Bendroflumethiazide (BioDeep_00000001897)
Secondary id: BioDeep_00000408896
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
+--3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
化学式: C15H14F3N3O4S2 (421.03778000000005)
中文名称: 苄氟噻嗪
谱图信息:
最多检出来源 Danio rerio(blood) 25%
分子结构信息
SMILES: C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2
InChI: InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
描述信息
Bendroflumethiazide is only found in individuals that have used or taken this drug. It is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
同义名列表
47 个代谢物同义名
+--3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide; +--3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide; 6-Trifluoromethyl-3-benzyl-7-sulphamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; Bristol-myers squibb brand OF bendroflumethiazide; Bristol myers squibb brand OF bendroflumethiazide; Schaper and brümmer brand OF bendroflumethiazide; Goldshield brand OF bendroflumethiazide; Apothecon brand OF bendroflumethiazide; Bendroflumethiazide goldshield brand; Bendroflumethiazide apothecon brand; Protea brand OF bendroflumethiazide; Knoll brand OF bendroflumethiazide; DDSA brand OF bendroflumethiazide; Berk brand OF bendroflumethiazide; leo Brand OF bendroflumethiazide; Bendroflumethiazide protea brand; Bendroflumethiazide knoll brand; Bendroflumethiazide berk brand; Bendroflumethiazide ddsa brand; Bendroflumethiazide leo brand; Benzylhydroflumethiazide; Benzhydroflumethiazide; Benzydroflumethiazide; Bendroflumethiazidum; BENDROFLUMETHIAZIDE; Bendroflumethazide; Bendroflumetiazida; Bendrofumethiazide; Bendrofluazide; neo NaClex; neo-NaClex; Esberizid; Benzide-m; Berkozide; Benzide m; Naturetin; NeoNaClex; BenzideM; Naturine; Aprinox; Benzide; Centyl; Urizid; Pluryl; BHFT
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:3013
- KEGG: C07758
- KEGGdrug: D00650
- PubChem: 2315
- HMDB: HMDB0014580
- DrugBank: DB00436
- ChEMBL: CHEMBL1684
- Wikipedia: Bendroflumethiazide
- MeSH: Bendroflumethiazide
- KNApSAcK: C00030040
- chemspider: 2225
- CAS: 73-48-3
- PMhub: MS000001407
- PubChem: 9960
- NIKKAJI: J1.428A
- RefMet: Bendroflumethiazide
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
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- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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