7-Ethoxyresorufin (BioDeep_00001877986)

Main id: BioDeep_00000009487

 


代谢物信息卡片


7-Ethoxyphenoxazone

化学式: C14H11NO3 (241.0738896)
中文名称: 乙氧基试卤灵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2
InChI: InChI=1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3

描述信息

同义名列表

2 个代谢物同义名

7-Ethoxyphenoxazone; 7-Ethoxyresorufin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chukwuebuka ThankGod Eze, Francesco Michelangeli, Adebayo Akeem Otitoloju, Obianuju Oluchukwu Eze, Omodele Ibraheem, Emeka Bright Ogbuene, Germaine Akinola Ogunwole. Occurrence of chemical pollutants in major e-waste sites in West Africa and usefulness of cytotoxicity and induction of ethoxyresorufin-O-deethylase (EROD) in determining the effects of some detected brominated flame retardants and e-waste soil-derived extracts. Environmental science and pollution research international. 2021 Mar; 28(9):10832-10846. doi: 10.1007/s11356-020-11155-7. [PMID: 33099733]
  • Devaraj Venkatapura Chandrashekar, Reza Mehvar. UPLC-MS/MS analysis of CYP1A-mediated ethoxyresorufin-O-deethylation activity in the rat kidney microsomes. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Sep; 1153(?):122272. doi: 10.1016/j.jchromb.2020.122272. [PMID: 32738524]
  • Y Kapelyukh, C J Henderson, N Scheer, A Rode, C R Wolf. Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice. Drug metabolism and disposition: the biological fate of chemicals. 2019 08; 47(8):907-918. doi: 10.1124/dmd.119.087718. [PMID: 31147315]
  • Xue Liu, Jong-Hyouk Park, A M Abd El-Aty, M E Assayed, Minoru Shimoda, Jae-Han Shim. Isolation of volatiles from Nigella sativa seeds using microwave-assisted extraction: effect of whole extracts on canine and murine CYP1A. Biomedical chromatography : BMC. 2013 Jul; 27(7):938-45. doi: 10.1002/bmc.2887. [PMID: 23629843]
  • Maria Vittoria Cangialosi, Ilaria Corsi, Stefano Bonacci, Cristiana Sensini, Nicola Cicero, Silvano Focardi, Antonio Mazzola. Screening of ecotoxicological, qualitative and reproductive variables in male European sea bass Dicentrarchus labrax (L.) reared in three different fish farms: Facility location and typology. Natural product research. 2013 Apr; 27(7):670-4. doi: 10.1080/14786419.2012.678353. [PMID: 22489960]
  • Roslyn S Thelingwani, Kariema Dhansay, Peter Smith, Kelly Chibale, Collen M Masimirembwa. Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa. Xenobiotica; the fate of foreign compounds in biological systems. 2012 Oct; 42(10):989-1000. doi: 10.3109/00498254.2012.681077. [PMID: 22533317]
  • Ahmad F Abdull Razis, Natalya Hanlon, Ewa Soltys, Veronika Krizova, Renato Iori, Kathryn E Plant, Nick Plant, Costas Ioannides. The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. Archives of toxicology. 2012 Oct; 86(10):1505-14. doi: 10.1007/s00204-012-0875-6. [PMID: 22643862]
  • Ahmad F Abdull Razis, Manuela Bagatta, Gina R De Nicola, Renato Iori, Nick Plant, Costas Ioannides. Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile. Journal of agricultural and food chemistry. 2012 Jun; 60(22):5556-64. doi: 10.1021/jf3011195. [PMID: 22594452]
  • Ahmad F Abdull Razis, Nattaya Konsue, Myrto Dervetzoglou, Kathryn E Plant, Nick Plant, Costas Ioannides. Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor. Molecular nutrition & food research. 2012 Mar; 56(3):425-34. doi: 10.1002/mnfr.201100548. [PMID: 22174033]
  • Ahmed Faizal Abdull Razis, Gina Rosalinda De Nicola, Eleonora Pagnotta, Renato Iori, Costas Ioannides. 4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent. Archives of toxicology. 2012 Feb; 86(2):183-94. doi: 10.1007/s00204-011-0750-x. [PMID: 21960141]
  • Wenshuo Zhang, Robert M Sargis, Paul A Volden, Christopher M Carmean, Xiao J Sun, Matthew J Brady. PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor. PloS one. 2012; 7(5):e37103. doi: 10.1371/journal.pone.0037103. [PMID: 22615911]
  • Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives. International journal of molecular sciences. 2012; 13(3):3101-3133. doi: 10.3390/ijms13033101. [PMID: 22489144]
  • Byung Hee Han, Meng-liang Zhou, Ananth K Vellimana, Eric Milner, David H Kim, Jacob K Greenberg, Wenhua Chu, Robert H Mach, Gregory J Zipfel. Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy. Molecular neurodegeneration. 2011 Dec; 6(?):86. doi: 10.1186/1750-1326-6-86. [PMID: 22192811]
  • Latiporn Udomsuk, Kanokwan Jarukamjorn, Waraporn Putalun, Tsutomu Sakuma, Yuki Kawasaki, Nobuo Nemoto. Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture. Journal of ethnopharmacology. 2011 Sep; 137(1):902-8. doi: 10.1016/j.jep.2011.06.047. [PMID: 21777665]
  • Yasuhiro Uno, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki. CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey. Biochemical pharmacology. 2011 Feb; 81(3):442-50. doi: 10.1016/j.bcp.2010.11.003. [PMID: 21070747]
  • Benjamin Lemaire, Michaël Beck, Mélanie Jaspart, Cathy Debier, Pedro Buc Calderon, Jean-Pierre Thomé, Jean-François Rees. Precision-Cut Liver Slices of Salmo salar as a tool to investigate the oxidative impact of CYP1A-mediated PCB 126 and 3-methylcholanthrene metabolism. Toxicology in vitro : an international journal published in association with BIBRA. 2011 Feb; 25(1):335-42. doi: 10.1016/j.tiv.2010.10.002. [PMID: 20946947]
  • Abdulqader A Alhaider, Mohamed A M El Gendy, Hesham M Korashy, Ayman O S El-Kadi. Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line. Journal of ethnopharmacology. 2011 Jan; 133(1):184-90. doi: 10.1016/j.jep.2010.09.012. [PMID: 20883769]
  • Ahmad F Abdull Razis, Manuela Bagatta, Gina R De Nicola, Renato Iori, Costas Ioannides. Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. Toxicology. 2010 Nov; 277(1-3):74-85. doi: 10.1016/j.tox.2010.08.080. [PMID: 20833222]
  • Hiroshi Yamazaki, Kana Horiuchi, Ryohji Takano, Taku Nagano, Makiko Shimizu, Masato Kitajima, Norie Murayama, Fumiaki Shono. Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling. International journal of environmental research and public health. 2010 09; 7(9):3406-21. doi: 10.3390/ijerph7093406. [PMID: 20948932]
  • Asoka Pathiratne, K A S Pathiratne, P K C De Seram. Assessment of biological effects of pollutants in a hyper eutrophic tropical water body, Lake Beira, Sri Lanka using multiple biomarker responses of resident fish, Nile tilapia (Oreochromis niloticus). Ecotoxicology (London, England). 2010 Aug; 19(6):1019-26. doi: 10.1007/s10646-010-0483-2. [PMID: 20229025]
  • Lisa B Helgason, Augustine Arukwe, Geir W Gabrielsen, Mikael Harju, Marit N Hegseth, Eldbjørg S Heimstad, Even H Jørgensen, Anne S Mortensen, Johannes Wolkers. Biotransformation of PCBs in Arctic seabirds: characterization of phase I and II pathways at transcriptional, translational and activity levels. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2010 Jun; 152(1):34-41. doi: 10.1016/j.cbpc.2010.02.009. [PMID: 20176133]
  • Ana Cecilia A X De-Oliveira, Renato S Carvalho, Flavio H M Paixão, Hellen S Tavares, Luciana S Gueiros, Carolina M Siqueira, Francisco J R Paumgartten. Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models. Malaria journal. 2010 Mar; 9(?):81. doi: 10.1186/1475-2875-9-81. [PMID: 20307316]
  • Fernando Postalli Rodrigues, José Pedro Friedmann Angeli, Mário Sérgio Mantovani, Carmen Luisa Barbosa Guedes, Berenice Quinzani Jordão. Genotoxic evaluation of an industrial effluent from an oil refinery using plant and animal bioassays. Genetics and molecular biology. 2010 Jan; 33(1):169-75. doi: 10.1590/s1415-47572010005000006. [PMID: 21637622]
  • Jong Sun Chang, Joon Tae Bae, Eun Jung Oh, Ji Young Kim, Sun Hee Park, Kap Rang Lee. Cancer preventive potential of methanol extracts of Hypsizigus marmoreus. Journal of medicinal food. 2009 Jun; 12(3):493-500. doi: 10.1089/jmf.2008.1050. [PMID: 19627196]
  • Quynh T Tran, Lijing Xu, Vinhthuy Phan, Shirlean B Goodwin, Mostafizur Rahman, Victor X Jin, Carrie H Sutter, Bill D Roebuck, Thomas W Kensler, E Olusegun George, Thomas R Sutter. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009 Mar; 30(3):480-6. doi: 10.1093/carcin/bgn292. [PMID: 19126641]
  • Neil Sidell, Lijuan Hao, Marzia Pasquali, J David McDonald. Carcinogenic effects in a phenylketonuria mouse model. PloS one. 2009; 4(1):e4292. doi: 10.1371/journal.pone.0004292. [PMID: 19172175]
  • A Messina, V Chirulli, P G Gervasi, V Longo. Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2. Xenobiotica; the fate of foreign compounds in biological systems. 2008 Dec; 38(12):1453-70. doi: 10.1080/00498250802474437. [PMID: 18949657]
  • Robert D Finn, Lesley A McLaughlin, Sebastien Ronseaux, Ian Rosewell, J Brian Houston, Colin J Henderson, C Roland Wolf. Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5. The Journal of biological chemistry. 2008 Nov; 283(46):31385-93. doi: 10.1074/jbc.m803496200. [PMID: 18805792]
  • Yukie Yanagiba, Yuki Ito, Osamu Yamanoshita, Shu-Yun Zhang, Gen Watanabe, Kazuyoshi Taya, Chun Mei Li, Yuko Inotsume, Michihiro Kamijima, Frank J Gonzalez, Tamie Nakajima. Styrene trimer may increase thyroid hormone levels via down-regulation of the aryl hydrocarbon receptor (AhR) target gene UDP-glucuronosyltransferase. Environmental health perspectives. 2008 Jun; 116(6):740-5. doi: 10.1289/ehp.10724. [PMID: 18560529]
  • Karin Broberg, Håkan Tinnerberg, Anna Axmon, Margareta Warholm, Agneta Rannug, Margareta Littorin. Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study. Environmental health : a global access science source. 2008 Apr; 7(?):15. doi: 10.1186/1476-069x-7-15. [PMID: 18447907]
  • Magnus Lundgren, Per Ola Darnerud, Ylva Molin, Hellmuth Lilienthal, Jonas Blomberg, Nils-Gunnar Ilbäck. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Toxicology. 2007 Dec; 242(1-3):100-8. doi: 10.1016/j.tox.2007.09.014. [PMID: 17964055]
  • Hwan Goo Kang, Sang Hee Jeong, Myung Haing Cho, Joon Hyoung Cho. Changes of biomarkers with oral exposure to benzo(a)pyrene, phenanthrene and pyrene in rats. Journal of veterinary science. 2007 Dec; 8(4):361-8. doi: 10.4142/jvs.2007.8.4.361. [PMID: 17993750]
  • Wei V Zhang, Iqbal Ramzan, Michael Murray. Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. The Journal of pharmacology and experimental therapeutics. 2007 Aug; 322(2):770-7. doi: 10.1124/jpet.107.124024. [PMID: 17522342]
  • Reddy P Kommaddi, Cheri M Turman, Bhagavatula Moorthy, Lihua Wang, Henry W Strobel, Vijayalakshmi Ravindranath. An alternatively spliced cytochrome P4501A1 in human brain fails to bioactivate polycyclic aromatic hydrocarbons to DNA-reactive metabolites. Journal of neurochemistry. 2007 Aug; 102(3):867-77. doi: 10.1111/j.1471-4159.2007.04599.x. [PMID: 17630984]
  • F Gagné, C Blaise, C André, C Gagnon, M Salazar. Neuroendocrine disruption and health effects in Elliptio complanata mussels exposed to aeration lagoons for wastewater treatment. Chemosphere. 2007 Jun; 68(4):731-43. doi: 10.1016/j.chemosphere.2006.12.101. [PMID: 17320148]
  • Daphnee S Pushparajah, Meera Umachandran, Kathryn E Plant, Nick Plant, Costas Ioannides. Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities. Toxicology. 2007 Feb; 231(1):68-80. doi: 10.1016/j.tox.2006.11.063. [PMID: 17178432]
  • Eivor Elovaara, Helene Stockmann-Juvala, Jouni Mikkola, Harry V Gelboin. Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats. Environmental toxicology and pharmacology. 2007 Jan; 23(1):64-72. doi: 10.1016/j.etap.2006.07.003. [PMID: 21783738]
  • Cristina Cionna, Francesca Maradonna, Ike Olivotto, Gianluca Pizzonia, Oliana Carnevali. Effects of nonylphenol on juveniles and adults in the grey mullet, Liza aurata. Reproductive toxicology (Elmsford, N.Y.). 2006 Oct; 22(3):449-54. doi: 10.1016/j.reprotox.2006.04.025. [PMID: 16919910]
  • D Marionnet, P Deschaux, S Reynaud. Possible implication of macrophages in the regulation of cytochrome P450 activities in carp (Cyprinus carpio). Fish & shellfish immunology. 2006 Jul; 21(1):80-91. doi: 10.1016/j.fsi.2005.10.006. [PMID: 16337134]
  • Rita Anne Garrick, Bruce R Woodin, Joanna Y Wilson, Bobby L Middlebrooks, John J Stegeman. Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquatic toxicology (Amsterdam, Netherlands). 2006 Mar; 76(3-4):295-305. doi: 10.1016/j.aquatox.2005.10.005. [PMID: 16290286]
  • Kazuhiko Hanada, Rie Ogawa, Kishin Son, Yuuki Sasaki, Akashi Kikkawa, Shiho Ichihara, Hiroyasu Ogata. Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes. Nephron. Physiology. 2006; 103(4):p179-86. doi: 10.1159/000092919. [PMID: 16645322]
  • Wei-Hung Chan, Wei-Zen Sun, Tzuu-Huei Ueng. Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. Journal of toxicology and environmental health. Part A. 2005 Sep; 68(17-18):1581-97. doi: 10.1080/15287390590967522. [PMID: 16076768]
  • Marcella Martignoni, Ruben de Kanter, Anna Moscone, Pietro Grossi, Mario Monshouwer. Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice. Cancer chemotherapy and pharmacology. 2005 Feb; 55(2):129-35. doi: 10.1007/s00280-004-0898-7. [PMID: 15592720]
  • Rita Anne Garrick, Bruce R Woodin, John J Stegeman. Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata. In vitro cellular & developmental biology. Animal. 2005 Jan; 41(1-2):57-63. doi: 10.1290/0409063.1. [PMID: 15926861]
  • Victoria Yoxall, Meera Umachandran, Judith Wilson, Peter Kentish, Costas Ioannides. Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat. Mutagenesis. 2005 Jan; 20(1):23-8. doi: 10.1093/mutage/gei002. [PMID: 15598702]
  • Markus M Forsberg, Risto O Juvonen, Petra Helisalmi, Jukka Leppänen, Joseph A Gogos, Maria Karayiorgou, Pekka T Männistö. Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice. Naunyn-Schmiedeberg's archives of pharmacology. 2004 Oct; 370(4):279-89. doi: 10.1007/s00210-004-0967-9. [PMID: 15378229]
  • M C E McFadyen, W T Melvin, G I Murray. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. British journal of cancer. 2004 Aug; 91(5):966-71. doi: 10.1038/sj.bjc.6602053. [PMID: 15280921]
  • Rajesh Krishnan, Girish B Maru. Inhibitory effect(s) of polymeric black tea polyphenol fractions on the formation of [(3)H]-B(a)P-derived DNA adducts. Journal of agricultural and food chemistry. 2004 Jun; 52(13):4261-9. doi: 10.1021/jf049979o. [PMID: 15212478]
  • Tzuu-Huei Ueng, Hui-Wu Wang, Chia-Chi Hung, Hui-Ling Chang. Effects of motorcycle exhaust inhalation exposure on cytochrome P-450 2B1, antioxidant enzymes, and lipid peroxidation in rat liver and lung. Journal of toxicology and environmental health. Part A. 2004 Jun; 67(11):875-88. doi: 10.1080/15287390490441283. [PMID: 15205042]
  • Jerzy Bełtowski, Andrzej Marciniak, Anna Jamroz-Wiśniewska, Ewelina Borkowska, Grazyna Wójcicka. Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C. Acta biochimica Polonica. 2004; 51(3):757-72. doi: 045103757. [PMID: 15448737]
  • Barbara C Spink, Mirza M Hussain, Barbara H Katz, Leslie Eisele, David C Spink. Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubin. Biochemical pharmacology. 2003 Dec; 66(12):2313-21. doi: 10.1016/j.bcp.2003.08.019. [PMID: 14637189]
  • Bhaskar Rege, Richard Krieg, Ning Gao, Mohamadi A Sarkar. Down-regulation of hepatic CYP3A in chronic renal insufficiency. Pharmaceutical research. 2003 Oct; 20(10):1600-6. doi: 10.1023/a:1026135317578. [PMID: 14620514]
  • Bertrand Piver, François Berthou, Yvonne Dreano, Danièle Lucas. Differential inhibition of human cytochrome P450 enzymes by epsilon-viniferin, the dimer of resveratrol: comparison with resveratrol and polyphenols from alcoholized beverages. Life sciences. 2003 Jul; 73(9):1199-213. doi: 10.1016/s0024-3205(03)00420-x. [PMID: 12818727]
  • Andrea Sapone, Alessandra Affatato, Donatella Canistro, Massimiliano Broccoli, Silvia Trespidi, Laura Pozzetti, Gian Luigi Biagi, Giorgio Cantelli-Forti, Moreno Paolini. Induction and suppression of cytochrome P450 isoenzymes and generation of oxygen radicals by procymidone in liver, kidney and lung of CD1 mice. Mutation research. 2003 Jun; 527(1-2):67-80. doi: 10.1016/s0027-5107(03)00055-1. [PMID: 12787915]
  • Hiroki Konishi, Kunihiko Morita, Tokuzo Minouchi, Akira Yamaji. Moricizine, an antiarrhythmic agent, as a potent inhibitor of hepatic microsomal CYP1A. Pharmacology. 2002 Dec; 66(4):190-8. doi: 10.1159/000065533. [PMID: 12393941]
  • Ralf Peter Meyer, Michael Podvinec, Urs A Meyer. Cytochrome P450 CYP1A1 accumulates in the cytosol of kidney and brain and is activated by heme. Molecular pharmacology. 2002 Nov; 62(5):1061-7. doi: 10.1124/mol.62.5.1061. [PMID: 12391268]
  • E Olatunde Farombi, Oluwatosin A Adaramoye, Godwin O Emerole. Influence of chloramphenicol on rat hepatic microsomal components and biomarkers of oxidative stress: protective role of antioxidants. Pharmacology & toxicology. 2002 Sep; 91(3):129-34. doi: 10.1034/j.1600-0773.2002.910307.x. [PMID: 12427113]
  • Yune-Fang Ueng, Han-Chieh Ko, Chieh-Fu Chen, Jong-Jing Wang, Kuo-Tung Chen. Modulation of drug-metabolizing enzymes by extracts of a herbal medicine Evodia rutaecarpa in C57BL/6J mice. Life sciences. 2002 Aug; 71(11):1267-77. doi: 10.1016/s0024-3205(02)01854-4. [PMID: 12106592]
  • J Bełtowski, A Marciniak, G Wójcicka, D Górny. The opposite effects of cyclic AMP-protein kinase a signal transduction pathway on renal cortical and medullary Na+,K+-ATPase activity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2002 Jun; 53(2):211-31. doi: NULL. [PMID: 12120897]
  • Thomas K H Chang, Jie Chen, Salete A Benetton. In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1. Drug metabolism and disposition: the biological fate of chemicals. 2002 Apr; 30(4):378-84. doi: 10.1124/dmd.30.4.378. [PMID: 11901090]
  • F Bryce, F Iverson, P Andrews, M Barker, W Cherry, R Mueller, O Pulido, S Hayward, S Fernie, D L Arnold. Effects elicited by toxaphene in the cynomolgus monkey (Macaca fascicularis): a pilot study. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2001 Dec; 39(12):1243-51. doi: 10.1016/s0278-6915(01)00068-0. [PMID: 11696398]
  • G J Schaaf, E M de Groene, R F Maas, J N Commandeur, J Fink-Gremmels. Characterization of biotransformation enzyme activities in primary rat proximal tubular cells. Chemico-biological interactions. 2001 Apr; 134(2):167-90. doi: 10.1016/s0009-2797(01)00151-x. [PMID: 11311212]
  • K Bagaté, M Grima, J L Imbs, W D Jong, J J Helwig, M Barthelmebs. Signal transduction pathways involved in kinin B(2) receptor-mediated vasodilation in the rat isolated perfused kidney. British journal of pharmacology. 2001 Apr; 132(8):1735-42. doi: 10.1038/sj.bjp.0704027. [PMID: 11309245]
  • M Vondracek, Z Xi, P Larsson, V Baker, K Mace, A Pfeifer, H Tjälve, M T Donato, M J Gomez-Lechon, R C Grafström. Cytochrome P450 expression and related metabolism in human buccal mucosa. Carcinogenesis. 2001 Mar; 22(3):481-8. doi: 10.1093/carcin/22.3.481. [PMID: 11238190]
  • J Marchetti, F Praddaude, R Rajerison, J L Ader, F Alhenc-Gelas. Bradykinin attenuates the [Ca(2+)](i) response to angiotensin II of renal juxtamedullary efferent arterioles via an EDHF. British journal of pharmacology. 2001 Feb; 132(3):749-59. doi: 10.1038/sj.bjp.0703851. [PMID: 11159728]
  • D M Silverstein, M Barac-Nieto, A Spitzer. Multiple arachidonic acid metabolites inhibit sodium-dependent phosphate transport in OK cells. Prostaglandins, leukotrienes, and essential fatty acids. 1999 Sep; 61(3):165-9. doi: 10.1054/plef.1999.0086. [PMID: 10582656]
  • S C Lin, C Y Chung, C L Chiang, S H Hsu. The influence of propolis ethanol extract on liver microsomal enzymes and glutathione after chronic alcohol administration. The American journal of Chinese medicine. 1999; 27(1):83-93. doi: 10.1142/s0192415x99000112. [PMID: 10354820]
  • W Klinger, H Oelschläger, D Rothley, E Karge, A Seeling. Interaction of chlormezanone enantiomers with rat liver microsomes. European journal of drug metabolism and pharmacokinetics. 1999 Jan; 24(1):63-8. doi: 10.1007/bf03190012. [PMID: 10412893]
  • J Bełtowski, D Górny, A Marciniak. Biphasic effect of protein kinase C on rat renal cortical Na+, K+-ATPase. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 1998 Dec; 49(4):627-39. doi: NULL. [PMID: 10069703]
  • A D Smirthwaite, J D Gaylor, R B Cousins, M H Grant. Cytotoxicity of bile in human Hep G2 cells and in primary cultures of rat hepatocytes. Artificial organs. 1998 Oct; 22(10):831-6. doi: 10.1046/j.1525-1594.1998.06088.x. [PMID: 9790080]
  • D Wu, S A Ramin, A I Cederbaum. Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture. Molecular and cellular biochemistry. 1997 Aug; 173(1-2):103-11. doi: 10.1023/a:1006831811622. [PMID: 9278260]
  • W Klinger, H Oelschläger, E Karge, D Rothley. Interaction of chlormezanone with rat liver microsomes and its degradation. European journal of drug metabolism and pharmacokinetics. 1997 Apr; 22(2):165-71. doi: 10.1007/bf03189801. [PMID: 9248786]
  • M Ominato, T Satoh, A I Katz. Regulation of Na-K-ATPase activity in the proximal tubule: role of the protein kinase C pathway and of eicosanoids. The Journal of membrane biology. 1996 Aug; 152(3):235-43. doi: 10.1007/s002329900101. [PMID: 8672085]
  • A Bader, E Knop, A Kern, K Böker, N Frühauf, O Crome, H Esselmann, C Pape, G Kempka, K F Sewing. 3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model. Experimental cell research. 1996 Jul; 226(1):223-33. doi: 10.1006/excr.1996.0222. [PMID: 8660959]
  • K Monostory, L Vereczkey. Interaction of theophylline and ipriflavone at the cytochrome P450 level. European journal of drug metabolism and pharmacokinetics. 1995 Jan; 20(1):43-7. doi: 10.1007/bf03192287. [PMID: 7588993]
  • J B Watkins, J W LaFollette, R A Sanders. Biotransformation in Egyptian spiny mouse Acomys cahirinus. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. 1995 Jan; 110(1):101-7. doi: 10.1016/0742-8413(94)00104-i. [PMID: 7749597]
  • J D Imig, A P Zou, P R Ortiz de Montellano, Z Sui, R J Roman. Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. The American journal of physiology. 1994 May; 266(5 Pt 2):H1879-85. doi: 10.1152/ajpheart.1994.266.5.h1879. [PMID: 8203587]
  • T Sergent-Engelen, V Delistrie, Y J Schneider. Phase I and II biotransformations in living CaCo 2 cells cultivated under serum-free conditions. Selective apical excretion of reaction products. Biochemical pharmacology. 1993 Oct; 46(8):1393-401. doi: 10.1016/0006-2952(93)90104-5. [PMID: 8240388]
  • P V Nerurkar, S S Park, P E Thomas, R W Nims, R A Lubet. Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 and 2B, respectively, in the rat and mouse. Biochemical pharmacology. 1993 Sep; 46(5):933-43. doi: 10.1016/0006-2952(93)90504-p. [PMID: 8373445]
  • D Fulton, J C McGiff, J Quilley. Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney. British journal of pharmacology. 1992 Nov; 107(3):722-5. doi: 10.1111/j.1476-5381.1992.tb14513.x. [PMID: 1472970]
  • J J Reiners, A Pavone, A R Cantu, C Auerbach, A M Malkinson. Differential expression of cytochrome P-450 in proliferating and quiescent cultures of murine lung epithelial cells. Biochemical and biophysical research communications. 1992 Feb; 183(1):193-8. doi: 10.1016/0006-291x(92)91627-3. [PMID: 1543490]
  • A O Oyekan, J C McGiff, J Quilley. Cytochrome P-450-dependent vasodilator responses to arachidonic acid in the isolated, perfused kidney of the rat. Circulation research. 1991 Apr; 68(4):958-65. doi: 10.1161/01.res.68.4.958. [PMID: 1901256]
  • D Werck-Reichhart, B Gabriac, H Teutsch, F Durst. Two cytochrome P-450 isoforms catalysing O-de-ethylation of ethoxycoumarin and ethoxyresorufin in higher plants. The Biochemical journal. 1990 Sep; 270(3):729-35. doi: 10.1042/bj2700729. [PMID: 2241905]
  • J M Jacobs, P R Sinclair, W J Bement, R W Lambrecht, J F Sinclair, J A Goldstein. Oxidation of uroporphyrinogen by methylcholanthrene-induced cytochrome P-450. Essential role of cytochrome P-450d. The Biochemical journal. 1989 Feb; 258(1):247-53. doi: 10.1042/bj2580247. [PMID: 2930512]
  • D R Dutton, A Parkinson. Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. Archives of biochemistry and biophysics. 1989 Feb; 268(2):617-29. doi: 10.1016/0003-9861(89)90329-9. [PMID: 2536534]
  • H Wynne, E Mutch, O F James, M D Rawlins, K W Woodhouse. The effect of age on mono-oxygenase enzyme kinetics in rat liver microsomes. Age and ageing. 1987 May; 16(3):153-8. doi: 10.1093/ageing/16.3.153. [PMID: 3604796]
  • D M Grant, M E Campbell, B K Tang, W Kalow. Biotransformation of caffeine by microsomes from human liver. Kinetics and inhibition studies. Biochemical pharmacology. 1987 Apr; 36(8):1251-60. doi: 10.1016/0006-2952(87)90078-5. [PMID: 3593412]
  • M Pesonen, T Andersson. Subcellular localization and properties of cytochrome P-450 and UDP glucuronosyltransferase in the rainbow trout kidney. Biochemical pharmacology. 1987 Mar; 36(6):823-9. doi: 10.1016/0006-2952(87)90170-5. [PMID: 3105537]
  • C R Wolf, J B Hook, E A Lock. Differential destruction of cytochrome P-450-dependent monooxygenases in rat and mouse kidney following hexachloro-1:3-butadiene administration. Molecular pharmacology. 1983 Jan; 23(1):206-12. doi: NULL. [PMID: 6865899]
  • R Toftgård, O G Nilsen. Effects of xylene and xylene isomers on cytochrome P-450 and in vitro enzymatic activities in rat liver, kidney and lung. Toxicology. 1982; 23(2-3):197-212. doi: 10.1016/0300-483x(82)90098-1. [PMID: 7112593]
  • R B Franklin, M J Vodicnik. Sex steroids and extrahepatic mixed-function oxidase activity. Journal of steroid biochemistry. 1981 Apr; 14(4):367-75. doi: 10.1016/0022-4731(81)90156-4. [PMID: 7230799]
  • R J Pohl, J R Fouts. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Analytical biochemistry. 1980 Sep; 107(1):150-5. doi: 10.1016/0003-2697(80)90505-9. [PMID: 6776841]
  • M D Burke, S Orrenius. The effect of albumin on the metabolism of ethoxyresorufin through O-deethylation and sulphate-conjugation using isolated rat hepatocytes. Biochemical pharmacology. 1978; 27(11):1533-8. doi: 10.1016/0006-2952(78)90481-1. [PMID: 697896]
  • G C Varnam, M K Jeacock, D A Shepherd. Activities of ketone body utilising enzymes in tissues of fed and fasted sheep. Research in veterinary science. 1978 Jan; 24(1):124-5. doi: 10.1016/s0034-5288(18)33113-8. [PMID: 24243]
  • H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor. The Biochemical journal. 1975 Dec; 152(3):601-7. doi: 10.1042/bj1520601. [PMID: 5997]