alpha-Hydroxytamoxifen (BioDeep_00001875956)

Main id: BioDeep_00000011252

 


代谢物信息卡片


alpha-Hydroxytamoxifen

化学式: C26H29NO2 (387.2198)
中文名称:
谱图信息: 最多检出来源 Ailuropoda melanoleuca(urine) 52.97%

分子结构信息

SMILES: CC(/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1)O
InChI: InChI=1S/C26H29NO2/c1-20(28)25(21-10-6-4-7-11-21)26(22-12-8-5-9-13-22)23-14-16-24(17-15-23)29-19-18-27(2)3/h4-17,20,28H,18-19H2,1-3H3/b26-25-

描述信息

同义名列表

2 个代谢物同义名

alpha-Hydroxytamoxifen; alpha-Hydroxytamoxifen



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ALB, CAT, CYP1A1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, HPGDS, SULT2A1
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP2B6, CYP2E1
Endoplasmic reticulum membrane 14 CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, FMO1, FMO3
Nucleus 1 ALB
cytosol 4 ALB, CAT, HPGDS, SULT2A1
centrosome 1 ALB
nucleoplasm 2 HPGDS, SLC3A2
Cell membrane 1 SLC3A2
Multi-pass membrane protein 1 SLC45A2
Synapse 1 SLC3A2
cell junction 1 SLC3A2
cell surface 1 SLC3A2
Golgi apparatus 1 ALB
lysosomal membrane 1 SLC3A2
mitochondrial inner membrane 2 CYP1A1, CYP2E1
plasma membrane 4 CYP2C19, CYP2C8, CYP2C9, SLC3A2
Membrane 8 CAT, CYP1B1, CYP2A6, CYP2D6, CYP3A4, CYP3A5, SLC3A2, SLC45A2
apical plasma membrane 1 SLC3A2
basolateral plasma membrane 1 SLC3A2
extracellular exosome 3 ALB, CAT, SLC3A2
Lysosome membrane 1 SLC3A2
endoplasmic reticulum 4 ALB, CYP2D6, FMO1, FMO3
extracellular space 1 ALB
mitochondrion 4 CAT, CYP1A1, CYP1B1, CYP2D6
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 15 CAT, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, FMO3, HPGDS
Microsome membrane 10 CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C9, CYP2D6, CYP2E1, CYP3A4, CYP3A5, FMO3
Secreted 1 ALB
extracellular region 2 ALB, CAT
Single-pass membrane protein 3 CYP2D6, FMO1, FMO3
mitochondrial matrix 1 CAT
anchoring junction 2 ALB, SLC3A2
Melanosome membrane 1 SLC45A2
Single-pass type II membrane protein 1 SLC3A2
Apical cell membrane 1 SLC3A2
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
ciliary basal body 1 ALB
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 SLC3A2
Melanosome 1 SLC3A2
basal plasma membrane 1 SLC3A2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, FMO1
platelet alpha granule lumen 1 ALB
cytoplasmic microtubule 1 CYP2A6
catalase complex 1 CAT
amino acid transport complex 1 SLC3A2
apical pole of neuron 1 SLC3A2
ciliary transition fiber 1 ALB


文献列表

  • David H Phillips, Alan Hewer, Martin R Osborne, Kathleen J Cole, Cyd Churchill, Volker M Arlt. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment. Mutagenesis. 2005 Jul; 20(4):297-303. doi: 10.1093/mutage/gei038. [PMID: 15928012]