Devapamil (BioDeep_00001876713)

Main id: BioDeep_00000009563

 


代谢物信息卡片


5-(N-(3-METHOXYPHENETHYL)-N-METHYLAMINO)-2-ISOPROPYL-2-(3,4-DIMETHOXYPHENYL)PENTANENITRILE

化学式: C26H36N2O3 (424.2726)
中文名称: 地伐帕米
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(CCCN(C)CCC1=CC(=CC=C1)OC)(C#N)C2=CC(=C(C=C2)OC)OC
InChI: InChI=1S/C26H36N2O3/c1-20(2)26(19-27,22-11-12-24(30-5)25(18-22)31-6)14-8-15-28(3)16-13-21-9-7-10-23(17-21)29-4/h7,9-12,17-18,20H,8,13-16H2,1-6H3

描述信息

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

3 个代谢物同义名

5-(N-(3-METHOXYPHENETHYL)-N-METHYLAMINO)-2-ISOPROPYL-2-(3,4-DIMETHOXYPHENYL)PENTANENITRILE; Devapamil; Devapamil



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, BGLAP, EDN1, GNAQ, PLA2G12A, RYR1
Endosome membrane 1 SLC6A4
Nucleus 2 GNAQ, PLCZ1
cytosol 3 AVP, PLCZ1, PRKCQ
dendrite 2 AVP, BGLAP
nucleoplasm 2 CD2, PLCZ1
Cell membrane 6 ABCB1, ADRB3, CD2, GNAQ, PTAFR, SLC6A4
Lipid-anchor 1 GNAQ
Multi-pass membrane protein 7 ABCB1, ADRB3, CACNA1D, CACNA1I, PTAFR, RYR1, SLC6A4
Synapse 2 GNAQ, SLC6A4
cell cortex 1 RYR1
cell surface 2 ABCB1, CD2
Golgi apparatus 2 CD2, GNAQ
Golgi membrane 1 INS
lysosomal membrane 2 EGF, GNAQ
presynaptic membrane 1 SLC6A4
sarcolemma 1 RYR1
smooth endoplasmic reticulum 1 RYR1
Presynapse 1 SLC6A4
plasma membrane 12 ABCB1, ADRB3, CACNA1D, CACNA1I, CD2, EGF, F2, GNAQ, PRKCQ, PTAFR, RYR1, SLC6A4
Membrane 8 ABCB1, CACNA1D, CACNA1I, EGF, GNAQ, PTAFR, RYR1, SLC6A4
apical plasma membrane 1 ABCB1
extracellular exosome 6 A2ML1, ABCB1, EGF, F2, GNAQ, RYR1
extracellular space 8 A2ML1, AVP, BGLAP, EDN1, EGF, F2, INS, PTH
perinuclear region of cytoplasm 1 PLCZ1
protein-containing complex 1 CD2
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 CD2
Secreted 7 A2ML1, AVP, BGLAP, EDN1, F2, INS, PLA2G12A
extracellular region 10 A2ML1, AVP, BGLAP, CD2, EDN1, EGF, F2, INS, PLA2G12A, PTH
cytoplasmic side of plasma membrane 1 CD2
basal part of cell 1 EDN1
centriolar satellite 1 PRKCQ
photoreceptor outer segment 1 GNAQ
Nucleus membrane 1 GNAQ
nuclear membrane 1 GNAQ
external side of plasma membrane 1 CD2
perikaryon 1 BGLAP
Z disc 2 CACNA1D, RYR1
nucleolus 1 PLCZ1
cell-cell junction 1 CD2
vesicle 1 BGLAP
postsynaptic membrane 1 SLC6A4
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 SLC6A4
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
sarcoplasmic reticulum 1 RYR1
collagen-containing extracellular matrix 1 F2
secretory granule 1 AVP
receptor complex 1 ADRB3
Cell projection, neuron projection 1 SLC6A4
neuron projection 1 SLC6A4
blood microparticle 1 F2
organelle membrane 1 RYR1
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
heterotrimeric G-protein complex 1 GNAQ
I band 1 RYR1
monoatomic ion channel complex 1 CACNA1D
tertiary granule membrane 1 PTAFR
secretory granule lumen 1 INS
secretory granule membrane 1 PTAFR
Golgi lumen 3 BGLAP, F2, INS
endoplasmic reticulum lumen 3 BGLAP, F2, INS
platelet alpha granule lumen 1 EGF
voltage-gated calcium channel complex 2 CACNA1D, CACNA1I
transport vesicle 2 EDN1, INS
Sarcoplasmic reticulum membrane 1 RYR1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 AVP
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 2 AVP, EGF
calcium channel complex 1 RYR1
junctional sarcoplasmic reticulum membrane 1 RYR1
external side of apical plasma membrane 1 ABCB1
terminal cisterna 1 RYR1
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
ryanodine receptor complex 1 RYR1
serotonergic synapse 1 SLC6A4
L-type voltage-gated calcium channel complex 1 CACNA1D


文献列表

  • Paul Wilhelm Dierkes, Verena Wende, Peter Hochstrate, Wolf-Rüdiger Schlue. L-type Ca2+ channel antagonists block voltage-dependent Ca2+ channels in identified leech neurons. Brain research. 2004 Jul; 1013(2):159-67. doi: 10.1016/j.brainres.2004.03.038. [PMID: 15193524]
  • R Benterbusch, F W Herberg, W Melzer, R Thieleczek. Excitation-contraction coupling in a pre-vertebrate twitch muscle: the myotomes of Branchiostoma lanceolatum. The Journal of membrane biology. 1992 Sep; 129(3):237-52. doi: 10.1007/bf00232906. [PMID: 1433276]
  • V Höllt, M Kouba, M Dietel, G Vogt. Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochemical pharmacology. 1992 Jun; 43(12):2601-8. doi: 10.1016/0006-2952(92)90149-d. [PMID: 1352973]