Terfenadine (BioDeep_00000001999)
Secondary id: BioDeep_00000398462
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol
化学式: C32H41NO2 (471.31371260000003)
中文名称: 特非那定
谱图信息:
最多检出来源 Homo sapiens(blood) 12.21%
分子结构信息
SMILES: CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O
InChI: InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
描述信息
Terfenadine is only found in individuals that have used or taken this drug. In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine to H1-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier, CNS depression is minimal.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].
同义名列表
39 个代谢物同义名
alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol; CT Arzneimittel brand OF terfenadine; CT-Arzneimittel brand OF terfenadine; Mundipharma brand OF terfenadine; Merck dura brand OF terfenadine; Ratiopharm brand OF terfenadine; Stadapharm brand OF terfenadine; Cantabria brand OF terfenadine; Sigma-tau brand OF terfenadine; Sigma tau brand OF terfenadine; Dolorgiet brand OF terfenadine; Hoechst brand OF terfenadine; Heumann brand OF terfenadine; Aliud brand OF terfenadine; Wolff brand OF terfenadine; Bial brand OF terfenadine; Terfenadin ratiopharm; Terfenadin-ratiopharm; Balkis saft spezial; Terfenadin heumann; Terfenadin von CT; Terfenadin stada; Terfenadin al; terfenadine; Terfenidine; Terfemundin; Terfedura; Hisfedin; Triludan; Ternadin; Rapidal; Teldane; Seldane; Cyater; (±)-Terfenadine; MDL-991; Terfenadine; Terfenadine
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:9453
- KEGG: C07463
- KEGGdrug: D00521
- KEGGdrug: D82079
- PubChem: 5405
- HMDB: HMDB0014486
- Metlin: METLIN2765
- DrugBank: DB00342
- ChEMBL: CHEMBL17157
- Wikipedia: Terfenadine
- MeSH: Terfenadine
- chemspider: 5212
- CAS: 50679-08-8
- PMhub: MS000001620
- PubChem: 9666
- NIKKAJI: J9.749G
- RefMet: Terfenadine
- medchemexpress: HY-B1193
- KNApSAcK: 9453
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Myriam El Biali, Michael Wölfl-Duchek, Matthias Jackwerth, Severin Mairinger, Maria Weber, Karsten Bamminger, Stefan Poschner, Ivo Rausch, Natalie Schindler, Irene Hernández Lozano, Walter Jäger, Lukas Nics, Nicolas Tournier, Marcus Hacker, Markus Zeitlinger, Martin Bauer, Oliver Langer. St. John's wort extract with a high hyperforin content does not induce P-glycoprotein activity at the human blood-brain barrier.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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