Diamyl phthalate (BioDeep_00001873617)
Main id: BioDeep_00000001129
Industrial Pollutants
代谢物信息卡片
化学式: C18H26O4 (306.1831)
中文名称: 邻苯二甲酸二正戊酯, 邻苯二甲酸二戊酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCC
InChI: InChI=1S/C18H26O4/c1-3-5-9-13-21-17(19)15-11-7-8-12-16(15)18(20)22-14-10-6-4-2/h7-8,11-12H,3-6,9-10,13-14H2,1-2H3
描述信息
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].
Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant[1].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:34680
- KEGG: C14300
- PubChem: 8561
- ChEMBL: CHEMBL1503330
- CAS: 131-18-0
- PubChem: 17395300
- NIKKAJI: J46.841J
- medchemexpress: HY-W013816
- KNApSAcK: 34680
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 54828 - Cryptotaenia canadensis: 10.1016/S0040-4039(01)89914-7
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haiqiong Chen, Xiu Xin, Miaoqing Liu, Feifei Ma, Yige Yu, Jie Huang, Haipeng Dai, Zhongrong Li, Ren-Shan Ge. In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development.
Toxicology and applied pharmacology.
2021 05; 419(?):115514. doi:
10.1016/j.taap.2021.115514. [PMID: 33798595] - Nuria Vela, May Calín, María J Yáñez-Gascón, Isabel Garrido, Gabriel Pérez-Lucas, José Fenoll, Simón Navarro. Photocatalytic oxidation of six endocrine disruptor chemicals in wastewater using ZnO at pilot plant scale under natural sunlight.
Environmental science and pollution research international.
2018 Dec; 25(35):34995-35007. doi:
10.1007/s11356-018-1716-9. [PMID: 29558788] - Anika Engel, Thorsten Buhrke, Francine Imber, Sönke Jessel, Albrecht Seidel, Wolfgang Völkel, Alfonso Lampen. Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR.
Toxicology letters.
2017 Aug; 277(?):54-63. doi:
10.1016/j.toxlet.2017.05.028. [PMID: 28571686] - Leon Earl Gray, Johnathan Furr, Katoria R Tatum-Gibbs, Christy Lambright, Hunter Sampson, Bethany R Hannas, Vickie S Wilson, Andrew Hotchkiss, Paul M D Foster. Establishing the "Biological Relevance" of Dipentyl Phthalate Reductions in Fetal Rat Testosterone Production and Plasma and Testis Testosterone Levels.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 Jan; 149(1):178-91. doi:
10.1093/toxsci/kfv224. [PMID: 26454885] - Yanling Chen, David H Reese. Disruption of Retinol (Vitamin A) Signaling by Phthalate Esters: SAR and Mechanism Studies.
PloS one.
2016; 11(8):e0161167. doi:
10.1371/journal.pone.0161167. [PMID: 27532513] - Manori J Silva, Johnathan Furr, Ella Samandar, James L Preau, L Earl Gray, Larry L Needham, Antonia M Calafat. Urinary and serum metabolites of di-n-pentyl phthalate in rats.
Chemosphere.
2011 Jan; 82(3):431-6. doi:
10.1016/j.chemosphere.2010.09.052. [PMID: 20951405] - Kejun Liu, Kim P Lehmann, Madhabananda Sar, S Stanley Young, Kevin W Gaido. Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis.
Biology of reproduction.
2005 Jul; 73(1):180-92. doi:
10.1095/biolreprod.104.039404. [PMID: 15728792] - NULL. Reproductive toxicology. Di-n-pentylphthalate.
Environmental health perspectives.
1997 Feb; 105 Suppl 1(?):255-6. doi:
NULL. [PMID: 9114312] - N P Moore, D M Creasy, T J Gray, J A Timbrell. Urinary creatine profiles after administration of cell-specific testicular toxicants to the rat.
Archives of toxicology.
1992; 66(6):435-42. doi:
10.1007/bf02035135. [PMID: 1332651] - P Lindström, M Harris, M Ross, J C Lamb, R E Chapin. Comparison of changes in serum androgen binding protein with germinal epithelial damage and infertility induced by di-n-pentyl phthalate.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1988 Oct; 11(3):528-39. doi:
10.1016/0272-0590(88)90117-0. [PMID: 3220221] - D M Creasy, L M Beech, T J Gray, W H Butler. The ultrastructural effects of di-n-pentyl phthalate on the testis of the mature rat.
Experimental and molecular pathology.
1987 Jun; 46(3):357-71. doi:
10.1016/0014-4800(87)90056-6. [PMID: 3595805]
