Voriconazole (BioDeep_00000001916)

 

Secondary id: BioDeep_00000398900

human metabolite blood metabolite


代谢物信息卡片


(AlphaR,betas)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

化学式: C16H14F3N5O (349.115039)
中文名称: （R*,S*）-α-(2,4-二氟苯基)-5-氟-β-甲基-α-(1H-1,2,4-三唑-1-甲基)-4-嘧啶乙醇, 活力康唑, 伏立康唑
谱图信息: 最多检出来源 Homo sapiens(blood) 44.16%

分子结构信息

SMILES: CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
InChI: InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

描述信息

Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections.
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use > J02AC - Triazole and tetrazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

14 个代谢物同义名

(AlphaR,betas)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (R-(R*,s*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (AlphaR,betas)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (AlphaR,betas)-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (R-(R*,s*))-a-(2,4-difluorophenyl)-5-fluoro-b-methyl-a-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (R-(R*,s*))-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; Voriconazole Vfend; Voriconazolum; Voriconazole; Voriconazol; Vfend; VCZ



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yujiang Liu, Junxin Lin. Periprosthetic bacterial and fugal infection after total knee arthroplasty with one-stage debridement: a case report. Journal of medical case reports. 2024 Apr; 18(1):177. doi: 10.1186/s13256-024-04492-5. [PMID: 38610059]
  • Heba A Fayyaz, Magda A El-Massik, Mohammed Bahey-El-Din, Amany Abdel-Bary, Ossama Y Abdallah, Hoda M Eltaher. Targeted DPPC/DMPG surface-modified voriconazole lipid nanoparticles control invasive pulmonary aspergillosis in immunocompromised population: in-vitro and in-vivo assessment. International journal of pharmaceutics. 2024 Jan; 649(?):123663. doi: 10.1016/j.ijpharm.2023.123663. [PMID: 38061501]
  • Rosa Bellavita, Annarita Falanga, Francesco Merlino, Gabriella D'Auria, Nicola Molfetta, Anella Saviano, Francesco Maione, Umberto Galdiero, Maria Rosaria Catania, Stefania Galdiero, Paolo Grieco, Emanuela Roscetto, Lucia Falcigno, Elisabetta Buommino. Unveiling the mechanism of action of acylated temporin L analogues against multidrug-resistant Candida albicans. Journal of enzyme inhibition and medicinal chemistry. 2023 12; 38(1):36-50. doi: 10.1080/14756366.2022.2134359. [PMID: 36305289]
  • Armando Barragán-Reyes, Luis Esaú López Jácome, Diana Perales-Martínez, Alejandra Nava-Ruiz, María de Lourdes García Hernández, Patricia Cornejo-Juárez, Joaquín Rincón-Zuno, Adrián Camacho, Rafael Franco Cendejas, José M Feliciano Guzmán, Norma E Rivera-Martínez, Diego Ontañón-Zurita, Jesús Reséndiz-Sánchez, Eva Juárez-Hernández, Daniel Aguilar-Zapata. Fusariosis in Mexico: A 10-year retrospective series. Medical mycology. 2023 Dec; 61(12):. doi: 10.1093/mmy/myad112. [PMID: 37944000]
  • Qian Du, Mengmeng Teng, Luting Yang, Chao Meng, Yulan Qiu, Chuhui Wang, Jiaojiao Chen, Taotao Wang, Siying Chen, Yu Luo, Jinyao Sun, Yalin Dong. Metabolic characteristics of voriconazole - Induced liver injury in rats. Chemico-biological interactions. 2023 Sep; 383(?):110693. doi: 10.1016/j.cbi.2023.110693. [PMID: 37659626]
  • Yundi Zhang, Yue Du, Shuyu Ren, Yue Li, Xiaoming Zhang, Xiaohong Cao, Fengxi Liu, Huiying Zong, Yan Li. CYP3A5 Genotype-Dependent Drug-Drug Interaction Between Tacrolimus and Voriconazole in Chinese Kidney Transplant Patients. The Annals of pharmacotherapy. 2023 Sep; ?(?):10600280231197399. doi: 10.1177/10600280231197399. [PMID: 37702380]
  • Martin Hoenigl, Jeffrey D Jenks, Matthias Egger, Marcio Nucci, George R Thompson. Treatment of Fusarium Infection of the Central Nervous System: A Review of Past Cases to Guide Therapy for the Ongoing 2023 Outbreak in the United States and Mexico. Mycopathologia. 2023 Aug; ?(?):. doi: 10.1007/s11046-023-00790-6. [PMID: 37653167]
  • Kevin Ehemann, Andrés Contreras, Adriana Marcela Celis-Ramírez. In vitro sensitivity of Malassezia furfur isolates from HIV-positive and negative patients to antifungal agents. Biomedica : revista del Instituto Nacional de Salud. 2023 Aug; 43(Sp. 1):120-131. doi: 10.7705/biomedica.6871. [PMID: 37721914]
  • Chong Kei Lao, Jie-Hao Ou, Yun-Chen Fan, Ting-Shu Wu, Pei-Lun Sun. Clinical manifestations and susceptibility of Scedosporium/Lomentospora infections at a tertiary medical centre in Taiwan from 2014 to 2021: A retrospective cohort study. Mycoses. 2023 Jul; ?(?):. doi: 10.1111/myc.13632. [PMID: 37449538]
  • Omer Barda, Sudharsan Sadhasivam, Di Gong, Adi Doron-Faigenboim, Varda Zakin, Milton T Drott, Edward Sionov. Aneuploidy Formation in the Filamentous Fungus Aspergillus flavus in Response to Azole Stress. Microbiology spectrum. 2023 Jun; ?(?):e0433922. doi: 10.1128/spectrum.04339-22. [PMID: 37358460]
  • F Su, X-X Meng, C-Z Su, J-L Zhang. A case of drug-induced myopathy in alcoholic cirrhosis caused by voriconazole. European review for medical and pharmacological sciences. 2023 May; 27(9):3833-3836. doi: 10.26355/eurrev_202305_32288. [PMID: 37203807]
  • Ying Wang, Fangfang Bao, Xianmei Lu, Hong Liu, Furen Zhang. Case Report: Cutaneous Mycosis Caused by Purpureocillium lilacinum. The American journal of tropical medicine and hygiene. 2023 04; 108(4):693-695. doi: 10.4269/ajtmh.22-0608. [PMID: 36806492]
  • Armando Guevara, Andréia Ferreira Nery, Márcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrósio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F de Souza Lima, Vânia Aparecida Vicente, Rosane Christine Hahn. Molecular epidemiology and clinical-laboratory aspects of chromoblastomycosis in Mato Grosso, Brazil. Mycoses. 2022 Dec; 65(12):1146-1158. doi: 10.1111/myc.13505. [PMID: 35869803]
  • Alexandra Mpakosi, Maria Siopi, Georgia Vrioni, Maria Orfanidou, Athina Argyropoulou, Myrto Christofidou, Maria Kostoula, Stamatina Golegou, Anastasia Antoniadou, Eleni Vagiakou, Eleni Petrou, Evangelia Platsouka, Eleni Papadogeorgaki, Joseph Meletiadis, Irini Chatziralli, Panagiotis Theodossiadis, Georgios Petrikkos, Maria Drogari-Apiranthitou. Filamentous Fungal Keratitis in Greece: A 16-Year Nationwide Multicenter Survey. Mycopathologia. 2022 Dec; 187(5-6):439-453. doi: 10.1007/s11046-022-00666-1. [PMID: 36178544]
  • Ertan Sal, Jannik Stemler, Jon Salmanton-García, Iker Falces-Romero, László Kredics, Elisabeth Meyer, Benjamin Würstl, Cornelia Lass-Flörl, Zdenek Racil, Nikolay Klimko, Simone Cesaro, Anupma Jyoti Kindo, Hilmar Wisplinghoff, Philipp Koehler, Oliver A Cornely, Danila Seidel. Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry. The Journal of antimicrobial chemotherapy. 2022 09; 77(10):2850-2858. doi: 10.1093/jac/dkac235. [PMID: 35929089]
  • Malene Risum, Ulrik Malthe Overgaard, Niclas Rubek, Eva Kannik Haastrup, Rasmus Krøger Hare, Jannik Helweg-Larsen. Disseminated fusariosis with cerebral involvement in a patient with acute myeloid leukemia: Successful outcome with intrathecal -and systemic antifungal treatment. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022 Sep; 28(9):1324-1328. doi: 10.1016/j.jiac.2022.04.017. [PMID: 35641412]
  • David Lamas-Francis, Jose Llovo-Taboada, Daniel Navarro, Rosario Touriño, Teresa Rodríguez-Ares. Necrotizing scleritis due to Hormographiella aspergillata. European journal of ophthalmology. 2022 Aug; ?(?):11206721221118209. doi: 10.1177/11206721221118209. [PMID: 35915985]
  • Xiao-Hong Su, Wei-Peng Li, Qi Lin, Xiu-Jun Zheng, Ting Fang, Ying Jiang, Fu-Hua Peng. Case report: a special case of cryptococcal infection-related inflammatory syndrome in a non-HIV infected and non-transplant patient. BMC neurology. 2022 Jul; 22(1):247. doi: 10.1186/s12883-022-02773-4. [PMID: 35794548]
  • Shuqiao Cheng, Mimi Tang, Jie Du, Tao Yin. Effects of antifungal drugs on the plasma concentrations and dosage of tacrolimus in kidney transplant patients. European journal of hospital pharmacy : science and practice. 2022 Jul; 29(4):202-206. doi: 10.1136/ejhpharm-2020-002385. [PMID: 33020057]
  • Xiao-Bin Lin, Xiao-Guang Hu, Yan-Zhe Xia, Xiao-Man Liu, Tao Liang, Xiao Chen, Chang-Jie Cai. Voriconazole pharmacokinetics in a critically ill patient during extracorporeal membrane oxygenation. Journal of chemotherapy (Florence, Italy). 2022 Jul; 34(4):272-276. doi: 10.1080/1120009x.2021.2014725. [PMID: 34904531]
  • Amanpreet Kaur, Gurudutt Dubey, Nisha Sharma, Rajat Pant, Prasad V Bharatam, Kulbhushan Tikoo, Arvind K Bansal. High dose nanocrystalline solid dispersion powder of voriconazole for inhalation. International journal of pharmaceutics. 2022 Jun; 622(?):121827. doi: 10.1016/j.ijpharm.2022.121827. [PMID: 35589006]
  • Bo Wang, Yuerong Wang, Luwen Zhang, Fanbo Lu, Min Zhang, Yuanhong Xu. Surveillance Study of Epidemiology, Antifungal Susceptibility and Risk Factors of Invasive Candidiasis in Critically ill Patients. Clinical laboratory. 2022 Jun; 68(6):. doi: 10.7754/clin.lab.2021.211001. [PMID: 35704741]
  • Xinghua Fan, Hong Zhang, Zhipeng Wen, Xiaoli Zheng, Yi Yang, Jihong Yang. Effects of CYP2C19, CYP2C9 and CYP3A4 gene polymorphisms on plasma voriconazole levels in Chinese pediatric patients. Pharmacogenetics and genomics. 2022 06; 32(4):152-158. doi: 10.1097/fpc.0000000000000464. [PMID: 35081606]
  • Lu Chen, Lixian Li, Wanyi Chen. Use of Modeling and Simulation to Predict the Influence of Triazole Antifungal Agents on the Pharmacokinetics of Crizotinib. Clinical pharmacology in drug development. 2022 06; 11(6):724-733. doi: 10.1002/cpdd.1049. [PMID: 34995400]
  • Zhi-Peng Wen, Hong Zhang, Qin Li, Chu-Jiao Hu, Cheng-Li Yang, Xing-Hua Fan, Zhi-Chang Zheng, Ming Li, Lin Tan, Rong Tan, Bin-Yi Xia, Jing Ji, Yang Bai, Yi Yang, Xiao-Li Zheng, Ji-Hong Yang. UPLC-MS/MS method for the determination of voriconazole plasma concentration from pediatric patients with hematologic tumors: An application toward personalized therapy. Biomedical chromatography : BMC. 2022 Jun; 36(6):e5356. doi: 10.1002/bmc.5356. [PMID: 35178731]
  • Michael A Pfaller, Cecilia G Carvalhaes, Sean DeVries, Paul R Rhomberg, Mariana Castanheira. Impact of COVID-19 on the antifungal susceptibility profiles of isolates collected in a global surveillance program that monitors invasive fungal infections. Medical mycology. 2022 May; 60(5):. doi: 10.1093/mmy/myac028. [PMID: 35511210]
  • S Yildirim Arslan, Z Sahbudak Bal, G Guner Ozenen, N M Bilen, J Naghiyev, G Sakul, F Ozkinay, O Ergun, A Ozarslan, Z Kurugol. Successful treatment of hepatic and mesh Aspergillosis in a neonate with giant omphalocele. Journal de mycologie medicale. 2022 May; 32(2):101245. doi: 10.1016/j.mycmed.2022.101245. [PMID: 35063761]
  • Qiuya Lu, Xiaoshuang He, Jie Fang, Kaifeng Shi, Fengmei Hu, Xiaolan Bian, Xuefeng Wang. Simultaneous determination of linezolid and voriconazole serum concentrations using liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2022 Apr; 212(?):114659. doi: 10.1016/j.jpba.2022.114659. [PMID: 35182831]
  • Yunfei Li, Mimi Tang, Shusen Sun, Qin Hu, Sheng Deng. Successful treatment of Talaromyces marneffei infection in a kidney transplant recipient with voriconazole followed by itraconazole for the first time. Journal de mycologie medicale. 2022 Mar; 32(1):101214. doi: 10.1016/j.mycmed.2021.101214. [PMID: 34763148]
  • Pinar Bakir Ekinci, Emre Kara, Ahmet Gorkem Er, Ahmet Cagkan Inkaya, Kutay Demirkan, Omrum Uzun. Challenge in treating COVID-19 associate pulmonary aspergillosis: Supratherapeutic voriconazole levels. British journal of clinical pharmacology. 2022 03; 88(3):1387-1391. doi: 10.1111/bcp.14953. [PMID: 34174111]
  • Jennifer R Dusendang, Ekama Carlson, David S Lee, Sangeeta Marwaha, Shabnam Madani, Stacey E Alexeeff, Allison Webber, Nelson B Goes, Lisa J Herrinton. Cohort and nested case-control study of cutaneous squamous cell carcinoma in solid organ transplant recipients, by medication. Journal of the American Academy of Dermatology. 2022 03; 86(3):598-606. doi: 10.1016/j.jaad.2021.07.065. [PMID: 34384835]
  • Josefine Schulz, Robin Michelet, Jan F Joseph, Markus Zeitlinger, Fabian Schumacher, Gerd Mikus, Charlotte Kloft. A versatile high-performance LC-MS/MS assay for the quantification of voriconazole and its N-oxide metabolite in small sample volumes of multiple human matrices for biomedical applications. Journal of pharmaceutical and biomedical analysis. 2022 Feb; 210(?):114551. doi: 10.1016/j.jpba.2021.114551. [PMID: 34999435]
  • Marlon Barraza, Juan P Torres, Paulina Coria, René Miranda, Julia Palma, Patricio García, Manuel Azócar, M Elena Santolaya, Jorge Morales. [Evaluation dosing intravenous voriconazole three times a day vs twice daily for the treatment of invasive aspergillosis in immunocompromised children: therapeutic drugs monitoring and safety]. Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia. 2022 02; 39(1):14-19. doi: 10.4067/s0716-10182022000100014. [PMID: 35735275]
  • Gillian Gillespie, Deanne Jackson Rudd, Saijuan Zhang, Andrea Schaeffer, Charles Tomek, Patrick Larson, S Aubrey Stoch, Marian Iwamoto. A Phase 1 Trial to Evaluate the Relationship Between Fluoride Intake and Urinary Fluoride Excretion in Healthy Participants. Journal of clinical pharmacology. 2022 02; 62(2):190-198. doi: 10.1002/jcph.1956. [PMID: 34432899]
  • Nur Azizah Allameen, Jiacai Cho. Severe Polyarthralgia After Kidney Transplant. JAMA. 2022 Jan; 327(1):77-78. doi: 10.1001/jama.2021.18866. [PMID: 34914821]
  • Max Melchers, Barbara Festen, Bianca M den Dekker, Eline R M Mooren, Annelien L van Binsbergen, Sjoerd H W van Bree, Moniek Heusinkveld, Roel Schellaars, Jochem B Buil, Paul E Verweij, Arthur R H van Zanten. A 67-Year-Old Male Patient With COVID-19 With Worsening Respiratory Function and Acute Kidney Failure. Chest. 2022 01; 161(1):e5-e11. doi: 10.1016/j.chest.2021.08.045. [PMID: 35000717]
  • Yingxin Zhao, Peng Chen, Liping Dou, Fei Li, Meng Li, Lingmin Xu, Jing Chen, Mingyu Jia, Sai Huang, Nan Wang, Songhua Luan, Jinling Yang, Nan Bai, Daihong Liu. Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies. Drug design, development and therapy. 2022; 16(?):817-825. doi: 10.2147/dddt.s354270. [PMID: 35370398]
  • Satish Swain, Animesh Ray, Radhika Sarda, Surabhi Vyas, Gagandeep Singh, Pankaj Jorwal, Parul Kodan, Puneet Khanna, Immaculata Xess, Sanjeev Sinha, Naveet Wig, Anjan Trikha. COVID-19-associated subacute invasive pulmonary aspergillosis. Mycoses. 2022 Jan; 65(1):57-64. doi: 10.1111/myc.13369. [PMID: 34541719]
  • Yun He, Hai-Lin Zheng, Huan Mei, Gui-Xia Lv, Wei-da Liu, Xiao-Fang Li. Phaeohyphomycosis in China. Frontiers in cellular and infection microbiology. 2022; 12(?):895329. doi: 10.3389/fcimb.2022.895329. [PMID: 35770068]
  • Huiping Jiang, Jianqun Xiong, Lihua Tan, Ping Jin, Yi Sun, Lianjuan Yang, Jingwen Tan. In Vitro Interactions of Antifungal Agents and Everolimus Against Aspergillus Species. Frontiers in cellular and infection microbiology. 2022; 12(?):936814. doi: 10.3389/fcimb.2022.936814. [PMID: 35865820]
  • Xiao-Bin Lin, Ka Yin Lui, Peng-Hao Guo, Xiao-Man Liu, Tao Liang, Xiao-Guang Hu, Li Tong, Jing-Jing Wu, Yan-Zhe Xia, Pan Chen, Guo-Ping Zhong, Xiao Chen, Chang-Jie Cai. Population pharmacokinetic model-guided optimization of intravenous voriconazole dosing regimens in critically ill patients with liver dysfunction. Pharmacotherapy. 2022 01; 42(1):23-33. doi: 10.1002/phar.2634. [PMID: 34655497]
  • Kimitaka Suetsugu, Shota Muraki, Junshiro Fukumoto, Ryosuke Matsukane, Yasuo Mori, Takeshi Hirota, Toshihiro Miyamoto, Nobuaki Egashira, Koichi Akashi, Ichiro Ieiri. Effects of Letermovir and/or Methylprednisolone Coadministration on Voriconazole Pharmacokinetics in Hematopoietic Stem Cell Transplantation: A Population Pharmacokinetic Study. Drugs in R&D. 2021 Dec; 21(4):419-429. doi: 10.1007/s40268-021-00365-0. [PMID: 34655050]
  • Chinmay Nakhwa. Endogenous fungal endopthalmitis treated with intravitreal caspofungin in a COVID-19 recovered patient: A case report. Indian journal of ophthalmology. 2021 Dec; 69(12):3759-3761. doi: 10.4103/ijo.ijo_1192_21. [PMID: 34827041]
  • Ahmed K Kammoun, Alaa Khedr, Maha A Hegazy, Ahmed J Almalki, Khaled M Hosny, Walaa A Abualsunun, Samar S A Murshid, Rana B Bakhaidar. Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles. Drug delivery. 2021 Dec; 28(1):2229-2240. doi: 10.1080/10717544.2021.1992040. [PMID: 34668818]
  • Wessam H Abd-Elsalam, Yosra Ibrahim Nagy, Samar M Abouelatta. Tailoring thixotropic mixed-lipid nanoconstructs of voriconazole for the management of Vulvovaginal candidiasis: Formulation, statistical optimization, in vitro characterization and in vivo assessment. Drug delivery. 2021 Dec; 28(1):1877-1889. doi: 10.1080/10717544.2021.1974608. [PMID: 34519230]
  • Abby P Douglas, Olivia C Smibert, Ashish Bajel, Catriona L Halliday, Orly Lavee, Brendan McMullan, Michelle K Yong, Sebastiaan J van Hal, Sharon C-A Chen. Consensus guidelines for the diagnosis and management of invasive aspergillosis, 2021. Internal medicine journal. 2021 11; 51 Suppl 7(?):143-176. doi: 10.1111/imj.15591. [PMID: 34937136]
  • Francesca Gioia, Eta Filigheddu, Laura Corbella, Mario Fernández-Ruiz, Francisco López-Medrano, Ana Pérez-Ayala, Jose María Aguado, Maria Carmen Fariñas, Francisco Arnaiz, Jorge Calvo, Jose Maria Cifrian, Claudia Gonzalez-Rico, Elisa Vidal, Julian Torre-Cisneros, Maria Mar Ras, Sandra Pérez, Nuria Sabe, Leyre Monica López-Soria, Regino Jose Rodríguez-Alvarez, José Miguel Montejo, Maricela Valerio, Marina Machado, Patricia Muñoz, Laura Linares, Marta Bodro, Asuncion Moreno, Ana Fernández-Cruz, Rafael Cantón, Santiago Moreno, Pilar Martin-Davila, Jesús Fortún. Invasive aspergillosis in solid organ transplantation: Diagnostic challenges and differences in outcome in a Spanish national cohort (Diaspersot study). Mycoses. 2021 Nov; 64(11):1334-1345. doi: 10.1111/myc.13298. [PMID: 33934405]
  • Liuhan Dong, Nan Bai, Tianlin Wang, Yun Cai. Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of voriconazole in human cerebrospinal fluid. Analytical methods : advancing methods and applications. 2021 10; 13(39):4585-4593. doi: 10.1039/d1ay01103k. [PMID: 34532726]
  • Feng-Ru Huang, Chen Zhou, Xiao-Yan Zhang, Ye Shen, Hong-Wen Zhang, Yong-Qing Wang, Lu-Ning Sun. Impact of CYP2C19 genotype on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Oct; 51(10):1199-1206. doi: 10.1080/00498254.2021.1969481. [PMID: 34402388]
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