4-Hydroxyifosfamide (BioDeep_00001876857)
Main id: BioDeep_00000011261
代谢物信息卡片
化学式: C7H15Cl2N2O3P (276.0197)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 26.56%
分子结构信息
SMILES: C1COP(=O)(N(C1O)CCCl)NCCCl
InChI: InChI=1S/C7H15Cl2N2O3P/c8-2-4-10-15(13)11(5-3-9)7(12)1-6-14-15/h7,12H,1-6H2,(H,10,13)
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:80560
- KEGG: C16553
- PubChem: 308171
- ChEMBL: CHEMBL733
- CAS: 50892-10-9
- PubChem: 51090882
- NIKKAJI: J2.235.734D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alain Deroussent, Charles Skarbek, Adeline Maury, Hubert Chapuis, Estelle Daudigeos-Dubus, Ludivine Le Dret, Sylvère Durand, Patrick Couvreur, Didier Desmaële, Angelo Paci. Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography-tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jun; 992(?):30-5. doi:
10.1016/j.jchromb.2015.04.025. [PMID: 25939095] - Charles Skarbek, Lea L Lesueur, Hubert Chapuis, Alain Deroussent, Catherine Pioche Durieu, Aurore Daville, Joachim Caron, Michael Rivard, Thierry Martens, Jean-Rémi Bertrand, Eric Le Cam, Gilles Vassal, Patrick Couvreur, Didier Desmaele, Angelo Paci. Preactivated oxazaphosphorines designed for isophosphoramide mustard delivery as bulk form or nanoassemblies: synthesis and proof of concept.
Journal of medicinal chemistry.
2015 Jan; 58(2):705-17. doi:
10.1021/jm501224x. [PMID: 25494842] - Philipp Kiewe, Martin Neumann, Thomas Wagner, Sepp Seyfert, Heike Albrecht, Eckhard Thiel, Agnieszka Korfel. Penetration of ifosfamide and its active metabolite 4-OH-ifosfamide into cerebrospinal fluid of patients with CNS malignancies.
Cancer chemotherapy and pharmacology.
2011 Jan; 67(1):27-33. doi:
10.1007/s00280-010-1274-4. [PMID: 20182727] - T Kerbusch, R A Mathĵt, H J Keizer, J Ouwerkerk, S Rodenhuis, J H Schellens, J H Beijnen. Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma.
European journal of clinical pharmacology.
2001 Sep; 57(6-7):467-77. doi:
10.1007/s002280100322. [PMID: 11699611] - Y Hirano, T Ushiyama, K Suzuki, K Fujita. Clinical application of an in vitro chemosensitivity test, the Histoculture Drug Response Assay, to urological cancers: wide distribution of inhibition rates in bladder cancer and renal cell cancer.
Urological research.
1999 Dec; 27(6):483-8. doi:
10.1007/s002400050139. [PMID: 10651138] - T Kerbusch, A D Huitema, J J Kettenes-van den Bosch, H J Keizer, J Ouwerkerk, J de Kraker, J H Beijnen. High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Sep; 716(1-2):275-84. doi:
10.1016/s0378-4347(98)00298-9. [PMID: 9824241] - G P Kaijser, J De Kraker, A Bult, W J Underberg, J H Beijnen. Pharmacokinetics of ifosfamide and some metabolites in children.
Anticancer research.
1998 May; 18(3B):1941-9. doi:
NULL. [PMID: 9677448] - S K Brüggemann, J Kisro, T Wagner. Ifosfamide cytotoxicity on human tumor and renal cells: role of chloroacetaldehyde in comparison to 4-hydroxyifosfamide.
Cancer research.
1997 Jul; 57(13):2676-80. doi:
. [PMID: 9205076] - G P Kaijser, P G Ter Riet, J de Kraker, A Bult, J H Beijnen, W J Underberg. Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
1997 Mar; 15(6):773-81. doi:
10.1016/s0731-7085(96)01893-6. [PMID: 9172103] - V Kurowski, T Wagner. Urinary excretion of ifosfamide, 4-hydroxyifosfamide, 3- and 2-dechloroethylifosfamide, mesna, and dimesna in patients on fractionated intravenous ifosfamide and concomitant mesna therapy.
Cancer chemotherapy and pharmacology.
1997; 39(5):431-9. doi:
10.1007/s002800050594. [PMID: 9054957] - R F Struck, D M McCain, S W Tendian, K H Tillery. Quantification of 4-hydroxyifosfamide in plasma of ifosfamide-treated mice.
Cancer chemotherapy and pharmacology.
1997; 40(1):57-9. doi:
10.1007/s002800050625. [PMID: 9137530] - M Mohrmann, A Pauli, M Ritzer, B Schönfeld, B Seifert, M Brandis. Inhibition of sodium-dependent transport systems in LLC-PK1 cells by metabolites of ifosfamide.
Renal physiology and biochemistry.
1992 Nov; 15(6):289-301. doi:
10.1159/000173465. [PMID: 1282722] - I Ikeuchi, T Amano. Fluorometric determination of 4-hydroxyifosfamide in blood and urine.
Chemical & pharmaceutical bulletin.
1985 Jun; 33(6):2416-20. doi:
10.1248/cpb.33.2416. [PMID: 4064201] - K Misiura, A Okruszek, K Pankiewicz, W J Stec, Z Czownicki, B Utracka. Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in the urine.
Journal of medicinal chemistry.
1983 May; 26(5):674-9. doi:
10.1021/jm00359a010. [PMID: 6842506]
