NITROFEN (BioDeep_00001873638)
代谢物信息卡片
NITROFEN
化学式: C12H7Cl2NO3 (282.9802972)
中文名称: 除草醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1[N+](=O)[O-])OC2=C(C=C(C=C2)Cl)Cl
InChI: InChI=1S/C12H7Cl2NO3/c13-8-1-6-12(11(14)7-8)18-10-4-2-9(3-5-10)15(16)17/h1-7H
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yumiko Ito, Hiroyuki Tsuda, Kenji Imai, Rika Miki, Mayo Miura, Asuka Tachi, Sho Tano, Shima Hirako-Takamura, Yoshinori Moriyama, Takafumi Ushida, Tomoko Kobayashi, Seiji Sumigama, Hiroaki Kajiyama, Fumitaka Kikkawa, Tomomi Kotani. Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia.
Archives of biochemistry and biophysics.
2021 03; 700(?):108769. doi:
10.1016/j.abb.2021.108769. [PMID: 33484710] - Hajime Takayasu, Koki Hagiwara, Kouji Masumoto. Suppressed erythropoietin expression in a nitrofen-induced congenital diaphragmatic hernia.
Pediatric pulmonology.
2017 05; 52(5):606-615. doi:
10.1002/ppul.23640. [PMID: 27880037] - Shima Hirako, Hiroyuki Tsuda, Tomomi Kotani, Seiji Sumigama, Yukio Mano, Tomoko Nakano, Kenji Imai, Hua Li, Shinya Toyokuni, Fumitaka Kikkawa. Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia.
Phytotherapy research : PTR.
2016 Sep; 30(9):1474-80. doi:
10.1002/ptr.5645. [PMID: 27221220] - Balazs Kutasy, Florian Friedmacher, Lara Pes, David Coyle, Takashi Doi, Francesca Paradisi, Prem Puri. Antenatal retinoic acid administration increases trophoblastic retinol-binding protein dependent retinol transport in the nitrofen model of congenital diaphragmatic hernia.
Pediatric research.
2016 Apr; 79(4):614-20. doi:
10.1038/pr.2015.256. [PMID: 26672737] - Hiromizu Takahashi, Balazs Kutasy, Florian Friedmacher, Toshiaki Takahashi, Prem Puri. Expression of hepatic lipid droplets is decreased in the nitrofen model of congenital diaphragmatic hernia.
Pediatric surgery international.
2016 Feb; 32(2):155-60. doi:
10.1007/s00383-015-3827-4. [PMID: 26649853] - Hiromizu Takahashi, Balazs Kutasy, Lara Pes, Francesca Paradisi, Prem Puri. Decidual β-carotene-15,15'-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia.
Pediatric surgery international.
2015 Jan; 31(1):37-43. doi:
10.1007/s00383-014-3621-8. [PMID: 25344780] - Balazs Kutasy, Lara Pes, Florian Friedmacher, Francesca Paradisi, Prem Puri. Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia.
Pediatric surgery international.
2014 Oct; 30(10):1017-22. doi:
10.1007/s00383-014-3525-7. [PMID: 24972641] - Alejandro Hofmann, Jan-Hendrik Gosemann, Toshiaki Takahashi, Florian Friedmacher, Johannes W Duess, Prem Puri. Imbalance of caveolin-1 and eNOS expression in the pulmonary vasculature of experimental diaphragmatic hernia.
Birth defects research. Part B, Developmental and reproductive toxicology.
2014 Aug; 101(4):341-6. doi:
10.1002/bdrb.21117. [PMID: 25078423] - Alejandro D Hofmann, Florian Friedmacher, Manuela Hunziker, Hiromizu Takahashi, Johannes W Duess, Jan-Hendrik Gosemann, Prem Puri. Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Journal of pediatric surgery.
2014 Jun; 49(6):871-4; discussion 874. doi:
10.1016/j.jpedsurg.2014.01.015. [PMID: 24888825] - Balazs Kutasy, Florian Friedmacher, Lara Pes, Francesca Paradisi, Prem Puri. Increased uptake of dietary retinoids at the maternal-fetal barrier in the nitrofen model of congenital diaphragmatic hernia.
Journal of pediatric surgery.
2014 Jun; 49(6):866-70. doi:
10.1016/j.jpedsurg.2014.01.014. [PMID: 24888824] - Florian Friedmacher, Naho Fujiwara, Alejandro D Hofmann, Hiromizu Takahashi, Luis A J Alvarez, Jan-Hendrik Gosemann, Prem Puri. Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
Journal of pediatric surgery.
2014 Jun; 49(6):876-81; discussion 881. doi:
10.1016/j.jpedsurg.2014.01.017. [PMID: 24888826] - Balazs Kutasy, Florian Friedmacher, Johannes W Duess, Prem Puri. Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia.
Pediatric surgery international.
2014 Feb; 30(2):137-42. doi:
10.1007/s00383-013-3449-7. [PMID: 24352370] - Marina Romaní-Pérez, Verónica Outeiriño-Iglesias, Manuel Gil-Lozano, Lucas C González-Matías, Federico Mallo, Eva Vigo. Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats.
Endocrinology.
2013 Mar; 154(3):1144-55. doi:
10.1210/en.2012-1786. [PMID: 23354098] - Yoshiyuki Inoue, Naoki Hashizume, Erina Kikushima, Masanori Otsuka. Comparison of nitrofen uptake via water and food and its distribution in tissue of common carp, Cyprinus carpio L.
Bulletin of environmental contamination and toxicology.
2011 Sep; 87(3):287-91. doi:
10.1007/s00128-011-0356-2. [PMID: 21713387] - Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.
Toxicology.
2011 Feb; 280(3):77-87. doi:
10.1016/j.tox.2010.11.008. [PMID: 21115097] - Takashi Doi, Kaoru Sugimoto, Elke Ruttenstock, Jens Dingemann, Prem Puri. Prenatal treatment with retinoic acid activates parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung.
Pediatric surgery international.
2011 Jan; 27(1):47-52. doi:
10.1007/s00383-010-2726-y. [PMID: 20857298] - Ompal Singh, Zakia Khanam, Neelam Misra, Manoj Kumar Srivastava. Chamomile (Matricaria chamomilla L.): An overview.
Pharmacognosy reviews.
2011 Jan; 5(9):82-95. doi:
10.4103/0973-7847.79103. [PMID: 22096322] - David E Kling, Amanda J Cavicchio, Christina A Sollinger, Jay J Schnitzer, T Bernard Kinane, David S Newburg. Nitrofen induces apoptosis independently of retinaldehyde dehydrogenase (RALDH) inhibition.
Birth defects research. Part B, Developmental and reproductive toxicology.
2010 Jun; 89(3):223-32. doi:
10.1002/bdrb.20247. [PMID: 20549697] - Rosemary Castorina, Asa Bradman, Laura Fenster, Dana Boyd Barr, Roberto Bravo, Michelle G Vedar, Martha E Harnly, Thomas E McKone, Ellen A Eisen, Brenda Eskenazi. Comparison of current-use pesticide and other toxicant urinary metabolite levels among pregnant women in the CHAMACOS cohort and NHANES.
Environmental health perspectives.
2010 Jun; 118(6):856-63. doi:
10.1289/ehp.0901568. [PMID: 20129873] - Murat Kemal Cigdem, Goksel Kizil, Abdurrahman Onen, Murat Kizil, Yusuf Nergiz, Yusuf Celik. Is there a role for antioxidants in prevention of pulmonary hypoplasia in nitrofen-induced rat model of congenital diaphragmatic hernia?.
Pediatric surgery international.
2010 Apr; 26(4):401-6. doi:
10.1007/s00383-010-2552-2. [PMID: 20127338] - Chang Xu, Wenying Liu, Zhongxian Chen, Yuanxiang Wang, Zhongxun Xiong, Yi Ji. Effect of prenatal tetrandrine administration on transforming growth factor-beta1 level in the lung of nitrofen-induced congenital diaphragmatic hernia rat model.
Journal of pediatric surgery.
2009 Aug; 44(8):1611-20. doi:
10.1016/j.jpedsurg.2008.09.021. [PMID: 19635314] - I Windal, V Hanot, J Marchi, G Huysmans, I Van Overmeire, N Waegeneers, L Goeyens. PCB and organochlorine pesticides in home-produced eggs in Belgium.
The Science of the total environment.
2009 Jul; 407(15):4430-7. doi:
10.1016/j.scitotenv.2008.11.063. [PMID: 19150570] - Han Lin, Yonggang Wang, Zhongxun Xiong, Yunman Tang, Wenying Liu. Effect of antenatal tetrandrine administration on endothelin-1 and epidermal growth factor levels in the lungs of rats with experimental diaphragmatic hernia.
Journal of pediatric surgery.
2007 Oct; 42(10):1644-51. doi:
10.1016/j.jpedsurg.2007.05.017. [PMID: 17923190] - Nana Nakazawa, Hajime Takayasu, Sandra Montedonico, Prem Puri. Altered regulation of retinoic acid synthesis in nitrofen-induced hypoplastic lung.
Pediatric surgery international.
2007 May; 23(5):391-6. doi:
10.1007/s00383-006-1848-8. [PMID: 17203325] - Nana Nakazawa, Sandra Montedonico, Hajime Takayasu, Francesca Paradisi, Prem Puri. Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung.
Journal of pediatric surgery.
2007 Feb; 42(2):345-9. doi:
10.1016/j.jpedsurg.2006.10.028. [PMID: 17270546] - Sandra Montedonico, Nana Nakazawa, Toko Shinkai, John Bannigan, Prem Puri. Kidney development in the nitrofen-induced pulmonary hypoplasia and congenital diaphragmatic hernia in rats.
Journal of pediatric surgery.
2007 Jan; 42(1):239-43. doi:
10.1016/j.jpedsurg.2006.09.062. [PMID: 17208573] - Yonggang Wang, Wenying Liu, Han Lin. [Effect and significance of tetrandrine on epidermal growth factor and its receptor in the lung of congenital diaphragmatic hernia rat model].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2006 Nov; 20(11):1109-13. doi:
. [PMID: 17191579] - E C Jesudason, N P Smith, M G Connell, D G Spiller, M R H White, D G Fernig, P D Losty. Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth.
American journal of physiology. Lung cellular and molecular physiology.
2006 Oct; 291(4):L559-65. doi:
10.1152/ajplung.00498.2005. [PMID: 16603591] - Boris Chertin, Nana Nakazawa, Sandra Montedonico, Hideki Shima, Prem Puri. Altered renin-angiotensin system gene expression causes renal hypoplasia in the rats with nitrofen-induced diaphragmatic hernia.
Pediatric surgery international.
2006 Jan; 22(1):57-60. doi:
10.1007/s00383-005-1582-7. [PMID: 16292651] - Maria J Baptista, Gustavo Melo-Rocha, Carla Pedrosa, Sílvia Gonzaga, Antónia Teles, José Estevão-Costa, José C Areias, Alan W Flake, Adelino F Leite-Moreira, Jorge Correia-Pinto. Antenatal vitamin A administration attenuates lung hypoplasia by interfering with early instead of late determinants of lung underdevelopment in congenital diaphragmatic hernia.
Journal of pediatric surgery.
2005 Apr; 40(4):658-65. doi:
10.1016/j.jpedsurg.2005.01.034. [PMID: 15852274] - Masato Shinkai, Toko Shinkai, Martina E Pirker, Sandra Montedonico, Prem Puri. Effect of nitric oxide on the development of nitrofen-induced fetal hypoplastic lung explants.
Journal of pediatric surgery.
2005 Jan; 40(1):17-21. doi:
10.1016/j.jpedsurg.2004.09.007. [PMID: 15861370] - M J Rodriguez-Matas, S Gonzalez-Reyes, L Martínez, I Martínez, J I Rodriguez, J A Diez-Pardo, J A Tovar. The adrenal cortex in experimental congenital diaphragmatic hernia.
Journal of pediatric surgery.
2003 May; 38(5):682-4. doi:
10.1016/jpsu.2003.50182. [PMID: 12720169] - Nino Guarino, Prem Puri. Antenatal dexamethasone enhances endothelin-1 synthesis and gene expression in the heart in congenital diaphragmatic hernia in rats.
Journal of pediatric surgery.
2002 Nov; 37(11):1563-7. doi:
10.1053/jpsu.2002.36185. [PMID: 12407540] - T Oue, A Yoneda, H Shima, Y Taira, P Puri. Increased vascular endothelial growth factor peptide and gene expression in hypoplastic lung in nitrofen induced congenital diaphragmatic hernia in rats.
Pediatric surgery international.
2002 May; 18(4):221-6. doi:
10.1007/s003830100625. [PMID: 12021965] - S E Zgleszewski, R E Cilley, T M Krummel, M R Chinoy. Effects of dexamethasone, growth factors, and tracheal ligation on the development of nitrofen-exposed hypoplastic murine fetal lungs in organ culture.
Journal of pediatric surgery.
1999 Aug; 34(8):1187-95. doi:
10.1016/s0022-3468(99)90150-1. [PMID: 10466594] - A Losada, H Xia, L Migliazza, J A Diez-Pardo, P Santisteban, J A Tovar. Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1.
Pediatric surgery international.
1999; 15(3-4):188-91. doi:
10.1007/s003830050551. [PMID: 10370019] - R A Causak, S E Zgleszewski, L Zhang, R E Cilley, T M Krummel, M R Chinoy. Differential gene expression at gestational days 14 and 16 in normal and nitrogen-induced hypoplastic murine fetal lungs with coexistent diaphragmatic hernia.
Pediatric pulmonology.
1998 Nov; 26(5):301-11. doi:
10.1002/(sici)1099-0496(199811)26:5<301::aid-ppul1>3.0.co;2-b. [PMID: 9859898] - J A Tovar, B Qi, J A Diez-Pardo, L F Alfonso, A Arnaiz, F J Alvarez, A Valls-i-Soler, G Morreale de Escobar. Thyroid hormones in the pathogenesis of lung hypoplasia and immaturity induced in fetal rats by prenatal exposure to nitrofen.
Journal of pediatric surgery.
1997 Sep; 32(9):1295-7. doi:
10.1016/s0022-3468(97)90305-5. [PMID: 9314246] - B Qi, J A Diez-Pardo, J I Rodriguez, J A Tovar. Experimental ureterohydronephrosis in fetal rats.
Journal of pediatric surgery.
1996 Sep; 31(9):1247-51. doi:
10.1016/s0022-3468(96)90243-2. [PMID: 8887094] - A E Brandsma, A A ten Have-Opbroek, I M Vulto, J C Molenaar, D Tibboel. Alveolar epithelial composition and architecture of the late fetal pulmonary acinus: an immunocytochemical and morphometric study in a rat model of pulmonary hypoplasia and congenital diaphragmatic hernia.
Experimental lung research.
1994 Nov; 20(6):491-515. doi:
10.3109/01902149409031734. [PMID: 7882903] - X Z Yu. [Biological monitoring of workers exposed to nitrofen and experimental study on its skin permeability].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].
1993 Jul; 27(4):208-11. doi:
NULL. [PMID: 8143515] - D S Wickman, J R Siebert, D R Benjamin. Nitrofen-induced congenital diaphragmatic defects in CD1 mice.
Teratology.
1993 Feb; 47(2):119-25. doi:
10.1002/tera.1420470204. [PMID: 8446925] - J A Tovar, L F Alfonso, P Aldazabal, B Lopez de Torre, S Uriarte, J Vilanova. The kidney in the fetal rat model of congenital diaphragmatic hernia induced by nitrofen.
Journal of pediatric surgery.
1992 Oct; 27(10):1356-60. doi:
10.1016/0022-3468(92)90297-k. [PMID: 1403522] - D J Hoffman, J W Spann, L J LeCaptain, C M Bunck, B A Rattner. Developmental toxicity of diphenyl ether herbicides in nestling American kestrels.
Journal of toxicology and environmental health.
1991 Nov; 34(3):323-36. doi:
10.1080/15287399109531571. [PMID: 1942122] - G P Daston, B F Rehnberg, B Carver, R J Kavlock. Functional teratogens of the rat kidney. II. Nitrofen and ethylenethiourea.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1988 Oct; 11(3):401-15. doi:
10.1016/0272-0590(88)90105-4. [PMID: 3220215] - R J Kavlock, B R Hoyle, B F Rehnberg, E H Rogers. The significance of the dilated renal pelvis in the nitrofen-exposed rat fetus: effects on morphology and function.
Toxicology and applied pharmacology.
1988 Jun; 94(2):287-96. doi:
10.1016/0041-008x(88)90270-0. [PMID: 3388425] - T J Brown, J M Manson. Further characterization of the distribution and metabolism of nitrofen in the pregnant rat.
Teratology.
1986 Oct; 34(2):129-39. doi:
10.1002/tera.1420340202. [PMID: 3775667] - Y J Kang, L Zolna, J M Manson. Strain differences in response of Sprague-Dawley and Long Evans Hooded rats to the teratogen nitrofen.
Teratology.
1986 Oct; 34(2):213-23. doi:
10.1002/tera.1420340211. [PMID: 3775674] - F J Zeman, E R Hoogenboom, C Chase-Deesing, R J Kavlock, J L Semple. Effects on the fetus of maternal nitrofen exposure in the protein-deprived rat.
Toxicology.
1986 Jan; 38(1):55-68. doi:
10.1016/0300-483x(86)90172-1. [PMID: 3079931] - F J Zeman, H Heng, E R Hoogenboom, R J Kavlock, S Mahboob. Cell number and size in selected organs of fetuses of rats malnourished and exposed to nitrofen.
Teratogenesis, carcinogenesis, and mutagenesis.
1986; 6(4):339-47. doi:
10.1002/tcm.1770060409. [PMID: 2428123] - S Mahboob, E R Hoogenboom, R J Kavlock, F J Zeman. Effects on the fetal rat intestine of maternal malnutrition and exposure to nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether).
Teratogenesis, carcinogenesis, and mutagenesis.
1986; 6(1):45-57. doi:
10.1002/tcm.1770060106. [PMID: 2874636] - C Chase-Deesing, R J Kavlock, F J Zeman. Kidney morphology and function in the young of rats malnourished and exposed to nitrofen during pregnancy.
Journal of toxicology and environmental health.
1986; 19(1):1-21. doi:
10.1080/15287398609530902. [PMID: 3746936] - J S Ostby, L E Gray, R J Kavlock, J M Ferrell. The postnatal effects of prenatal exposure to low doses of nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether) in Sprague-Dawley rats.
Toxicology.
1985 Mar; 34(4):285-97. doi:
10.1016/0300-483x(85)90139-8. [PMID: 3992587] - G P O'Hara, P K Chan, J C Harris, S S Burke, J M Smith, A W Hayes. The effect of nitrofen [4-(2,4-dichlorophenoxy)nitrobenzene] on the reproductive performance of male rats.
Toxicology.
1983 Nov; 28(4):323-33. doi:
10.1016/0300-483x(83)90006-9. [PMID: 6648980] - R D Costlow, J M Hirsekorn, R G Stiratelli, G P O'Hara, D L Black, W W Kane, S S Burke, J M Smith, A W Hayes. The effects on rat pups when nitrofen (4-(2,4-dichlorophenoxy)nitrobenzene) was applied dermally to the dam during organogenesis.
Toxicology.
1983 Sep; 28(1-2):37-50. doi:
10.1016/0300-483x(83)90104-x. [PMID: 6636201] - R J Kavlock, L E Gray. Postnatal evaluation of morphological and functional effects of prenatal exposure to nitrofen in the Long-Evans rat.
Journal of toxicology and environmental health.
1983 Apr; 11(4-6):679-90. doi:
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Toxicology letters.
1983 Feb; 15(2-3):231-5. doi:
10.1016/0378-4274(83)90221-7. [PMID: 6829046] - R J Kavlock, J A Gray. Morphometric, biochemical, and physiological assessment of perinatally induced renal dysfunction.
Journal of toxicology and environmental health.
1983 Jan; 11(1):1-13. doi:
10.1080/15287398309530316. [PMID: 6219233] - J A Raub, R R Mercer, R J Kavlock, C J Setzer. Effects of prenatal nitrofen exposure on postnatal lung function in the rat.
Progress in clinical and biological research.
1983; 140(?):119-34. doi:
NULL. [PMID: 6672835] - R D Costlow, J M Manson. Distribution and metabolism of the teratogen nitrofen (2,4-dichloro-4'-nitro diphenyl ether) in pregnant rats.
Toxicology.
1983 Jan; 26(1):11-23. doi:
10.1016/0300-483x(83)90052-5. [PMID: 6829027] - S R Sharma, H S Sohi. Influence of herbicides on root rot of French beans (Phaseolus vulgaris L.), caused by Rhizoctonia solani.
Zentralblatt fur Mikrobiologie.
1983; 138(5):357-61. doi:
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Journal of environmental pathology and toxicology.
1980 Jun; 3(5-6):21-33. doi:
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Journal of agricultural and food chemistry.
1977 Sep; 25(5):1062-7. doi:
10.1021/jf60213a008. [PMID: 893828]