkonen, Nivonirina Robinot, Demetrius Albanes, Stephanie J Weinstein, Andriy Derkach, Joshua Sampson, Augustin Scalbert, Neal D Freedman. Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality.
Journal of the National Cancer Institute.
2020 03; 112(3):286-294. doi:
10.1093/jnci/djz122. [PMID: 31168595] - Kyoung Sub Kim, Yu Seok Youn, You Han Bae. Immune-triggered cancer treatment by intestinal lymphatic delivery of docetaxel-loaded nanoparticle.
Journal of controlled release : official journal of the Controlled Release Society.
2019 10; 311-312(?):85-95. doi:
10.1016/j.jconrel.2019.08.027. [PMID: 31461664] - Patricia Mitry, Nina Wawro, Sapna Sharma, Jennifer Kriebel, Anna Artati, Jerzy Adamski, Margit Heier, Christa Meisinger, Barbara Thorand, Harald Grallert, Annette Peters, Jakob Linseisen. Associations between usual food intake and faecal sterols and bile acids: results from the Cooperative Health Research in the Augsburg Region (KORA FF4) study.
The British journal of nutrition.
2019 08; 122(3):309-321. doi:
10.1017/s000711451900103x. [PMID: 31182174] - Issey Takehara, Nobuaki Watanabe, Daiki Mori, Osamu Ando, Hiroyuki Kusuhara. Effect of Rifampicin on the Plasma Concentrations of Bile Acid-O-Sulfates in Monkeys and Human Liver-Transplanted Chimeric Mice With or Without Bile Flow Diversion.
Journal of pharmaceutical sciences.
2019 08; 108(8):2756-2764. doi:
10.1016/j.xphs.2019.03.021. [PMID: 30905707] - Alvaro Alonso, Bing Yu, Yan V Sun, Lin Y Chen, Laura R Loehr, Wesley T O'Neal, Elsayed Z Soliman, Eric Boerwinkle. Serum Metabolomics and Incidence of Atrial Fibrillation (from the Atherosclerosis Risk in Communities Study).
The American journal of cardiology.
2019 06; 123(12):1955-1961. doi:
10.1016/j.amjcard.2019.03.017. [PMID: 30979411] - Qiangyuan Fan, Yongtai Zhang, Xuefeng Hou, Zhe Li, Kai Zhang, Qun Shao, Nianping Feng. Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo.
International journal of pharmaceutics.
2018 Dec; 552(1-2):360-370. doi:
10.1016/j.ijpharm.2018.10.005. [PMID: 30292894] - Qiyi He, Xiping Cui, Ding Shen, Yingshan Chen, Zhengyun Jiang, Rui Lv, Sergei A Eremin, Suqing Zhao. Development of a simple, rapid and high-throughput fluorescence polarization immunoassay for glycocholic acid in human urine.
Journal of pharmaceutical and biomedical analysis.
2018 Sep; 158(?):431-437. doi:
10.1016/j.jpba.2018.06.023. [PMID: 29945060] - Xiping Cui, Natalia Vasylieva, Ding Shen, Bogdan Barnych, Jun Yang, Qiyi He, Zhengyun Jiang, Suqing Zhao, Bruce D Hammock. Biotinylated single-chain variable fragment-based enzyme-linked immunosorbent assay for glycocholic acid.
The Analyst.
2018 Apr; 143(9):2057-2065. doi:
10.1039/c7an02024d. [PMID: 29629470] - Cheng Guo, Cong Xie, Peili Ding, Guangming Qin, Weimin Mo, Xiaoji Cao, Shu Zheng. Quantification of glycocholic acid in human serum by stable isotope dilution ultra performance liquid chromatography electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Jan; 1072(?):315-319. doi:
10.1016/j.jchromb.2017.11.037. [PMID: 29202363] - Xiping Cui, Natalia Vasylieva, Panpan Wu, Bogdan Barnych, Jun Yang, Ding Shen, Qiyi He, Shirley J Gee, Suqing Zhao, Bruce D Hammock. Development of an Indirect Competitive Enzyme-Linked Immunosorbent Assay for Glycocholic Acid Based on Chicken Single-Chain Variable Fragment Antibodies.
Analytical chemistry.
2017 10; 89(20):11091-11097. doi:
10.1021/acs.analchem.7b03190. [PMID: 28942640] - Mariapina D'Onofrio, Carlo Giorgio Barracchia, Andrea Bortot, Francesca Munari, Serena Zanzoni, Michael Assfalg. Molecular differences between human liver fatty acid binding protein and its T94A variant in their unbound and lipid-bound states.
Biochimica et biophysica acta. Proteins and proteomics.
2017 Sep; 1865(9):1152-1159. doi:
10.1016/j.bbapap.2017.06.025. [PMID: 28668637] - Veronika Thöni, Alexandra Pfister, Andreas Melmer, Barbara Enrich, Karin Salzmann, Susanne Kaser, Claudia Lamina, Christoph F Ebenbichler, Hubert Hackl, Herbert Tilg, Alexander R Moschen. Dynamics of Bile Acid Profiles, GLP-1, and FGF19 After Laparoscopic Gastric Banding.
The Journal of clinical endocrinology and metabolism.
2017 08; 102(8):2974-2984. doi:
10.1210/jc.2017-00235. [PMID: 28591793] - Xiao-Hong Yu, Jing Sun, Yan Wang, Ya-Bin Zhou. Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma.
Medicine.
2017 May; 96(21):e6998. doi:
10.1097/md.0000000000006998. [PMID: 28538412] - Hui Li, Su-Fang Fan, Yan Wang, Shi-Gang Shen, Dian-Xing Sun. Rapid Detection of Small Molecule Metabolites in Serum of Hepatocellular Carcinoma Patients Using Ultrafast Liquid Chromatography-Ion Trap-Time of Flight Tandem Mass Spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2017; 33(5):573-578. doi:
10.2116/analsci.33.573. [PMID: 28496060] - Alessandra Maroni, Maria Dorly Del Curto, Stefano Salmaso, Lucia Zema, Alice Melocchi, Paolo Caliceti, Andrea Gazzaniga. In vitro and in vivo evaluation of an oral multiple-unit formulation for colonic delivery of insulin.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 Nov; 108(?):76-82. doi:
10.1016/j.ejpb.2016.08.002. [PMID: 27519826] - Quan-Fu Li, Yan-Mei Zhan, Yong-Gang Zhong, Bo Zhang, Chang-Qing Ge. Macromolecular Crowding Agents-Assisted Imprinted Polymers For Analysis Of Glycocholic Acid In Human Plasma And Urine.
Biomedical chromatography : BMC.
2016 Nov; 30(11):1706-1713. doi:
10.1002/bmc.3737. [PMID: 27061917] - Hongmin Xu, Lei Zhang, Huan Kang, Jiandong Zhang, Jie Liu, Shuye Liu. Serum Metabonomics of Mild Acute Pancreatitis.
Journal of clinical laboratory analysis.
2016 Nov; 30(6):990-998. doi:
10.1002/jcla.21969. [PMID: 27169745] - Monika Rau, Bruno Stieger, Maria J Monte, Johannes Schmitt, Daniel Jahn, Isabelle Frey-Wagner, Tina Raselli, Jose J G Marin, Beat Müllhaupt, Gerhard Rogler, Andreas Geier. Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal Inflammation.
Inflammatory bowel diseases.
2016 10; 22(10):2382-9. doi:
10.1097/mib.0000000000000879. [PMID: 27580383] - Shyamchand Mayengbam, James D House, Michel Aliani. Investigation of vitamin B₆ inadequacy, induced by exposure to the anti-B₆ factor 1-amino D-proline, on plasma lipophilic metabolites of rats: a metabolomics approach.
European journal of nutrition.
2016 Apr; 55(3):1213-23. doi:
10.1007/s00394-015-0934-x. [PMID: 26009005] - Gergő Horváth, Ákos Bencsura, Ágnes Simon, Gregory P Tochtrop, Gregory T DeKoster, Douglas F Covey, David P Cistola, Orsolya Toke. Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
The FEBS journal.
2016 Feb; 283(3):541-55. doi:
10.1111/febs.13610. [PMID: 26613247] - Guixia Ling, Tianhong Zhang, Peng Zhang, Jin Sun, Zhonggui He. Synergistic and complete reversal of the multidrug resistance of mitoxantrone hydrochloride by three-in-one multifunctional lipid-sodium glycocholate nanocarriers based on simultaneous BCRP and Bcl-2 inhibition.
International journal of nanomedicine.
2016 ; 11(?):4077-91. doi:
10.2147/ijn.s95767. [PMID: 27601896] - James E Heubi, Kenneth D R Setchell, Pinky Jha, Donna Buckley, Wujuan Zhang, Philip Rosenthal, Carol Potter, Simon Horslen, David Suskind. Treatment of bile acid amidation defects with glycocholic acid.
Hepatology (Baltimore, Md.).
2015 Jan; 61(1):268-74. doi:
10.1002/hep.27401. [PMID: 25163551] - Xingguo Cheng, Youcai Zhang, Curtis D Klaassen. Decreased bile-acid synthesis in livers of hepatocyte-conditional NADPH-cytochrome P450 reductase-null mice results in increased bile acids in serum.
The Journal of pharmacology and experimental therapeutics.
2014 Oct; 351(1):105-13. doi:
10.1124/jpet.114.216796. [PMID: 25034404] - Toshihiro Kobayashi, Yuriko Matsumura, Toshihiko Ozawa, Hiroyuki Yanai, Atsuo Iwasawa, Toshiaki Kamachi, Kouichi Fujiwara, Noriaki Tanaka, Masahiro Kohno. Exploration of novel predictive markers in rat plasma of the early stages of chronic renal failure.
Analytical and bioanalytical chemistry.
2014 Feb; 406(5):1365-76. doi:
10.1007/s00216-013-7472-2. [PMID: 24232639] - Lina Luo, Shelli Schomaker, Christopher Houle, Jiri Aubrecht, Jennifer L Colangelo. Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):12-25. doi:
10.1093/toxsci/kft221. [PMID: 24085190] - Filippo Favretto, Michael Assfalg, Mariana Gallo, Daniel Oscar Cicero, Mariapina D'Onofrio, Henriette Molinari. Ligand binding promiscuity of human liver fatty acid binding protein: structural and dynamic insights from an interaction study with glycocholate and oleate.
Chembiochem : a European journal of chemical biology.
2013 Sep; 14(14):1807-19. doi:
10.1002/cbic.201300156. [PMID: 23757005] - Aihua Zhang, Hui Sun, Guangli Yan, Ying Han, Yuan Ye, Xijun Wang. Urinary metabolic profiling identifies a key role for glycocholic acid in human liver cancer by ultra-performance liquid-chromatography coupled with high-definition mass spectrometry.
Clinica chimica acta; international journal of clinical chemistry.
2013 Mar; 418(?):86-90. doi:
10.1016/j.cca.2012.12.024. [PMID: 23313056] - Habtom W Ressom, Jun Feng Xiao, Leepika Tuli, Rency S Varghese, Bin Zhou, Tsung-Heng Tsai, Mohammad R Nezami Ranjbar, Yi Zhao, Jinlian Wang, Cristina Di Poto, Amrita K Cheema, Mahlet G Tadesse, Radoslav Goldman, Kirti Shetty. Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis.
Analytica chimica acta.
2012 Sep; 743(?):90-100. doi:
10.1016/j.aca.2012.07.013. [PMID: 22882828] - Suzanne C Schiffman, Yan Li, Robert C G Martin. The association of manganese superoxide dismutase expression in Barrett's esophageal progression with MnTBAP and curcumin oil therapy.
The Journal of surgical research.
2012 Aug; 176(2):535-41. doi:
10.1016/j.jss.2011.11.1013. [PMID: 22316666] - Kim Frisch, Steen Jakobsen, Michael Sørensen, Ole Lajord Munk, Aage K O Alstrup, Peter Ott, Alan F Hofmann, Susanne Keiding. [N-methyl-11C]cholylsarcosine, a novel bile acid tracer for PET/CT of hepatic excretory function: radiosynthesis and proof-of-concept studies in pigs.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 May; 53(5):772-8. doi:
10.2967/jnumed.111.098731. [PMID: 22454486] - Nilanjana Das, Parshotam Madan, Senshang Lin. Statistical optimization of insulin-loaded Pluronic F-127 gels for buccal delivery of basal insulin.
Pharmaceutical development and technology.
2012 May; 17(3):363-74. doi:
10.3109/10837450.2010.542164. [PMID: 21214425] - Gergo Horváth, Péter Király, Gábor Tárkányi, Orsolya Toke. Internal motions and exchange processes in human ileal bile acid binding protein as studied by backbone (15)N nuclear magnetic resonance spectroscopy.
Biochemistry.
2012 Mar; 51(9):1848-61. doi:
10.1021/bi201588q. [PMID: 22329738] - Haiqiang Jiang, Lei Nie, Yunlun Li, Jun Xie. Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription.
Journal of separation science.
2012 Feb; 35(4):483-9. doi:
10.1002/jssc.201100769. [PMID: 22282408] - Youcai Zhang, Pallavi B Limaye, Lois D Lehman-McKeeman, Curtis D Klaassen. Dysfunction of organic anion transporting polypeptide 1a1 alters intestinal bacteria and bile acid metabolism in mice.
PloS one.
2012; 7(4):e34522. doi:
10.1371/journal.pone.0034522. [PMID: 22496825] - Elaine Studer, Xiqiao Zhou, Renping Zhao, Yun Wang, Kazuaki Takabe, Masayuki Nagahashi, William M Pandak, Paul Dent, Sarah Spiegel, Ruihua Shi, Weiren Xu, Xuyuan Liu, Pat Bohdan, Luyong Zhang, Huiping Zhou, Phillip B Hylemon. Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
Hepatology (Baltimore, Md.).
2012 Jan; 55(1):267-76. doi:
10.1002/hep.24681. [PMID: 21932398] - Matilda Nicklasson, Åsa Sjöling, Astrid von Mentzer, Firdausi Qadri, Ann-Mari Svennerholm. Expression of colonization factor CS5 of enterotoxigenic Escherichia coli (ETEC) is enhanced in vivo and by the bile component Na glycocholate hydrate.
PloS one.
2012; 7(4):e35827. doi:
10.1371/journal.pone.0035827. [PMID: 22563407] - Monalisa Mohapatra, Ashok K Mishra. Effect of submicellar concentrations of conjugated and unconjugated bile salts on the lipid bilayer membrane.
Langmuir : the ACS journal of surfaces and colloids.
2011 Nov; 27(22):13461-7. doi:
10.1021/la203028s. [PMID: 21973323] - Andréa Tiengo, Eliana Maria Pettirossi Motta, Flavia Maria Netto. Chemical composition and bile acid binding activity of products obtained from amaranth (Amaranthus cruentus) seeds.
Plant foods for human nutrition (Dordrecht, Netherlands).
2011 Nov; 66(4):370-5. doi:
10.1007/s11130-011-0253-1. [PMID: 21901402] - Xiaoqiang Xiang, Juha Vakkilainen, Janne T Backman, Pertti J Neuvonen, Mikko Niemi. No significant effect of the SLCO1B1 polymorphism on the pharmacokinetics of ursodeoxycholic acid.
European journal of clinical pharmacology.
2011 Nov; 67(11):1159-67. doi:
10.1007/s00228-011-1070-z. [PMID: 21655991] - Dong-Ho Oh, Kyeung-Hwa Chun, Sang-Ok Jeon, Jeong-Won Kang, Sangkil Lee. Enhanced transbuccal salmon calcitonin (sCT) delivery: effect of chemical enhancers and electrical assistance on in vitro sCT buccal permeation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Oct; 79(2):357-63. doi:
10.1016/j.ejpb.2011.05.010. [PMID: 21683790] - Silvia Petersen, Frank Steiniger, Dagmar Fischer, Alfred Fahr, Heike Bunjes. The physical state of lipid nanoparticles influences their effect on in vitro cell viability.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Sep; 79(1):150-61. doi:
10.1016/j.ejpb.2011.03.022. [PMID: 21458564] - Tianlu Chen, Guoxiang Xie, Xiaoying Wang, Jia Fan, Yunping Qiu, Xiaojiao Zheng, Xin Qi, Yu Cao, Mingming Su, Xiaoyan Wang, Lisa X Xu, Yun Yen, Ping Liu, Wei Jia. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma.
Molecular & cellular proteomics : MCP.
2011 Jul; 10(7):M110.004945. doi:
10.1074/mcp.m110.004945. [PMID: 21518826] - Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, William J Zavadoski, Mark P Molloy, John D Baker, Max Kuhn, Over Cabrera, Judith L Treadway. Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
BMC genomics.
2011 Jun; 12(?):281. doi:
10.1186/1471-2164-12-281. [PMID: 21631939] - Jing Chen, Xiaoyan Zhang, Rui Cao, Xin Lu, Sumin Zhao, Agnes Fekete, Qiang Huang, Philippe Schmitt-Kopplin, Yisheng Wang, Zhiliang Xu, Xiaoping Wan, Xiaohua Wu, Naiqing Zhao, Congjian Xu, Guowang Xu. Serum 27-nor-5β-cholestane-3,7,12,24,25 pentol glucuronide discovered by metabolomics as potential diagnostic biomarker for epithelium ovarian cancer.
Journal of proteome research.
2011 May; 10(5):2625-32. doi:
10.1021/pr200173q. [PMID: 21456628] - Jiang-shan Lian, Wei Liu, Shao-rui Hao, Yong-zheng Guo, Hai-jun Huang, De-ying Chen, Qing Xie, Xiao-ping Pan, Wei Xu, Wen-xia Yuan, Lan-juan Li, Jian-rong Huang. A serum metabonomic study on the difference between alcohol- and HBV-induced liver cirrhosis by ultraperformance liquid chromatography coupled to mass spectrometry plus quadrupole time-of-flight mass spectrometry.
Chinese medical journal.
2011 May; 124(9):1367-73. doi:
. [PMID: 21740750] - Jing He, Lu Chen, Cheng Liang. [Clinical analysis of fetal death cases in intrahepatic cholestasis of pregnancy].
Zhonghua fu chan ke za zhi.
2011 May; 46(5):333-7. doi:
. [PMID: 21733367] - Eamon P Rafferty, Alastair R Wylie, Katharine H Hand, Chris E Elliott, David J Grieve, Brian D Green. Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R(-/-) mice.
Biological chemistry.
2011 Apr; 392(6):539-46. doi:
10.1515/bc.2011.050. [PMID: 21521075] - Satish C Kalhan, Lining Guo, John Edmison, Srinivasan Dasarathy, Arthur J McCullough, Richard W Hanson, Mike Milburn. Plasma metabolomic profile in nonalcoholic fatty liver disease.
Metabolism: clinical and experimental.
2011 Mar; 60(3):404-13. doi:
10.1016/j.metabol.2010.03.006. [PMID: 20423748] - Jauricque Ursulla Kongo-Dia-Moukala, Hui Zhang, Pierre Claver Irakoze. In vitro binding capacity of bile acids by defatted corn protein hydrolysate.
International journal of molecular sciences.
2011 Feb; 12(2):1066-80. doi:
10.3390/ijms12021066. [PMID: 21541043] - Xue Qiao, Min Ye, De-lin Pan, Wen-juan Miao, Cheng Xiang, Jian Han, De-an Guo. Differentiation of various traditional Chinese medicines derived from animal bile and gallstone: simultaneous determination of bile acids by liquid chromatography coupled with triple quadrupole mass spectrometry.
Journal of chromatography. A.
2011 Jan; 1218(1):107-17. doi:
10.1016/j.chroma.2010.10.116. [PMID: 21111425] - Rima Kaddurah-Daouk, Rebecca A Baillie, Hongjie Zhu, Zhao-Bang Zeng, Michelle M Wiest, Uyen Thao Nguyen, Katie Wojnoonski, Steven M Watkins, Miles Trupp, Ronald M Krauss. Enteric microbiome metabolites correlate with response to simvastatin treatment.
PloS one.
2011; 6(10):e25482. doi:
10.1371/journal.pone.0025482. [PMID: 22022402] - Jocelyn Trottier, Andrzej Białek, Patrick Caron, Robert J Straka, Piotr Milkiewicz, Olivier Barbier. Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.
PloS one.
2011; 6(7):e22094. doi:
10.1371/journal.pone.0022094. [PMID: 21760958] - Oceania D'Apolito, Pierluigi Pianese, Gennaro Salvia, Angelo Campanozzi, Massimo Pettoello-Mantovani, Antonio Dello Russo, Gaetano Corso. Plasma levels of conjugated bile acids in newborns after a short period of parenteral nutrition.
JPEN. Journal of parenteral and enteral nutrition.
2010 Sep; 34(5):538-41. doi:
10.1177/0148607110374059. [PMID: 20852182] - N Mori, T Yokooji, Y Kamio, T Murakami. Increased intestinal absorption of mizoribine, an immunosuppressive agent, in cholestatic rats.
Die Pharmazie.
2010 Jul; 65(7):457-60. doi:
NULL. [PMID: 20662310] - David C Turner, Fuchang Yin, James T Kindt, Hailing Zhang. Molecular dynamics simulations of glycocholate-oleic acid mixed micelle assembly.
Langmuir : the ACS journal of surfaces and colloids.
2010 Apr; 26(7):4687-92. doi:
10.1021/la903573m. [PMID: 20112949] - Rahul C Deo, Luke Hunter, Gregory D Lewis, Guillaume Pare, Ramachandran S Vasan, Daniel Chasman, Thomas J Wang, Robert E Gerszten, Frederick P Roth. Interpreting metabolomic profiles using unbiased pathway models.
PLoS computational biology.
2010 Feb; 6(2):e1000692. doi:
10.1371/journal.pcbi.1000692. [PMID: 20195502] - James R Reed. The use of liposomes in the study of drug metabolism: a method to incorporate the enzymes of the cytochrome p450 monooxygenase system into phospholipid, bilayer vesicles.
Methods in molecular biology (Clifton, N.J.).
2010; 606(?):11-20. doi:
10.1007/978-1-60761-447-0_2. [PMID: 20013386] - Ellen Hildebrandt, David J McGee. Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent.
BMC microbiology.
2009 Dec; 9(?):258. doi:
10.1186/1471-2180-9-258. [PMID: 20003432] - Ying Zhao, Desheng Zhai, Hui He, Junhua Liu, Tingting Li, Xijing Chen, Hui Ji. Matrine improves 17alpha-ethinyl estradiol-induced acute cholestasis in rats.
Hepatology research : the official journal of the Japan Society of Hepatology.
2009 Nov; 39(11):1144-9. doi:
10.1111/j.1872-034x.2009.00557.x. [PMID: 19619254] - Jing Fang, Wen-Li Gou, Qi-Ling Li. [Effect of integrative Chinese and Western medicine in treating pregnant women with intrahepatic cholestasis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2009 Oct; 29(10):869-71. doi:
. [PMID: 20073212] - Carsten Gnewuch, Gerhard Liebisch, Thomas Langmann, Benjamin Dieplinger, Thomas Mueller, Meinhard Haltmayer, Hans Dieplinger, Alexandra Zahn, Wolfgang Stremmel, Gerhard Rogler, Gerd Schmitz. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease.
World journal of gastroenterology.
2009 Jul; 15(25):3134-41. doi:
10.3748/wjg.15.3134. [PMID: 19575493] - Tyler F Daniels, Karen M Killinger, Jennifer J Michal, Raymond W Wright, Zhihua Jiang. Lipoproteins, cholesterol homeostasis and cardiac health.
International journal of biological sciences.
2009 Jun; 5(5):474-88. doi:
10.7150/ijbs.5.474. [PMID: 19584955] - Do Kyung Lee, Seok Jang, Eun Hye Baek, Mi Jin Kim, Kyung Soon Lee, Hea Soon Shin, Myung Jun Chung, Jin Eung Kim, Kang Oh Lee, Nam Joo Ha. Lactic acid bacteria affect serum cholesterol levels, harmful fecal enzyme activity, and fecal water content.
Lipids in health and disease.
2009 Jun; 8(?):21. doi:
10.1186/1476-511x-8-21. [PMID: 19515264] - Yoshifumi Murata, Youko Kodama, Daijirou Hirai, Kyouko Kofuji, Susumu Kawashima. Properties of an oral preparation containing a chitosan salt.
Molecules (Basel, Switzerland).
2009 Feb; 14(2):755-62. doi:
10.3390/molecules14020755. [PMID: 19223823] - Xinjie Zhao, Andreas Peter, Jens Fritsche, Michaela Elcnerova, Andreas Fritsche, Hans-Ulrich Häring, Erwin D Schleicher, Guowang Xu, Rainer Lehmann. Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?.
American journal of physiology. Endocrinology and metabolism.
2009 Feb; 296(2):E384-93. doi:
10.1152/ajpendo.90748.2008. [PMID: 19066319] - Maria Vertzoni, Helen Archontaki, Christos Reppas. Determination of intralumenal individual bile acids by HPLC with charged aerosol detection.
Journal of lipid research.
2008 Dec; 49(12):2690-5. doi:
10.1194/jlr.d800039-jlr200. [PMID: 18693215] - Paramjeet Kaur, Kwonho Kim. Pharmacokinetics and brain uptake of diazepam after intravenous and intranasal administration in rats and rabbits.
International journal of pharmaceutics.
2008 Nov; 364(1):27-35. doi:
10.1016/j.ijpharm.2008.07.030. [PMID: 18760341] - Jiarong Chen, Tomohiro Terada, Ken Ogasawara, Toshiya Katsura, Ken-ichi Inui. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F247-52. doi:
10.1152/ajprenal.00139.2008. [PMID: 18480179] - Akhlesh Kumar Jain, Roop K Khar, Farhan J Ahmed, Prakash V Diwan. Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2008 Jun; 69(2):426-35. doi:
10.1016/j.ejpb.2007.12.001. [PMID: 18295464] - Zhou Xu, Jian-Chu Ke, Ai-Yun Xing. [Study on relationship between expression of familial intrahepatic cholestasis 1 mRNA in placenta and Intrahepatic cholestasis of pregnancy].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2008 May; 39(3):430-3. doi:
. [PMID: 18575333] - James R Reed, Lauren M Brignac-Huber, Wayne L Backes. Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Mar; 36(3):582-8. doi:
10.1124/dmd.107.018473. [PMID: 18048487] - Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Torbjörn Lundstedt, Per Lek, Serge Rezzi, Ziad Ramadan, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model.
Molecular systems biology.
2008; 4(?):157. doi:
10.1038/msb4100190. [PMID: 18197175] - Mikael Gunnarsson, Sigrid Leide-Svegborn, Kristina Stenström, Göran Skog, Lars-Erik Nilsson, Ola Thorsson, Ragnar Hellborg, Sören Mattsson. Long-term biokinetics and radiation exposure of patients undergoing 14C-glycocholic acid and 14C-xylose breath tests.
Cancer biotherapy & radiopharmaceuticals.
2007 Dec; 22(6):762-71. doi:
10.1089/cbr.2007.0350. [PMID: 18158767] - Shi-Ying Cai, Liangshi Xiong, Charles G Wray, Nazzareno Ballatori, James L Boyer. The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Sep; 293(3):R1400-9. doi:
10.1152/ajpregu.00781.2006. [PMID: 17567710] - Shin-ya Morita, Aya Kobayashi, Yasukazu Takanezawa, Noriyuki Kioka, Tetsurou Handa, Hiroyuki Arai, Michinori Matsuo, Kazumitsu Ueda. Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4.
Hepatology (Baltimore, Md.).
2007 Jul; 46(1):188-99. doi:
10.1002/hep.21591. [PMID: 17523162] - Ying H Pan, Brian J Bahnson. Structural basis for bile salt inhibition of pancreatic phospholipase A2.
Journal of molecular biology.
2007 Jun; 369(2):439-50. doi:
10.1016/j.jmb.2007.03.034. [PMID: 17434532] - Marta Vicens, Rocio I R Macias, Oscar Briz, Alfonso Rodriguez, Mohamad Y El-Mir, Manuel Medarde, Jose J G Marin. Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.
Biochemical pharmacology.
2007 Feb; 73(3):394-404. doi:
10.1016/j.bcp.2006.10.014. [PMID: 17134679] - François-Pierre J Martin, Marc-Emmanuel Dumas, Yulan Wang, Cristina Legido-Quigley, Ivan K S Yap, Huiru Tang, Séverine Zirah, Gerard M Murphy, Olivier Cloarec, John C Lindon, Norbert Sprenger, Laurent B Fay, Sunil Kochhar, Peter van Bladeren, Elaine Holmes, Jeremy K Nicholson. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model.
Molecular systems biology.
2007; 3(?):112. doi:
10.1038/msb4100153. [PMID: 17515922] - Dean M Robinson, Gillian M Keating. Colesevelam: a review of its use in hypercholesterolemia.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2007; 7(6):453-65. doi:
10.2165/00129784-200707060-00009. [PMID: 18076213]
