Anandamide (BioDeep_00001871795)
Main id: BioDeep_00000002570
PANOMIX_OTCML-2023
代谢物信息卡片
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine
化学式: C22H37NO2 (347.2824)
中文名称: 花生四烯酰乙醇胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(NCCO)(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
描述信息
An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:2700
- KEGG: C11695
- PubChem: 5281969
- ChEMBL: CHEMBL15848
- LipidMAPS: LMFA08040001
- CAS: 924894-98-4
- CAS: 94421-68-8
- MetaboLights: MTBLC2700
- PubChem: 13860
- PDB-CCD: E7Y
- 3DMET: B04313
- NIKKAJI: J535.861B
- RefMet: Arachidonoyl-EA
- KNApSAcK: 2700
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Matthew P O'Donohue, Khalisa Amir Hamzah, David Nichols, Luke J Ney. Trauma film viewing and intrusive memories: Relationship between salivary alpha amylase, endocannabinoids, and cortisol.
Psychoneuroendocrinology.
2024 Jun; 164(?):107007. doi:
10.1016/j.psyneuen.2024.107007. [PMID: 38503195] - Oscar David Lopez-Cortes, Francisco Trujillo-Sánchez, Erika Sierra-Ruelas, Erika Martinez-Lopez, Vincenzo Di Marzo, Barbara Vizmanos. Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.
International journal of obesity (2005).
2024 Feb; 48(2):188-201. doi:
10.1038/s41366-023-01428-9. [PMID: 38114812] - Katarzyna Stachowicz. Deciphering the mechanisms of reciprocal regulation or interdependence at the cannabinoid CB1 receptors and cyclooxygenase-2 level: Effects on mood, cognitive implications, and synaptic signaling.
Neuroscience and biobehavioral reviews.
2023 Oct; ?(?):105439. doi:
10.1016/j.neubiorev.2023.105439. [PMID: 37898448] - Besma Boubertakh, Olivier Courtemanche, David Marsolais, Vincenzo Di Marzo, Cristoforo Silvestri. New role for the anandamide metabolite prostaglandin F2α ethanolamide: Rolling preadipocyte proliferation.
Journal of lipid research.
2023 Sep; ?(?):100444. doi:
10.1016/j.jlr.2023.100444. [PMID: 37730163] - Jessica Schwerdtfeger, Helga Sauerwein, Elke Albrecht, Gemma Mazzuoli-Weber, Dirk von Soosten, Sven Dänicke, Björn Kuhla. The effect of N-arachidonoylethanolamide administration on energy and fat metabolism of early lactating dairy cows.
Scientific reports.
2023 09; 13(1):14665. doi:
10.1038/s41598-023-41938-0. [PMID: 37673919] - Emmanuel Bäckryd, Andreas Themistocleous, Niclas Stensson, Andrew S C Rice, Solomon Tesfaye, David L Bennett, Björn Gerdle, Bijar Ghafouri. Serum levels of endocannabinoids and related lipids in painful vs painless diabetic neuropathy: results from the Pain in Neuropathy Study.
Pain.
2023 Aug; ?(?):. doi:
10.1097/j.pain.0000000000003015. [PMID: 37578507] - Adrien Paquot, Juan Bestard-Escalas, Giulio G Muccioli. Set up and validation of a sensitive method to quantify prostaglandins, prostaglandin-glycerol esters and prostaglandin-ethanolamides, as well as their respective precursors.
Prostaglandins & other lipid mediators.
2023 Jun; ?(?):106763. doi:
10.1016/j.prostaglandins.2023.106763. [PMID: 37391027] - Guanghui Tang, Ying-Jie Lim, Wei Wang, Zi Ye, Chong-Jing Zhang, Shao Q Yao. Orthogonal Strategies for Profiling Potential Cellular Targets of Anandamide and Cannabidiol.
Chemistry (Weinheim an der Bergstrasse, Germany).
2023 Jun; ?(?):e202300682. doi:
10.1002/chem.202300682. [PMID: 37265377] - Mauro Maccarrone, Vincenzo Di Marzo, Juerg Gertsch, Uwe Grether, Allyn C Howlett, Tian Hua, Alexandros Makriyannis, Daniele Piomelli, Natsuo Ueda, Mario van der Stelt. Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years.
Pharmacological reviews.
2023 May; ?(?):. doi:
10.1124/pharmrev.122.000600. [PMID: 37164640] - Anastasia Levichev, Serge Faumont, Rachel Z Berner, Zhifeng Purcell, Amanda M White, Kathy Chicas-Cruz, Shawn R Lockery. The conserved endocannabinoid anandamide modulates olfactory sensitivity to induce hedonic feeding in C. elegans.
Current biology : CB.
2023 Apr; ?(?):. doi:
10.1016/j.cub.2023.03.013. [PMID: 37084730] - Goldie Wolfson, Ronit Vogt Sionov, Reem Smoum, Maya Korem, Itzhack Polacheck, Doron Steinberg. Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the Cariogenic Streptococcus mutans.
International journal of molecular sciences.
2023 Mar; 24(7):. doi:
10.3390/ijms24076177. [PMID: 37047147] - Nuha Anajirih, Saoirse E O'Sullivan, Stephen Ph Alexander. Endocannabinoid hydrolases differentially distribute in platelets and red blood cells and are differentially released by thrombin.
Prostaglandins & other lipid mediators.
2023 Feb; 164(?):106692. doi:
10.1016/j.prostaglandins.2022.106692. [PMID: 36372184] - Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju. MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer.
Cell death & disease.
2023 01; 14(1):62. doi:
10.1038/s41419-023-05584-8. [PMID: 36702852] - Raphael Mechoulam. A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology.
Annual review of pharmacology and toxicology.
2023 Jan; 63(?):1-13. doi:
10.1146/annurev-pharmtox-051921-083709. [PMID: 35850522] - Alzbeta Svobodova, Vladimir Vrkoslav, Ingrida Smeringaiova, Katerina Jirsova. Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.
PloS one.
2023; 18(1):e0279863. doi:
10.1371/journal.pone.0279863. [PMID: 36638082] - Elliot D Mock, Berend Gagestein, Mario van der Stelt. Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities.
Progress in lipid research.
2023 01; 89(?):101194. doi:
10.1016/j.plipres.2022.101194. [PMID: 36150527] - Faizy Ahmed, Alexa Torrens, Stephen V Mahler, Francesca Ferlenghi, Marilyn A Huestis, Daniele Piomelli. A Sensitive Ultrahigh-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Analysis of Phytocannabinoids and Endocannabinoids in Plasma and Brain.
Cannabis and cannabinoid research.
2022 Nov; ?(?):. doi:
10.1089/can.2022.0216. [PMID: 36367975] - Wahid Zada, Jonathan W VanRyzin, Miguel Perez-Pouchoulen, Samantha L Baglot, Matthew N Hill, Ghulam Abbas, Sarah M Clark, Umer Rashid, Margaret M McCarthy, Abdul Mannan. Fatty acid amide hydrolase inhibition and N-arachidonoylethanolamine modulation by isoflavonoids: A novel target for upcoming antidepressants.
Pharmacology research & perspectives.
2022 10; 10(5):e00999. doi:
10.1002/prp2.999. [PMID: 36029006] - Berend Gagestein, Anna F Stevens, Domenico Fazio, Bogdan I Florea, Tom van der Wel, Alexander T Bakker, Filomena Fezza, Hans den Dulk, Herman S Overkleeft, Mauro Maccarrone, Mario van der Stelt. Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437.
ACS chemical biology.
2022 05; 17(5):1174-1183. doi:
10.1021/acschembio.2c00122. [PMID: 35482948] - Sepideh Khaksar, Mona Salimi, Hadi Zeinoddini, Nima Naderi. The Role of the Possible Receptors and Intracellular Pathways in Protective Effect of Exogenous Anandamide in Kindling Model of Epilepsy.
Neurochemical research.
2022 May; 47(5):1226-1242. doi:
10.1007/s11064-021-03517-5. [PMID: 35112235] - Patricia Rivera, Santiago Guerra-Cantera, Antonio Vargas, Francisca Díaz, Rocío García-Úbeda, Rubén Tovar, María Teresa Ramírez-López, Jesús Argente, Fernando Rodríguez de Fonseca, Juan Suárez, Julie A Chowen. Maternal hypercaloric diet affects factors involved in lipid metabolism and the endogenous cannabinoid systems in the hypothalamus of adult offspring: sex-specific response of astrocytes to palmitic acid and anandamide.
Nutritional neuroscience.
2022 May; 25(5):931-944. doi:
10.1080/1028415x.2020.1821519. [PMID: 32954972] - Sherif S Abdel Mageed, Ramy M Ammar, Noha N Nassar, Helmy Moawad, Ahmed S Kamel. Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat.
Neuropharmacology.
2022 04; 207(?):108935. doi:
10.1016/j.neuropharm.2021.108935. [PMID: 34968475] - Stacey Herriage, Guangping Chen, Carey Pope. Concentration-dependent effects of chlorpyrifos oxon on peroxisome proliferator-activated receptor signaling in MCF-7 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Feb; 78(?):105268. doi:
10.1016/j.tiv.2021.105268. [PMID: 34756920] - Chanté Muller, Diane L Lynch, Dow P Hurst, Patricia H Reggio. TRPV1 Activation by Anandamide via a Unique Lipid Pathway.
Journal of chemical information and modeling.
2021 12; 61(12):5742-5746. doi:
10.1021/acs.jcim.1c00893. [PMID: 34780173] - Ahmed Ramadan, Asmaa R Khalaf, Ahmed El Ray, Yasmin Saad. Serum anandamide level as a potential indicator for nonalcoholic fatty liver disease severity.
European journal of gastroenterology & hepatology.
2021 12; 33(1S Suppl 1):e363-e367. doi:
10.1097/meg.0000000000002092. [PMID: 33731590] - Isabel van Ackern, Angela Kuhla, Björn Kuhla. A Role for Peripheral Anandamide and 2-Arachidonoylglycerol in Short-Term Food Intake and Orexigenic Hypothalamic Responses in a Species with Continuous Nutrient Delivery.
Nutrients.
2021 Oct; 13(10):. doi:
10.3390/nu13103587. [PMID: 34684588] - Kunming Tao, Jiao Zhu, Kai Wei, Xiaoyan Meng, Mei Zhu, Yong Tao, Zhijie Lu, Weifeng Yu. Cannabinoid Receptor-2 Activation in Keratinocytes Contributes to Elevated Peripheral β-Endorphin Levels in Patients With Obstructive Jaundice.
Anesthesia and analgesia.
2021 07; 133(1):251-262. doi:
10.1213/ane.0000000000005405. [PMID: 33560661] - M Gaisberger, J Fuchs, M Riedl, S Edtinger, R Reischl, G Grasmann, B Hölzl, F Landauer, H Dobias, F Eckstein, M Offenbächer, M Ritter, M Winklmayr. Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study.
International journal of biometeorology.
2021 Jul; 65(7):1151-1160. doi:
10.1007/s00484-021-02095-z. [PMID: 33649972] - Karla Johanna Ruth Hoyer-Allo, Martin Richard Späth, Ruth Hanssen, Marc Johnsen, Susanne Brodesser, Kathrin Kaufmann, Katharina Kiefer, Felix Carlo Koehler, Heike Göbel, Torsten Kubacki, Franziska Grundmann, Bernhard Schermer, Jens Brüning, Thomas Benzing, Volker Burst, Roman-Ulrich Müller. Modulation of Endocannabinoids by Caloric Restriction Is Conserved in Mice but Is Not Required for Protection from Acute Kidney Injury.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115485. [PMID: 34067475] - Carolin Redlich, Andrea Dlugos, Matthew Nicholas Hill, Sachin Patel, Dominika Korn, Verena Enneking, Katharina Foerster, Volker Arolt, Katharina Domschke, Udo Dannlowski, Ronny Redlich. The endocannabinoid system in humans: significant associations between anandamide, brain function during reward feedback and a personality measure of reward dependence.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2021 04; 46(5):1020-1027. doi:
10.1038/s41386-020-00870-x. [PMID: 33007775] - Virna Margarita Martín Giménez, Feres José Mocayar Marón, Sebastián García, Luciana Mazzei, Manuel Guevara, Roberto Yunes, Walter Manucha. Central nervous system, peripheral and hemodynamic effects of nanoformulated anandamide in hypertension.
Advances in medical sciences.
2021 Mar; 66(1):72-80. doi:
10.1016/j.advms.2020.12.003. [PMID: 33388673] - Jianzheng He, Alice Mei Xien Tan, Si Yun Ng, Menglong Rui, Fengwei Yu. Cannabinoids modulate food preference and consumption in Drosophila melanogaster.
Scientific reports.
2021 02; 11(1):4709. doi:
10.1038/s41598-021-84180-2. [PMID: 33633260] - Simone Grasso, Marco Santonico, Giorgio Pennazza, Alessandro Zompanti, Alessandra Piccoli, Tiziana Bisogno, Mauro Maccarrone. BIONOTE as an Innovative Biosensor for Measuring Endocannabinoid Levels.
Sensors (Basel, Switzerland).
2021 Jan; 21(2):. doi:
10.3390/s21020489. [PMID: 33445599] - Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall. Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):1-11. doi:
10.1124/jpet.120.000163. [PMID: 33087396] - Gregory T Carter, Ryan J McLaughlin, Carrie Cuttler, Garrett J Sauber, Douglas L Weeks, Cecilia J Hillard, Michael D Weiss. Endocannabinoids and related lipids in serum from patients with amyotrophic lateral sclerosis.
Muscle & nerve.
2021 01; 63(1):120-126. doi:
10.1002/mus.27096. [PMID: 33094490] - Mohammad Bashashati, Emma Leishman, Heather Bradshaw, Solmaz Sigaroodi, Eric Tatro, Tamis Bright, Richard McCallum, Irene Sarosiek. Plasma endocannabinoids and cannabimimetic fatty acid derivatives are altered in gastroparesis: A sex- and subtype-dependent observation.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2021 01; 33(1):e13961. doi:
10.1111/nmo.13961. [PMID: 32779297] - Karl Kevala, Michel Lagarde, Arthur A Spector, Hee-Yong Kim. Biosynthesis of N-Docosahexanoylethanolamine from Unesterified Docosahexaenoic Acid and Docosahexaenoyl-Lysophosphatidylcholine in Neuronal Cells.
International journal of molecular sciences.
2020 Nov; 21(22):. doi:
10.3390/ijms21228768. [PMID: 33233525] - Katharina Klatt-Schreiner, Lucie Valek, Jun-Suk Kang, Alexander Khlebtovsky, Sandra Trautmann, Lisa Hahnefeld, Yannick Schreiber, Robert Gurke, Dominique Thomas, Annett Wilken-Schmitz, Sabine Wicker, Georg Auburger, Gerd Geisslinger, Jörn Lötsch, Waltraud Pfeilschifter, Ruth Djaldetti, Irmgard Tegeder. High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society.
2020 10; 35(10):1822-1833. doi:
10.1002/mds.28186. [PMID: 32652698] - Elisabeth J Harfmann, Timothy L McAuliffe, Eric R Larson, Stacy A Claesges, Garrett Sauber, Cecilia J Hillard, Joseph S Goveas. Circulating endocannabinoid concentrations in grieving adults.
Psychoneuroendocrinology.
2020 10; 120(?):104801. doi:
10.1016/j.psyneuen.2020.104801. [PMID: 32682172] - Sophie Castonguay-Paradis, Sébastien Lacroix, Gabrielle Rochefort, Lydiane Parent, Julie Perron, Cyril Martin, Benoît Lamarche, Frédéric Raymond, Nicolas Flamand, Vincenzo Di Marzo, Alain Veilleux. Dietary fatty acid intake and gut microbiota determine circulating endocannabinoidome signaling beyond the effect of body fat.
Scientific reports.
2020 09; 10(1):15975. doi:
10.1038/s41598-020-72861-3. [PMID: 32994521] - Valentina Notarstefano, Giorgia Gioacchini, Elisabetta Giorgini, Nina Montik, Andrea Ciavattini, Anna Rita Polidori, Fulvia Antonia Candela, Lisa Vaccari, Maurizio Cignitti, Oliana Carnevali. The Impact of Controlled Ovarian Stimulation Hormones on the Metabolic State and Endocannabinoid System of Human Cumulus Cells.
International journal of molecular sciences.
2020 Sep; 21(19):. doi:
10.3390/ijms21197124. [PMID: 32992491] - Aruna Kilaru, Kent D Chapman. The endocannabinoid system.
Essays in biochemistry.
2020 09; 64(3):485-499. doi:
10.1042/ebc20190086. [PMID: 32648908] - E Appiah-Kusi, R Wilson, M Colizzi, E Foglia, E Klamerus, A Caldwell, M G Bossong, P McGuire, S Bhattacharyya. Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids.
Psychological medicine.
2020 08; 50(11):1862-1871. doi:
10.1017/s0033291719001946. [PMID: 31422779] - Fatemeh Haidari, Vahideh Aghamohammadi, Majid Mohammadshahi, Kambiz Ahmadi-Angali, Mohammad Asghari-Jafarabadi. Whey protein supplementation reducing fasting levels of anandamide and 2-AG without weight loss in pre-menopausal women with obesity on a weight-loss diet.
Trials.
2020 Jul; 21(1):657. doi:
10.1186/s13063-020-04586-7. [PMID: 32680548] - Michał Biernacki, Marta Baranowska-Kuczko, Gabriella N Niklińska, Elżbieta Skrzydlewska. The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension.
Biomolecules.
2020 07; 10(7):. doi:
10.3390/biom10071022. [PMID: 32664225] - Inês B Correia-Sá, Cláudia M Carvalho, Paula V Serrão, Ana I Loureiro, Carlos Fernandes-Lopes, Marisa Marques, Maria A Vieira-Coelho. A new role for anandamide: defective link between the systemic and skin endocannabinoid systems in hypertrophic human wound healing.
Scientific reports.
2020 07; 10(1):11134. doi:
10.1038/s41598-020-68058-3. [PMID: 32636441] - Niclas Stensson, Björn Gerdle, Malin Ernberg, Kaisa Mannerkorpi, Eva Kosek, Bijar Ghafouri. Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia.
Medicine and science in sports and exercise.
2020 07; 52(7):1617-1628. doi:
10.1249/mss.0000000000002293. [PMID: 32168104] - Mathijs Drummen, Lea Tischmann, Blandine Gatta-Cherifi, Daniela Cota, Isabelle Matias, Anne Raben, Tanja Adam, Margriet Westerterp-Plantenga. Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.
The Journal of clinical endocrinology and metabolism.
2020 07; 105(7):. doi:
10.1210/clinem/dgaa193. [PMID: 32333763] - Lea Tischmann, Mathijs Drummen, Peter J Joris, Blandine Gatta-Cherifi, Anne Raben, Mikael Fogelholm, Isabelle Matias, Daniela Cota, Ronald P Mensink, Margriet S Westerterp-Plantenga, Tanja C Adam. Effects of a High-Protein Diet on Cardiometabolic Health, Vascular Function, and Endocannabinoids-A PREVIEW Study.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051512. [PMID: 32455987] - Dorian Forte, Flaminia Fanelli, Marco Mezzullo, Martina Barone, Giulia Corradi, Giuseppe Auteri, Daniela Bartoletti, Marina Martello, Emanuela Ottaviani, Carolina Terragna, Antonio Curti, Uberto Pagotto, Francesca Palandri, Michele Cavo, Lucia Catani. Disease-Specific Derangement of Circulating Endocannabinoids and N-Acylethanolamines in Myeloproliferative Neoplasms.
International journal of molecular sciences.
2020 May; 21(9):. doi:
10.3390/ijms21093399. [PMID: 32403407] - Beatrice Pflüger-Müller, James A Oo, Jan Heering, Timothy Warwick, Ewgenij Proschak, Stefan Günther, Mario Looso, Flávia Rezende, Christian Fork, Gerd Geisslinger, Dominique Thomas, Robert Gurke, Dieter Steinhilber, Marcel Schulz, Matthias S Leisegang, Ralf P Brandes. The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells.
Basic research in cardiology.
2020 04; 115(3):34. doi:
10.1007/s00395-020-0793-3. [PMID: 32323032] - Hassendrini N Peiris, Kanchan Vaswani, Olivia Holland, Yong Qin Koh, Fatema B Almughlliq, Sarah Reed, Murray D Mitchell. Altered productions of prostaglandins and prostamides by human amnion in response to infectious and inflammatory stimuli identified by mutliplex mass spectrometry.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 03; 154(?):102059. doi:
10.1016/j.plefa.2020.102059. [PMID: 32014738] - Luca Carnevali, Rosario Statello, Federica Vacondio, Francesca Ferlenghi, Gilberto Spadoni, Silvia Rivara, Marco Mor, Andrea Sgoifo. Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2020 03; 32(?):77-87. doi:
10.1016/j.euroneuro.2019.12.119. [PMID: 31948828] - József Haller, Laszlo Krecsak, János Zámbori. Double-blind placebo controlled trial of the anxiolytic effects of a standardized Echinacea extract.
Phytotherapy research : PTR.
2020 Mar; 34(3):660-668. doi:
10.1002/ptr.6558. [PMID: 31876052] - B M Fonseca, S C Cunha, D Gonçalves, A Mendes, J Braga, G Correia-da-Silva, N A Teixeira. Decidual NK cell-derived conditioned medium from miscarriages affects endometrial stromal cell decidualisation: endocannabinoid anandamide and tumour necrosis factor-α crosstalk.
Human reproduction (Oxford, England).
2020 02; 35(2):265-274. doi:
10.1093/humrep/dez260. [PMID: 31990346] - Patryk Remiszewski, Iwona Jarocka-Karpowicz, Michał Biernacki, Anna Jastrząb, Eberhard Schlicker, Marek Toczek, Ewa Harasim-Symbor, Anna Pędzińska-Betiuk, Barbara Malinowska. Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism.
International journal of molecular sciences.
2020 Feb; 21(4):. doi:
10.3390/ijms21041295. [PMID: 32075117] - Gianfranca Carta, Elisabetta Murru, Romina Vargiu, Maria Collu, Manolo Carta, Sebastiano Banni, Roberto Stancampiano. Essential fatty acids deficient diet modulates N-Acylethanolamide profile in rat's tissues.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 02; 153(?):102053. doi:
10.1016/j.plefa.2020.102053. [PMID: 31978675] - Pal Pacher, Natalya M Kogan, Raphael Mechoulam. Beyond THC and Endocannabinoids.
Annual review of pharmacology and toxicology.
2020 01; 60(?):637-659. doi:
10.1146/annurev-pharmtox-010818-021441. [PMID: 31580774] - Björn Kuhla, Volkhard Kaever, Armin Tuchscherer, Angela Kuhla. Involvement of Plasma Endocannabinoids and the Hypothalamic Endocannabinoid System in Increasing Feed Intake after Parturition of Dairy Cows.
Neuroendocrinology.
2020; 110(3-4):246-257. doi:
10.1159/000501208. [PMID: 31141804] - Erin C Hanlon. Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide).
Psychoneuroendocrinology.
2020 01; 111(?):104471. doi:
10.1016/j.psyneuen.2019.104471. [PMID: 31610409] - Hamid Moradi, Christina Park, Elani Streja, Donovan A Argueta, Nicholas V DiPatrizio, Amy S You, Connie M Rhee, Nosratola D Vaziri, Kamyar Kalantar-Zadeh, Daniele Piomelli. Circulating Endocannabinoids and Mortality in Hemodialysis Patients.
American journal of nephrology.
2020; 51(2):86-95. doi:
10.1159/000505444. [PMID: 31935741] - Vinicius R Acquaro Junior, Germán Augusto Goméz-Ríos, Marcos Tascon, Maria Eugênia Costa Queiroz, Janusz Pawliszyn. Analysis of endocannabinoids in plasma samples by biocompatible solid-phase microextraction devices coupled to mass spectrometry.
Analytica chimica acta.
2019 Dec; 1091(?):135-145. doi:
10.1016/j.aca.2019.09.002. [PMID: 31679567] - Natalia Battista, Monica Bari, Tiziana Bisogno. N-Acyl Amino Acids: Metabolism, Molecular Targets, and Role in Biological Processes.
Biomolecules.
2019 12; 9(12):. doi:
10.3390/biom9120822. [PMID: 31817019] - P Bachkangi, A H Taylor, Monica Bari, Mauro Maccarrone, Justin C Konje. Prediction of preterm labour from a single blood test: The role of the endocannabinoid system in predicting preterm birth in high-risk women.
European journal of obstetrics, gynecology, and reproductive biology.
2019 Dec; 243(?):1-6. doi:
10.1016/j.ejogrb.2019.09.029. [PMID: 31618675] - Stefano Vanni, Laura Riccardi, Giulia Palermo, Marco De Vivo. Structure and Dynamics of the Acyl Chains in the Membrane Trafficking and Enzymatic Processing of Lipids.
Accounts of chemical research.
2019 11; 52(11):3087-3096. doi:
10.1021/acs.accounts.9b00134. [PMID: 31364837] - R Gurke, D Thomas, Y Schreiber, S M G Schäfer, S C Fleck, G Geisslinger, N Ferreirós. Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics.
Talanta.
2019 Nov; 204(?):386-394. doi:
10.1016/j.talanta.2019.06.004. [PMID: 31357310] - Alessia Santori, Paola Colucci, Giulia Federica Mancini, Maria Morena, Maura Palmery, Viviana Trezza, Stefano Puglisi-Allegra, Matthew N Hill, Patrizia Campolongo. Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory.
Psychoneuroendocrinology.
2019 10; 108(?):155-162. doi:
10.1016/j.psyneuen.2019.06.018. [PMID: 31302498] - Gautam Mahajan, Moo-Yeal Lee, Chandrasekhar Kothapalli. Biophysical and biomechanical properties of neural progenitor cells as indicators of developmental neurotoxicity.
Archives of toxicology.
2019 10; 93(10):2979-2992. doi:
10.1007/s00204-019-02549-9. [PMID: 31428840] - Ruben Bartholomäus, Simon Nicolussi, Alice Baumann, Mark Rau, Ana Catarina Simão, Jürg Gertsch, Karl-Heinz Altmann. Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies.
ChemMedChem.
2019 09; 14(17):1590-1596. doi:
10.1002/cmdc.201900390. [PMID: 31322825] - Jacob D Meyer, Kevin M Crombie, Dane B Cook, Cecilia J Hillard, Kelli F Koltyn. Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder.
Medicine and science in sports and exercise.
2019 09; 51(9):1909-1917. doi:
10.1249/mss.0000000000002006. [PMID: 30973483] - Cristina Miralpeix, Anna Fosch, Josefina Casas, Miguel Baena, Laura Herrero, Dolors Serra, Rosalía Rodríguez-Rodríguez, Núria Casals. Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice.
Journal of lipid research.
2019 07; 60(7):1260-1269. doi:
10.1194/jlr.m092742. [PMID: 31138606] - Amit Kumar, Marika Premoli, Francesca Aria, Sara Anna Bonini, Giuseppina Maccarinelli, Alessandra Gianoncelli, Maurizio Memo, Andrea Mastinu. Cannabimimetic plants: are they new cannabinoidergic modulators?.
Planta.
2019 Jun; 249(6):1681-1694. doi:
10.1007/s00425-019-03138-x. [PMID: 30877436] - Pablo Romero-Sanchiz, Raquel Nogueira-Arjona, Antoni Pastor, Pedro Araos, Antonia Serrano, Anna Boronat, Nuria Garcia-Marchena, Fermin Mayoral, Antonio Bordallo, Francisco Alen, Juan Suárez, Rafael de la Torre, Francisco J Pavón, Fernando Rodríguez de Fonseca. Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants.
Neuropharmacology.
2019 05; 149(?):212-220. doi:
10.1016/j.neuropharm.2019.02.026. [PMID: 30822499] - Alexandra Schumann-Gillett, Megan L O'Mara. Lipid-Based Inhibitors Act Directly on GlyT2.
ACS chemical neuroscience.
2019 03; 10(3):1668-1678. doi:
10.1021/acschemneuro.8b00586. [PMID: 30516373] - Arão Belitardo de Oliveira, Marco Tulio de Mello, Serio Tufik, Mario Fernando Prieto Peres. Weight loss and improved mood after aerobic exercise training are linked to lower plasma anandamide in healthy people.
Physiology & behavior.
2019 03; 201(?):191-197. doi:
10.1016/j.physbeh.2018.12.018. [PMID: 30578894] - J D Pressly, H Soni, S Jiang, J Wei, R Liu, B M Moore, A Adebiyi, F Park. Activation of the cannabinoid receptor 2 increases renal perfusion.
Physiological genomics.
2019 03; 51(3):90-96. doi:
10.1152/physiolgenomics.00001.2019. [PMID: 30707046] - Maria Scherma, Paolo Masia, Valentina Satta, Walter Fratta, Paola Fadda, Gianluigi Tanda. Brain activity of anandamide: a rewarding bliss?.
Acta pharmacologica Sinica.
2019 Mar; 40(3):309-323. doi:
10.1038/s41401-018-0075-x. [PMID: 30050084] - John T Szilagyi, Gabriella M Composto-Wahler, Laurie B Joseph, Bingbing Wang, Todd Rosen, Jeffrey D Laskin, Lauren M Aleksunes. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis.
Pharmacological research.
2019 03; 141(?):331-342. doi:
10.1016/j.phrs.2019.01.002. [PMID: 30610963] - Magdalena Grill, Christoph Högenauer, Andreas Blesl, Johannes Haybaeck, Nicole Golob-Schwarzl, Nerea Ferreirós, Dominique Thomas, Robert Gurke, Martin Trötzmüller, Harald C Köfeler, Birgit Gallé, Rudolf Schicho. Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer.
Scientific reports.
2019 02; 9(1):2358. doi:
10.1038/s41598-019-38865-4. [PMID: 30787385] - Dagmar Koethe, Franziska Pahlisch, Martin Hellmich, Cathrin Rohleder, Juliane K Mueller, Andreas Meyer-Lindenberg, E Fuller Torrey, Daniele Piomelli, F Markus Leweke. Familial abnormalities of endocannabinoid signaling in schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2019 02; 20(2):117-125. doi:
10.1080/15622975.2018.1449966. [PMID: 29521179] - Gabriela Aguilera-Portillo, Edgar Rangel-López, Juana Villeda-Hernández, Anahí Chavarría, Pilar Castellanos, Zubeyir Elmazoglu, Çimen Karasu, Isaac Túnez, Gibrán Pedraza, Mina Königsberg, Abel Santamaría. The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation.
Molecular neurobiology.
2019 Feb; 56(2):844-856. doi:
10.1007/s12035-018-1129-2. [PMID: 29802570] - Laura Kind, Petri Kursula. Structural properties and role of the endocannabinoid lipases ABHD6 and ABHD12 in lipid signalling and disease.
Amino acids.
2019 Feb; 51(2):151-174. doi:
10.1007/s00726-018-2682-8. [PMID: 30564946] - Juan A Páez, Nuria E Campillo. Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases.
Current medicinal chemistry.
2019; 26(18):3300-3340. doi:
10.2174/0929867325666180226095132. [PMID: 29484980] - Dipanjan Chanda, Dietbert Neumann, Jan F C Glatz. The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target.
Prostaglandins, leukotrienes, and essential fatty acids.
2019 01; 140(?):51-56. doi:
10.1016/j.plefa.2018.11.016. [PMID: 30553404] - Caitlin A D Jagla, Caitlin E Scott, Yaliang Tang, Changjiang Qiao, Gabriel E Mateo-Semidey, Guillermo A Yudowski, Dai Lu, Debra A Kendall. Pyrimidinyl Biphenylureas Act as Allosteric Modulators to Activate Cannabinoid Receptor 1 and Initiate β-Arrestin-Dependent Responses.
Molecular pharmacology.
2019 01; 95(1):1-10. doi:
10.1124/mol.118.112854. [PMID: 30322873] - Anne Lise Ferrara, Fabiana Piscitelli, Angelica Petraroli, Roberta Parente, Maria Rosaria Galdiero, Gilda Varricchi, Giancarlo Marone, Massimo Triggiani, Vincenzo Di Marzo, Stefania Loffredo. Altered Metabolism of Phospholipases, Diacylglycerols, Endocannabinoids, and N-Acylethanolamines in Patients with Mastocytosis.
Journal of immunology research.
2019; 2019(?):5836476. doi:
10.1155/2019/5836476. [PMID: 31355297] - Huan Huang, Avery L McIntosh, Gregory G Martin, Lawrence J Dangott, Ann B Kier, Friedhelm Schroeder. Structural and Functional Interaction of Δ9-Tetrahydrocannabinol with Liver Fatty Acid Binding Protein (FABP1).
Biochemistry.
2018 10; 57(41):6027-6042. doi:
10.1021/acs.biochem.8b00744. [PMID: 30232874] - Ashfaq Ahmad, Sara K Dempsey, Zdravka Daneva, Ningjun Li, Justin L Poklis, Pin-Lan Li, Joseph K Ritter. Modulation of mean arterial pressure and diuresis by renomedullary infusion of a selective inhibitor of fatty acid amide hydrolase.
American journal of physiology. Renal physiology.
2018 10; 315(4):F967-F976. doi:
10.1152/ajprenal.00090.2018. [PMID: 29846106] - Isabel Forner-Piquer, Stefania Santangeli, Francesca Maradonna, Alessandro Rabbito, Fabiana Piscitelli, Hamid R Habibi, Vincenzo Di Marzo, Oliana Carnevali. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate.
Environmental pollution (Barking, Essex : 1987).
2018 Oct; 241(?):1-8. doi:
10.1016/j.envpol.2018.05.007. [PMID: 29793103] - Tanya J Little, Nada Cvijanovic, Nicholas V DiPatrizio, Donovan A Argueta, Christopher K Rayner, Christine Feinle-Bisset, Richard L Young. Plasma endocannabinoid levels in lean, overweight, and obese humans: relationships to intestinal permeability markers, inflammation, and incretin secretion.
American journal of physiology. Endocrinology and metabolism.
2018 10; 315(4):E489-E495. doi:
10.1152/ajpendo.00355.2017. [PMID: 29438631] - Sascha Heinitz, Alessio Basolo, Daniele Piomelli, Jonathan Krakoff, Paolo Piaggi. Endocannabinoid Anandamide Mediates the Effect of Skeletal Muscle Sphingomyelins on Human Energy Expenditure.
The Journal of clinical endocrinology and metabolism.
2018 10; 103(10):3757-3766. doi:
10.1210/jc.2018-00780. [PMID: 30113648] - Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewska. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma.
Prostaglandins & other lipid mediators.
2018 09; 138(?):54-63. doi:
10.1016/j.prostaglandins.2018.09.001. [PMID: 30201316] - Katja Wingenfeld, Lucia Dettenborn, Clemens Kirschbaum, Wei Gao, Christian Otte, Stefan Roepke. Reduced levels of the endocannabinoid arachidonylethanolamide (AEA) in hair in patients with borderline personality disorder - a pilot study.
Stress (Amsterdam, Netherlands).
2018 07; 21(4):366-369. doi:
10.1080/10253890.2018.1451837. [PMID: 29546791] - Avery L McIntosh, Huan Huang, Danilo Landrock, Gregory G Martin, Shengrong Li, Ann B Kier, Friedhelm Schroeder. Impact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse Hepatocytes.
Lipids.
2018 06; 53(6):561-580. doi:
10.1002/lipd.12071. [PMID: 30203570] - Lisa E Flannery, Rebecca J Henry, Daniel M Kerr, David P Finn, Michelle Roche. FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex.
Journal of neuroscience research.
2018 06; 96(6):989-1001. doi:
10.1002/jnr.24120. [PMID: 28726298] - Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J Barrantes, Henri Chahinian. Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter.
Biomolecules.
2018 05; 8(2):. doi:
10.3390/biom8020031. [PMID: 29789479] - Avery L McIntosh, Gregory G Martin, Huan Huang, Danilo Landrock, Ann B Kier, Friedhelm Schroeder. Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation.
Journal of lipid research.
2018 04; 59(4):646-657. doi:
10.1194/jlr.m082644. [PMID: 29414765] - Sascha Heinitz, Alessio Basolo, Paolo Piaggi, Daniele Piomelli, Reiner Jumpertz von Schwartzenberg, Jonathan Krakoff. Peripheral Endocannabinoids Associated With Energy Expenditure in Native Americans of Southwestern Heritage.
The Journal of clinical endocrinology and metabolism.
2018 03; 103(3):1077-1087. doi:
10.1210/jc.2017-02257. [PMID: 29300902] - Sumner H Burstein. N-Acyl Amino Acids (Elmiric Acids): Endogenous Signaling Molecules with Therapeutic Potential.
Molecular pharmacology.
2018 03; 93(3):228-238. doi:
10.1124/mol.117.110841. [PMID: 29138268]
