Thiamcol (BioDeep_00000001986)

   


代谢物信息卡片


2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

化学式: C12H15Cl2NO5S (355.004796)
中文名称: 甲砜霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CS(=O)(=O)C1=CC=C(C=C1)C(C(CO)NC(=O)C(Cl)Cl)O
InChI: InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01B - Amphenicols > J01BA - Amphenicols
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
C784 - Protein Synthesis Inhibitor

同义名列表

7 个代谢物同义名

2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide; (+)-Thiamphenicol; Dextrosulphenidol; thiamphenicol; Racefenicol; Thiocymetin; Thiamcol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xiang-Yu Tang, Wen-Min Yin, Guang Yang, Jun-Fang Cui, Jian-Hua Cheng, Fei Yang, Xiao-Yu Li, Chun-Yan Wu, Sen-Gen Zhu. Biochar reduces antibiotic transport by altering soil hydrology and enhancing antibiotic sorption. Journal of hazardous materials. 2024 Jul; 472(?):134468. doi: 10.1016/j.jhazmat.2024.134468. [PMID: 38703680]
  • Xing Zhang, Yiming Huo, Yifei Kong, Wenlin Zhou, Feiju Qin, Xiaolong Hu. Effects of short-term florfenicol exposure on the gene expression pattern, midgut microbiota, and metabolome in the lepidopteran model silkworm (Bombyx mori). The Science of the total environment. 2024 Feb; 912(?):169099. doi: 10.1016/j.scitotenv.2023.169099. [PMID: 38056650]
  • Lin Zhang, Jing Qiu, Yameng Li, Linjuan He, Mingcai Mao, Tiancai Wang, Yecan Pan, Zishu Li, Xiyan Mu, Yongzhong Qian. Maternal transfer of florfenicol impacts development and disrupts metabolic pathways in F1 offspring zebrafish by destroying mitochondria. Ecotoxicology and environmental safety. 2023 Mar; 252(?):114597. doi: 10.1016/j.ecoenv.2023.114597. [PMID: 36739738]
  • Yuxuan Zhang, Peiyong Guo, Yanmei Wu, Meixian Wang, Jun Deng, Haitao Su, Yinshi Sun. Effects of natural nanoparticles on the acute toxicity, chronic effect, and oxidative stress response of phenicol antibiotics in Daphnia magna. Environmental science and pollution research international. 2023 Feb; 30(8):21535-21547. doi: 10.1007/s11356-022-23695-1. [PMID: 36272006]
  • Xinhui Li, Fei Zhao, Chen Fu, Yanyu Yang, Qianru Xu, Yinfei Hao, Xueqing Shi, Dong Chen, Xuejun Bi, Zhilin Gong, Shujian Wu, Haifeng Zhang. Early- and whole-life exposures to florfenicol disrupts lipid metabolism and induces obesogenic effects in zebrafish (Danio rerio). Chemosphere. 2022 Dec; 308(Pt 3):136429. doi: 10.1016/j.chemosphere.2022.136429. [PMID: 36115475]
  • Wei Liu, Ying Liu, Siyuan Fang, Weiyu Yao, Xiao Wang, Yongzhan Bao, Wanyu Shi. Salvia miltiorrhiza polysaccharides alleviates florfenicol-induced liver metabolic disorder in chicks by regulating drug and amino acid metabolic signaling pathways. Poultry science. 2022 Sep; 101(9):101989. doi: 10.1016/j.psj.2022.101989. [PMID: 35841637]
  • Xiaoming Wang, Yue Wang, Ci Fang, Qianmei Gong, Jinhu Huang, Yujuan Zhang, Liping Wang. Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers. Poultry science. 2022 Jul; 101(7):101947. doi: 10.1016/j.psj.2022.101947. [PMID: 35688033]
  • Chunyu Lu, Lu Zhang, Yuqing Cui, Guozhong Jin, Yongzhan Bao, Wanyu Shi. Proteome and transcriptome explore the mechanism of Salvia miltiorrhiza polysaccharides to relieve florfenicol-induced kidney injury in broilers. Environmental science and pollution research international. 2022 Jun; 29(30):45872-45884. doi: 10.1007/s11356-022-19114-0. [PMID: 35150422]
  • Wei Liu, Xiao Wang, Ying Liu, Siyuan Fang, Zhanjun Wu, Chao Han, Wanyu Shi, Yongzhan Bao. Effects of early florfenicol exposure on glutathione signaling pathway and PPAR signaling pathway in chick liver. Ecotoxicology and environmental safety. 2022 Jun; 237(?):113529. doi: 10.1016/j.ecoenv.2022.113529. [PMID: 35487170]
  • Avishek Bardhan, Thangapalam Jawahar Abraham, Jasmine Singha, Suchismita Saha, Sudeshna Sarker, Prasanna Kumar Patil. The effects of extended feeding of florfenicol coated medicated diets on the safety, serum biomarkers and blood cells morphology of Nile tilapia Oreochromis niloticus (L.). Environmental science and pollution research international. 2022 Jun; 29(26):39914-39927. doi: 10.1007/s11356-021-18418-x. [PMID: 35112251]
  • Fábio S Zanuzzo, Rebeccah M Sandrelli, Ellen de Fátima C Peroni, Jennifer R Hall, Matthew L Rise, Anthony K Gamperl. Atlantic Salmon (Salmo salar) bacterial and viral innate immune responses are not impaired by florfenicol or tetracycline administration. Fish & shellfish immunology. 2022 Apr; 123(?):298-313. doi: 10.1016/j.fsi.2022.02.034. [PMID: 35189324]
  • Xiao Wang, Wei Liu, Guozhong Jin, Zhanjun Wu, Di Zhang, Yongzhan Bao, Wanyu Shi. Salvia miltiorrhiza polysaccharides alleviates florfenicol induced kidney injury in chicks via inhibiting oxidative stress and apoptosis. Ecotoxicology and environmental safety. 2022 Mar; 233(?):113339. doi: 10.1016/j.ecoenv.2022.113339. [PMID: 35219255]
  • Sicong Li, Bin Wang, Min Zhang, Dingsheng Yuan, Jinliang Li, Xuting Li, Ge Liang. Effects of berberine on the pharmacokinetics of florfenicol and levels of cytochrome P450 3A37, multidrug resistance 1, and chicken xenobiotic-sensing orphan nuclear receptor mRNA expression in broilers. Veterinary medicine and science. 2022 03; 8(2):619-625. doi: 10.1002/vms3.660. [PMID: 34766459]
  • Kai Yang, Sanguo Ren, Meng Mei, Yuanpei Jin, Wei Xiang, Zunji Shi, Zhihui Ai, Li Yi, Bo Xie. Removal of antibiotic thiamphenicol by bacterium Aeromonas hydrophila HS01. World journal of microbiology & biotechnology. 2022 Jan; 38(3):37. doi: 10.1007/s11274-021-03223-y. [PMID: 35018528]
  • Majid Gholami-Ahangaran, Maryam Karimi-Dehkordi, Abdolrasul Namjoo, Hasan Shojaei, Asiye Ahmadi-Dastgerdi. The co-administration effects of florfenicol and lasalocid on performance, biochemical and pathological parameters of muscle, heart, liver, kidney and sciatic nerve in broiler chickens. Veterinary medicine and science. 2022 01; 8(1):211-218. doi: 10.1002/vms3.626. [PMID: 34498431]
  • A Bello, B Poźniak, A Smutkiewicz, M Świtała. The influence of the site of drug administration on florfenicol pharmacokinetics in turkeys. Poultry science. 2022 Jan; 101(1):101536. doi: 10.1016/j.psj.2021.101536. [PMID: 34784513]
  • Yumeng Geng, Chunyu Lu, Guozhong Jin, Shuying Li, Yuqing Cui, Chao Han, Wanyu Shi, Yongzhan Bao. Study on the mechanism of Salvia miltiorrhiza polysaccharides in relieving liver injury of broilers induced by florfenicol. Environmental science and pollution research international. 2022 Jan; 29(3):3372-3385. doi: 10.1007/s11356-021-15687-4. [PMID: 34389946]
  • Fahimeh Nematollahi, Tahoora Shomali, Bahman Abdi-Hachesoo, Azizollah Khodakaram-Tafti. Effect of prophylactic vitamin C administration on the efficiency of florfenicol or sulfadiazine-trimethoprim antimicrobial therapy in chickens with staphylococcal arthritis. Tropical animal health and production. 2021 Dec; 54(1):25. doi: 10.1007/s11250-021-03033-2. [PMID: 34957533]
  • T Rairat, Y Chi, S-K Chang, C-Y Hsieh, N Chuchird, C-C Chou. Differential effects of aquatic anaesthetics on the pharmacokinetics of antibiotics: Examples using florfenicol in Nile tilapia (Oreochromis niloticus). Journal of fish diseases. 2021 Oct; 44(10):1579-1586. doi: 10.1111/jfd.13480. [PMID: 34152617]
  • Mingrong Qian, Jianmei Wang, Xiaofeng Ji, Hua Yang, Biao Tang, Hu Zhang, Guiling Yang, Zhiwei Bao, Yuanxiang Jin. Sub-chronic exposure to antibiotics doxycycline, oxytetracycline or florfenicol impacts gut barrier and induces gut microbiota dysbiosis in adult zebrafish (Daino rerio). Ecotoxicology and environmental safety. 2021 Sep; 221(?):112464. doi: 10.1016/j.ecoenv.2021.112464. [PMID: 34198189]
  • Chao Han, Yuqing Cui, Yiwei Guo, Di Zhang, Xiao Wang, Yumeng Geng, Wanyu Shi, Yongzhan Bao. Proteome and transcriptome analysis revealed florfenicol via affected drug metabolism and lipid metabolism induce liver injury of broilers. Poultry science. 2021 Sep; 100(9):101228. doi: 10.1016/j.psj.2021.101228. [PMID: 34293615]
  • Xuting Li, Sicong Li, Bin Wang, Min Zhang, Dingsheng Yuan, Jinliang Li, Ge Liang. Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats. The Journal of veterinary medical science. 2021 Aug; 83(8):1338-1344. doi: 10.1292/jvms.20-0641. [PMID: 34176823]
  • Sonia Nina Coccitto, Simona Fioriti, Marzia Cinthi, Gianluca Morroni, Elisabetta Di Giannatale, Marina Mingoia, Andrea Brenciani, Eleonora Giovanetti. Detection of phenicol-oxazolidinone resistance gene optrA in Aerococcus viridans from bovine faeces, Italy. The Journal of antimicrobial chemotherapy. 2021 08; 76(9):2479-2481. doi: 10.1093/jac/dkab162. [PMID: 34008028]
  • Bin Li, Yi Hu, Yujie Guo, Renjie Xu, Xiaoping Fang, Xuecheng Xiao, Cuiping Jiang, Shan Lu. Coamorphous System of Florfenicol-Oxymatrine for Improving the Solubility and Dissolution Rate of Florfenicol: Preparation, Characterization and Molecular Dynamics Simulation. Journal of pharmaceutical sciences. 2021 06; 110(6):2544-2554. doi: 10.1016/j.xphs.2021.02.005. [PMID: 33577826]
  • Dimitra Kogiannou, Chrysanthi Nikoloudaki, Pantelis Katharios, Adriana Triga, George Rigos. Evaluation of absorption and depletion of florfenicol in European seabass Dicentrarchus labrax. Veterinary medicine and science. 2021 05; 7(3):987-997. doi: 10.1002/vms3.415. [PMID: 33369159]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Chao Han, Xiao Wang, Di Zhang, Yuanyuan Wei, Yuqing Cui, Wanyu Shi, Yongzhan Bao. Synergistic use of florfenicol and Salvia miltiorrhiza polysaccharide can enhance immune responses in broilers. Ecotoxicology and environmental safety. 2021 Mar; 210(?):111825. doi: 10.1016/j.ecoenv.2020.111825. [PMID: 33412284]
  • He Guo, Zhen Li, Liangrui Xiang, Nan Jiang, Ying Zhang, Huijuan Wang, Jie Li. Efficient removal of antibiotic thiamphenicol by pulsed discharge plasma coupled with complex catalysis using graphene-WO3-Fe3O4 nanocomposites. Journal of hazardous materials. 2021 02; 403(?):123673. doi: 10.1016/j.jhazmat.2020.123673. [PMID: 32829229]
  • Xiao Wang, Chao Han, Yuqing Cui, Yumeng Geng, Yuanyuan Wei, Wanyu Shi, Yongzhan Bao. Florfenicol induces renal toxicity in chicks by promoting oxidative stress and apoptosis. Environmental science and pollution research international. 2021 Jan; 28(1):936-946. doi: 10.1007/s11356-020-10550-4. [PMID: 32827115]
  • Xiao Wang, Chao Han, Yuqing Cui, Shuying Li, Guozhong Jin, Wanyu Shi, Yongzhan Bao. Florfenicol causes excessive lipid peroxidation and apoptosis induced renal injury in broilers. Ecotoxicology and environmental safety. 2021 Jan; 207(?):111282. doi: 10.1016/j.ecoenv.2020.111282. [PMID: 32949928]
  • Tirawat Rairat, Yu-Shin Kuo, Chao-Chia Chang, Chia-Yu Hsieh, Chi-Chung Chou. Bath immersion pharmacokinetics of florfenicol in Nile tilapia (Oreochromis niloticus). Journal of veterinary pharmacology and therapeutics. 2020 Nov; 43(6):520-526. doi: 10.1111/jvp.12887. [PMID: 32573800]
  • Mohamed Aboubakr, Ahmed Soliman. Pharmacokinetics of thiamphenicol in Japanese quails (Coturnix japonica) after single intravenous and oral administrations. Journal of veterinary pharmacology and therapeutics. 2020 Sep; 43(5):512-515. doi: 10.1111/jvp.12902. [PMID: 32779236]
  • Wei Zhang, Chun-Ping Liu, Shi-Qi Chen, Meng-Jiao Liu, Li Zhang, Shi-Yu Lin, Gang Shu, Zhi-Xiang Yuan, Ju-Chun Lin, Guang-Neng Peng, Zhi-Jun Zhong, Li-Zi Yin, Lin Zhao, Hua-Lin Fu. Poloxamer modified florfenicol instant microparticles for improved oral bioavailability. Colloids and surfaces. B, Biointerfaces. 2020 Sep; 193(?):111078. doi: 10.1016/j.colsurfb.2020.111078. [PMID: 32422561]
  • Marta Pastor-Belda, Natalia Campillo, Natalia Arroyo-Manzanares, Manuel Hernández-Córdoba, Pilar Viñas. Determination of amphenicol antibiotics and their glucuronide metabolites in urine samples using liquid chromatography with quadrupole time-of-flight mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122122. doi: 10.1016/j.jchromb.2020.122122. [PMID: 32334391]
  • Tingyuan Zhu, Suzhen Liu, Yuanyuan Ying, Lei Xu, Yabo Liu, Junjie Jin, Jun Ying, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Qiyu Bao, Peizhen Li. Genomic and functional characterization of fecal sample strains of Proteus cibarius carrying two floR antibiotic resistance genes and a multiresistance plasmid-encoded cfr gene. Comparative immunology, microbiology and infectious diseases. 2020 Apr; 69(?):101427. doi: 10.1016/j.cimid.2020.101427. [PMID: 32058867]
  • Chao Han, Yuanyuan Wei, Yuqing Cui, Yumemg Geng, Yongzhan Bao, Wanyu Shi. Florfenicol induces oxidative stress and hepatocyte apoptosis in broilers via Nrf2 pathway. Ecotoxicology and environmental safety. 2020 Mar; 191(?):110239. doi: 10.1016/j.ecoenv.2020.110239. [PMID: 31991393]
  • Samy A Elgeddawy, Hazem M Shaheen, Yasser S El-Sayed, Magdy Abd Elaziz, Ashraf Darwish, Dalia Samak, Gaber E Batiha, Rehab A Mady, May Bin-Jumah, Ahmed A Allam, Mahmoud Alagawany, Ayman E Taha, Amany El-Mleeh, Sabry A A El-Sayed, Mohamed E Abd El-Hack, Shaaban S Elnesr. Effects of the dietary inclusion of a probiotic or prebiotic on florfenicol pharmacokinetic profile in broiler chicken. Journal of animal physiology and animal nutrition. 2020 Mar; 104(2):549-557. doi: 10.1111/jpn.13317. [PMID: 32017274]
  • Yabo Liu, Fei Wu, Qing Chen, Yuanyuan Ying, Yi Jiang, Junwan Lu, Xi Lin, Kewei Li, Teng Xu, Qiyu Bao, Liyan Ni. Comparative genomics analysis of Raoultella planticola S25 isolated from duck in China, with florfenicol resistance. Comparative immunology, microbiology and infectious diseases. 2020 Feb; 68(?):101398. doi: 10.1016/j.cimid.2019.101398. [PMID: 31775114]
  • Yuying Huang, Yihai Wang, Jingwen Xu, Jianying Feng, Xiangjiu He. Propacin, a coumarinolignoid isolated from durian, inhibits the lipopolysaccharide-induced inflammatory response in macrophages through the MAPK and NF-κB pathways. Food & function. 2020 Jan; 11(1):596-605. doi: 10.1039/c9fo02202c. [PMID: 31859327]
  • DanNa Zhou, YaChao Li, LingLi Huang, MingRong Qian, Dong Li, GuiZhi Sun, Bo Yang. A reliable and cost-efficient TLC-HPLC method for determining total florfenicol residues in porcine edible tissues. Food chemistry. 2020 Jan; 303(?):125399. doi: 10.1016/j.foodchem.2019.125399. [PMID: 31470274]
  • M S El-Gohary, Adel M El Gamal, A A Atia, M F El-Dakroury. Treatment Trial of Nile Tilapia (Oreochromis niloticus) Experimentally Infected with Vibrio alginolyticus Isolated from Sea bass (Dicentrarchus labrax). Pakistan journal of biological sciences : PJBS. 2020 Jan; 23(12):1591-1600. doi: 10.3923/pjbs.2020.1591.1600. [PMID: 33274891]
  • Fan Yang, Chao-Shuo Zhang, Han Wang, Fang Yang. Depletion study and withdrawal period calculation of florfenicol in the crucian carp (Carassius auratus) following multiple intramuscular injections. Journal of veterinary pharmacology and therapeutics. 2020 Jan; 43(1):79-86. doi: 10.1111/jvp.12822. [PMID: 31691990]
  • Audrey Martinez, Seenivasan Subbiah, Paul Stonum, Tiffanie Brooks, Shanoy Anderson, Odia Osemwegie, Ernest E Smith. Characterization of serotonin following exposure to antibiotics in white-tailed deer. General and comparative endocrinology. 2020 01; 285(?):113265. doi: 10.1016/j.ygcen.2019.113265. [PMID: 31473183]
  • Kamelia Osman, Tara Rava Zolnikov, Jihan Badr, Heba Naim, Mai Hanafy, Aalaa Saad, Ayman Elbehiry. Vancomycin and florfenicol resistant Enterococcus faecalis and Enterococcus faecium isolated from human urine in an Egyptian urban-rural community. Acta tropica. 2020 Jan; 201(?):105209. doi: 10.1016/j.actatropica.2019.105209. [PMID: 31600524]
  • Rosemary Booth, Sharon Nyari. Clinical comparison of five anti-chlamydial antibiotics in koalas (Phascolarctos cinereus). PloS one. 2020; 15(7):e0236758. doi: 10.1371/journal.pone.0236758. [PMID: 32730301]
  • Sicong Li, Xuting Li, Rui Yang, Bin Wang, Jinliang Li, Liang Cao, Songyang Xiao, Wei Huang. Effects of anemoside B4 on pharmacokinetics of florfenicol and mRNA expression of CXR, MDR1, CYP3A37 and UGT1E in broilers. The Journal of veterinary medical science. 2019 Dec; 81(12):1804-1809. doi: 10.1292/jvms.19-0293. [PMID: 31611492]
  • M Lis, M Szczypka, A Suszko-Pawłowska, M Świtała, P Pawłowski, B Obmińska-Mrukowicz. Modulation of lymphocyte subsets and humoral immune response by florfenicol administered to sheep red blood cell-immunized broiler chickens. Polish journal of veterinary sciences. 2019 Dec; 22(4):481-487. doi: 10.24425/pjvs.2019.129980. [PMID: 31867932]
  • Guoqing Fan, Li Zhang, Yun Shen, Gang Shu, Zhixiang Yuan, Juchun Lin, Wei Zhang, Guangneng Peng, Zhijun Zhong, Lizi Yin, Hualin Fu. Comparative muscle irritation and pharmacokinetics of florfenicol-hydroxypropyl-β-cyclodextrin inclusion complex freeze-dried powder injection and florfenicol commercial injection in beagle dogs. Scientific reports. 2019 11; 9(1):16739. doi: 10.1038/s41598-019-53304-0. [PMID: 31723173]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Pei Li, Jianzhi Ye, Shaodong Zeng, Chunliang Yang. Florfenicol alleviated lipopolysaccharide (LPS)-induced inflammatory responses in Ctenopharyngodon idella through inhibiting toll / NF-κB signaling pathways. Fish & shellfish immunology. 2019 Nov; 94(?):479-484. doi: 10.1016/j.fsi.2019.08.073. [PMID: 31472264]
  • Murugesan Sathiya Deepika, Ramar Thangam, Tharumasivam Siva Vijayakumar, Rajendran Sasirekha, R T V Vimala, Srinivasan Sivasubramanian, Sridhar Arun, Manikandan Dinesh Babu, Ramasamy Thirumurugan. Antibacterial synergy between rutin and florfenicol enhances therapeutic spectrum against drug resistant Aeromonas hydrophila. Microbial pathogenesis. 2019 Oct; 135(?):103612. doi: 10.1016/j.micpath.2019.103612. [PMID: 31252064]
  • Yuqing Huang, Xiaoxuan Chen, Huan Wang, Hui Zhao, Yaner Luo, Zhixin Wu. Pharmacokinetics of florfenicol in blunt-snout bream (Megalobrama amblycephala) at two water temperatures with single-dose oral administration. Journal of veterinary pharmacology and therapeutics. 2019 Sep; 42(5):564-571. doi: 10.1111/jvp.12773. [PMID: 31197852]
  • Nima Shiry, Siyavash Soltanian, Tahoora Shomali, Hamed Paknejad, Seyed Hossein Hoseinifar. Immunomodulatory effects of orally administrated florfenicol in rainbow trout (Oncorhynchus mykiss) following experimental challenge with streptococcosis/lactococcosis. International immunopharmacology. 2019 Aug; 73(?):236-245. doi: 10.1016/j.intimp.2019.05.007. [PMID: 31108388]
  • Tirawat Rairat, Chia-Yu Hsieh, Wipavee Thongpiam, Chi-Chung Chou. Pharmacokinetic-pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels. Journal of fish diseases. 2019 Aug; 42(8):1181-1190. doi: 10.1111/jfd.13040. [PMID: 31157416]
  • Mingrong Qian, Danna Zhou, Qianyong Wang, Jindong Gao, Dong Li, Yachao Li, Bo Yang. A reliable, simple and cost-efficient TLC-HPLC method for simultaneously determining florfenicol and florfenicol amine in porcine urine: application to residue surveillance. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2019 Aug; 36(8):1218-1227. doi: 10.1080/19440049.2019.1627004. [PMID: 31192771]
  • Chang Sun, Deming Dong, Sinan He, Liwen Zhang, Xun Zhang, Chaoqian Wang, Xiuyi Hua, Zhiyong Guo. Multimedia fate modeling of antibiotic sulfamethoxazole, lincomycin, and florfenicol in a seasonally ice-covered river receiving WWTP effluents. Environmental science and pollution research international. 2019 Jun; 26(17):17351-17361. doi: 10.1007/s11356-019-05121-1. [PMID: 31016586]
  • Francisco Arriagada, Germán Günther, Irene Zabala, Jorge Rubio-Retama, Javier Morales. Development and Characterization of Florfenicol-Loaded BSA Nanoparticles as Controlled Release Carrier. AAPS PharmSciTech. 2019 May; 20(5):202. doi: 10.1208/s12249-019-1419-7. [PMID: 31140015]
  • Zhixin Lei, Qianying Liu, Haseeb Khaliq, Jiyue Cao, Qigai He. Resistant cutoff values and optimal scheme establishments for florfenicol against Escherichia coli with PK-PD modeling analysis in pigs. Journal of veterinary pharmacology and therapeutics. 2019 May; 42(3):324-335. doi: 10.1111/jvp.12754. [PMID: 30801741]
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