Cephalexin (BioDeep_00000002201)

Secondary id: BioDeep_00000419369

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C16H17N3O4S (347.094)
中文名称: 头孢氨苄
谱图信息: 最多检出来源 Homo sapiens(blood) 26.27%

分子结构信息

SMILES: CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccccc3)C2SC1
InChI: InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)

描述信息

Cephalexin is only found in individuals that have used or taken this drug. It is a semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
CONFIDENCE standard compound; INTERNAL_ID 1046

同义名列表

56 个代谢物同义名

(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-{[Amino(phenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-Β-(D-α-amino-α-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-b-(D-a-Amino-a-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-Β-(D-α-amino-α-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-b-(D-a-Amino-a-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid; 7-(D-a-Aminophenylacetamido)desacetoxycephalosporanic acid; 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanate; 7-(D-Α-aminophenylacetamido)desacetoxycephalosporanic acid; Cephalexin, monosodium salt, (6R-(6alpha,7beta))-isomer; 7-(D-Α-aminophenylacetamido)desacetoxycephalosporanate; 7-(D-a-Aminophenylacetamido)desacetoxycephalosporanate; Cephalexin, (6R-(6alpha,7alpha(r*)))-isomer; Cephalexin, (6R-(6alpha,7beta(s*)))-isomer; Monohydrochloride, monohydrate cephalexin; Cephalexin monohydrochloride, monohydrate; Monohydrate cephalexin monohydrochloride; Cephalexin, (6R-(6alpha,7beta))-isomer; Monohydrochloride, cephalexin; Cephalexin monohydrochloride; Cephalexin, monosodium salt; Monosodium salt cephalexin; Hydrochloride, cephalexin; Cephalexin hydrochloride; Hemihydrate, cephalexin; Monohydrate, cephalexin; Cephalexin monohydrate; Cephalexin hemihydrate; Dihydride, cephalexin; Cephalexin dihydride; Cephalexin 1-hydrate; Cephalexin hydrate; Cephalexinum; Cefalexinum; Cephalexine; Cefalessina; Cephacillin; Cephalexin; Cefalexina; Ceporexine; Cefalexine; Ceporexin; Cefalexin; Cepastar; Palitrex; Cepexin; Keforal; Celexin; Keflex; CEX; Cephalexin

数据库引用编号

23 个数据库交叉引用编号

ChEBI: CHEBI:3534
KEGG: C06895
KEGGdrug: D00263
PubChem: 27447
PubChem: 2666
HMDB: HMDB0014707
Metlin: METLIN66816
Metlin: METLIN85026
Metlin: METLIN1637
DrugBank: DB00567
ChEMBL: CHEMBL287590
ChEMBL: CHEMBL1727
Wikipedia: Cefalexin
MeSH: Cephalexin
chemspider: 25541
CAS: 108260-04-4
CAS: 15686-71-2
CAS: 34632-04-7
MoNA: AU104601
PMhub: MS000002114
PubChem: 9112
NIKKAJI: J3.133J
KNApSAcK: 3534

分类词条

Cephalosporins

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	6	ABCB1, ACE, ALB, CAT, CD34, DHFR
Peripheral membrane protein	1	CYP27A1
Mitochondrion membrane	1	CYP27A1
Nucleus	1	ALB
cytosol	5	ALB, CAT, DHFR, GPT, PRKCQ
centrosome	1	ALB
Cell membrane	5	ABCB1, ACE, MAG, SLC15A2, SLC47A1
Multi-pass membrane protein	5	ABCB1, SLC15A1, SLC15A2, SLC22A6, SLC47A1
cell surface	1	ABCB1
Golgi apparatus	1	ALB
Golgi membrane	1	INS
mitochondrial inner membrane	1	CYP27A1
Lysosome	2	ACE, CD34
endosome	1	ACE
plasma membrane	11	ABCB1, ACE, CD34, IFNLR1, IGHE, MAG, PRKCQ, SLC15A1, SLC15A2, SLC22A6, SLC47A1
Membrane	10	ABCB1, ACE, CAT, CD34, IFNLR1, MAG, SLC15A1, SLC15A2, SLC22A6, SLC47A1
apical plasma membrane	5	ABCB1, CD34, SLC15A1, SLC15A2, SLC47A1
basolateral plasma membrane	2	SLC22A6, SLC47A1
brush border	1	SLC15A1
caveola	1	SLC22A6
extracellular exosome	8	ABCB1, ACE, ALB, CAT, GPT, LYZ, SLC15A2, SLC22A6
endoplasmic reticulum	1	ALB
extracellular space	7	ACE, ALB, CRP, IGHE, IL6, INS, LYZ
perinuclear region of cytoplasm	1	CD34
mitochondrion	3	CAT, CYP27A1, DHFR
protein-containing complex	3	ALB, CAT, SLC22A6
intracellular membrane-bounded organelle	1	CAT
Single-pass type I membrane protein	5	ACE, CD34, IFNLR1, IGHE, MAG
Secreted	5	ACE, ALB, CRP, IL6, INS
extracellular region	9	ACE, ALB, CAT, CD34, CRP, IGHE, IL6, INS, LYZ
Single-pass membrane protein	1	MAG
mitochondrial matrix	2	CAT, CYP27A1
anchoring junction	1	ALB
centriolar satellite	1	PRKCQ
external side of plasma membrane	2	ACE, CD34
Apical cell membrane	4	ABCB1, SLC15A1, SLC15A2, SLC47A1
Mitochondrion inner membrane	1	CYP27A1
Membrane raft	1	MAG
focal adhesion	1	CAT
Peroxisome	1	CAT
Peroxisome matrix	1	CAT
peroxisomal matrix	1	CAT
peroxisomal membrane	1	CAT
ciliary basal body	1	ALB
IgE immunoglobulin complex	1	IGHE
Cytoplasmic vesicle, phagosome membrane	1	SLC15A2
phagocytic vesicle membrane	1	SLC15A2
centriole	1	ALB
brush border membrane	1	ACE
spindle pole	1	ALB
blood microparticle	1	ALB
sperm midpiece	1	ACE
Basolateral cell membrane	1	SLC22A6
[Isoform 2]: Cell membrane	1	IGHE
intercellular bridge	1	CD34
endosome lumen	1	INS
myelin sheath	1	MAG
basal plasma membrane	3	ACE, CD34, SLC22A6
ficolin-1-rich granule lumen	1	CAT
secretory granule lumen	2	CAT, INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	ALB, IL6, INS
platelet alpha granule lumen	1	ALB
specific granule lumen	1	LYZ
tertiary granule lumen	1	LYZ
transport vesicle	1	INS
paranode region of axon	1	MAG
Schmidt-Lanterman incisure	1	MAG
azurophil granule lumen	1	LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
immunological synapse	1	PRKCQ
aggresome	1	PRKCQ
Basal cell membrane	1	SLC22A6
external side of apical plasma membrane	1	ABCB1
[Isoform 3]: Cell membrane	1	IGHE
[Isoform 1]: Secreted	1	IGHE
IgE B cell receptor complex	1	IGHE
immunoglobulin complex, circulating	1	IGHE
compact myelin	1	MAG
catalase complex	1	CAT
interleukin-6 receptor complex	1	IL6
myelin sheath adaxonal region	1	MAG
[Angiotensin-converting enzyme, soluble form]: Secreted	1	ACE
[Isoform Testis-specific]: Cell membrane	1	ACE
mesaxon	1	MAG
glomerular endothelium fenestra	1	CD34
ciliary transition fiber	1	ALB
interleukin-28 receptor complex	1	IFNLR1

文献列表

Pascaline Sanga, Haitham Saad Al-Mashriqi, Jing Xiao, Jia Chen, Hongdeng Qiu. Streamlined fabrication of AuPtRh trimetallic nanoparticles supported on Ti3C2MXene for enhanced photocatalytic activity in cephalosporins degradation. Journal of colloid and interface science. 2024 Mar; 658(?):188-198. doi: 10.1016/j.jcis.2023.12.062. [PMID: 38100975]
Masumeh Nasrollahzadeh, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani-Farahani, Mahsa Mohiti-Asli. Drug in adhesive transdermal patch containing antibiotic-loaded solid lipid nanoparticles. Journal of bioscience and bioengineering. 2022 Nov; 134(5):471-476. doi: 10.1016/j.jbiosc.2022.08.003. [PMID: 36151004]
M Hamdi Abdulkareem, I Abbas Abood, M Munis Dakheel. Antimicrobial Resistance of Tannin Extract against E. coli Isolates from Sheep. Archives of Razi Institute. 2022 Apr; 77(2):697-701. doi: 10.22092/ari.2022.356982.1955. [PMID: 36284977]
Daniel Aparecido da Silva Rodrigues, Camila Cristina Rodrigues Ferreira da Cunha, Daiana Rocha do Espirito Santo, André Luis Corrêa de Barros, Andressa Rezende Pereira, Silvana de Queiroz Silva, Aníbal da Fonseca Santiago, Robson José de Cássia Franco Afonso. Removal of cephalexin and erythromycin antibiotics, and their resistance genes, by microalgae-bacteria consortium from wastewater treatment plant secondary effluents. Environmental science and pollution research international. 2021 Dec; 28(47):67822-67832. doi: 10.1007/s11356-021-15351-x. [PMID: 34268682]
Xiaozhi Lv, Guoping Zhong, Herui Yao, Junyan Wu, Suiwen Ye. Bioequivalence of cefalexin in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics. 2021 Nov; 59(11):725-733. doi: 10.5414/cp203986. [PMID: 34448694]
Richard J Everts, Sharon J Gardiner, Mei Zhang, Ronald Begg, Stephen T Chambers, John Turnidge, Evan J Begg. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. The Journal of infection. 2021 08; 83(2):182-189. doi: 10.1016/j.jinf.2021.05.037. [PMID: 34081957]
Emily Parsons, Catherine Albert, Melissa Forouhar, Anjali Kunz, Rebecca Sainato. Recurrent Severe Staphylococcus epidermidis Urinary Tract Infections in a 7-Year-Old Boy. Clinical pediatrics. 2021 07; 60(8):346-349. doi: 10.1177/00099228211021277. [PMID: 34100657]
Nancy Acelas, Sandra M Lopera, Jazmín Porras, Ricardo A Torres-Palma. Evaluating the Removal of the Antibiotic Cephalexin from Aqueous Solutions Using an Adsorbent Obtained from Palm Oil Fiber. Molecules (Basel, Switzerland). 2021 Jun; 26(11):. doi: 10.3390/molecules26113340. [PMID: 34199337]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Camila Beccaria, Celina Baravalle, Paula Silvestrini, María S Renna, Ana I Molineri, Marcelo L Signorini, Verónica E Neder, Guillermo A Suarez Archilla, Luis F Calvinho, Bibiana E Dallard. Efficacy of Panax ginseng extract combined with cephalexin as a dry cow therapy. The Journal of dairy research. 2021 Feb; 88(1):64-68. doi: 10.1017/s0022029921000017. [PMID: 33731240]
Geoff Rhodes, Ya-Hui Chuang, Raymond Hammerschmidt, Wei Zhang, Stephen A Boyd, Hui Li. Uptake of cephalexin by lettuce, celery, and radish from water. Chemosphere. 2021 Jan; 263(?):127916. doi: 10.1016/j.chemosphere.2020.127916. [PMID: 33297013]
Li-Min Liang, Jun-Jie Zhou, Feng Xu, Pei-Hua Liu, Lan Qin, Li Liu, Xiao-Dong Liu. Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation. Acta pharmacologica Sinica. 2020 Nov; 41(11):1465-1475. doi: 10.1038/s41401-020-0408-4. [PMID: 32341465]
Cheng-Yuan Yan, Yu-Zhou Liu, Zhong-Hua Xu, Hao-Yu Yang, Jin Li. Comparison of Antibacterial Effect of Cationic Peptide LL-37 and Cefalexin on Clinical Staphylococcus aureus-induced Infection after Femur Fracture Fixation. Orthopaedic surgery. 2020 Aug; 12(4):1313-1318. doi: 10.1111/os.12754. [PMID: 32725811]
Stacy Lynn Harmon, Iram Nadeem. Recurrent urinary tract infections caused by Raoultella planticola after kidney transplant. Transplant infectious disease : an official journal of the Transplantation Society. 2019 Dec; 21(6):e13196. doi: 10.1111/tid.13196. [PMID: 31610079]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Jianzhou He, Yaozhong Zhang, Yang Guo, Geoff Rhodes, Junghoon Yeom, Hui Li, Wei Zhang. Photocatalytic degradation of cephalexin by ZnO nanowires under simulated sunlight: Kinetics, influencing factors, and mechanisms. Environment international. 2019 11; 132(?):105105. doi: 10.1016/j.envint.2019.105105. [PMID: 31437644]
Lina Wang, Xiaowei Li, Yingyu Wang, Chengfei Wang, Dongyang Ye, Lan Zhou, Xue Hu, Yuebin Ke, Xi Xia. Determination of cephalexin residual level using ultra-high-performance liquid chromatography-tandem mass spectrometry: Residue depletion study in swine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):233-238. doi: 10.1016/j.jchromb.2019.06.003. [PMID: 31233944]
Kasumi Suzuki, Montira Yossapol, Michiyo Sugiyama, Tetsuo Asai. Effects of Antimicrobial Administration on the Prevalence of Antimicrobial-Resistant Escherichia coli in Broiler Flocks. Japanese journal of infectious diseases. 2019 May; 72(3):179-184. doi: 10.7883/yoken.jjid.2018.277. [PMID: 30700654]
Yongjun Hu, David E Smith. In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice. Drug metabolism and disposition: the biological fate of chemicals. 2019 03; 47(3):173-183. doi: 10.1124/dmd.118.084236. [PMID: 30593545]
Bindu Ganapathineedi, Alaap Mehta, Susmitha Dande, Anjali Shinde, Gary Barsky, Nadew Sebro. Bullous Pemphigoid with Atypical Skin Lesions and Acute Interstitial Nephritis: A Case Report and Focused Literature Review. The American journal of case reports. 2019 Feb; 20(?):212-218. doi: 10.12659/ajcr.911422. [PMID: 30773528]
Lic A Perea, Ricardo E Palma-Goyes, Jorge Vazquez-Arenas, Issis Romero-Ibarra, Carlos Ostos, Ricardo A Torres-Palma. Efficient cephalexin degradation using active chlorine produced on ruthenium and iridium oxide anodes: Role of bath composition, analysis of degradation pathways and degradation extent. The Science of the total environment. 2019 Jan; 648(?):377-387. doi: 10.1016/j.scitotenv.2018.08.148. [PMID: 30121037]
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai. Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. PloS one. 2019; 14(4):e0214862. doi: 10.1371/journal.pone.0214862. [PMID: 30951542]
Etthel M Windels, Zacchari Ben Meriem, Taiyeb Zahir, Kevin J Verstrepen, Pascal Hersen, Bram Van den Bergh, Jan Michiels. Enrichment of persisters enabled by a ß-lactam-induced filamentation method reveals their stochastic single-cell awakening. Communications biology. 2019; 2(?):426. doi: 10.1038/s42003-019-0672-3. [PMID: 31815194]
Mei Zhang, Grant A Moore, Paul K L Chin, Richard Everts, Evan J Begg. Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma. Therapeutic drug monitoring. 2018 12; 40(6):682-692. doi: 10.1097/ftd.0000000000000555. [PMID: 30015652]
Shaylyn Vogler, Emily Pavich. Pyelonephritis treatment in the community emergency department: Cephalosporins vs. first-line agents. The American journal of emergency medicine. 2018 11; 36(11):2054-2057. doi: 10.1016/j.ajem.2018.08.016. [PMID: 30119986]
Ali Rayegan, Alireza Allafchian, Ismaeil Abdolhosseini Sarsari, Parviz Kameli. Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin. International journal of biological macromolecules. 2018 Jul; 113(?):317-328. doi: 10.1016/j.ijbiomac.2018.02.134. [PMID: 29481957]
E Angulo, L Bula, I Mercado, A Montaño, N Cubillán. Bioremediation of Cephalexin with non-living Chlorella sp., biomass after lipid extraction. Bioresource technology. 2018 Jun; 257(?):17-22. doi: 10.1016/j.biortech.2018.02.079. [PMID: 29477662]
Mostafa Leili, Mehdi Fazlzadeh, Amit Bhatnagar. Green synthesis of nano-zero-valent iron from Nettle and Thyme leaf extracts and their application for the removal of cephalexin antibiotic from aqueous solutions. Environmental technology. 2018 May; 39(9):1158-1172. doi: 10.1080/09593330.2017.1323956. [PMID: 28443364]
Rajiv Sinha, Subhasis Saha, Biplab Maji, Yincent Tse. Antibiotics for performing voiding cystourethrogram: a randomised control trial. Archives of disease in childhood. 2018 03; 103(3):230-234. doi: 10.1136/archdischild-2017-313266. [PMID: 28855226]
Li-Yang Cheng, Cheng-Zhang Yang, Hui-Zi Li, Min Li, Ai-Min Bai, Yu Ouyang, Yan-Jun Hu. Probing the interaction of cephalosporin with bovine serum albumin: A structural and comparative perspective. Luminescence : the journal of biological and chemical luminescence. 2018 Feb; 33(1):209-218. doi: 10.1002/bio.3403. [PMID: 28976065]
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Mohamed Abdel-Aziz Elzayat, Ashton Barnett-Vanes, Mohamed Farag Elmorsy Dabour, Feng Cheng. Prevalence of undiagnosed asymptomatic bacteriuria and associated risk factors during pregnancy: a cross-sectional study at two tertiary centres in Cairo, Egypt. BMJ open. 2017 03; 7(3):e013198. doi: 10.1136/bmjopen-2016-013198. [PMID: 28325856]
Elsa Fonte, Pedro Ferreira, Lúcia Guilhermino. Temperature rise and microplastics interact with the toxicity of the antibiotic cefalexin to juveniles of the common goby (Pomatoschistus microps): Post-exposure predatory behaviour, acetylcholinesterase activity and lipid peroxidation. Aquatic toxicology (Amsterdam, Netherlands). 2016 Nov; 180(?):173-185. doi: 10.1016/j.aquatox.2016.09.015. [PMID: 27721112]
Qian Li, Tianlong Zhang, Liujiao Bian. Recognition and binding of β-lactam antibiotics to bovine serum albumin by frontal affinity chromatography in combination with spectroscopy and molecular docking. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Mar; 1014(?):90-101. doi: 10.1016/j.jchromb.2016.02.005. [PMID: 26882128]
Hiroshi Arakawa, Taichi Ohmachi, Kiko Ichiba, Hiroki Kamioka, Takumi Tomono, Masahiko Kanagawa, Yoko Idota, Yasuko Hatano, Kentaro Yano, Kaori Morimoto, Takuo Ogihara. Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors. Journal of pharmaceutical sciences. 2016 Jan; 105(1):339-42. doi: 10.1016/j.xphs.2015.11.024. [PMID: 26852864]
Krishna M Baradhi, Subhan Ahmed, Malcolm L Buford. The Case Acute renal failure after antibiotic treatment for bronchitis. Diagnosis: Pigment nephropathy from cephalexin-induced immune hemolytic anemia. Kidney international. 2015 Jun; 87(6):1269-70. doi: 10.1038/ki.2014.152. [PMID: 26024043]
Julie Autmizguine, Kevin M Watt, Yves Théorêt, Nastya Kassir, C Laferrière, Stefan Parent, Bruce Tapiéro, Philippe Ovetchkine. Pharmacokinetics and pharmacodynamics of oral cephalexin in children with osteoarticular infections. The Pediatric infectious disease journal. 2013 Dec; 32(12):1340-4. doi: 10.1097/inf.0b013e3182a222a6. [PMID: 23811740]
G Vijaya, R Cartwright, A Derpapas, P Gallo, R Fernando, V Khullar. Changes in nerve growth factor level and symptom severity following antibiotic treatment for refractory overactive bladder. International urogynecology journal. 2013 Sep; 24(9):1523-8. doi: 10.1007/s00192-012-2038-y. [PMID: 23376905]
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