Penconazole (BioDeep_00000002099)

 

Secondary id: BioDeep_00000419488

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


1-(2,4-dichloro-beta-Propylphenethyl)-1H-1,2,4-triazole

化学式: C13H15Cl2N3 (283.0643)
中文名称: 戊菌唑, 戊唑醇
谱图信息: 最多检出来源 Homo sapiens(blood) 38.94%

分子结构信息

SMILES: CCCC(CN1C=NC=N1)C1=C(Cl)C=C(Cl)C=C1
InChI: InChI=1S/C13H15Cl2N3/c1-2-3-10(7-18-9-16-8-17-18)12-5-4-11(14)6-13(12)15/h4-6,8-10H,2-3,7H2,1H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9666; ORIGINAL_PRECURSOR_SCAN_NO 9664
CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9722; ORIGINAL_PRECURSOR_SCAN_NO 9721
CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9751; ORIGINAL_PRECURSOR_SCAN_NO 9750
CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9670; ORIGINAL_PRECURSOR_SCAN_NO 9668
CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9676; ORIGINAL_PRECURSOR_SCAN_NO 9675
CONFIDENCE standard compound; INTERNAL_ID 411; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9793; ORIGINAL_PRECURSOR_SCAN_NO 9792
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3107
D016573 - Agrochemicals
D010575 - Pesticides

同义名列表

5 个代谢物同义名

1-(2,4-dichloro-beta-Propylphenethyl)-1H-1,2,4-triazole; 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole; Penconazole; PEN; Penconazole



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AQP7, AR, BCL2, CASP3, CAT, DMP1, HPGDS, MYL7, TBX2
Peripheral membrane protein 2 ACHE, HK1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 9 ACHE, AR, BCL2, CASP3, DMP1, GATA4, NOTO, PRM2, TBX2
cytosol 10 AR, BCL2, CASP3, CAT, DMP1, GPT, GSR, HK1, HPGDS, MYL7
nuclear body 1 GATA4
nucleoplasm 7 AR, CASP3, DMP1, GATA4, HPGDS, PRM2, TBX2
RNA polymerase II transcription regulator complex 1 GATA4
Cell membrane 2 ACHE, AQP7
Multi-pass membrane protein 1 AQP7
Synapse 1 ACHE
cell cortex 1 AQP7
cell surface 1 ACHE
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 HK1
plasma membrane 4 ACHE, AQP7, AR, IFNLR1
Membrane 7 ACHE, AQP7, AR, BCL2, CAT, IBSP, IFNLR1
basolateral plasma membrane 1 AQP7
extracellular exosome 4 BMP3, CAT, GPT, GSR
endoplasmic reticulum 1 BCL2
extracellular space 4 ACHE, BMP3, IBSP, IFNB1
perinuclear region of cytoplasm 1 ACHE
mitochondrion 4 BCL2, CAT, GSR, HK1
protein-containing complex 3 AR, BCL2, CAT
intracellular membrane-bounded organelle 2 CAT, HPGDS
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IFNLR1
Secreted 4 ACHE, BMP3, IBSP, IFNB1
extracellular region 6 ACHE, BMP3, CAT, DMP1, IBSP, IFNB1
Mitochondrion outer membrane 2 BCL2, HK1
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HK1
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
transcription regulator complex 1 TBX2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 GSR
Secreted, extracellular space, extracellular matrix 1 DMP1
dendritic spine 1 MYL7
cell-cell junction 1 AQP7
vesicle 1 IBSP
Membrane raft 1 HK1
pore complex 1 BCL2
focal adhesion 1 CAT
extracellular matrix 1 DMP1
Peroxisome 1 CAT
basement membrane 1 ACHE
myofibril 1 MYL7
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
nuclear speck 1 AR
chromatin 4 AR, GATA4, NOTO, TBX2
Chromosome 1 PRM2
Lipid-anchor, GPI-anchor 1 ACHE
Lipid droplet 1 AQP7
myosin complex 1 MYL7
Cytoplasmic vesicle membrane 1 AQP7
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 DMP1
male germ cell nucleus 1 PRM2
A band 1 MYL7
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
nucleosome 1 PRM2
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Jana Jaklová Dytrtová, Kateřina Bělonožníková, Michal Jakl, Josef Chmelík, Ishak Kovač, Helena Ryšlavá. Non-target biotransformation enzymes as a target for triazole-zinc mixtures. Chemico-biological interactions. 2023 Jul; ?(?):110625. doi: 10.1016/j.cbi.2023.110625. [PMID: 37422065]
  • Nadiia Mosiichuk, Viktor Husak, Kenneth B Storey, Volodymyr Lushchak. Acute Exposure to the Penconazole-Containing Fungicide Topas Induces Metabolic Stress in Goldfish. Chemical research in toxicology. 2021 12; 34(12):2441-2449. doi: 10.1021/acs.chemrestox.1c00174. [PMID: 34793142]
  • Maryam Rezayian, Vahid Niknam, Hassan Ebrahimzadeh. Penconazole and calcium ameliorate drought stress in canola by upregulating the antioxidative enzymes. Functional plant biology : FPB. 2020 08; 47(9):825-839. doi: 10.1071/fp19341. [PMID: 32579878]
  • Siman Ma, Jia Lun, Yanru Liu, Zhen Jiang, Xingjie Guo. Enantioseparation and Determination of Penconazole in Rat Plasma by Chiral LC-MS/MS: Application to a Stereoselective Toxicokinetic Study. Molecules (Basel, Switzerland). 2020 Jun; 25(13):. doi: 10.3390/molecules25132964. [PMID: 32605157]
  • Zhiyuan Meng, Li Liu, Yexun Xi, Ming Jia, Sen Yan, Sinuo Tian, Wei Sun, Wentao Zhu, Xuefeng Li, Zhiqiang Zhou. Different effects of exposure to penconazole and its enantiomers on hepatic glycolipid metabolism of male mice. Environmental pollution (Barking, Essex : 1987). 2020 Feb; 257(?):113555. doi: 10.1016/j.envpol.2019.113555. [PMID: 31733957]
  • Zhiyuan Meng, Li Liu, Ming Jia, Ruisheng Li, Sen Yan, Sinuo Tian, Wei Sun, Zhiqiang Zhou, Wentao Zhu. Impacts of Penconazole and Its Enantiomers Exposure on Gut Microbiota and Metabolic Profiles in Mice. Journal of agricultural and food chemistry. 2019 Jul; 67(30):8303-8311. doi: 10.1021/acs.jafc.9b02856. [PMID: 31298535]
  • Burak Polat, Osman Tiryaki. Determination of some pesticide residues in conventional-grown and IPM-grown tomato by using QuEChERS method. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2019; 54(2):112-117. doi: 10.1080/03601234.2018.1531663. [PMID: 30602326]
  • Rosa Mercadante, Elisa Polledri, Federico Maria Rubino, Stefan Mandic-Rajcevic, Andrea Vaiani, Claudio Colosio, Angelo Moretto, Silvia Fustinoni. Assessment of penconazole exposure in winegrowers using urinary biomarkers. Environmental research. 2019 01; 168(?):54-61. doi: 10.1016/j.envres.2018.09.013. [PMID: 30268961]
  • Maryam Rezayian, Vahid Niknam, Hassan Ebrahimzadeh. Improving tolerance against drought in canola by penconazole and calcium. Pesticide biochemistry and physiology. 2018 Jul; 149(?):123-136. doi: 10.1016/j.pestbp.2018.06.007. [PMID: 30033008]
  • Mariem Chaâbane, Awatef Elwej, Imen Ghorbel, Sabrine Chelly, Hela Mnif, Tahia Boudawara, Semia Ellouze Chaabouni, Najiba Zeghal, Nejla Soudani. Penconazole alters redox status, cholinergic function and lung's histoarchitecture of adult rats: Reversal effect of vitamin E. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jun; 102(?):645-652. doi: 10.1016/j.biopha.2018.03.113. [PMID: 29602133]
  • Mariem Chaâbane, Mohamed Koubaa, Nejla Soudani, Awatef Elwej, Malek Grati, Kamel Jamoussi, Tahia Boudawara, Semia Ellouze Chaabouni, Najiba Zeghal. Nitraria retusa fruit prevents penconazole-induced kidney injury in adult rats through modulation of oxidative stress and histopathological changes. Pharmaceutical biology. 2017 Dec; 55(1):1061-1073. doi: 10.1080/13880209.2016.1278455. [PMID: 28198206]
  • M Chaâbane, I Ghorbel, A Elwej, H Mnif, T Boudawara, S Ellouze Chaâbouni, N Zeghal, N Soudani. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Human & experimental toxicology. 2017 Aug; 36(8):854-866. doi: 10.1177/0960327116672911. [PMID: 27738198]
  • Viktor V Husak, Nadia M Mosiichuk, Janet M Storey, Kenneth B Storey, Volodymyr I Lushchak. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2017 Mar; 193(?):1-8. doi: 10.1016/j.cbpc.2016.12.003. [PMID: 27979696]
  • R Mercadante, E Polledri, S Scurati, A Moretto, S Fustinoni. Identification of Metabolites of the Fungicide Penconazole in Human Urine. Chemical research in toxicology. 2016 07; 29(7):1179-86. doi: 10.1021/acs.chemrestox.6b00149. [PMID: 27268969]
  • Mariem Chaâbane, Meriem Tir, Safa Hamdi, Ons Boudawara, Kamel Jamoussi, Tahia Boudawara, Raoudha Ellouze Ghorbel, Najiba Zeghal, Nejla Soudani. Improvement of Heart Redox States Contributes to the Beneficial Effects of Selenium Against Penconazole-Induced Cardiotoxicity in Adult Rats. Biological trace element research. 2016 Feb; 169(2):261-70. doi: 10.1007/s12011-015-0426-0. [PMID: 26150403]
  • Lei Jiang, Jing Ling Lin, Lin Xian Jia, Ying Liu, Bo Pan, Yi Yang, Yong Lin. Effects of two different organic amendments addition to soil on sorption-desorption, leaching, bioavailability of penconazole and the growth of wheat (Triticum aestivum L.). Journal of environmental management. 2016 Feb; 167(?):130-8. doi: 10.1016/j.jenvman.2015.10.013. [PMID: 26683765]
  • Magali Lago, Ana Aguiar, André Natário, Carla Fernandes, Miguel Faria, Eugénia Pinto. Does fungicide application in vineyards induce resistance to medical azoles in Aspergillus species?. Environmental monitoring and assessment. 2014 Sep; 186(9):5581-93. doi: 10.1007/s10661-014-3804-8. [PMID: 24833021]
  • Maria Marinozzi, Laura Coppola, Elga Monaci, Dimitrios G Karpouzas, Evangelia Papadopoulou, Urania Menkissoglu-Spiroudi, Costantino Vischetti. The dissipation of three fungicides in a biobed organic substrate and their impact on the structure and activity of the microbial community. Environmental science and pollution research international. 2013 Apr; 20(4):2546-55. doi: 10.1007/s11356-012-1165-9. [PMID: 22965543]
  • Marie-Anne Guglielmi, Françoise Rocher, Sandrine Legros, Jean-Louis Bonnemain, Jean-François Chollet. A non-destructive method for testing two components of the behaviour of soil-applied agricultural chemicals over a long period. Pest management science. 2012 Jun; 68(6):897-905. doi: 10.1002/ps.3248. [PMID: 22271588]
  • Eveline Snelders, Simone M T Camps, Anna Karawajczyk, Gijs Schaftenaar, Gert H J Kema, Henrich A van der Lee, Corné H Klaassen, Willem J G Melchers, Paul E Verweij. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PloS one. 2012; 7(3):e31801. doi: 10.1371/journal.pone.0031801. [PMID: 22396740]
  • Karen S Galea, Laura MacCalman, Kate Jones, John Cocker, Paul Teedon, Anne J Sleeuwenhoek, John W Cherrie, Martie van Tongeren. Biological monitoring of pesticide exposures in residents living near agricultural land. BMC public health. 2011 Nov; 11(?):856. doi: 10.1186/1471-2458-11-856. [PMID: 22074397]
  • Audrey Sombardier, Marie-Cécile Dufour, Dominique Blancard, Marie-France Corio-Costet. Sensitivity of Podosphaera aphanis isolates to DMI fungicides: distribution and reduced cross-sensitivity. Pest management science. 2010 Jan; 66(1):35-43. doi: 10.1002/ps.1827. [PMID: 19728323]
  • Ahmed A Romeh, Tarek M Mekky, Rady A Ramadan, Mohamed Y Hendawi. Dissipation of profenofos, imidacloprid and penconazole in tomato fruits and products. Bulletin of environmental contamination and toxicology. 2009 Dec; 83(6):812-7. doi: 10.1007/s00128-009-9852-z. [PMID: 19760343]
  • Kevin C Gough, Shila Patel, Claire A Baker, Ben C Maddison. Development of immunoassays for the detection of the fungicide penconazole and its urinary metabolite. Journal of agricultural and food chemistry. 2009 Oct; 57(20):9393-9. doi: 10.1021/jf9031469. [PMID: 19803521]
  • Glynn C Percival, Kelly Noviss. Triazole induced drought tolerance in horse chestnut (Aesculus hippocastanum). Tree physiology. 2008 Nov; 28(11):1685-92. doi: 10.1093/treephys/28.11.1685. [PMID: 18765373]
  • Rosa Ma González-Rodríguez, Raquel Rial-Otero, Beatriz Cancho-Grande, Jesús Simal-Gándara. Determination of 23 pesticide residues in leafy vegetables using gas chromatography-ion trap mass spectrometry and analyte protectants. Journal of chromatography. A. 2008 Jul; 1196-1197(?):100-9. doi: 10.1016/j.chroma.2008.02.087. [PMID: 18343389]
  • G Gilardi, M L Gullino, A Garibaldi. Effect of fungicides and of biocontrol agents against powdery mildew of turnip. Communications in agricultural and applied biological sciences. 2008; 73(2):21-9. doi: . [PMID: 19226738]
  • A Bermúdez-Couso, M Arias-Estévez, J C Nóvoa-Muñoz, E López-Periago, B Soto-González, J Simal-Gándara. Seasonal distributions of fungicides in soils and sediments of a small river basin partially devoted to vineyards. Water research. 2007 Nov; 41(19):4515-25. doi: 10.1016/j.watres.2007.06.029. [PMID: 17624393]
  • N Bellí, S Marín, V Sanchis, A J Ramos. Impact of fungicides on Aspergillus carbonarius growth and ochratoxin A production on synthetic grape-like medium and on grapes. Food additives and contaminants. 2006 Oct; 23(10):1021-9. doi: 10.1080/02652030600778702. [PMID: 16982524]
  • E Conte, E Rossi, G Spera, V Pompi, F Carfi', A R Spadoni, M Rosati, M R Montereali, L Donnarumma, W Perconti. Presence of plant protection products in three agricultural areas of Regione Lazio. Communications in agricultural and applied biological sciences. 2003; 68(4 Pt B):865-74. doi: . [PMID: 15151325]