Paracetamol (BioDeep_00000229669)
Main id: BioDeep_00000398390
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
4-Acetamidophenol
化学式: C8H9NO2 (151.0633254)
中文名称: 对乙酰氨基苯酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)Nc(c1)ccc(O)c1
InChI: InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
描述信息
N - Nervous system > N02 - Analgesics > N02B - Other analgesics and antipyretics > N02BE - Anilides
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 243
D058633 - Antipyretics
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
3 个代谢物同义名
数据库引用编号
41 个数据库交叉引用编号
- ChEBI: CHEBI:46195
- KEGG: C06804
- PubChem: 1983
- HMDB: HMDB01859
- DrugBank: DB00316
- ChEMBL: CHEMBL112
- MeSH: Acetaminophen
- CAS: 8055-08-1
- CAS: 103-90-2
- MoNA: EA024313
- MoNA: EA024351
- MoNA: EA024364
- MoNA: EA024361
- MoNA: EA024312
- MoNA: EA024360
- MoNA: EA024359
- MoNA: EA024362
- MoNA: EA024308
- MoNA: EA024353
- MoNA: EA024305
- MoNA: EA024314
- MoNA: EA024303
- MoNA: EA024357
- MoNA: MT000047
- MoNA: EA024309
- MoNA: EA024302
- MoNA: EA024355
- MoNA: EA024301
- MoNA: EA024304
- MoNA: EA024311
- MoNA: EA024356
- MoNA: EA024307
- MoNA: EA024352
- MoNA: EA024358
- MoNA: EA024354
- MoNA: EA024310
- MoNA: EA024306
- PubChem: 9023
- KNApSAcK: C00044491
- PDB-CCD: TYL
- NIKKAJI: J4.025H
分类词条
相关代谢途径
Reactome(10)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 408015 - Streptomyces xiamenensis: 10.1080/14786419.2018.1508148
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kexin Xiao, Hongyu Li, Yuening Li, Bo Zhan, Xiaohua Fang, Bingjie Zhao, Xiaofei Zhang, Yumei Wu, Fan Wang, Yanyan Jia. Protective effects and mechanism of Sangyu granule on acetaminophen-induced liver injury in mice.
Journal of ethnopharmacology.
2024 Sep; 331(?):118282. doi:
10.1016/j.jep.2024.118282. [PMID: 38701935] - Yubing Li, Xinyu Deng, Qichao Hu, Yuan Chen, Wenwen Zhang, Xuhua Qin, Feng Wei, Xiaohua Lu, Xiao Ma, Jinhao Zeng, Thomas Efferth. Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Journal of ethnopharmacology.
2024 Jul; 329(?):118107. doi:
10.1016/j.jep.2024.118107. [PMID: 38599475] - Ruixin Liu, Haijing Jiang, Wenjie Yang, Zhijuan Zheng, Xiaoming Wang, Zhenhua Tian, Danyang Wang, Dongfang Kan, Dan Zhang, Zhixin Tang. Peroxynitrite imaging in ferroptosis-mediated drug-induced liver injury with a near-infrared fluorescence probe.
Analytica chimica acta.
2024 Jun; 1309(?):342673. doi:
10.1016/j.aca.2024.342673. [PMID: 38772656] - Wanling Yang, Yiyao Liang, Yujie Liu, Yunan Yao, Zhiqian Yu, Baizhong Chen, Yi Cai, Minyan Wei, Guodong Zheng. Enhancement of hepatoprotective activity of limonin from citrus seeds against acetaminophen-induced liver injury by HSCCC purification and liposomal encapsulation.
Fitoterapia.
2024 Jun; 175(?):105899. doi:
10.1016/j.fitote.2024.105899. [PMID: 38471575] - Tingwen Zhang, Yue Zhong, Yan Shi, Chengcheng Feng, Lu Xu, Zheng Chen, Xin Sun, Yan Zhao, Xialin Sun. Multi-omics reveals that 5-O-methylvisammioside prevention acute liver injury in mice by regulating the TNF/MAPK/NF-κB/arachidonic acid pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155550. doi:
10.1016/j.phymed.2024.155550. [PMID: 38522313] - Diana Belen Onofre-Camarena, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, José Roberto Jerónimo Juárez, Selene Elizabeth Herrera-Vázquez. Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio.
Environmental pollution (Barking, Essex : 1987).
2024 May; 349(?):123997. doi:
10.1016/j.envpol.2024.123997. [PMID: 38636837] - Luying Zhao, Xiangting Zhang, Zhuofeng Chen, Yuning Lai, Jun Xu, Ruoru Zhou, Peipei Ma, Weimin Cai, Yuan Zeng, Xiao Wu, Huiya Ying, Fujun Yu. Cynarin alleviates acetaminophen-induced acute liver injury through the activation of Keap1/Nrf2-mediated lipid peroxidation defense via the AMPK/SIRT3 signaling pathway.
Food & function.
2024 May; 15(9):4954-4969. doi:
10.1039/d3fo05025d. [PMID: 38602356] - Yaping Wang, Jenna Ren, Shunlin Ren. Larsucosterol: endogenous epigenetic regulator for treating chronic and acute liver diseases.
American journal of physiology. Endocrinology and metabolism.
2024 May; 326(5):E577-E587. doi:
10.1152/ajpendo.00406.2023. [PMID: 38381400] - Steven D Karlen, Vitaliy I Timokhin, Canan Sener, Justin K Mobley, Troy Runge, John Ralph. Production of Biomass-Derived p-Hydroxybenzamide: Synthesis of p-Aminophenol and Paracetamol.
ChemSusChem.
2024 Apr; 17(8):e202400234. doi:
10.1002/cssc.202400234. [PMID: 38441462] - Esra Aktas Senocak, Necati Utlu, Seyda Kurt, Sefa Kucukler, Fatih Mehmet Kandemir. Sodium Pentaborate Prevents Acetaminophen-Induced Hepatorenal Injury by Suppressing Oxidative Stress, Lipid Peroxidation, Apoptosis, and Inflammatory Cytokines in Rats.
Biological trace element research.
2024 Mar; 202(3):1164-1173. doi:
10.1007/s12011-023-03755-4. [PMID: 37393388] - Chao Xu, Fang Yan, Yulan Zhao, Hartmut Jaeschke, Jianguo Wu, Li Fang, Lifang Zhao, Yuanfei Zhao, Li Wang. Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy.
Toxicological sciences : an official journal of the Society of Toxicology.
2024 Feb; 198(1):50-60. doi:
10.1093/toxsci/kfad132. [PMID: 38180883] - Peter K Kurotschka, Alice Serafini, Mark H Ebell. [Top 5 Research Studies of the month for Italian Primary Care Physicians: January 2024.].
Recenti progressi in medicina.
2024 Feb; 115(2):85-89. doi:
10.1701/4197.41842. [PMID: 38291934] - Yaxin Xiong, Qingyang Shi, Jun Li, Nathan Darlucio Sy, Daniel Schlenk, Jay Gan. Methylation and Demethylation of Emerging Contaminants in Plants.
Environmental science & technology.
2024 Jan; 58(4):1998-2006. doi:
10.1021/acs.est.3c03171. [PMID: 38240245] - Yongyan Ren, Zhenxia Xu, Zhixian Qiao, Xu Wang, Chen Yang. Flaxseed Lignan Alleviates the Paracetamol-Induced Hepatotoxicity Associated with Regulation of Gut Microbiota and Serum Metabolome.
Nutrients.
2024 Jan; 16(2):. doi:
10.3390/nu16020295. [PMID: 38257189] - Amir Nili-Ahmadabadi, Saeb Abdpour, Navid Omidifar, Seyyed Alireza Hashemi, Seyyed Mojtaba Mousavi, Maryam Nili Ahmadabadi. Therapeutic potentials of N-acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen-induced acute hepatotoxicity in rat.
Chemical biology & drug design.
2024 Jan; 103(1):e14430. doi:
10.1111/cbdd.14430. [PMID: 38230777] - Elsayed Hamed Ali Bakr, Areej Abdulhamid Hamdan Almuraee. Protective Effect of Black Seed and Lettuce Oils Against Paracetamol-Induced Hepatotoxicity in Rats.
Pakistan journal of biological sciences : PJBS.
2024 Jan; 27(2):59-68. doi:
10.3923/pjbs.2024.59.68. [PMID: 38516747] - Gamal Shams, Somia Abd Allah, Raghda Ezzat, Mahmoud A Said. Ameliorative effects of berberine and selenium against paracetamol-induced hepatic toxicity in rats.
Open veterinary journal.
2024 Jan; 14(1):292-303. doi:
10.5455/ovj.2024.v14.i1.26. [PMID: 38633147] - Shiqi Yuan, Yitong Ling, Xiaxuan Huang, Shanyuan Tan, Wanyue Li, Anding Xu, Jun Lyu. Associations between the use of common nonsteroidal anti-inflammatory drugs, genetic susceptibility and dementia in participants with chronic pain: A prospective study based on 194,758 participants from the UK Biobank.
Journal of psychiatric research.
2024 01; 169(?):152-159. doi:
10.1016/j.jpsychires.2023.11.030. [PMID: 38039689] - Natsuko F Inagaki, Hiroki Nakanishi, Takayo Ohto, Hideo Shindou, Takao Shimizu. LPCAT3/LPLAT12 deficiency in the liver ameliorates acetaminophen-induced acute liver injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2024 01; 38(1):e23328. doi:
10.1096/fj.202301744r. [PMID: 38019192] - Yong-Heng Lin, Yu-Che Lin, Yung-Te Hou. Prospective Application of Tannic Acid in Acetaminophen (APAP)-Induced Acute Liver Failure.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010317. [PMID: 38203487] - Loredana Nicoleta Hilițanu, Liliana Mititelu-Tarțău, Eliza Grațiela Popa, Beatrice Rozalina Bucă, Irina Luciana Gurzu, Paula Alina Fotache, Ana-Maria Pelin, Daniela Angelica Pricop, Liliana Lăcrămioara Pavel. Chitosan Soft Matter Vesicles Loaded with Acetaminophen as Promising Systems for Modified Drug Release.
Molecules (Basel, Switzerland).
2023 Dec; 29(1):. doi:
10.3390/molecules29010057. [PMID: 38202640] - Jiuyan Chen, Qiang Zhang, Weifeng Chen, Usman Farooq, Taotao Lu, Bin Wang, Jinzhi Ni, Huiying Zhang, Zhichong Qi. Mobility of antipyretic drugs with different molecular structures in saturated soil porous media.
Environmental science. Processes & impacts.
2023 Dec; 25(12):2092-2101. doi:
10.1039/d3em00358b. [PMID: 37905737] - Zainul Amiruddin Zakaria, Adibah Sahmat, Azfar Hizami Azmi, Amal Syahirah Nur Zainol, Maizatul Hasyima Omar, Tavamani Balan, Arifah Abdul Kadir, Syahriel Abdullah, Roro Azizah, Lilis Sulistyorini. Liver protective effect of chloroform extract of Bauhinia purpurea leaves is attributed partly to its antioxidant action and the presence of flavonoids.
Pharmaceutical biology.
2023 Dec; 61(1):1152-1161. doi:
10.1080/13880209.2023.2241510. [PMID: 37559390] - Lizbeth Martínez-Acevedo, Moises Job Galindo-Pérez, Gustavo Vidal-Romero, Alicia Del Real, María de la Luz Zambrano-Zaragoza, David Quintanar-Guerrero. Effect of magnesium stearate solid lipid nanoparticles as a lubricant on the properties of tablets by direct compression.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2023 Dec; 193(?):262-273. doi:
10.1016/j.ejpb.2023.11.004. [PMID: 37944711] - Xiaoyangzi Li, Ruyang Lao, Jiawei Lei, Yuting Chen, Qi Zhou, Ting Wang, Yingpeng Tong. Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review.
Molecules (Basel, Switzerland).
2023 Dec; 28(23):. doi:
10.3390/molecules28237901. [PMID: 38067630] - Tingyu You, Yu Li, Bowen Li, Shuai Wu, Xiangfu Jiang, Dongdong Fu, Jiao Xin, Yan Huang, Lei Jin, Chengmu Hu. Caveolin-1 protects against liver damage exacerbated by acetaminophen in non-alcoholic fatty liver disease by inhibiting the ERK/HIF-1α pathway.
Molecular immunology.
2023 11; 163(?):104-115. doi:
10.1016/j.molimm.2023.09.003. [PMID: 37769575] - José Herrera-Muñoz, Alejandro Cabrera-Reina, Sara Miralles-Cuevas, Samuel Piña, Ricardo Salazar-González. Simultaneous degradation of contaminants of emerging concern and disinfection by solar photoelectro-Fenton process at circumneutral pH in a solar electrochemical raceway pond reactor.
Chemosphere.
2023 Nov; 341(?):139978. doi:
10.1016/j.chemosphere.2023.139978. [PMID: 37660793] - Ghizlane Nouioura, Tayeb Kettani, Meryem Tourabi, Layla Tahiri Elousrouti, Omkulthom Al Kamaly, Samar Zuhair Alshawwa, Abdelaaty A Shahat, Abdulsalam Alhalmi, Badiaa Lyoussi, Elhoussine Derwich. The Protective Potential of Petroselinum crispum (Mill.) Fuss. on Paracetamol-Induced Hepatio-Renal Toxicity and Antiproteinuric Effect: A Biochemical, Hematological, and Histopathological Study.
Medicina (Kaunas, Lithuania).
2023 Oct; 59(10):. doi:
10.3390/medicina59101814. [PMID: 37893532] - Devaraj Ezhilarasan, Karthik Shree Harini, Munusamy Karthick, Chandrabose Selvaraj. Ethyl gallate concurrent administration protects against acetaminophen-induced acute liver injury in mice: An in vivo and in silico approach.
Chemical biology & drug design.
2023 Oct; ?(?):. doi:
10.1111/cbdd.14369. [PMID: 37817304] - Peng Tang, Huiyin Wu, Mengru Wang, Yongpeng Wang, Ruihan Zhang, Xingjie Zhang, Xiaoli Li, Bin Liang, Weilie Xiao. Layer-by-layer reinforced-mediated sustained-release nanoantioxidants for long-lasting prevention against drug-induced liver injury.
Colloids and surfaces. B, Biointerfaces.
2023 Oct; 230(?):113489. doi:
10.1016/j.colsurfb.2023.113489. [PMID: 37574617] - Larissa Córdova Turones, Lucas S Machado, Boniek G Vaz, Gerlon de Almeida R Oliveira, Lorrane Kelle da Silva Moreira, Dionys de Souza Almeida, Aline Nazareth Martins, James Oluwagbamigbe Fajemiroye, José Luís R Martins, Paulo César Ghedini, Hericles Mesquita Campos, Fernanda Cristina A Dos Santos, Cinthia Rio Branco da Silva, Luciano M Lião, Eric de Souza Gil, Elson Alves Costa, Ricardo Menegatti. Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291.
Inflammopharmacology.
2023 Oct; 31(5):2451-2465. doi:
10.1007/s10787-023-01324-8. [PMID: 37667090] - Xianpeng Xu, Xinghong Liu, Jiongke Li, Xinxing Deng, Tianrong Dai, Qingjie Ji, Dajing Xiong, Hui Xie. Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence.
Clinical reviews in allergy & immunology.
2023 Oct; 65(2):188-205. doi:
10.1007/s12016-023-08964-2. [PMID: 37490237] - Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity.
Journal of ethnopharmacology.
2023 Sep; ?(?):117185. doi:
10.1016/j.jep.2023.117185. [PMID: 37714225] - Rabia Manzar, Shazma Massey, Laiba Arshad, Irva Waqar. Exploring the potential of natural polymers from plants as tablet binder and accessing their release profiles: A comparative analysis.
Pakistan journal of pharmaceutical sciences.
2023 Sep; 36(5(Special)):1663-1670. doi:
". [PMID: 38008965] - Masykur, Nurdin, Lukman Hakim, Rosnizar, Widya Sari, Munira Ulfa, Novi Yana Sari, Ria Ceriana. Effect of Ethanol Extract of Soursop (Annona muricata L.) Stem Bark on Rat Liver Function.
Pakistan journal of biological sciences : PJBS.
2023 Sep; 26(10):516-528. doi:
10.3923/pjbs.2023.516.528. [PMID: 38110557] - Mercedes Hinojosa, Isabel Oller, José María Quiroga, Sixto Malato, Agata Egea-Corbacho, Asunción Acevedo-Merino. Solar photo-Fenton optimization at neutral pH for microcontaminant removal at pilot plant scale.
Environmental science and pollution research international.
2023 Sep; 30(42):96208-96218. doi:
10.1007/s11356-023-28988-7. [PMID: 37566324] - Mahak Jain, Pilla Sai Kiran, Partha Sarathi Ghosal, Ashok Kumar Gupta. Development of microbial fuel cell integrated constructed wetland (CMFC) for removal of paracetamol and diclofenac in hospital wastewater.
Journal of environmental management.
2023 Aug; 344(?):118686. doi:
10.1016/j.jenvman.2023.118686. [PMID: 37536238] - Yiwen Hu, Mengcheng Li, Yongpeng Wang, Qingwang Xue, Xiaodong Luo, Afsar Khan, Tianrui Zhao, Yaping Liu, Zhengxuan Wang, Yudan Wang, Guiguang Cheng. Protective effect of hot-water and ethanol-aqueous extracts from Anneslea fragrans against acetaminophen-induced acute liver injury in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Jul; 179(?):113973. doi:
10.1016/j.fct.2023.113973. [PMID: 37506865] - Fatemeh Gheybi, Alireza Khooei, Azam Hoseinian, Maham Doagooyan, Kebria Houshangi, Mahmoud Reza Jaafari, Arash Papi, Zahra Khoddamipour, Amirhossein Sahebkar, Seyedeh Hoda Alavizadeh. Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study.
Biochemical and biophysical research communications.
2023 Jul; 676(?):103-108. doi:
10.1016/j.bbrc.2023.07.045. [PMID: 37506470] - C Salgado Costa, F Bahl, G S Natale, T M Mac Loughlin, D J G Marino, A Venturino, S Rodriguez-Mozaz, L H M L M Santos. First evidence of environmental bioaccumulation of pharmaceuticals on adult native anurans (Rhinella arenarum) from Argentina.
Environmental pollution (Barking, Essex : 1987).
2023 Jul; 334(?):122231. doi:
10.1016/j.envpol.2023.122231. [PMID: 37481029] - Lukman La Basy, Triana Hertiani, Retno Murwanti, Ema Damayanti. Investigation of Cox-2 inhibition of Laportea decumana (Roxb). Wedd extract to support its analgesic potential.
Journal of ethnopharmacology.
2023 Jul; ?(?):116857. doi:
10.1016/j.jep.2023.116857. [PMID: 37453622] - Haysem M Alhassen, Fiona J Dyer, Ross M Thompson. The photolytic breakdown of caffeine and paracetamol residues in surface water.
Water environment research : a research publication of the Water Environment Federation.
2023 Jul; ?(?):e10909. doi:
10.1002/wer.10909. [PMID: 37429828] - Roni Roy, Jony Roy, Israt Jahan Liya, Mohammad Anwarul Basher, Muhammed Yusuf Miah. Antipyretic and antinociceptive effects of methanolic extract of C. iria L. tuber.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116860. doi:
10.1016/j.jep.2023.116860. [PMID: 37419227] - Elsayed Hamed Ali Bakr, Reema Abdulrahman Saad Alyamani. Immunomodulatory Protective Effects of Nigella sativa and Lactuca sativa Oils on Liver Intoxication in Experimental Animals.
Pakistan journal of biological sciences : PJBS.
2023 Jul; 26(8):434-441. doi:
10.3923/pjbs.2023.434.441. [PMID: 37937337] - Taylan Dolu, Bilgehan Nas. Dissemination of nonsteroidal anti-inflammatory drugs (NSAIDs) and metabolites from wastewater treatment plant to soils and agricultural crops via real-scale different agronomic practices.
Environmental research.
2023 06; 227(?):115731. doi:
10.1016/j.envres.2023.115731. [PMID: 36958380] - Taha Messelmani, Anne Le Goff, Fabrice Soncin, Françoise Gilard, Zied Souguir, Nathalie Maubon, Bertrand Gakière, Cécile Legallais, Eric Leclerc, Rachid Jellali. Investigation of the metabolomic crosstalk between liver sinusoidal endothelial cells and hepatocytes exposed to paracetamol using organ-on-chip technology.
Toxicology.
2023 06; 492(?):153550. doi:
10.1016/j.tox.2023.153550. [PMID: 37209942] - Irma Putri Damayanti, Neni Susilaningsih, Trilaksana Nugroho, Suhartono Suhartono, Suryono Suryono, Hardhono Susanto, Ari Suwondo, Endang Mahati. The Effect of Curcumin Nanoparticles on Paracetamol-Induced Liver Injury in Male Wistar Rats.
Pharmaceutical nanotechnology.
2023 Jun; ?(?):. doi:
10.2174/2211738511666230601105536. [PMID: 37264664] - Chao Xiong, Yuan Jia, Xie Wu, Yanyan Zhao, Su Yuan, Fuxia Yan, Daniel I Sessler. Early Postoperative Acetaminophen Administration and Severe Acute Kidney Injury After Cardiac Surgery.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2023 06; 81(6):675-683.e1. doi:
10.1053/j.ajkd.2022.11.009. [PMID: 36586561] - Ming-Chuan Ho, Ru-Ying Yang, Guan-Fu Chen, Wei-Hsiang Chen. The effect of metformin and drinking water quality variation on haloacetamide formation during chlor(am)ination of acetaminophen.
Journal of environmental management.
2023 Jun; 335(?):117603. doi:
10.1016/j.jenvman.2023.117603. [PMID: 36893720] - Tianli Tang, Yimeng Wang, Chao Wang, Yufei Zhao, Xiangping Nie. Acetaminophen exposure alters the DNA methylation pattern of Mugilogobius chulae, along with the changes in the Nrf2-Keap1 signaling pathway.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2023 May; 270(?):109655. doi:
10.1016/j.cbpc.2023.109655. [PMID: 37187267] - Mitsue Hibino, Masatoshi Maeki, Manabu Tokeshi, Yoichi Ishitsuka, Hideyoshi Harashima, Yuma Yamada. A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury.
Scientific reports.
2023 05; 13(1):6961. doi:
10.1038/s41598-023-33893-7. [PMID: 37164988] - Seir Antonio Salazar Mercado, Diana Gabriela Vega Galvis. Paracetamol ecotoxicological bioassay using the bioindicators Lens culinaris Med. and Pisum sativum L.
Environmental science and pollution research international.
2023 May; 30(22):61965-61976. doi:
10.1007/s11356-023-26475-7. [PMID: 36934188] - Nathan K McLain, Melissa Y Gomez, Emma W Gachomo. Acetaminophen Levels Found in Recycled Wastewater Alter Soil Microbial Community Structure and Functional Diversity.
Microbial ecology.
2023 May; 85(4):1448-1462. doi:
10.1007/s00248-022-02022-8. [PMID: 35507048] - Yunong Zeng, Rong Wu, Fangzhao Wang, Shan Li, Lei Li, Yanru Li, Ping Qin, Mingyuan Wei, Junhao Yang, Jie Wu, Ali Chen, Guibao Ke, Zhengzheng Yan, Hong Yang, Zhongqing Chen, Zhang Wang, Wei Xiao, Yong Jiang, Xia Chen, Zhenhua Zeng, Xiaoshan Zhao, Peng Chen, Shenhai Gong. Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice.
Cell host & microbe.
2023 Apr; ?(?):. doi:
10.1016/j.chom.2023.04.002. [PMID: 37100057] - Xue He, Shi-Min Liang, Hong-Qian Wang, Li Tao, Fei-Fei Sun, Yan Wang, Cheng Zhang, Yi-Chao Huang, De-Xiang Xu, Xi Chen. Mitoquinone protects against acetaminophen-induced liver injury in an FSP1-dependent and GPX4-independent manner.
Toxicology and applied pharmacology.
2023 04; 465(?):116452. doi:
10.1016/j.taap.2023.116452. [PMID: 36894071] - D Shah, N Mahurkar, D Gadhave, R Nikhate, K Kakad. Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation.
Annales pharmaceutiques francaises.
2023 Apr; ?(?):. doi:
10.1016/j.pharma.2023.04.003. [PMID: 37060939] - Yeping Yu, Ling Chang, Qingluan Hu, Jianjun Zhu, Jianjun Zhang, Qiang Xia, Jie Zhao. P2rx1 deficiency alleviates acetaminophen-induced acute liver failure by regulating the STING signaling pathway.
Cell biology and toxicology.
2023 Apr; ?(?):. doi:
10.1007/s10565-023-09800-1. [PMID: 37046119] - Štěpán Zezulka, Marie Kummerová, Ján Šmeringai, Petr Babula, Jan Tříska. Ambiguous changes in photosynthetic parameters of Lemna minor L. after short-term exposure to naproxen and paracetamol: Can the risk be ignored?.
Aquatic toxicology (Amsterdam, Netherlands).
2023 Apr; 259(?):106537. doi:
10.1016/j.aquatox.2023.106537. [PMID: 37060818] - Jintao Li, Qiuxia Lu, Meihao Peng, Jiaqing Liao, Bowen Zhang, Di Yang, Peng Huang, Yixi Yang, Qi Zhao, Bo Han, Jian Li. Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Journal of ethnopharmacology.
2023 Apr; 305(?):116069. doi:
10.1016/j.jep.2022.116069. [PMID: 36572326] - Kassahun Dires Ayenew, Yared Wasihun. Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats.
BMC complementary medicine and therapies.
2023 Apr; 23(1):99. doi:
10.1186/s12906-023-03931-y. [PMID: 37005601] - Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Jia-Ting Huang, Hui-Ling Chen, Bing Han, Li-Shun Wang. Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction.
Liver international : official journal of the International Association for the Study of the Liver.
2023 04; 43(4):865-877. doi:
10.1111/liv.15512. [PMID: 36627827] - Ruowei Zhao, Qing Zhang, Wenjing Liu, Yifan Lin, Yuhui He, Dennis Chang, Shaohua Li, Wen Xu, Yanxiang Lin, Yanfang Zheng, Xian Zhou, Mingqing Huang. Pien Tze Huang attenuated acetaminophen-induced liver injury by autophagy mediated-NLRP3 inflammasome inhibition.
Journal of ethnopharmacology.
2023 Mar; ?(?):116285. doi:
10.1016/j.jep.2023.116285. [PMID: 36933874] - Qi Yu, Jin Zou, Chenxiao Yu, Guanwei Peng, Guorong Fan, Linyu Wang, Shangxing Chen, Limin Lu, Zongde Wang. Nitrogen Doped Porous Biochar/β-CD-MOFs Heterostructures: Bi-Functional Material for Highly Sensitive Electrochemical Detection and Removal of Acetaminophen.
Molecules (Basel, Switzerland).
2023 Mar; 28(6):. doi:
10.3390/molecules28062437. [PMID: 36985408] - Mohamed I Badawy, Fatma A El-Gohary, Mahmoud S Abdel-Wahed, Tarek A Gad-Allah, Mohamed E M Ali. Mass flow and consumption calculations of pharmaceuticals in sewage treatment plant with emphasis on the fate and risk quotient assessment.
Scientific reports.
2023 03; 13(1):3500. doi:
10.1038/s41598-023-30477-3. [PMID: 36859508] - Wendell Pimentel-Almeida, Ana Gabriela Itokazu, Heitor Alexandre Gonçalves Bazani, Marcelo Maraschin, Oder Henrique Coutinho Rodrigues, Rafaela Gordo Corrêa, Susane Lopes, Gizelle Inácio Almerindo, Rodolfo Moresco. Beach-cast Sargassum cymosum macroalgae: biochar production and apply to adsorption of Acetaminophen in batch and fixed-bed adsorption processes.
Environmental technology.
2023 Mar; 44(7):974-987. doi:
10.1080/09593330.2021.1989058. [PMID: 34605747] - Alparslan Koç, Mustafa Gazi, Ali Caner Sayar, Didem Onk, Muhammet Ali Arı, Bahadır Süleyman, Ahmet Gökhan Ağgül, Fikret Altındağ, Durdu Altuner, Halis Süleyman. Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats.
General physiology and biophysics.
2023 Mar; 42(2):201-208. doi:
10.4149/gpb_2022055. [PMID: 36896949] - Weiyun Wang, Yaru Chu, Pengyuan Zhang, Zhuo Liang, Zhenlin Fan, Xueqiang Guo, Guangdong Zhou, Wenjie Ren. Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis.
International immunopharmacology.
2023 Mar; 116(?):109790. doi:
10.1016/j.intimp.2023.109790. [PMID: 36736223] - Sangeetha Nithiyanandam, Sabina Evan Prince. Caesalpinia bonducella Counteracts Paracetamol-Instigated Hepatic Toxicity via Modulating TNF-α and IL-6/10 Expression and Bcl-2 and Caspase-8/3 Signalling.
Applied biochemistry and biotechnology.
2023 Feb; ?(?):. doi:
10.1007/s12010-023-04392-2. [PMID: 36853441] - Qian Li, Wen Zhang, Nuo Cheng, Yadi Zhu, Hao Li, Shuijun Zhang, Wenzhi Guo, Guangbo Ge. Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 113(?):154726. doi:
10.1016/j.phymed.2023.154726. [PMID: 36863308] - Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan. Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation.
Food & function.
2023 Feb; 14(4):1884-1896. doi:
10.1039/d2fo02716j. [PMID: 36723004] - Mengjuan Wei, Xinnan Gu, Han Li, Zhiyong Zheng, Zhimiao Qiu, Yuchen Sheng, Bin Lu, Zhengtao Wang, Lili Ji. EGR1 is crucial for the chlorogenic acid-provided promotion on liver regeneration and repair after APAP-induced liver injury.
Cell biology and toxicology.
2023 Feb; ?(?):. doi:
10.1007/s10565-023-09795-9. [PMID: 36809385] - Jinghao Zhao, Shang Shi, Xiaoyu Zhang, Yaping Liu, Minglong Yuan, Guiguang Cheng, Yudan Wang. Confusoside, a dihydrochalcone glucoside, prevents acetaminophen-induced liver injury by modulating the Nrf2/NF-κB/caspase signaling pathway.
Food & function.
2023 Feb; ?(?):. doi:
10.1039/d2fo03497b. [PMID: 36786681] - Hyunseong Kim, Jinyoung Hong, Junseon Lee, Wanjin Jeon, Changhwan Yeo, Yoonjae Lee, Seungho Baek, Inhyuk Ha. Curcuma aromatica Salisb. Protects from Acetaminophen-Induced Hepatotoxicity by Regulating the Sirt1/HO-1 Signaling Pathway.
Nutrients.
2023 Feb; 15(4):. doi:
10.3390/nu15040808. [PMID: 36839166] - Juan Manuel Peralta-Hernández, Enric Brillas. A critical review over the removal of paracetamol (acetaminophen) from synthetic waters and real wastewaters by direct, hybrid catalytic, and sequential ozonation processes.
Chemosphere.
2023 Feb; 313(?):137411. doi:
10.1016/j.chemosphere.2022.137411. [PMID: 36460148] - Hong Zhang, Xin-Nan Gu, Meng-Juan Wei, Li-Li Ji. [Discovery of miRNA and target signal molecules involved in inhibition of chlorogenic acid on N-acetyl-p-aminophenol-induced hepatotoxicity based on microRNA array].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Feb; 48(4):1014-1022. doi:
10.19540/j.cnki.cjcmm.20221017.401. [PMID: 36872272] - Hosny Abd El Fadil, Amany Behairy, Lamiaa L M Ebraheim, Yasmina M Abd-Elhakim, Heba Hussein Fathy. The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats.
Environmental science and pollution research international.
2023 Jan; ?(?):. doi:
10.1007/s11356-023-25152-z. [PMID: 36637651] - Chuanxia Yao, Yiwen Wang, DanDan Gong, Tian Feng, Yaqiong Zhang, Chunhui Wang, Maorong Wang, Jin Zhu. Anti-TLR4 IgG2 Prevents Acetaminophen-induced Acute Liver Injury through the Toll-like Receptor 4/MAPKs Signaling Pathway in Mice.
Current molecular medicine.
2023; 23(5):453-469. doi:
10.2174/1566524022666220516141728. [PMID: 35578873] - Gabriela R de Souza, Ana Cecilia A X De-Oliveira, Vitor Soares, Thamyris Perez De-Souza, Nancy S Barbi, Francisco J R Paumgartten, Antonio J R da Silva. Protective effects of a chemically characterized extract from solanum torvum leaves on acetaminophen-induced liver injury.
Drug and chemical toxicology.
2023 Jan; 46(1):122-135. doi:
10.1080/01480545.2021.2012905. [PMID: 35105269] - Zahra Mokhtari, Mahdieh Raeeszadeh, Loghman Akradi. Comparative Effect of the Active Substance of Thyme with N-Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity.
Analytical cellular pathology (Amsterdam).
2023; 2023(?):1714884. doi:
10.1155/2023/1714884. [PMID: 37056637] - Jinqiu Tao, Cailin Xue, Xiaodong Wang, Huihui Chen, Qiaoyu Liu, Chunping Jiang, Wenjie Zhang. GAS1 Promotes Ferroptosis of Liver Cells in Acetaminophen-Induced Acute Liver Failure.
International journal of medical sciences.
2023; 20(12):1616-1630. doi:
10.7150/ijms.85114. [PMID: 37859699] - Sanjeeb Mohapatra, Daniel Snow, Patrick Shea, Andy Gálvez-Rodríguez, Manish Kumar, Lokesh P Padhye, Suparna Mukherji. Photodegradation of a mixture of five pharmaceuticals commonly found in wastewater: Experimental and computational analysis.
Environmental research.
2023 01; 216(Pt 3):114659. doi:
10.1016/j.envres.2022.114659. [PMID: 36328221] - Shrilekha Chilvery, Amit Yelne, Amit Khurana, Mohd Aslam Saifi, Sapana Bansod, Pratibha Anchi, Chandraiah Godugu. Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 108(?):154510. doi:
10.1016/j.phymed.2022.154510. [PMID: 36332383] - Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan. Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice.
Journal of immunology research.
2023; 2023(?):1116841. doi:
10.1155/2023/1116841. [PMID: 37663051] - Xiankuan Li, Ying Zhao, Sihan Gong, Tianbao Song, Jiaming Ge, Jiarong Li, Jian Zhang, Kun Fu, Yanchao Zheng, Lin Ma. Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy.
Bioorganic chemistry.
2023 01; 130(?):106272. doi:
10.1016/j.bioorg.2022.106272. [PMID: 36403334] - Xiangfu Jiang, Yu Li, Dongdong Fu, Tingyu You, Shuai Wu, Jiao Xin, Jiagen Wen, Yan Huang, Chengmu Hu. Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway.
International immunopharmacology.
2023 Jan; 114(?):109558. doi:
10.1016/j.intimp.2022.109558. [PMID: 36700765] - Yiwei Liu, Yu Xue, Zhiqin Zhang, Jingmin Ji, Caige Li, Kangning Zheng, Junlan Lu, Yuting Gao, Yi Gong, Yuman Zhang, Xinli Shi. Wolfberry enhanced the abundance of Akkermansia muciniphila by YAP1 in mice with acetaminophen-induced liver injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 01; 37(1):e22689. doi:
10.1096/fj.202200945r. [PMID: 36468767] - Fusheng Guo, Yihui Gao, Xiaobao Li, Xiaoguang Lei. Natural Product 2-Oxokolavenol Is a Novel FXR Agonist.
Molecules (Basel, Switzerland).
2022 Dec; 27(24):. doi:
10.3390/molecules27248968. [PMID: 36558100] - Nida Sohail, Maria Azam, Hafiza Farhat, Khan Hira, Faizah Urooj, Shamim A Qureshi, Jehan Ara, Muhammad Shaiq Ali, Syed Ehteshamul-Haque. Ulva fasciata, a green alga, attenuates the kidney and liver dysfunctions in rats induced by acetaminophen.
Drug and chemical toxicology.
2022 Dec; ?(?):1-14. doi:
10.1080/01480545.2022.2150206. [PMID: 36476192] - Xinyu Deng, Yubing Li, Xing Li, Zhenpeng Zhang, Shu Dai, Hefei Wu, Fangling Zhang, Qichao Hu, Yuan Chen, Jinhao Zeng, Xiao Ma. Paeoniflorin Protects against Acetaminophen-Induced Liver Injury in Mice via JNK Signaling Pathway.
Molecules (Basel, Switzerland).
2022 Dec; 27(23):. doi:
10.3390/molecules27238534. [PMID: 36500627] - Rasha M Hussein, Mohamed A Kandeil, Norhan A Mohammed, Rasha A Khallaf. Evaluation of the hepatoprotective effect of curcumin-loaded solid lipid nanoparticles against paracetamol overdose toxicity: Role of inducible nitric oxide synthase.
Journal of liposome research.
2022 Dec; 32(4):365-375. doi:
10.1080/08982104.2022.2032737. [PMID: 35132919] - Katrine D Galsgaard, Emilie Elmelund, Christian D Johansen, Anna B Bomholt, Hüsün S Kizilkaya, Frederik Ceutz, Jenna E Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M Sørensen, Thomas Kruse, Jesper F Lau, Mette M Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J Holst, Nicolai J Wewer Albrechtsen. Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Molecular metabolism.
2022 12; 66(?):101639. doi:
10.1016/j.molmet.2022.101639. [PMID: 36400402] - M Rajamehala, A Muthukumara Pandian, M Rajasimman, B Gopalakrishnan. Synthesis of metal-based functional nanocomposite material and its application for the elimination of paracetamol from synthetic wastewater.
Chemosphere.
2022 Dec; 308(Pt 3):136530. doi:
10.1016/j.chemosphere.2022.136530. [PMID: 36150496] - Andrew McPherson Heitman, Robert R Bies, Sorell L Schwartz. A Physiologically-Based Pharmacokinetic Model of the Brain Considering Regional Lipid Variance.
The Journal of pharmacology and experimental therapeutics.
2022 12; 383(3):217-226. doi:
10.1124/jpet.122.001256. [PMID: 36167416] - Jing Zhao, Kaixin Ding, Manting Hou, Yuanhua Li, Xiaorong Hou, Wenzhang Dai, Zhiyong Li, Jun Zhao, Wenlong Liu, Zhaofang Bai. Schisandra chinensis essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy.
Pharmaceutical biology.
2022 Dec; 60(1):958-967. doi:
10.1080/13880209.2022.2067569. [PMID: 35588406] - Kyung-A Hwang, YuJin Hwang, Hye-Jeong Hwang, NaYeong Park. Hepatoprotective Effects of Radish (Raphanus sativus L.) on Acetaminophen-Induced Liver Damage via Inhibiting Oxidative Stress and Apoptosis.
Nutrients.
2022 Nov; 14(23):. doi:
10.3390/nu14235082. [PMID: 36501112] - Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill, Muhammad Torequl Islam. GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study.
Life sciences.
2022 Nov; 309(?):121044. doi:
10.1016/j.lfs.2022.121044. [PMID: 36208657] - Hadis Goodarzi, Fatemeh Valizadeh, Fatemeh Ghasemi, Farzad Ebrahimzade, Seyedeh Hanieh Seifosadat, Bahram Delfan, Nadereh Taee. Comparing the effect of body wash with marshmallow plant and lukewarm water on reducing the temperature of febrile children: a randomized clinical trial.
BMC complementary medicine and therapies.
2022 Nov; 22(1):293. doi:
10.1186/s12906-022-03762-3. [PMID: 36369081] - Kaiyang Liu, Xi Chen, Yue Ren, Chaoqun Liu, Anlei Yuan, Lulu Zheng, Beiyan Li, Yanling Zhang. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation.
Toxicology and applied pharmacology.
2022 11; 454(?):116251. doi:
10.1016/j.taap.2022.116251. [PMID: 36150480] - Meng-Si Luo, Guan-Jiang Huang. The efficacy of peritonsillar injection of bupivacaine vs intravenous acetaminophen on post-tonsillectomy pain in children.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2022 11; 279(11):5459-5461. doi:
10.1007/s00405-021-07146-0. [PMID: 34671857]