4-Pyridoxic acid (BioDeep_00000229620)
Main id: BioDeep_00000001121
human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
化学式: C8H9NO4 (183.0532)
中文名称: 4-吡哆酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=C1O)C(=O)O)CO
InChI: InChI=1S/C8H9NO4/c1-4-7(11)6(8(12)13)5(3-10)2-9-4/h2,10-11H,3H2,1H3,(H,12,13)
描述信息
4-Pyridoxic acid is a catabolic product of vitamin B6 which is excreted in the urine.
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:17405
- KEGG: C00847
- PubChem: 6723
- HMDB: HMDB00017
- MeSH: Pyridoxic Acid
- CAS: 82-82-6
- MoNA: MT000123
- PubChem: 4104
- 3DMET: B00188
- NIKKAJI: J41.097G
- RefMet: 4-Pyridoxic acid
- medchemexpress: HY-113493
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-127
- KNApSAcK: 17405
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 9646 - Ailuropoda melanoleuca: 10.1371/JOURNAL.PONE.0143417
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 5691 - Trypanosoma brucei:
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Lei Xu, Yu-Jing Fang, Meng-Meng Che, Alinuer Abulimiti, Chu-Yi Huang, Cai-Xia Zhang. Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study.
Nutrients.
2022 Jun; 14(12):. doi:
10.3390/nu14122389
. [PMID: 35745119] - Justin Towner, Brian Rago, David Rodrigues, Manoli Vourvahis, Chris Holliman. A novel hydrophilic interaction chromatography assay characterization of 4-pyridoxic acid, an emergent renal organic anion transporter 1/3 transporter biomarker.
Bioanalysis.
2021 Sep; 13(18):1391-1400. doi:
10.4155/bio-2021-0110
. [PMID: 34551579] - Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 08; 78(2):226-235.e1. doi:
10.1053/j.ajkd.2020.12.005
. [PMID: 33421453] - Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami-Hodjegan, Aleksandra Galetin. Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.
CPT: pharmacometrics & systems pharmacology.
2021 05; 10(5):467-477. doi:
10.1002/psp4.12610
. [PMID: 33704919] - Huai Huang, Li-Ying Shi, Li-Liang Wei, Yu-Shuai Han, Wen-Jing Yi, Zhi-Wen Pan, Ting-Ting Jiang, Jing Chen, Hui-Hui Tu, Zhi-Bin Li, Yu-Ting Hu, Ji-Cheng Li. Plasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis.
Clinica chimica acta; international journal of clinical chemistry.
2019 Nov; 498(?):135-142. doi:
10.1016/j.cca.2019.08.017
. [PMID: 31442449] - Tomomitsu Sado, Setsuko Nakata, Takahisa Tsuno, Masanori Sato, Yuka Misawa, Shoko Yamauchi, Yuji Inaba, Daisuke Kobayashi, Keiji Wada. Concentrations of various forms of vitamin B6 in ginkgo seed poisoning.
Brain & development.
2019 Mar; 41(3):292-295. doi:
10.1016/j.braindev.2018.10.007
. [PMID: 30366747] - Daisuke Kobayashi. [Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2019; 139(1):1-6. doi:
10.1248/yakushi.18-00136
. [PMID: 30606915] - Hong Shen, Vinay K Holenarsipur, T Thanga Mariappan, Dieter M Drexler, Joseph L Cantone, Prabhakar Rajanna, Shashyendra Singh Gautam, Yueping Zhang, Jinping Gan, Petia A Shipkova, Punit Marathe, W Griffith Humphreys. Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
The Journal of pharmacology and experimental therapeutics.
2019 01; 368(1):136-145. doi:
10.1124/jpet.118.252643
. [PMID: 30361237] - Tiina Jääskeläinen, Olli Kärkkäinen, Jenna Jokkala, Kaisa Litonius, Seppo Heinonen, Seppo Auriola, Marko Lehtonen, Kati Hanhineva, Hannele Laivuori. A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.
Scientific reports.
2018 10; 8(1):14616. doi:
10.1038/s41598-018-32804-5
. [PMID: 30279541] - Tomoyuki Akiyama, Takuo Kubota, Keiichi Ozono, Toshimi Michigami, Daisuke Kobayashi, Shinji Takeyari, Yuichiro Sugiyama, Masahiro Noda, Daisuke Harada, Noriyuki Namba, Atsushi Suzuki, Maiko Utoyama, Sachiko Kitanaka, Mitsugu Uematsu, Yusuke Mitani, Kunihiro Matsunami, Shigeru Takishima, Erika Ogawa, Katsuhiro Kobayashi. Pyridoxal 5'-phosphate and related metabolites in hypophosphatasia: Effects of enzyme replacement therapy.
Molecular genetics and metabolism.
2018 09; 125(1-2):174-180. doi:
10.1016/j.ymgme.2018.07.006
. [PMID: 30049651] - Hong Shen, David M Nelson, Regina V Oliveira, Yueping Zhang, Colleen A Mcnaney, Xiaomei Gu, Weiqi Chen, Ching Su, Michael D Reily, Petia A Shipkova, Jinping Gan, Yurong Lai, Punit Marathe, W Griffith Humphreys. Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug metabolism and disposition: the biological fate of chemicals.
2018 02; 46(2):178-188. doi:
10.1124/dmd.117.077586
. [PMID: 29162614] - Hui Zuo, Grethe S Tell, Per M Ueland, Ottar Nygård, Stein E Vollset, Øivind Midttun, Klaus Meyer, Arve Ulvik. The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK).
The American journal of clinical nutrition.
2018 01; 107(1):105-112. doi:
10.1093/ajcn/nqx012
. [PMID: 29381795] - Tomoyuki Akiyama, Yumiko Hayashi, Yoshiyuki Hanaoka, Takashi Shibata, Mari Akiyama, Hiroki Tsuchiya, Tokito Yamaguchi, Katsuhiro Kobayashi. Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children.
Clinica chimica acta; international journal of clinical chemistry.
2017 Sep; 472(?):118-122. doi:
10.1016/j.cca.2017.07.032
. [PMID: 28778380] - D W Sullivan, R C Peterson, C V Mujer, S C Gad. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats.
Human & experimental toxicology.
2017 Jul; 36(7):718-726. doi:
10.1177/0960327116661023
. [PMID: 27507076] - Björn Gylling, Robin Myte, Jörn Schneede, Göran Hallmans, Jenny Häggström, Ingegerd Johansson, Arve Ulvik, Per M Ueland, Bethany Van Guelpen, Richard Palmqvist. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
The American journal of clinical nutrition.
2017 04; 105(4):897-904. doi:
10.3945/ajcn.116.139337
. [PMID: 28275126] - Joyce Y Huang, Lesley M Butler, Øivind Midttun, Woon-Puay Koh, Per M Ueland, Renwei Wang, Aizhen Jin, Yu-Tang Gao, Jian-Min Yuan. Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations.
Cancer causes & control : CCC.
2016 Dec; 27(12):1447-1456. doi:
10.1007/s10552-016-0822-6
. [PMID: 27830400] - Déborah Mathis, Lucia Abela, Monique Albersen, Céline Bürer, Lisa Crowther, Karin Beese, Hans Hartmann, Levinus A Bok, Eduard Struys, Sorina M Papuc, Anita Rauch, Martin Hersberger, Nanda M Verhoeven-Duif, Barbara Plecko. The value of plasma vitamin B6 profiles in early onset epileptic encephalopathies.
Journal of inherited metabolic disease.
2016 09; 39(5):733-741. doi:
10.1007/s10545-016-9955-8
. [PMID: 27342130] - Arve Ulvik, Eva R Pedersen, Gard Ft Svingen, Adrian McCann, Øivind Midttun, Ottar Nygård, Per M Ueland. Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease.
The American journal of clinical nutrition.
2016 06; 103(6):1417-25. doi:
10.3945/ajcn.115.126342
. [PMID: 27169836] - Sigrid Kalle, Risto Tanner, Jürgen Arund, Ruth Tomson, Merike Luman, Ivo Fridolin. 4-Pyridoxic Acid in the Spent Dialysate: Contribution to Fluorescence and Optical Monitoring.
PloS one.
2016; 11(9):e0162346. doi:
10.1371/journal.pone.0162346
. [PMID: 27598005] - Daisuke Kobayashi, Teruki Yoshimura, Atsushi Johno, Mika Ishikawa, Keiko Sasaki, Keiji Wada. Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration.
Nutrition research (New York, N.Y.).
2015 Jul; 35(7):637-42. doi:
10.1016/j.nutres.2015.05.015
. [PMID: 26092494] - Tonia C Carter, Faith Pangilinan, Anne M Molloy, Ruzong Fan, Yifan Wang, Barry Shane, Eileen R Gibney, Øivind Midttun, Per M Ueland, Cheryl D Cropp, Yoonhee Kim, Alexander F Wilson, Joan E Bailey-Wilson, Lawrence C Brody, James L Mills. Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.
The Journal of nutrition.
2015 Jul; 145(7):1386-93. doi:
10.3945/jn.114.208769
. [PMID: 25972531] - Hui Zuo, Per M Ueland, Simone J P M Eussen, Grethe S Tell, Stein E Vollset, Ottar Nygård, Øivind Midttun, Klaus Meyer, Arve Ulvik. Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study.
International journal of cancer.
2015 Jun; 136(12):2932-9. doi:
10.1002/ijc.29345
. [PMID: 25404109] - Wilfred A Nix, Rudolf Zirwes, Volkhard Bangert, Raimund Peter Kaiser, Matthias Schilling, Ulrike Hostalek, Rima Obeid. Vitamin B status in patients with type 2 diabetes mellitus with and without incipient nephropathy.
Diabetes research and clinical practice.
2015 Jan; 107(1):157-65. doi:
10.1016/j.diabres.2014.09.058
. [PMID: 25458341] - Monique Albersen, Marjolein Bosma, Judith J M Jans, Floris C Hofstede, Peter M van Hasselt, Monique G M de Sain-van der Velden, Gepke Visser, Nanda M Verhoeven-Duif. Vitamin B6 in plasma and cerebrospinal fluid of children.
PloS one.
2015; 10(3):e0120972. doi:
10.1371/journal.pone.0120972
. [PMID: 25760040] - Per Magne Ueland, Arve Ulvik, Luisa Rios-Avila, Øivind Midttun, Jesse F Gregory. Direct and Functional Biomarkers of Vitamin B6 Status.
Annual review of nutrition.
2015; 35(?):33-70. doi:
10.1146/annurev-nutr-071714-034330
. [PMID: 25974692] - Monique Albersen, Marjolein Bosma, Jurjen J Luykx, Judith J M Jans, Steven C Bakker, Eric Strengman, Paul J Borgdorff, Peter J M Keijzers, Eric P A van Dongen, Peter Bruins, Monique G M de Sain-van der Velden, Gepke Visser, Nine V V A M Knoers, Roel A Ophoff, Nanda M Verhoeven-Duif. Vitamin B-6 vitamers in human plasma and cerebrospinal fluid.
The American journal of clinical nutrition.
2014 Aug; 100(2):587-92. doi:
10.3945/ajcn.113.082008
. [PMID: 24808484] - Arve Ulvik, Øivind Midttun, Eva R Pedersen, Simone Jpm Eussen, Ottar Nygård, Per M Ueland. Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
The American journal of clinical nutrition.
2014 Jul; 100(1):250-5. doi:
10.3945/ajcn.114.083196
. [PMID: 24808485] - Rona Cabo, Karolina Kozik, Maciej Milanowski, Sigrunn Hernes, Audun Slettan, Margaretha Haugen, Shu Ye, Rune Blomhoff, M Azam Mansoor. A simple high-performance liquid chromatography (HPLC) method for the measurement of pyridoxal-5-phosphate and 4-pyridoxic acid in human plasma.
Clinica chimica acta; international journal of clinical chemistry.
2014 Jun; 433(?):150-6. doi:
10.1016/j.cca.2014.03.003
. [PMID: 24657184] - Huawei Zhang, Peng Fu, Beilei Ke, Shuping Wang, Min Li, Lin Han, Chengcheng Peng, Weidong Zhang, Runhui Liu. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang.
Journal of ethnopharmacology.
2014 May; 154(1):55-64. doi:
10.1016/j.jep.2014.03.007
. [PMID: 24709313] - Magdalena Jankowska, Marcin Marszałł, Alicja Dębska-Ślizień, Juan J Carrero, Bengt Lindholm, Wojciech Czarnowski, Bolesław Rutkowski, Piotr Trzonkowski. Vitamin B6 and the immunity in kidney transplant recipients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2013 Jan; 23(1):57-64. doi:
10.1053/j.jrn.2012.01.023
. [PMID: 22445054] - Svetlana Dolina, Dov Margalit, Sergey Malitsky, Eugeny Pressman, Aharon Rabinkov. Epilepsy as a pyridoxine-dependent condition: quantified urinary biomarkers for status evaluation and monitoring antiepileptic treatment.
Medical hypotheses.
2012 Aug; 79(2):157-64. doi:
10.1016/j.mehy.2012.04.022
. [PMID: 22647618] - Arve Ulvik, Øivind Midttun, Eva Ringdal Pedersen, Ottar Nygård, Per M Ueland. Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris.
The American journal of clinical nutrition.
2012 May; 95(5):1072-8. doi:
10.3945/ajcn.111.029751
. [PMID: 22492365] - Louise Clement, Mallory Boylan, Virginia Miller, Judy Driskell, David Giraud, Hadil Subih. Vitamin B-6 vitamer levels in plasma and related symptoms in hemodialysis subjects taking low- and high-dose renal multivitamin supplements.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2012 Apr; 82(2):130-6. doi:
10.1024/0300-9831/a000102
. [PMID: 23065838] - Antonysunil Adaikalakoteswari, Naila Rabbani, Sarwono Waspadji, Askandar Tjokroprawiro, Sri H K S Kariadi, John M F Adam, Paul J Thornalley. Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.
Diabetes research and clinical practice.
2012 Mar; 95(3):415-24. doi:
10.1016/j.diabres.2011.10.042
. [PMID: 22133652] - Chen-Tai Hou, Ying-Hsun Wu, Pei-Ning Huang, Chien-Hsiang Cheng, Yi-Chia Huang. Higher plasma pyridoxal 5'-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status.
Clinical nutrition (Edinburgh, Scotland).
2011 Aug; 30(4):478-83. doi:
10.1016/j.clnu.2011.01.014
. [PMID: 21349613] - William R Wikoff, Megha A Nagle, Valentina L Kouznetsova, Igor F Tsigelny, Sanjay K Nigam. Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).
Journal of proteome research.
2011 Jun; 10(6):2842-51. doi:
10.1021/pr200093w
. [PMID: 21476605] - Hsin-Yueh Chang, Jason T C Tzen, Su-Jen Lin, Yi-Ting Wu, En-Pei Isabel Chiang. Long-term prednisolone treatments increase bioactive vitamin B6 synthesis in vivo.
The Journal of pharmacology and experimental therapeutics.
2011 Apr; 337(1):102-9. doi:
10.1124/jpet.110.174839
. [PMID: 21205917] - Arjun Sengupta, Angika Basant, Soumita Ghosh, Shobhona Sharma, Haripalsingh M Sonawat. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria.
Journal of parasitology research.
2011; 2011(?):901854. doi:
10.1155/2011/901854
. [PMID: 21772982] - Veronika Ragaller, Peter Lebzien, Wiebke Bigalke, Karl-Heinz Südekum, Liane Hüthera, Gerhard Flachowsky. Effects of folic acid supplementation to rations differing in the concentrate to roughage ratio on ruminal fermentation, nutrient flow at the duodenum, and on serum and milk variables of dairy cows.
Archives of animal nutrition.
2010 Dec; 64(6):484-503. doi:
10.1080/1745039x.2010.520407
. [PMID: 21214021] - Simone J P M Eussen, Stein Emil Vollset, Steinar Hustad, Øivind Midttun, Klaus Meyer, Ase Fredriksen, Per Magne Ueland, Mazda Jenab, Nadia Slimani, Paolo Boffetta, Kim Overvad, Ole Thorlacius-Ussing, Anne Tjønneland, Anja Olsen, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Sophie Morois, Cornelia Weikert, Tobias Pischon, Jakob Linseisen, Rudolf Kaaks, Antonia Trichopoulou, Demosthenes Zilis, Michael Katsoulis, Domenico Palli, Valeria Pala, Paolo Vineis, Rosario Tumino, Salvatore Panico, Petra H M Peeters, H Bas Bueno-de-Mesquita, Fränzel J B van Duijnhoven, Guri Skeie, Xavier Muñoz, Carmen Martínez, Miren Dorronsoro, Eva Ardanaz, Carmen Navarro, Laudina Rodríguez, Bethany VanGuelpen, Richard Palmqvist, Jonas Manjer, Ulrika Ericson, Sheila Bingham, Kay-Tee Khaw, Teresa Norat, Elio Riboli. Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2010 Oct; 19(10):2549-61. doi:
10.1158/1055-9965.epi-10-0407
. [PMID: 20813848] - Christopher J Bates, Mohammed A Mansoor, Kristina D Pentieva, Mark Hamer, Gita D Mishra. Biochemical risk indices, including plasma homocysteine, that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of People Aged 65 Years and Over.
The British journal of nutrition.
2010 Sep; 104(6):893-9. doi:
10.1017/s0007114510001236
. [PMID: 20398433] - Martin Busch, Andrea Göbert, Sybille Franke, Undine Ott, Jens Gerth, Andreas Müller, Günter Stein, Roland Bitsch, Gunter Wolf. Vitamin B6 metabolism in chronic kidney disease--relation to transsulfuration, advanced glycation and cardiovascular disease.
Nephron. Clinical practice.
2010; 114(1):c38-46. doi:
10.1159/000245068
. [PMID: 19816042] - Simone J P M Eussen, Stein Emil Vollset, Steinar Hustad, Øivind Midttun, Klaus Meyer, Ase Fredriksen, Per Magne Ueland, Mazda Jenab, Nadia Slimani, Pietro Ferrari, Antonio Agudo, Núria Sala, Gabriel Capellá, Giuseppe Del Giudice, Domenico Palli, Heiner Boeing, Cornelia Weikert, H Bas Bueno-de-Mesquita, Frederike L Büchner, Fátima Carneiro, Franco Berrino, Paolo Vineis, Rosario Tumino, Salvatore Panico, Göran Berglund, Jonas Manjer, Roger Stenling, Göran Hallmans, Carmen Martínez, Larraitz Arrizola, Aurelio Barricarte, Carmen Navarro, Laudina Rodriguez, Sheila Bingham, Jakob Linseisen, Rudolf Kaaks, Kim Overvad, Anne Tjønneland, Petra H M Peeters, Mattijs E Numans, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Sophie Morois, Antonia Trichopoulou, Eiliv Lund, Mario Plebani, Elio Riboli, Carlos A González. Vitamins B2 and B6 and genetic polymorphisms related to one-carbon metabolism as risk factors for gastric adenocarcinoma in the European prospective investigation into cancer and nutrition.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2010 Jan; 19(1):28-38. doi:
10.1158/1055-9965.epi-08-1096
. [PMID: 20056620] - Tsutomu Fukuwatari, Erina Yoshida, Kei Takahashi, Katsumi Shibata. Effect of fasting on the urinary excretion of water-soluble vitamins in humans and rats.
Journal of nutritional science and vitaminology.
2010; 56(1):19-26. doi:
10.3177/jnsv.56.19
. [PMID: 20354342] - Toshiharu Yagi, Ryutaro Murayama, Huong Thi Viet Do, Youhei Ide, Andrew Njagi Mugo, Yu Yoshikane. Development of simultaneous enzymatic assay method for all six individual vitamin B6 forms and pyridoxine-beta-glucoside.
Journal of nutritional science and vitaminology.
2010; 56(3):157-63. doi:
10.3177/jnsv.56.157
. [PMID: 20651455] - Marcin L Marszałł, Anna Lebiedzińska, Wojciech Czarnowski, Ryszard Makarowski, Mateusz Kłos, Piotr Szefer. Application of the high-performance liquid chromatography method with coulometric detection for determination of vitamin B(6) in human plasma and serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Oct; 877(27):3151-8. doi:
10.1016/j.jchromb.2009.08.014
. [PMID: 19733133] - S R Zwart, G E Crawford, P L Gillman, G Kala, A S Rodgers, A Rogers, A M Inniss, B L Rice, K Ericson, S Coburn, Y Bourbeau, E Hudson, G Mathew, D E Dekerlegand, C F Sams, M A Heer, W H Paloski, S M Smith. Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans.
Journal of applied physiology (Bethesda, Md. : 1985).
2009 Jul; 107(1):54-62. doi:
10.1152/japplphysiol.91136.2008
. [PMID: 19074571] - Øivind Midttun, Steinar Hustad, Per M Ueland. Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2009 May; 23(9):1371-9. doi:
10.1002/rcm.4013
. [PMID: 19337982] - Michael E Rybak, Christine M Pfeiffer. A simplified protein precipitation and filtration procedure for determining serum vitamin B6 by high-performance liquid chromatography.
Analytical biochemistry.
2009 May; 388(1):175-7. doi:
10.1016/j.ab.2009.02.014
. [PMID: 19232315] - Kei Takahashi, Alato Okuno, Tsutomu Fukuwatari, Katsumi Shibata. Comparison of the nicotinamide catabolism among rat strains.
Bioscience, biotechnology, and biochemistry.
2009 Feb; 73(2):274-9. doi:
10.1271/bbb.80372
. [PMID: 19202300] - Bram Bekaert, Matthew L Cooper, Fiona R Green, Helene McNulty, Kristina Pentieva, John M Scott, Anne M Molloy, Margaret P Rayman. Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly.
Molecular nutrition & food research.
2008 Nov; 52(11):1324-33. doi:
10.1002/mnfr.200700353
. [PMID: 18683819] - Tsutomu Fukuwatari, Hideko Wada, Katsumi Shibata. Age-related alterations of B-group vitamin contents in urine, blood and liver from rats.
Journal of nutritional science and vitaminology.
2008 Oct; 54(5):357-62. doi:
10.3177/jnsv.54.357
. [PMID: 19001766] - P G Massé, C C Tranchant, J L Jougleux, S P Coburn, D E Cole. Cardiovascular disease-risk factors in middle-aged osteopaenic women treated with calcium alone or combined to three nutrients essential to artery and bone collagen.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association.
2008 Apr; 21(2):117-28. doi:
10.1111/j.1365-277x.2008.00852.x
. [PMID: 18339052] - Paddy Jim Baggot, Anna Jane Y Eliseo, Nathaniel G DeNicola, Jeremy A Kalamarides, James D Shoemaker. Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
Fetal diagnosis and therapy.
2008; 23(4):254-7. doi:
10.1159/000123610
. [PMID: 18417989] - Øivind Midttun, Steinar Hustad, Jørn Schneede, Stein E Vollset, Per M Ueland. Plasma vitamin B-6 forms and their relation to transsulfuration metabolites in a large, population-based study.
The American journal of clinical nutrition.
2007 Jul; 86(1):131-8. doi:
10.1093/ajcn/86.1.131
. [PMID: 17616772] - Sue-Joan Chang, Li-Ju Hsiao, Yi-Chun Lee, Shou-Ying Hsuen. Vitamin B6 status assessment in relation to dietary intake in high school students aged 16-18 years.
The British journal of nutrition.
2007 Apr; 97(4):764-9. doi:
10.1017/s0007114507665167
. [PMID: 17349090] - C-H Cheng, S-J Chang, B-J Lee, K-L Lin, Y-C Huang. Vitamin B6 supplementation increases immune responses in critically ill patients.
European journal of clinical nutrition.
2006 Oct; 60(10):1207-13. doi:
10.1038/sj.ejcn.1602439
. [PMID: 16670691] - D Majchrzak, I Singer, M Männer, P Rust, D Genser, K-H Wagner, I Elmadfa. B-vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans.
Annals of nutrition & metabolism.
2006; 50(6):485-91. doi:
10.1159/000095828
. [PMID: 16988496] - Katsumi Shibata, Chisato Takahashi, Tsutomu Fukuwatari, Ryuzo Sasaki. Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats.
Journal of nutritional science and vitaminology.
2005 Dec; 51(6):385-91. doi:
10.3177/jnsv.51.385
. [PMID: 16521696] - Oivind Midttun, Steinar Hustad, Einar Solheim, Jørn Schneede, Per M Ueland. Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in human plasma by liquid chromatography-tandem mass spectrometry.
Clinical chemistry.
2005 Jul; 51(7):1206-16. doi:
10.1373/clinchem.2005.051169
. [PMID: 15976101] - Yi-Chia Huang, Han-Hsin Chang, Shih-Chien Huang, Chien-Hsiung Cheng, Bor-Jen Lee, Su-Ya Cheng, Kuo-Hsiung Su. Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill.
Nutrition (Burbank, Los Angeles County, Calif.).
2005 Jul; 21(7-8):779-85. doi:
10.1016/j.nut.2004.11.013
. [PMID: 15975484] - En-Pei I Chiang, Jacob Selhub, Pamela J Bagley, Gerard Dallal, Ronenn Roubenoff. Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis.
Arthritis research & therapy.
2005; 7(6):R1404-11. doi:
10.1186/ar1839
. [PMID: 16277693] - En-Pei Chiang, Donald E Smith, Jacob Selhub, Gerard Dallal, Yi-Cheng Wang, Ronenn Roubenoff. Inflammation causes tissue-specific depletion of vitamin B6.
Arthritis research & therapy.
2005; 7(6):R1254-62. doi:
10.1186/ar1821
. [PMID: 16277678] - Michael E Rybak, Christine M Pfeiffer. Clinical analysis of vitamin B(6): determination of pyridoxal 5'-phosphate and 4-pyridoxic acid in human serum by reversed-phase high-performance liquid chromatography with chlorite postcolumn derivatization.
Analytical biochemistry.
2004 Oct; 333(2):336-44. doi:
10.1016/j.ab.2004.06.036
. [PMID: 15450810] - Priscille G Massé, J Dennis Mahuren, Carole Tranchant, Juliana Dosy. B-6 vitamers and 4-pyridoxic acid in the plasma, erythrocytes, and urine of postmenopausal women.
The American journal of clinical nutrition.
2004 Oct; 80(4):946-51. doi:
10.1093/ajcn/80.4.946
. [PMID: 15447904] - Yoshihide Ogawa, Noriko Machida, Masahide Jahana, Munehisa Gakiya, Yoshiaki Chinen, Masami Oda, Makoto Morozumi, Kimio Sugaya. Major factors modulating the serum oxalic acid level in hemodialysis patients.
Frontiers in bioscience : a journal and virtual library.
2004 Sep; 9(?):2901-8. doi:
10.2741/1446
. [PMID: 15353324] - Agnes Kaelin, Jean-Paul Casez, Philippe Jaeger. Vitamin B6 metabolites in idiopathic calcium stone formers: no evidence for a link to hyperoxaluria.
Urological research.
2004 Feb; 32(1):61-8. doi:
10.1007/s00240-003-0386-2
. [PMID: 14628106] - Kirstine S Krogholm, Jóhanna Haraldsdóttir, Pia Knuthsen, Salka E Rasmussen. Urinary total flavonoid excretion but not 4-pyridoxic acid or potassium can be used as a biomarker for the intake of fruits and vegetables.
The Journal of nutrition.
2004 Feb; 134(2):445-51. doi:
10.1093/jn/134.2.445
. [PMID: 14747687] - O A Obeid, K Johnston, P W Emery. Plasma taurine and cysteine levels following an oral methionine load: relationship with coronary heart disease.
European journal of clinical nutrition.
2004 Jan; 58(1):105-9. doi:
10.1038/sj.ejcn.1601755
. [PMID: 14679374] - Sue-Joan Chang, Li-Ju Hsiao, Shou-Ying Hsuen. Assessment of vitamin B-6 estimated average requirement and recommended dietary allowance for adolescents aged 13-15 years using vitamin B-6 intake, nutritional status and anthropometry.
The Journal of nutrition.
2003 Oct; 133(10):3191-4. doi:
10.1093/jn/133.10.3191
. [PMID: 14519809] - Dinesh Talwar, Tara Quasim, Donald C McMillan, John Kinsella, Cathy Williamson, Denis St J O'Reilly. Optimisation and validation of a sensitive high-performance liquid chromatography assay for routine measurement of pyridoxal 5-phosphate in human plasma and red cells using pre-column semicarbazide derivatisation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Jul; 792(2):333-43. doi:
10.1016/s1570-0232(03)00320-9
. [PMID: 12860041] - Yi-Chia Huang, Sue-Joan Chang, Yu-Ting Chiu, Han-Hsin Chang, Chien-Hsiang Cheng. The status of plasma homocysteine and related B-vitamins in healthy young vegetarians and nonvegetarians.
European journal of nutrition.
2003 Apr; 42(2):84-90. doi:
10.1007/s00394-003-0387-5
. [PMID: 12638029] - Dinesh Talwar, Tara Quasim, Donald C McMillan, John Kinsella, Cathy Williamson, Denis St J O'Reilly. Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response.
Clinical chemistry.
2003 Mar; 49(3):515-8. doi:
10.1373/49.3.515
. [PMID: 12600973] - Mustafa Vakur Bor, Helga Refsum, Marianne R Bisp, Øyvind Bleie, Jorn Schneede, Jan Erik Nordrehaug, Per Magne Ueland, Ottar Kjell Nygard, Ebba Nexø. Plasma vitamin B6 vitamers before and after oral vitamin B6 treatment: a randomized placebo-controlled study.
Clinical chemistry.
2003 Jan; 49(1):155-61. doi:
10.1373/49.1.155
. [PMID: 12507972] - Jan Aleszczyk. [Connection between changing the vitamin and immune status and the character of the throat microflora in patients with chronic tonsillitis].
Otolaryngologia polska = The Polish otolaryngology.
2003; 57(2):221-4. doi:
NULL
. [PMID: 12894427] - Ho-Kyung Kwak, Christine M Hansen, James E Leklem, Karin Hardin, Terry D Shultz. Improved vitamin B-6 status is positively related to lymphocyte proliferation in young women consuming a controlled diet.
The Journal of nutrition.
2002 Nov; 132(11):3308-13. doi:
10.1093/jn/132.11.3308
. [PMID: 12421844] - Terje Apeland, Mohammad A Mansoor, Kristina Pentieva, Helene McNulty, Ingebjørg Seljeflot, Roald E Strandjord. The effect of B-vitamins on hyperhomocysteinemia in patients on antiepileptic drugs.
Epilepsy research.
2002 Oct; 51(3):237-47. doi:
10.1016/s0920-1211(02)00153-5
. [PMID: 12399074] - Sue-Joan Chang, Yi-Chia Huang, Li-Ju Hsiao, Yi-Chun Lee, Shou-Ying Hsuen. Determination of vitamin B-6 estimated average requirement and recommended dietary allowance for children aged 7-12 years using vitamin B-6 intake, nutritional status and anthropometry.
The Journal of nutrition.
2002 Oct; 132(10):3130-4. doi:
10.1093/jn/131.10.3130
. [PMID: 12368406] - Melissa C Nelson, Babette S Zemel, Deborah A Kawchak, Elizabeth M Barden, Edward A Frongillo, Stephen P Coburn, Kwaku Ohene-Frempong, Virginia A Stallings. Vitamin B6 status of children with sickle cell disease.
Journal of pediatric hematology/oncology.
2002 Aug; 24(6):463-9. doi:
10.1097/00043426-200208000-00011
. [PMID: 12218594] - Marianne R Bisp, Mustafa Vakur Bor, Else-Marie Heinsvig, Morten A Kall, Ebba Nexø. Determination of vitamin B6 vitamers and pyridoxic acid in plasma: development and evaluation of a high-performance liquid chromatographic assay.
Analytical biochemistry.
2002 Jun; 305(1):82-9. doi:
10.1006/abio.2002.5638
. [PMID: 12018948] - Y-C Huang, P-H Lan, C-H Cheng, B-J Lee, M-N Kan. Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan.
European journal of clinical nutrition.
2002 May; 56(5):387-92. doi:
10.1038/sj.ejcn.1601321
. [PMID: 12001008] - Armando Lindner, Daniel D Bankson, Catherine Stehman-Breen, J Dennis Mahuren, Stephen P Coburn. Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2002 Jan; 39(1):134-45. doi:
10.1053/ajkd.2002.29904
. [PMID: 11774112] - Stephen P Coburn, Robert D Reynolds, J Dennis Mahuren, Wayne E Schaltenbrand, Yao Wang, Karen L Ericson, Michael P Whyte, Yvonne M Zubovic, Paula J Ziegler, David L Costill, William J Fink, David R Pearson, Thomas A Pauly, K George Thampy, Jacobo Wortsman. Elevated plasma 4-pyridoxic acid in renal insufficiency.
The American journal of clinical nutrition.
2002 Jan; 75(1):57-64. doi:
10.1093/ajcn/75.1.57
. [PMID: 11756060] - C M Hansen, T D Shultz, H K Kwak, H S Memon, J E Leklem. Assessment of vitamin B-6 status in young women consuming a controlled diet containing four levels of vitamin B-6 provides an estimated average requirement and recommended dietary allowance.
The Journal of nutrition.
2001 Jun; 131(6):1777-86. doi:
10.1093/jn/131.6.1777
. [PMID: 11385067] - Q V Nguyen, A Kälin, U Drouve, J P Casez, P Jaeger. Sensitivity to meat protein intake and hyperoxaluria in idiopathic calcium stone formers.
Kidney international.
2001 Jun; 59(6):2273-81. doi:
10.1046/j.1523-1755.2001.00744.x
. [PMID: 11380831] - J A Driskell, D W Giraud, S H Mitmesser. Vitamin B-6 intakes and plasma B-6 vitamer concentrations of men and women, 19-50 years of age.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2000 Sep; 70(5):221-5. doi:
10.1024/0300-9831.70.5.221
. [PMID: 11068702] - L A Kharitonchik, V M Kodentsova, O A Vrzhesinskaia, S N Denisova, V B Spirichev. [Vitamin B 6 metabolism in phenylketonuria].
Voprosy meditsinskoi khimii.
2000 Jan; 46(1):81-8. doi:
NULL
. [PMID: 10802890] - C J Bates, K D Pentieva, A Prentice. An appraisal of vitamin B6 status indices and associated confounders, in young people aged 4-18 years and in people aged 65 years and over, in two national British surveys.
Public health nutrition.
1999 Dec; 2(4):529-35. doi:
10.1017/s1368980099000713
. [PMID: 10656472] - K D Pentieva, C J Bates, A Prentice, T J Cole. North-south differences in some indices of Vitamin B6 nutritional status in older British people.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
1999 Nov; 69(6):371-7. doi:
10.1024/0300-9831.69.6.371
. [PMID: 10642894] - C M Hansen, M A Evans, T D Shultz. Application of the bootstrap procedure provides an alternative to standard statistical procedures in the estimation of the vitamin B-6 requirement.
The Journal of nutrition.
1999 Oct; 129(10):1915-9. doi:
10.1093/jn/129.10.1915
. [PMID: 10498768] - I L Wei. The influence of dietary restriction on vitamin B-6 vitamer distribution and on vitamin B-6 metabolizing enzymes in rats.
Journal of the American College of Nutrition.
1999 Apr; 18(2):144-51. doi:
10.1080/07315724.1999.10718842
. [PMID: 10204830] - M A Mansoor, O Kristensen, T Hervig, C J Bates, K Pentieva, H Vefring, A Osland, T Berge, P A Drabløs, O Hetland, S Rolfsen. Plasma total homocysteine response to oral doses of folic acid and pyridoxine hydrochloride (vitamin B6) in healthy individuals. Oral doses of vitamin B6 reduce concentrations of serum folate.
Scandinavian journal of clinical and laboratory investigation.
1999 Apr; 59(2):139-46. doi:
10.1080/00365519950185878
. [PMID: 10353328] - T Hayakawa, Y Iida, H Tsuge. Konjac mannan improves the vitamin B-6 status of rats fed a vitamin B-6-deficient diet.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
1999 Mar; 69(2):106-12. doi:
10.1024/0300-9831.69.2.106
. [PMID: 10218147] - C J Bates, K D Pentieva, A Prentice, M A Mansoor, S Finch. Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over.
The British journal of nutrition.
1999 Mar; 81(3):191-201. doi:
. [PMID: 10434845]
- C J Bates, K D Pentieva, N Matthews, A Macdonald. A simple, sensitive and reproducible assay for pyridoxal 5'-phosphate and 4-pyridoxic acid in human plasma.
Clinica chimica acta; international journal of clinical chemistry.
1999 Feb; 280(1-2):101-11. doi:
10.1016/s0009-8981(98)00173-9
. [PMID: 10090528] - Y C Huang, W Chen, M A Evans, M E Mitchell, T D Shultz. Vitamin B-6 requirement and status assessment of young women fed a high-protein diet with various levels of vitamin B-6.
The American journal of clinical nutrition.
1998 Feb; 67(2):208-20. doi:
10.1093/ajcn/67.2.208
. [PMID: 9459368] - C M Hansen, J E Leklem, L T Miller. Changes in vitamin B-6 status indicators of women fed a constant protein diet with varying levels of vitamin B-6.
The American journal of clinical nutrition.
1997 Dec; 66(6):1379-87. doi:
10.1093/ajcn/66.6.1379
. [PMID: 9394690] - J H Brussaard, M R Löwik, H van den Berg, H A Brants, W Bemelmans. Dietary and other determinants of vitamin B6 parameters.
European journal of clinical nutrition.
1997 Nov; 51 Suppl 3(?):S39-45. doi:
. [PMID: 9598767]
- J H Brussaard, M R Löwik, H van den Berg, H A Brants, C Kistemaker. Micronutrient status, with special reference to vitamin B6.
European journal of clinical nutrition.
1997 Nov; 51 Suppl 3(?):S32-8. doi:
. [PMID: 9598766]