4-Pyridoxic acid (BioDeep_00000229620)

Main id: BioDeep_00000001121

 

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


4-Pyridoxic acid

化学式: C8H9NO4 (183.0531554)
中文名称: 4-吡哆酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC=C(C(=C1O)C(=O)O)CO
InChI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)

描述信息

4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine.

同义名列表

1 个代谢物同义名

4-Pyridoxic acid



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Xu, Yu-Jing Fang, Meng-Meng Che, Alinuer Abulimiti, Chu-Yi Huang, Cai-Xia Zhang. Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122389. [PMID: 35745119]
  • Justin Towner, Brian Rago, David Rodrigues, Manoli Vourvahis, Chris Holliman. A novel hydrophilic interaction chromatography assay characterization of 4-pyridoxic acid, an emergent renal organic anion transporter 1/3 transporter biomarker. Bioanalysis. 2021 Sep; 13(18):1391-1400. doi: 10.4155/bio-2021-0110. [PMID: 34551579]
  • Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 08; 78(2):226-235.e1. doi: 10.1053/j.ajkd.2020.12.005. [PMID: 33421453]
  • Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami-Hodjegan, Aleksandra Galetin. Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters. CPT: pharmacometrics & systems pharmacology. 2021 05; 10(5):467-477. doi: 10.1002/psp4.12610. [PMID: 33704919]
  • Huai Huang, Li-Ying Shi, Li-Liang Wei, Yu-Shuai Han, Wen-Jing Yi, Zhi-Wen Pan, Ting-Ting Jiang, Jing Chen, Hui-Hui Tu, Zhi-Bin Li, Yu-Ting Hu, Ji-Cheng Li. Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis. Clinica chimica acta; international journal of clinical chemistry. 2019 Nov; 498(?):135-142. doi: 10.1016/j.cca.2019.08.017. [PMID: 31442449]
  • Tomomitsu Sado, Setsuko Nakata, Takahisa Tsuno, Masanori Sato, Yuka Misawa, Shoko Yamauchi, Yuji Inaba, Daisuke Kobayashi, Keiji Wada. Concentrations of various forms of vitamin B6 in ginkgo seed poisoning. Brain & development. 2019 Mar; 41(3):292-295. doi: 10.1016/j.braindev.2018.10.007. [PMID: 30366747]
  • Daisuke Kobayashi. [Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2019; 139(1):1-6. doi: 10.1248/yakushi.18-00136. [PMID: 30606915]
  • Hong Shen, Vinay K Holenarsipur, T Thanga Mariappan, Dieter M Drexler, Joseph L Cantone, Prabhakar Rajanna, Shashyendra Singh Gautam, Yueping Zhang, Jinping Gan, Petia A Shipkova, Punit Marathe, W Griffith Humphreys. Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects. The Journal of pharmacology and experimental therapeutics. 2019 01; 368(1):136-145. doi: 10.1124/jpet.118.252643. [PMID: 30361237]
  • Tiina Jääskeläinen, Olli Kärkkäinen, Jenna Jokkala, Kaisa Litonius, Seppo Heinonen, Seppo Auriola, Marko Lehtonen, Kati Hanhineva, Hannele Laivuori. A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants. Scientific reports. 2018 10; 8(1):14616. doi: 10.1038/s41598-018-32804-5. [PMID: 30279541]
  • Tomoyuki Akiyama, Takuo Kubota, Keiichi Ozono, Toshimi Michigami, Daisuke Kobayashi, Shinji Takeyari, Yuichiro Sugiyama, Masahiro Noda, Daisuke Harada, Noriyuki Namba, Atsushi Suzuki, Maiko Utoyama, Sachiko Kitanaka, Mitsugu Uematsu, Yusuke Mitani, Kunihiro Matsunami, Shigeru Takishima, Erika Ogawa, Katsuhiro Kobayashi. Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy. Molecular genetics and metabolism. 2018 09; 125(1-2):174-180. doi: 10.1016/j.ymgme.2018.07.006. [PMID: 30049651]
  • Hong Shen, David M Nelson, Regina V Oliveira, Yueping Zhang, Colleen A Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D Reily, Petia A Shipkova, Jinping Gan, Yurong Lai, Punit Marathe, W Griffith Humphreys. Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys. Drug metabolism and disposition: the biological fate of chemicals. 2018 02; 46(2):178-188. doi: 10.1124/dmd.117.077586. [PMID: 29162614]
  • Hui Zuo, Grethe S Tell, Per M Ueland, Ottar Nygård, Stein E Vollset, Øivind Midttun, Klaus Meyer, Arve Ulvik. The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK). The American journal of clinical nutrition. 2018 01; 107(1):105-112. doi: 10.1093/ajcn/nqx012. [PMID: 29381795]
  • Tomoyuki Akiyama, Yumiko Hayashi, Yoshiyuki Hanaoka, Takashi Shibata, Mari Akiyama, Hiroki Tsuchiya, Tokito Yamaguchi, Katsuhiro Kobayashi. Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children. Clinica chimica acta; international journal of clinical chemistry. 2017 Sep; 472(?):118-122. doi: 10.1016/j.cca.2017.07.032. [PMID: 28778380]
  • D W Sullivan, R C Peterson, C V Mujer, S C Gad. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats. Human & experimental toxicology. 2017 Jul; 36(7):718-726. doi: 10.1177/0960327116661023. [PMID: 27507076]
  • Björn Gylling, Robin Myte, Jörn Schneede, Göran Hallmans, Jenny Häggström, Ingegerd Johansson, Arve Ulvik, Per M Ueland, Bethany Van Guelpen, Richard Palmqvist. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status. The American journal of clinical nutrition. 2017 04; 105(4):897-904. doi: 10.3945/ajcn.116.139337. [PMID: 28275126]
  • Joyce Y Huang, Lesley M Butler, Øivind Midttun, Woon-Puay Koh, Per M Ueland, Renwei Wang, Aizhen Jin, Yu-Tang Gao, Jian-Min Yuan. Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations. Cancer causes & control : CCC. 2016 Dec; 27(12):1447-1456. doi: 10.1007/s10552-016-0822-6. [PMID: 27830400]
  • Déborah Mathis, Lucia Abela, Monique Albersen, Céline Bürer, Lisa Crowther, Karin Beese, Hans Hartmann, Levinus A Bok, Eduard Struys, Sorina M Papuc, Anita Rauch, Martin Hersberger, Nanda M Verhoeven-Duif, Barbara Plecko. The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies. Journal of inherited metabolic disease. 2016 09; 39(5):733-741. doi: 10.1007/s10545-016-9955-8. [PMID: 27342130]
  • Arve Ulvik, Eva R Pedersen, Gard Ft Svingen, Adrian McCann, Øivind Midttun, Ottar Nygård, Per M Ueland. Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease. The American journal of clinical nutrition. 2016 06; 103(6):1417-25. doi: 10.3945/ajcn.115.126342. [PMID: 27169836]
  • Sigrid Kalle, Risto Tanner, Jürgen Arund, Ruth Tomson, Merike Luman, Ivo Fridolin. 4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring. PloS one. 2016; 11(9):e0162346. doi: 10.1371/journal.pone.0162346. [PMID: 27598005]
  • Daisuke Kobayashi, Teruki Yoshimura, Atsushi Johno, Mika Ishikawa, Keiko Sasaki, Keiji Wada. Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration. Nutrition research (New York, N.Y.). 2015 Jul; 35(7):637-42. doi: 10.1016/j.nutres.2015.05.015. [PMID: 26092494]
  • Tonia C Carter, Faith Pangilinan, Anne M Molloy, Ruzong Fan, Yifan Wang, Barry Shane, Eileen R Gibney, Øivind Midttun, Per M Ueland, Cheryl D Cropp, Yoonhee Kim, Alexander F Wilson, Joan E Bailey-Wilson, Lawrence C Brody, James L Mills. Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults. The Journal of nutrition. 2015 Jul; 145(7):1386-93. doi: 10.3945/jn.114.208769. [PMID: 25972531]
  • Hui Zuo, Per M Ueland, Simone J P M Eussen, Grethe S Tell, Stein E Vollset, Ottar Nygård, Øivind Midttun, Klaus Meyer, Arve Ulvik. Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study. International journal of cancer. 2015 Jun; 136(12):2932-9. doi: 10.1002/ijc.29345. [PMID: 25404109]
  • Wilfred A Nix, Rudolf Zirwes, Volkhard Bangert, Raimund Peter Kaiser, Matthias Schilling, Ulrike Hostalek, Rima Obeid. Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy. Diabetes research and clinical practice. 2015 Jan; 107(1):157-65. doi: 10.1016/j.diabres.2014.09.058. [PMID: 25458341]
  • Monique Albersen, Marjolein Bosma, Judith J M Jans, Floris C Hofstede, Peter M van Hasselt, Monique G M de Sain-van der Velden, Gepke Visser, Nanda M Verhoeven-Duif. Vitamin B6 in plasma and cerebrospinal fluid of children. PloS one. 2015; 10(3):e0120972. doi: 10.1371/journal.pone.0120972. [PMID: 25760040]
  • Per Magne Ueland, Arve Ulvik, Luisa Rios-Avila, Øivind Midttun, Jesse F Gregory. Direct and Functional Biomarkers of Vitamin B6 Status. Annual review of nutrition. 2015; 35(?):33-70. doi: 10.1146/annurev-nutr-071714-034330. [PMID: 25974692]
  • Monique Albersen, Marjolein Bosma, Jurjen J Luykx, Judith J M Jans, Steven C Bakker, Eric Strengman, Paul J Borgdorff, Peter J M Keijzers, Eric P A van Dongen, Peter Bruins, Monique G M de Sain-van der Velden, Gepke Visser, Nine V V A M Knoers, Roel A Ophoff, Nanda M Verhoeven-Duif. Vitamin B-6 vitamers in human plasma and cerebrospinal fluid. The American journal of clinical nutrition. 2014 Aug; 100(2):587-92. doi: 10.3945/ajcn.113.082008. [PMID: 24808484]
  • Arve Ulvik, Øivind Midttun, Eva R Pedersen, Simone Jpm Eussen, Ottar Nygård, Per M Ueland. Evidence for increased catabolism of vitamin B-6 during systemic inflammation. The American journal of clinical nutrition. 2014 Jul; 100(1):250-5. doi: 10.3945/ajcn.114.083196. [PMID: 24808485]
  • Rona Cabo, Karolina Kozik, Maciej Milanowski, Sigrunn Hernes, Audun Slettan, Margaretha Haugen, Shu Ye, Rune Blomhoff, M Azam Mansoor. A simple high-performance liquid chromatography (HPLC) method for the measurement of pyridoxal-5-phosphate and 4-pyridoxic acid in human plasma. Clinica chimica acta; international journal of clinical chemistry. 2014 Jun; 433(?):150-6. doi: 10.1016/j.cca.2014.03.003. [PMID: 24657184]
  • Huawei Zhang, Peng Fu, Beilei Ke, Shuping Wang, Min Li, Lin Han, Chengcheng Peng, Weidong Zhang, Runhui Liu. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. Journal of ethnopharmacology. 2014 May; 154(1):55-64. doi: 10.1016/j.jep.2014.03.007. [PMID: 24709313]
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  • Svetlana Dolina, Dov Margalit, Sergey Malitsky, Eugeny Pressman, Aharon Rabinkov. Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment. Medical hypotheses. 2012 Aug; 79(2):157-64. doi: 10.1016/j.mehy.2012.04.022. [PMID: 22647618]
  • Arve Ulvik, Øivind Midttun, Eva Ringdal Pedersen, Ottar Nygård, Per M Ueland. Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. The American journal of clinical nutrition. 2012 May; 95(5):1072-8. doi: 10.3945/ajcn.111.029751. [PMID: 22492365]
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  • Antonysunil Adaikalakoteswari, Naila Rabbani, Sarwono Waspadji, Askandar Tjokroprawiro, Sri H K S Kariadi, John M F Adam, Paul J Thornalley. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation. Diabetes research and clinical practice. 2012 Mar; 95(3):415-24. doi: 10.1016/j.diabres.2011.10.042. [PMID: 22133652]
  • Chen-Tai Hou, Ying-Hsun Wu, Pei-Ning Huang, Chien-Hsiang Cheng, Yi-Chia Huang. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status. Clinical nutrition (Edinburgh, Scotland). 2011 Aug; 30(4):478-83. doi: 10.1016/j.clnu.2011.01.014. [PMID: 21349613]
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