Cephalexin (BioDeep_00000002201)

Secondary id: BioDeep_00000419369

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C16H17N3O4S (347.09397220000005)
中文名称: 头孢氨苄
谱图信息: 最多检出来源 Homo sapiens(blood) 5.19%

分子结构信息

SMILES: CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccccc3)C2SC1
InChI: InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)

描述信息

Cephalexin is only found in individuals that have used or taken this drug. It is a semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of cephaloridine or cephalothin, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms. [PubChem]Cephalexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
CONFIDENCE standard compound; INTERNAL_ID 1046

同义名列表

55 个代谢物同义名

(6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-{[Amino(phenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-Β-(D-α-amino-α-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-b-(D-a-Amino-a-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid; 7-Β-(D-α-amino-α-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-b-(D-a-Amino-a-phenylacetylamino)-3-methyl-3-cephem-4-carboxylate; 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid; 7-(D-a-Aminophenylacetamido)desacetoxycephalosporanic acid; 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanate; 7-(D-Α-aminophenylacetamido)desacetoxycephalosporanic acid; Cephalexin, monosodium salt, (6R-(6alpha,7beta))-isomer; 7-(D-Α-aminophenylacetamido)desacetoxycephalosporanate; 7-(D-a-Aminophenylacetamido)desacetoxycephalosporanate; Cephalexin, (6R-(6alpha,7alpha(r*)))-isomer; Cephalexin, (6R-(6alpha,7beta(s*)))-isomer; Monohydrochloride, monohydrate cephalexin; Cephalexin monohydrochloride, monohydrate; Monohydrate cephalexin monohydrochloride; Cephalexin, (6R-(6alpha,7beta))-isomer; Monohydrochloride, cephalexin; Cephalexin monohydrochloride; Cephalexin, monosodium salt; Monosodium salt cephalexin; Hydrochloride, cephalexin; Cephalexin hydrochloride; Hemihydrate, cephalexin; Monohydrate, cephalexin; Cephalexin monohydrate; Cephalexin hemihydrate; Dihydride, cephalexin; Cephalexin dihydride; Cephalexin 1-hydrate; Cephalexin hydrate; Cephalexinum; Cefalexinum; Cephalexine; Cefalessina; Cephacillin; Cephalexin; Cefalexina; Ceporexine; Cefalexine; Ceporexin; Cefalexin; Cepastar; Palitrex; Cepexin; Keforal; Celexin; Keflex; CEX

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:3534
KEGG: C06895
KEGGdrug: D00263
PubChem: 27447
PubChem: 2666
HMDB: HMDB0014707
Metlin: METLIN66816
Metlin: METLIN85026
Metlin: METLIN1637
DrugBank: DB00567
ChEMBL: CHEMBL287590
ChEMBL: CHEMBL1727
Wikipedia: Cefalexin
MeSH: Cephalexin
chemspider: 25541
CAS: 108260-04-4
CAS: 15686-71-2
CAS: 34632-04-7
MoNA: AU104601
PMhub: MS000002114
PubChem: 9112
NIKKAJI: J3.133J

分类词条

Cephalosporins

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Pascaline Sanga, Haitham Saad Al-Mashriqi, Jing Xiao, Jia Chen, Hongdeng Qiu. Streamlined fabrication of AuPtRh trimetallic nanoparticles supported on Ti3C2MXene for enhanced photocatalytic activity in cephalosporins degradation. Journal of colloid and interface science. 2024 Mar; 658(?):188-198. doi: 10.1016/j.jcis.2023.12.062. [PMID: 38100975]
Masumeh Nasrollahzadeh, Fariba Ganji, Seyed Mojtaba Taghizadeh, Ebrahim Vasheghani-Farahani, Mahsa Mohiti-Asli. Drug in adhesive transdermal patch containing antibiotic-loaded solid lipid nanoparticles. Journal of bioscience and bioengineering. 2022 Nov; 134(5):471-476. doi: 10.1016/j.jbiosc.2022.08.003. [PMID: 36151004]
M Hamdi Abdulkareem, I Abbas Abood, M Munis Dakheel. Antimicrobial Resistance of Tannin Extract against E. coli Isolates from Sheep. Archives of Razi Institute. 2022 Apr; 77(2):697-701. doi: 10.22092/ari.2022.356982.1955. [PMID: 36284977]
Daniel Aparecido da Silva Rodrigues, Camila Cristina Rodrigues Ferreira da Cunha, Daiana Rocha do Espirito Santo, André Luis Corrêa de Barros, Andressa Rezende Pereira, Silvana de Queiroz Silva, Aníbal da Fonseca Santiago, Robson José de Cássia Franco Afonso. Removal of cephalexin and erythromycin antibiotics, and their resistance genes, by microalgae-bacteria consortium from wastewater treatment plant secondary effluents. Environmental science and pollution research international. 2021 Dec; 28(47):67822-67832. doi: 10.1007/s11356-021-15351-x. [PMID: 34268682]
Xiaozhi Lv, Guoping Zhong, Herui Yao, Junyan Wu, Suiwen Ye. Bioequivalence of cefalexin in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics. 2021 Nov; 59(11):725-733. doi: 10.5414/cp203986. [PMID: 34448694]
Richard J Everts, Sharon J Gardiner, Mei Zhang, Ronald Begg, Stephen T Chambers, John Turnidge, Evan J Begg. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. The Journal of infection. 2021 08; 83(2):182-189. doi: 10.1016/j.jinf.2021.05.037. [PMID: 34081957]
Emily Parsons, Catherine Albert, Melissa Forouhar, Anjali Kunz, Rebecca Sainato. Recurrent Severe Staphylococcus epidermidis Urinary Tract Infections in a 7-Year-Old Boy. Clinical pediatrics. 2021 07; 60(8):346-349. doi: 10.1177/00099228211021277. [PMID: 34100657]
Nancy Acelas, Sandra M Lopera, Jazmín Porras, Ricardo A Torres-Palma. Evaluating the Removal of the Antibiotic Cephalexin from Aqueous Solutions Using an Adsorbent Obtained from Palm Oil Fiber. Molecules (Basel, Switzerland). 2021 Jun; 26(11):. doi: 10.3390/molecules26113340. [PMID: 34199337]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Camila Beccaria, Celina Baravalle, Paula Silvestrini, María S Renna, Ana I Molineri, Marcelo L Signorini, Verónica E Neder, Guillermo A Suarez Archilla, Luis F Calvinho, Bibiana E Dallard. Efficacy of Panax ginseng extract combined with cephalexin as a dry cow therapy. The Journal of dairy research. 2021 Feb; 88(1):64-68. doi: 10.1017/s0022029921000017. [PMID: 33731240]
Geoff Rhodes, Ya-Hui Chuang, Raymond Hammerschmidt, Wei Zhang, Stephen A Boyd, Hui Li. Uptake of cephalexin by lettuce, celery, and radish from water. Chemosphere. 2021 Jan; 263(?):127916. doi: 10.1016/j.chemosphere.2020.127916. [PMID: 33297013]
Li-Min Liang, Jun-Jie Zhou, Feng Xu, Pei-Hua Liu, Lan Qin, Li Liu, Xiao-Dong Liu. Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation. Acta pharmacologica Sinica. 2020 Nov; 41(11):1465-1475. doi: 10.1038/s41401-020-0408-4. [PMID: 32341465]
Cheng-Yuan Yan, Yu-Zhou Liu, Zhong-Hua Xu, Hao-Yu Yang, Jin Li. Comparison of Antibacterial Effect of Cationic Peptide LL-37 and Cefalexin on Clinical Staphylococcus aureus-induced Infection after Femur Fracture Fixation. Orthopaedic surgery. 2020 Aug; 12(4):1313-1318. doi: 10.1111/os.12754. [PMID: 32725811]
Stacy Lynn Harmon, Iram Nadeem. Recurrent urinary tract infections caused by Raoultella planticola after kidney transplant. Transplant infectious disease : an official journal of the Transplantation Society. 2019 Dec; 21(6):e13196. doi: 10.1111/tid.13196. [PMID: 31610079]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Jianzhou He, Yaozhong Zhang, Yang Guo, Geoff Rhodes, Junghoon Yeom, Hui Li, Wei Zhang. Photocatalytic degradation of cephalexin by ZnO nanowires under simulated sunlight: Kinetics, influencing factors, and mechanisms. Environment international. 2019 11; 132(?):105105. doi: 10.1016/j.envint.2019.105105. [PMID: 31437644]
Lina Wang, Xiaowei Li, Yingyu Wang, Chengfei Wang, Dongyang Ye, Lan Zhou, Xue Hu, Yuebin Ke, Xi Xia. Determination of cephalexin residual level using ultra-high-performance liquid chromatography-tandem mass spectrometry: Residue depletion study in swine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):233-238. doi: 10.1016/j.jchromb.2019.06.003. [PMID: 31233944]
Kasumi Suzuki, Montira Yossapol, Michiyo Sugiyama, Tetsuo Asai. Effects of Antimicrobial Administration on the Prevalence of Antimicrobial-Resistant Escherichia coli in Broiler Flocks. Japanese journal of infectious diseases. 2019 May; 72(3):179-184. doi: 10.7883/yoken.jjid.2018.277. [PMID: 30700654]
Yongjun Hu, David E Smith. In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice. Drug metabolism and disposition: the biological fate of chemicals. 2019 03; 47(3):173-183. doi: 10.1124/dmd.118.084236. [PMID: 30593545]
Bindu Ganapathineedi, Alaap Mehta, Susmitha Dande, Anjali Shinde, Gary Barsky, Nadew Sebro. Bullous Pemphigoid with Atypical Skin Lesions and Acute Interstitial Nephritis: A Case Report and Focused Literature Review. The American journal of case reports. 2019 Feb; 20(?):212-218. doi: 10.12659/ajcr.911422. [PMID: 30773528]
Lic A Perea, Ricardo E Palma-Goyes, Jorge Vazquez-Arenas, Issis Romero-Ibarra, Carlos Ostos, Ricardo A Torres-Palma. Efficient cephalexin degradation using active chlorine produced on ruthenium and iridium oxide anodes: Role of bath composition, analysis of degradation pathways and degradation extent. The Science of the total environment. 2019 Jan; 648(?):377-387. doi: 10.1016/j.scitotenv.2018.08.148. [PMID: 30121037]
Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai. Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. PloS one. 2019; 14(4):e0214862. doi: 10.1371/journal.pone.0214862. [PMID: 30951542]
Etthel M Windels, Zacchari Ben Meriem, Taiyeb Zahir, Kevin J Verstrepen, Pascal Hersen, Bram Van den Bergh, Jan Michiels. Enrichment of persisters enabled by a ß-lactam-induced filamentation method reveals their stochastic single-cell awakening. Communications biology. 2019; 2(?):426. doi: 10.1038/s42003-019-0672-3. [PMID: 31815194]
Mei Zhang, Grant A Moore, Paul K L Chin, Richard Everts, Evan J Begg. Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma. Therapeutic drug monitoring. 2018 12; 40(6):682-692. doi: 10.1097/ftd.0000000000000555. [PMID: 30015652]
Shaylyn Vogler, Emily Pavich. Pyelonephritis treatment in the community emergency department: Cephalosporins vs. first-line agents. The American journal of emergency medicine. 2018 11; 36(11):2054-2057. doi: 10.1016/j.ajem.2018.08.016. [PMID: 30119986]
Ali Rayegan, Alireza Allafchian, Ismaeil Abdolhosseini Sarsari, Parviz Kameli. Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin. International journal of biological macromolecules. 2018 Jul; 113(?):317-328. doi: 10.1016/j.ijbiomac.2018.02.134. [PMID: 29481957]
E Angulo, L Bula, I Mercado, A Montaño, N Cubillán. Bioremediation of Cephalexin with non-living Chlorella sp., biomass after lipid extraction. Bioresource technology. 2018 Jun; 257(?):17-22. doi: 10.1016/j.biortech.2018.02.079. [PMID: 29477662]
Mostafa Leili, Mehdi Fazlzadeh, Amit Bhatnagar. Green synthesis of nano-zero-valent iron from Nettle and Thyme leaf extracts and their application for the removal of cephalexin antibiotic from aqueous solutions. Environmental technology. 2018 May; 39(9):1158-1172. doi: 10.1080/09593330.2017.1323956. [PMID: 28443364]
Rajiv Sinha, Subhasis Saha, Biplab Maji, Yincent Tse. Antibiotics for performing voiding cystourethrogram: a randomised control trial. Archives of disease in childhood. 2018 03; 103(3):230-234. doi: 10.1136/archdischild-2017-313266. [PMID: 28855226]
Li-Yang Cheng, Cheng-Zhang Yang, Hui-Zi Li, Min Li, Ai-Min Bai, Yu Ouyang, Yan-Jun Hu. Probing the interaction of cephalosporin with bovine serum albumin: A structural and comparative perspective. Luminescence : the journal of biological and chemical luminescence. 2018 Feb; 33(1):209-218. doi: 10.1002/bio.3403. [PMID: 28976065]
C O'Halloran, N Walsh, M C O'Grady, L Barry, C Hooton, G D Corcoran, B Lucey. Assessment of the comparability of CLSI, EUCAST and Stokes antimicrobial susceptibility profiles for Escherichia coli uropathogenic isolates. British journal of biomedical science. 2018 Jan; 75(1):24-29. doi: 10.1080/09674845.2017.1392736. [PMID: 29210602]
Muhammad M Hammami, Ahmed Yusuf, Faduma S Shire, Rajaa Hussein, Reem Al-Swayeh. Does the placebo effect modulate drug bioavailability? Randomized cross-over studies of three drugs. Journal of negative results in biomedicine. 2017 May; 16(1):10. doi: 10.1186/s12952-017-0075-2. [PMID: 28535819]
Mohamed Abdel-Aziz Elzayat, Ashton Barnett-Vanes, Mohamed Farag Elmorsy Dabour, Feng Cheng. Prevalence of undiagnosed asymptomatic bacteriuria and associated risk factors during pregnancy: a cross-sectional study at two tertiary centres in Cairo, Egypt. BMJ open. 2017 03; 7(3):e013198. doi: 10.1136/bmjopen-2016-013198. [PMID: 28325856]
Elsa Fonte, Pedro Ferreira, Lúcia Guilhermino. Temperature rise and microplastics interact with the toxicity of the antibiotic cefalexin to juveniles of the common goby (Pomatoschistus microps): Post-exposure predatory behaviour, acetylcholinesterase activity and lipid peroxidation. Aquatic toxicology (Amsterdam, Netherlands). 2016 Nov; 180(?):173-185. doi: 10.1016/j.aquatox.2016.09.015. [PMID: 27721112]
Qian Li, Tianlong Zhang, Liujiao Bian. Recognition and binding of β-lactam antibiotics to bovine serum albumin by frontal affinity chromatography in combination with spectroscopy and molecular docking. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Mar; 1014(?):90-101. doi: 10.1016/j.jchromb.2016.02.005. [PMID: 26882128]
Hiroshi Arakawa, Taichi Ohmachi, Kiko Ichiba, Hiroki Kamioka, Takumi Tomono, Masahiko Kanagawa, Yoko Idota, Yasuko Hatano, Kentaro Yano, Kaori Morimoto, Takuo Ogihara. Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors. Journal of pharmaceutical sciences. 2016 Jan; 105(1):339-42. doi: 10.1016/j.xphs.2015.11.024. [PMID: 26852864]
Krishna M Baradhi, Subhan Ahmed, Malcolm L Buford. The Case Acute renal failure after antibiotic treatment for bronchitis. Diagnosis: Pigment nephropathy from cephalexin-induced immune hemolytic anemia. Kidney international. 2015 Jun; 87(6):1269-70. doi: 10.1038/ki.2014.152. [PMID: 26024043]
Julie Autmizguine, Kevin M Watt, Yves Théorêt, Nastya Kassir, C Laferrière, Stefan Parent, Bruce Tapiéro, Philippe Ovetchkine. Pharmacokinetics and pharmacodynamics of oral cephalexin in children with osteoarticular infections. The Pediatric infectious disease journal. 2013 Dec; 32(12):1340-4. doi: 10.1097/inf.0b013e3182a222a6. [PMID: 23811740]
G Vijaya, R Cartwright, A Derpapas, P Gallo, R Fernando, V Khullar. Changes in nerve growth factor level and symptom severity following antibiotic treatment for refractory overactive bladder. International urogynecology journal. 2013 Sep; 24(9):1523-8. doi: 10.1007/s00192-012-2038-y. [PMID: 23376905]
Aaron T Wolman, Michael R Gionfriddo, Gregory A Heindel, Paran Mukhija, Sarah Witkowski, Ajay Bommareddy, Adam L Vanwert. Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics. Drug metabolism and disposition: the biological fate of chemicals. 2013 Apr; 41(4):791-800. doi: 10.1124/dmd.112.049569. [PMID: 23344796]
Ken Grime, Stuart W Paine. Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. Drug metabolism and disposition: the biological fate of chemicals. 2013 Feb; 41(2):372-8. doi: 10.1124/dmd.112.049312. [PMID: 23139379]
Ticiano Gomes do Nascimento, Eduardo de Jesus Oliveira, Irinaldo Diniz Basílio Júnior, João Xavier de Araújo-Júnior, Rui Oliveira Macêdo. Short-term stability studies of ampicillin and cephalexin in aqueous solution and human plasma: Application of least squares method in Arrhenius equation. Journal of pharmaceutical and biomedical analysis. 2013 Jan; 73(?):59-64. doi: 10.1016/j.jpba.2012.04.010. [PMID: 22559990]
Jessica N Lange, Kyle D Wood, Hayes Wong, Richard Otto, Patrick W Mufarrij, John Knight, Haluk Akpinar, Ross P Holmes, Dean G Assimos. Sensitivity of human strains of Oxalobacter formigenes to commonly prescribed antibiotics. Urology. 2012 Jun; 79(6):1286-9. doi: 10.1016/j.urology.2011.11.017. [PMID: 22656407]
Iram Shaifali, Uma Gupta, Syed Esam Mahmood, Jawed Ahmed. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North American journal of medical sciences. 2012 Apr; 4(4):163-9. doi: 10.4103/1947-2714.94940. [PMID: 22536558]
Yushan Huang, Taixiang Wu, Linmiao Zeng, Sheng Li. Chinese medicinal herbs for sore throat. The Cochrane database of systematic reviews. 2012 Mar; ?(3):CD004877. doi: 10.1002/14651858.cd004877.pub3. [PMID: 22419300]
Amira Peco-Antić, Dusan Paripović, Svetlana Buljugić, Divna Kruscić, Brankica Spasojević, Mirjana Cvetković, Mirjana Kostić, Suzana Laban-Nestorović, Gordana Milosevski-Lomić. Antibiotic resistance of uropathogens in newborns and young children with acute pyelonephritis. Srpski arhiv za celokupno lekarstvo. 2012 Mar; 140(3-4):179-83. doi: . [PMID: 22650104]
Yi Ding, Yan-Yan Jia, Fan Li, Wen-Xing Liu, Cheng-Tao Lu, Yan-Rong Zhu, Jing Yang, Li-Kun Ding, Lin Yang, Ai-Dong Wen. The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin. British journal of clinical pharmacology. 2012 Mar; 73(3):422-7. doi: 10.1111/j.1365-2125.2011.04098.x. [PMID: 22023069]
Janak Kishore. Isolation, identification & characterization of Proteus penneri--a missed rare pathogen. The Indian journal of medical research. 2012 Mar; 135(?):341-5. doi: . [PMID: 22561620]
Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa, Yuichi Sugiyama. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. The Journal of pharmacology and experimental therapeutics. 2012 Feb; 340(2):393-403. doi: 10.1124/jpet.111.184986. [PMID: 22072731]
Colleen R Kelly, Lauren de Leon, Niren Jasutkar. Fecal microbiota transplantation for relapsing Clostridium difficile infection in 26 patients: methodology and results. Journal of clinical gastroenterology. 2012 Feb; 46(2):145-9. doi: 10.1097/mcg.0b013e318234570b. [PMID: 22157239]
Pankaj Baral, Sanjiv Neupane, Bishnu Prasad Marasini, Kashi Ram Ghimire, Binod Lekhak, Basudha Shrestha. High prevalence of multidrug resistance in bacterial uropathogens from Kathmandu, Nepal. BMC research notes. 2012 Jan; 5(?):38. doi: 10.1186/1756-0500-5-38. [PMID: 22260454]
Adrián Zapata-Vázquez, Mario Sánchez-Sánchez, Alicia del-Río-Robledo, Héctor Silos-Espino, Catarino Perales-Segovia, Silvia Flores-Benítez, Mario Martín González-Chavira, Luis Lorenzo Valera-Montero. Phytophthora capsici epidemic dispersion on commercial pepper fields in Aguascalientes, Mexico. TheScientificWorldJournal. 2012; 2012(?):341764. doi: 10.1100/2012/341764. [PMID: 22629131]
Kátia Brandt, Carla R Taddei, Elizabeth H Takagi, Fernanda F Oliveira, Rubens T D Duarte, Isabel Irino, Marina B Martinez, Magda Carneiro-Sampaio. Establishment of the bacterial fecal community during the first month of life in Brazilian newborns. Clinics (Sao Paulo, Brazil). 2012; 67(2):113-23. doi: 10.6061/clinics/2012(02)05. [PMID: 22358235]
Le-Qian Hu, Chun-Ling Yin, Ya-Hui Du, Zhi-Peng Zeng. Simultaneous and Direct Determination of Vancomycin and Cephalexin in Human Plasma by Using HPLC-DAD Coupled with Second-Order Calibration Algorithms. Journal of analytical methods in chemistry. 2012; 2012(?):256963. doi: 10.1155/2012/256963. [PMID: 22577613]
Takeo Nakanishi, Akimasa Fukushi, Masanobu Sato, Mayuko Yoshifuji, Tomoka Gose, Yoshiyuki Shirasaka, Kazuyo Ohe, Masato Kobayashi, Keiichi Kawai, Ikumi Tamai. Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Molecular pharmaceutics. 2011 Dec; 8(6):2142-50. doi: 10.1021/mp200096r. [PMID: 21999946]
Raul Raz. Urinary tract infection in postmenopausal women. Korean journal of urology. 2011 Dec; 52(12):801-8. doi: 10.4111/kju.2011.52.12.801. [PMID: 22216390]
N H Bexfield, C Andres-Abdo, T J Scase, F Constantino-Casas, P J Watson. Chronic hepatitis in the English springer spaniel: clinical presentation, histological description and outcome. The Veterinary record. 2011 Oct; 169(16):415. doi: 10.1136/vr.d4665. [PMID: 21852307]
Md Rafiqul Alam, Joong Ryong Ji, Min Su Kim, Nam Soo Kim. Biomarkers for identifying the early phases of osteoarthritis secondary to medial patellar luxation in dogs. Journal of veterinary science. 2011 Sep; 12(3):273-80. doi: 10.4142/jvs.2011.12.3.273. [PMID: 21897101]
Monzer Fanun, Vassiliki Papadimitriou, Aristotelis Xenakis. Characterization of cephalexin loaded nonionic microemulsions. Journal of colloid and interface science. 2011 Sep; 361(1):115-21. doi: 10.1016/j.jcis.2011.05.042. [PMID: 21658706]
Peter Damborg, Ingrid B Gaustad, John E Olsen, Luca Guardabassi. Selection of CMY-2 producing Escherichia coli in the faecal flora of dogs treated with cephalexin. Veterinary microbiology. 2011 Aug; 151(3-4):404-8. doi: 10.1016/j.vetmic.2011.03.015. [PMID: 21497459]
G A Albarellos, L Montoya, P C Quaine, M F Landoni. Pharmacokinetics and bioavailability of a long-acting formulation of cephalexin after intramuscular administration to cats. Research in veterinary science. 2011 Aug; 91(1):129-131. doi: 10.1016/j.rvsc.2010.08.001. [PMID: 20800248]
L Ambros, V Kreil, L Tarragona, A Monfrinotti, R Hallu, M Rebuelto. Comparative pharmacokinetics of intravenous cephalexin in pregnant, lactating, and nonpregnant, nonlactating goats. Journal of veterinary pharmacology and therapeutics. 2011 Aug; 34(4):397-402. doi: 10.1111/j.1365-2885.2010.01232.x. [PMID: 20950353]
Tanja Ilić, Sanda Gračan, Adela Arapović, Vesna Capkun, Mirna Subat-Dežulović, Marijan Saraga. Changes in bacterial resistance patterns in children with urinary tract infections on antimicrobial prophylaxis at University Hospital in Split. Medical science monitor : international medical journal of experimental and clinical research. 2011 Jul; 17(7):CR355-61. doi: 10.12659/msm.881845. [PMID: 21709628]
Alexandra Christine Helena Frankland Sawaya, Ildenize Barbosa da Silva Cunha, Maria Cristina Marcucci. Analytical methods applied to diverse types of Brazilian propolis. Chemistry Central journal. 2011 Jun; 5(1):27. doi: 10.1186/1752-153x-5-27. [PMID: 21631940]
Cliodna A M McNulty, Gemma M Lasseter, André Charlett, Andy Lovering, Rebecca Howell-Jones, Alasdair Macgowan, Mike Thomas. Does laboratory antibiotic susceptibility reporting influence primary care prescribing in urinary tract infection and other infections?. The Journal of antimicrobial chemotherapy. 2011 Jun; 66(6):1396-404. doi: 10.1093/jac/dkr088. [PMID: 21398297]
Zofia Wańkowicz, Anna Grzywacz, Marek Saracyn, Henryk Zieliński. Multiple renal abscesses leading to nephrectomy of the solitary kidney in a young female with type 1 diabetes and history of recurrent urinary tract infections. Archives of medical science : AMS. 2011 Apr; 7(2):349-52. doi: 10.5114/aoms.2011.22091. [PMID: 22291780]
N Mori, Y Shimomukai, T Yokooji, M Ishiguro, Y Kamio, T Murakami. Modulation in concentrative nucleoside transporters-mediated intestinal absorption of mizoribine, an immunosuppressive agent, in lipopolysaccharide-treated rats. Die Pharmazie. 2011 Mar; 66(3):207-11. doi: . [PMID: 21553652]
Parviz Ayazi, Seyed Alireza Moshiri, Abolfazl Mahyar, Mona Moradi. The effect of vitamin A on renal damage following acute pyelonephritis in children. European journal of pediatrics. 2011 Mar; 170(3):347-50. doi: 10.1007/s00431-010-1297-1. [PMID: 20853007]
Praveen Rishi, Simran Preet, Prabhjot Kaur. Effect of L. plantarum cell-free extract and co-trimoxazole against Salmonella Typhimurium: a possible adjunct therapy. Annals of clinical microbiology and antimicrobials. 2011 Feb; 10(?):9. doi: 10.1186/1476-0711-10-9. [PMID: 21352573]
Wipawadee Sianglum, Potjanee Srimanote, Wijit Wonglumsom, Kanokwan Kittiniyom, Supayang P Voravuthikunchai. Proteome analyses of cellular proteins in methicillin-resistant Staphylococcus aureus treated with rhodomyrtone, a novel antibiotic candidate. PloS one. 2011 Feb; 6(2):e16628. doi: 10.1371/journal.pone.0016628. [PMID: 21326597]
Ziaaedin Ghorashi, Sona Ghorashi, Hassan Soltani-Ahari, Nariman Nezami. Demographic features and antibiotic resistance among children hospitalized for urinary tract infection in northwest Iran. Infection and drug resistance. 2011; 4(?):171-6. doi: 10.2147/idr.s24171. [PMID: 22114509]
Iman K Behiry, Emad A Abada, Entsar A Ahmed, Rania S Labeeb. Enteropathogenic Escherichia coli associated with diarrhea in children in Cairo, Egypt. TheScientificWorldJournal. 2011; 11(?):2613-9. doi: 10.1100/2011/485381. [PMID: 22262949]
Sang-Wook Han, Malinee Sriariyanun, Sang-Won Lee, Manoj Sharma, Ofir Bahar, Zachary Bower, Pamela C Ronald. Small protein-mediated quorum sensing in a Gram-negative bacterium. PloS one. 2011; 6(12):e29192. doi: 10.1371/journal.pone.0029192. [PMID: 22174954]
S Saeidnia, Ar Gohari, N Mokhber-Dezfuli, F Kiuchi. A review on phytochemistry and medicinal properties of the genus Achillea. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(3):173-86. doi: ". [PMID: 22615655]
Rui Liu, Audrey May Yi Tang, Yen Ling Tan, Lie Michael George Limenta, Edmund Jon Deoon Lee. Effects of sodium bicarbonate and ammonium chloride pre-treatments on PEPT2 (SLC15A2) mediated renal clearance of cephalexin in healthy subjects. Drug metabolism and pharmacokinetics. 2011; 26(1):87-93. doi: 10.2133/dmpk.dmpk-10-rg-039. [PMID: 21084767]
Anna-Maria Nässl, Isabel Rubio-Aliaga, Manuela Sailer, Hannelore Daniel. The intestinal peptide transporter PEPT1 is involved in food intake regulation in mice fed a high-protein diet. PloS one. 2011; 6(10):e26407. doi: 10.1371/journal.pone.0026407. [PMID: 22031831]
Daniele Minardi, Gianluca d'Anzeo, Daniele Cantoro, Alessandro Conti, Giovanni Muzzonigro. Urinary tract infections in women: etiology and treatment options. International journal of general medicine. 2011; 4(?):333-43. doi: 10.2147/ijgm.s11767. [PMID: 21674026]
Rose McGready, Vanaporn Wuthiekanun, Elizabeth A Ashley, Saw Oo Tan, Mupawjay Pimanpanarak, Samuel Jacher Viladpai-Nguen, Wilarat Jesadapanpong, Stuart D Blacksell, Stephane Proux, Nicholas P Day, Pratap Singhasivanon, Nicholas J White, François Nosten, Sharon J Peacock. Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings. The American journal of tropical medicine and hygiene. 2010 Dec; 83(6):1322-9. doi: 10.4269/ajtmh.2010.10-0332. [PMID: 21118943]
Hong-Qi Chen, Jun Yang, Min Zhang, Yu-Kun Zhou, Tong-Yi Shen, Zhao-Xin Chu, Ming Zhang, Xiao-Min Hang, Yan-Qun Jiang, Huan-Long Qin. Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice. American journal of physiology. Gastrointestinal and liver physiology. 2010 Dec; 299(6):G1287-97. doi: 10.1152/ajpgi.00196.2010. [PMID: 20884889]
Mark G Papich, Jennifer L Davis, Amanda M Floerchinger. Pharmacokinetics, protein binding, and tissue distribution of orally administered cefpodoxime proxetil and cephalexin in dogs. American journal of veterinary research. 2010 Dec; 71(12):1484-91. doi: 10.2460/ajvr.71.12.1484. [PMID: 21118001]
Fernando Antonini, Cassiano Costa Silva Pereira, Eduardo Varela Parente, Fabiano Goulart Azambuja. Management of osteonecrosis of the jaws in patients with history of bisphosphonates therapy. The Journal of craniofacial surgery. 2010 Nov; 21(6):1962-6. doi: 10.1097/scs.0b013e3181f4ee4e. [PMID: 21119470]
Aftab S Chishti, Erich C Maul, Rubén J Nazario, Jeffrey S Bennett, Stefan G Kiessling. A guideline for the inpatient care of children with pyelonephritis. Annals of Saudi medicine. 2010 Sep; 30(5):341-9. doi: 10.4103/0256-4947.68549. [PMID: 20716830]
Shingo Watanabe, Masahiro Tsuda, Tomohiro Terada, Toshiya Katsura, Ken-Ichi Inui. Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice. The Journal of pharmacology and experimental therapeutics. 2010 Aug; 334(2):651-6. doi: 10.1124/jpet.110.169433. [PMID: 20484555]
Ya-Wen He, Ji'en Wu, Jae-Soon Cha, Lian-Hui Zhang. Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production. BMC microbiology. 2010 Jul; 10(?):187. doi: 10.1186/1471-2180-10-187. [PMID: 20615263]
Shilpa Arora, Pushpa Devi, Usha Arora, Bimla Devi. Prevalence of Methicillin-resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Hospital in Northern India. Journal of laboratory physicians. 2010 Jul; 2(2):78-81. doi: 10.4103/0974-2727.72154. [PMID: 21346901]
R Chakupurakal, M Ahmed, D N Sobithadevi, S Chinnappan, T Reynolds. Urinary tract pathogens and resistance pattern. Journal of clinical pathology. 2010 Jul; 63(7):652-4. doi: 10.1136/jcp.2009.074617. [PMID: 20501451]
Michael Pennick. Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatric disease and treatment. 2010 Jun; 6(?):317-27. doi: 10.2147/ndt.s9749. [PMID: 20628632]
Jian Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jian Cang, Huijun Sun, Ying Gao, Taiichi Kaku, Kexin Liu. Pharmacokinetic interaction between JBP485 and cephalexin in rats. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jun; 38(6):930-8. doi: 10.1124/dmd.110.032060. [PMID: 20219852]
Adenike Adedayo O Ogunshe, Abosede Oyeyemi Fawole, Victoria Abosede Ajayi. Microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy. The Pan African medical journal. 2010 May; 5(?):12. doi: 10.4314/pamj.v5i1.56188. [PMID: 21293739]
Alex Avdeef, Kin Y Tam. How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?. Journal of medicinal chemistry. 2010 May; 53(9):3566-84. doi: 10.1021/jm901846t. [PMID: 20373811]
Amélie Leclerc, Anthony C G Abrams-Ogg, Stephen A Kruth, Dorothee Bienzle. Effects of lithium carbonate on carboplatin-induced thrombocytopenia in dogs. American journal of veterinary research. 2010 May; 71(5):555-63. doi: 10.2460/ajvr.71.5.555. [PMID: 20433382]
Sreyashi Sarkar, Arnab Pramanik, Anindita Mitra, Joydeep Mukherjee. Bioprocessing data for the production of marine enzymes. Marine drugs. 2010 Apr; 8(4):1323-72. doi: 10.3390/md8041323. [PMID: 20479981]
Mariana G Spolidorio, Marcelo B Labruna, Elenice Mantovani, Paulo E Brandao, Leonardo J Richtzenhain, Natalino H Yoshinari. Novel spotted fever group rickettsiosis, Brazil. Emerging infectious diseases. 2010 Mar; 16(3):521-3. doi: 10.3201/eid1603.091338. [PMID: 20202436]
Rula M Darwish, Talal A Aburjai. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC complementary and alternative medicine. 2010 Feb; 10(?):9. doi: 10.1186/1472-6882-10-9. [PMID: 20187978]
Vesna Stojanović, Biljana Milosević. [Resistence of Escherichia coli, the most frequent cause of urinary tract infection in children, to antibiotics]. Medicinski pregled. 2010 Jan; 63(1-2):109-12. doi: 10.2298/mpns1002109s. [PMID: 20873320]
A R Gohari, S Saeidnia, K Mollazadeh, N Yassa, M Malmir, A R Shahverdi. Isolation of a new quinic acid derivative and its antibacterial modulating activity. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2010; 18(1):69-73. doi: ". [PMID: 22615597]
Tsunehisa Takahashi, Tomomi Kaku, Takashi Sato, Kazuhiro Watanabe, Juichi Sato. Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2. Journal of natural medicines. 2010 Jan; 64(1):55-62. doi: 10.1007/s11418-009-0371-3. [PMID: 20091240]
John Mitchell. Small molecule immunosensing using surface plasmon resonance. Sensors (Basel, Switzerland). 2010; 10(8):7323-46. doi: 10.3390/s100807323. [PMID: 22163605]