Zeaxanthin dipalmitate (BioDeep_00000018805)

Main id: BioDeep_00000001059

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[4-(Hexadecanoyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]-3,5,5-trimethylcyclohex-3-en-1-yl hexadecanoic acid

化学式: C72H116O4 (1044.8873)
中文名称: 酸浆果红素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)OC1CC(=C(C(C1)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CC(CC2(C)C)OC(=O)CCCCCCCCCCCCCCC)C)C)C)C
InChI: InChI=1S/C72H116O4/c1-13-15-17-19-21-23-25-27-29-31-33-35-37-49-69(73)75-65-55-63(7)67(71(9,10)57-65)53-51-61(5)47-41-45-59(3)43-39-40-44-60(4)46-42-48-62(6)52-54-68-64(8)56-66(58-72(68,11)12)76-70(74)50-38-36-34-32-30-28-26-24-22-20-18-16-14-2/h39-48,51-54,65-66H,13-38,49-50,55-58H2,1-12H3/b40-39+,45-41+,46-42+,53-51+,54-52+,59-43+,60-44+,61-47+,62-48+

描述信息

Zeaxanthin dipalmitate is found in green vegetables. Zeaxanthin dipalmitate is a constituent of Physalis species, asparagus (Asparagus officinalis), beans and others
Constituent of Physalis subspecies, asparagus (Asparagus officinalis), beans and others. Zeaxanthin dipalmitate is found in sea-buckthornberry and green vegetables.
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

9 个代谢物同义名

4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[4-(Hexadecanoyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]-3,5,5-trimethylcyclohex-3-en-1-yl hexadecanoic acid; 4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[4-(hexadecanoyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]-3,5,5-trimethylcyclohex-3-en-1-yl hexadecanoate; Zeaxanthin dipalmitic acid; Xanthophyll dipalmitate; Zeaxanthin dipalmitate; Physalien; Physalin; HELENIEN; Physalien



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2, CEL, CYP2E1, GFAP, ISCU, MAPK14, MAPK8, P2RX7, RAF1, STAT3
Peripheral membrane protein 1 CYP2E1
Endoplasmic reticulum membrane 2 BCL2, CYP2E1
Nucleus 6 BCL2, ISCU, MAPK14, MAPK8, RAF1, STAT3
cytosol 9 BCL2, CLC, GFAP, GPT, ISCU, MAPK14, MAPK8, RAF1, STAT3
nucleoplasm 3 MAPK14, MAPK8, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 3 ADIPOR1, P2RX7, RAF1
Cytoplasmic granule 1 CLC
Multi-pass membrane protein 2 ADIPOR1, P2RX7
Synapse 1 MAPK8
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 RAF1
mitochondrial inner membrane 1 CYP2E1
neuromuscular junction 1 P2RX7
neuronal cell body 1 P2RX7
postsynapse 1 P2RX7
Cytoplasm, cytosol 1 CLC
Presynapse 1 P2RX7
plasma membrane 5 ADIPOR1, P2RX7, PRSS27, RAF1, STAT3
Membrane 3 ADIPOR1, BCL2, P2RX7
axon 1 MAPK8
extracellular exosome 3 CEL, CFH, GPT
endoplasmic reticulum 1 BCL2
extracellular space 5 CCL2, CEL, CFH, CLC, PNLIP
mitochondrion 5 BCL2, ISCU, MAPK14, P2RX7, RAF1
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 CYP2E1
Microsome membrane 1 CYP2E1
Secreted 5 CCL2, CEL, CFH, CLC, PNLIP
extracellular region 7 CCL2, CEL, CFH, CLC, MAPK14, PNLIP, PRSS27
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, RAF1
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 ISCU
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 P2RX7
cell-cell junction 1 P2RX7
Mitochondrion inner membrane 1 CYP2E1
pore complex 1 BCL2
collagen-containing extracellular matrix 1 CLC
intermediate filament 1 GFAP
nuclear speck 1 MAPK14
chromatin 1 STAT3
cell projection 1 GFAP
[Isoform 1]: Mitochondrion 1 ISCU
spindle pole 1 MAPK14
blood microparticle 1 CFH
cell body 1 GFAP
myelin sheath 1 BCL2
pseudopodium 1 RAF1
intermediate filament cytoskeleton 1 GFAP
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
serine-type endopeptidase complex 1 CFH
iron-sulfur cluster assembly complex 1 ISCU
mitochondrial 1 ISCU
basal dendrite 1 MAPK8
CRLF-CLCF1 complex 1 CLC
cytoplasmic side of lysosomal membrane 1 GFAP
bleb 1 P2RX7
symbiont cell surface 1 CFH
BAD-BCL-2 complex 1 BCL2
CNTFR-CLCF1 complex 1 CLC


文献列表

  • Feng Liu, Xiaobin Liu, Yamin Zhou, Yankun Yu, Ke Wang, Zhengqun Zhou, Hao Gao, Kwok-Fai So, Noga Vardi, Ying Xu. Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways. Journal of neurochemistry. 2021 09; 158(5):1131-1150. doi: 10.1111/jnc.15472. [PMID: 34265077]
  • Jia-Tang Long, Hong-Xia Fan, Zheng-Qun Zhou, Wan-Yang Sun, Qing-Wen Li, Ying Wang, Min Ma, Hao Gao, Hui Zhi. The major zeaxanthin dipalmitate derivatives from wolfberry. Journal of Asian natural products research. 2020 Aug; 22(8):746-753. doi: 10.1080/10286020.2019.1621855. [PMID: 31163996]
  • Hao Gao, Yi Lv, Yingxia Liu, Jingjing Li, Xiaogang Wang, Zhengqun Zhou, George L Tipoe, Songying Ouyang, Yutong Guo, Jinhong Zhang, Xiangfeng Hao, Wei Li, Kazuo Koike, Kwok-Fai So, Jia Xiao. Wolfberry-Derived Zeaxanthin Dipalmitate Attenuates Ethanol-Induced Hepatic Damage. Molecular nutrition & food research. 2019 06; 63(11):e1801339. doi: 10.1002/mnfr.201801339. [PMID: 30938072]
  • Judith Hempel, Anja Fischer, Monique Fischer, Josef Högel, Anja Bosy-Westphal, Reinhold Carle, Ralf M Schweiggert. Effect of aggregation form on bioavailability of zeaxanthin in humans: a randomised cross-over study. The British journal of nutrition. 2017 Nov; 118(9):698-706. doi: 10.1017/s0007114517002653. [PMID: 29185931]
  • Jing-Jing Li, Hao Gao, Yi Lv, Mian-Huan Li, Chao-Ran Ren, Kwok-Fai So, Jia Xiao. Zeaxanthin dipalmitate alleviates hepatic injury induced by superimposed chronic hepatitis B and non-alcoholic steatohepatitis in non-obese mice. Journal of Asian natural products research. 2017 Sep; 19(9):910-923. doi: 10.1080/10286020.2017.1349759. [PMID: 28816082]
  • Judith Hempel, Christopher N Schädle, Jasmin Sprenger, Annerose Heller, Reinhold Carle, Ralf M Schweiggert. Ultrastructural deposition forms and bioaccessibility of carotenoids and carotenoid esters from goji berries (Lycium barbarum L.). Food chemistry. 2017 Mar; 218(?):525-533. doi: 10.1016/j.foodchem.2016.09.065. [PMID: 27719945]
  • Chureeporn Chitchumroonchokchai, Mark L Failla. Hydrolysis of zeaxanthin esters by carboxyl ester lipase during digestion facilitates micellarization and uptake of the xanthophyll by Caco-2 human intestinal cells. The Journal of nutrition. 2006 Mar; 136(3):588-94. doi: 10.1093/jn/136.3.588. [PMID: 16484529]
  • Yong Peng, Chen Ma, Yawei Li, Kelvin Sze-Yin Leung, Zhi-Hong Jiang, Zhongzhen Zhao. Quantification of zeaxanthin dipalmitate and total carotenoids in Lycium fruits (Fructus Lycii). Plant foods for human nutrition (Dordrecht, Netherlands). 2005 Dec; 60(4):161-4. doi: 10.1007/s11130-005-9550-5. [PMID: 16395626]
  • Dietmar E Breithaupt, Philipp Weller, Maike Wolters, Andreas Hahn. Comparison of plasma responses in human subjects after the ingestion of 3R,3R'-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R'-zeaxanthin using chiral high-performance liquid chromatography. The British journal of nutrition. 2004 May; 91(5):707-13. doi: 10.1079/bjn20041105. [PMID: 15137922]
  • Hong Pyo Kim, Eun Ju Lee, Young Chul Kim, Jinwoong Kim, Hye Kyung Kim, Jae-Hak Park, Sun Yeou Kim, Young Choong Kim. Zeaxanthin dipalmitate from Lycium chinense fruit reduces experimentally induced hepatic fibrosis in rats. Biological & pharmaceutical bulletin. 2002 Mar; 25(3):390-2. doi: 10.1248/bpb.25.390. [PMID: 11913541]
  • H P Kim, S Y Kim, E J Lee, Y C Kim, Y C Kim. Zeaxanthin dipalmitate from Lycium chinense has hepatoprotective activity. Research communications in molecular pathology and pharmacology. 1997 Sep; 97(3):301-14. doi: . [PMID: 9387190]
  • K M Lovette, H Y Chuang, A F Mohammad, R G Mason. The subcellular distribution and partial characterization of cholinesterase activities of canine platelets. Biochimica et biophysica acta. 1976 Apr; 428(2):355-68. doi: 10.1016/0304-4165(76)90043-x. [PMID: 6047]