Diadenosine triphosphate (BioDeep_00001869672)

Main id: BioDeep_00000006087

 

natural product


代谢物信息卡片


Diadenosine triphosphate

化学式: C20H27N10O16P3 (756.0819)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C([C@H]1[C@@H]([C@@H]([C@@H](n2cnc3c(N)ncnc23)O1)O)O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O
InChI: InChI=1S/C20H27N10O16P3/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1

描述信息

同义名列表

2 个代谢物同义名

Diadenosine triphosphate; P1,P3-Bis(5'-adenosyl) triphosphate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 FHIT, ITPR3, KARS1, NT5C2, SPHK1, WARS1
Peripheral membrane protein 2 KARS1, SPHK1
Endosome membrane 1 SPHK1
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 6 FHIT, KARS1, REPIN1, SPHK1, TRIM33, WARS1
cytosol 7 FHIT, KARS1, NT5C2, PRKCQ, REPIN1, SPHK1, WARS1
dendrite 1 P2RY1
nucleoplasm 6 CD2, ITPR3, KARS1, REPIN1, SPHK1, TRIM33
Cell membrane 7 CD2, FCGR3B, KARS1, P2RX1, P2RY1, P2RY2, SPHK1
Early endosome membrane 1 SPHK1
Multi-pass membrane protein 5 ITPR3, KCNA3, P2RX1, P2RY1, P2RY2
Synapse 1 SPHK1
cell surface 2 CD2, P2RY1
glutamatergic synapse 3 KCNA3, P2RX1, P2RY1
Golgi apparatus 1 CD2
Golgi membrane 1 INS
neuronal cell body 1 ITPR3
postsynapse 1 P2RX1
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 2 NT5C2, REPIN1
Presynapse 1 SPHK1
plasma membrane 14 CD2, CSF2, F2, FCGR3B, FHIT, IFNLR1, ITPR3, KARS1, KCNA3, P2RX1, P2RY1, P2RY2, PRKCQ, SPHK1
Membrane 5 IFNLR1, ITPR3, KCNA3, P2RX1, SPHK1
apical plasma membrane 1 P2RY1
axon 1 KCNA3
basolateral plasma membrane 1 P2RY1
brush border 1 ITPR3
extracellular exosome 3 F2, FCGR3B, WARS1
endoplasmic reticulum 1 ITPR3
extracellular space 4 CSF2, F2, INS, KARS1
perinuclear region of cytoplasm 1 KCNA3
mitochondrion 2 FHIT, KARS1
protein-containing complex 3 CD2, P2RX1, WARS1
intracellular membrane-bounded organelle 2 CSF2, SPHK1
postsynaptic density 1 P2RY1
Single-pass type I membrane protein 2 CD2, IFNLR1
Secreted 4 CSF2, F2, INS, KARS1
extracellular region 5 CD2, CSF2, F2, FCGR3B, INS
cytoplasmic side of plasma membrane 1 CD2
Single-pass membrane protein 1 FCGR3B
mitochondrial matrix 2 KARS1, NUDT2
centriolar satellite 1 PRKCQ
nuclear membrane 1 REPIN1
external side of plasma membrane 3 CD2, FCGR3B, P2RX1
nucleolus 1 ITPR3
Membrane, clathrin-coated pit 1 SPHK1
apical part of cell 1 ITPR3
cell-cell junction 1 CD2
clathrin-coated pit 1 SPHK1
postsynaptic membrane 3 KCNA3, P2RX1, P2RY1
presynaptic active zone membrane 2 P2RX1, P2RY1
Membrane raft 2 KCNA3, P2RX1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 F2
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
cilium 1 P2RY1
chromatin 1 TRIM33
Chromosome 1 REPIN1
blood microparticle 1 F2
Lipid-anchor, GPI-anchor 1 FCGR3B
[Isoform 2]: Cell membrane 1 KCNA3
fibrillar center 1 FHIT
endosome lumen 1 INS
specific granule membrane 1 P2RX1
cell body 1 P2RY1
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 INS
secretory granule membrane 3 FCGR3B, ITPR3, P2RX1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 2 F2, INS
endocytic vesicle 1 SPHK1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
platelet dense tubular network membrane 1 ITPR3
[Isoform 1]: Cell membrane 1 KCNA3
aminoacyl-tRNA synthetase multienzyme complex 1 KARS1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
transport vesicle membrane 1 ITPR3
[Isoform Mitochondrial]: Mitochondrion 1 KARS1
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 KARS1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Anita Śliwińska, Marcin R Naliwajski, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek. In Vitro Response of Polyscias filicifolia (Araliaceae) Shoots to Elicitation with Alarmone-Diadenosine Triphosphate, Methyl Jasmonate, and Salicylic Acid. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020419. [PMID: 33671225]
  • Małgorzata Pietrowska-Borek, Łukasz Czekała, Sarai Belchí-Navarro, María Angeles Pedreño, Andrzej Guranowski. Diadenosine triphosphate is a novel factor which in combination with cyclodextrins synergistically enhances the biosynthesis of trans-resveratrol in Vitis vinifera cv. Monastrell suspension cultured cells. Plant physiology and biochemistry : PPB. 2014 Nov; 84(?):271-276. doi: 10.1016/j.plaphy.2014.09.019. [PMID: 25310254]
  • Anna Schulz, Vera Jankowski, Walter Zidek, Joachim Jankowski. Highly sensitive, selective and rapid LC-MS method for simultaneous quantification of diadenosine polyphosphates in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):91-6. doi: 10.1016/j.jchromb.2014.05.018. [PMID: 24869945]
  • David G Watson, Francesca Tonelli, Manal Alossaimi, Leon Williamson, Edmond Chan, Irina Gorshkova, Evgeny Berdyshev, Robert Bittman, Nigel J Pyne, Susan Pyne. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cellular signalling. 2013 Apr; 25(4):1011-7. doi: 10.1016/j.cellsig.2013.01.002. [PMID: 23314175]
  • Ronald A Albright, William C Chang, Donna Robert, Deborah L Ornstein, Wenxiang Cao, Lynn Liu, Meredith E Redick, J Isaac Young, Enrique M De La Cruz, Demetrios T Braddock. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov; 120(22):4432-40. doi: 10.1182/blood-2012-04-425215. [PMID: 22995898]
  • Eva Schepers, Griet Glorieux, Vera Jankowski, Annemieke Dhondt, Joachim Jankowski, Raymond Vanholder. Dinucleoside polyphosphates: newly detected uraemic compounds with an impact on leucocyte oxidative burst. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2010 Aug; 25(8):2636-44. doi: 10.1093/ndt/gfq080. [PMID: 20190246]
  • Kamil Olejnik, Monika W Murcha, James Whelan, Elzbieta Kraszewska. Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates. The FEBS journal. 2007 Sep; 274(18):4877-85. doi: 10.1111/j.1742-4658.2007.06009.x. [PMID: 17824959]
  • Andrzej Guranowski, Otto Miersch, Paul E Staswick, Walter Suza, Claus Wasternack. Substrate specificity and products of side-reactions catalyzed by jasmonate:amino acid synthetase (JAR1). FEBS letters. 2007 Mar; 581(5):815-20. doi: 10.1016/j.febslet.2007.01.049. [PMID: 17291501]
  • Andrea Vecchione, Tommaso Prayer Galetti, Marina Gardiman, Hideshi Ishii, Enrico Giarnieri, Francesco Pagano, Leonard G Gomella, Carlo M Croce, Raffaele Baffa. Collecting duct carcinoma of the kidney: an immunohistochemical study of 11 cases. BMC urology. 2004 Sep; 4(?):11. doi: 10.1186/1471-2490-4-11. [PMID: 15357873]
  • Joachim Jankowski, Vera Jankowski, Udo Laufer, Markus van der Giet, Lars Henning, Martin Tepel, Walter Zidek, Hartmut Schlüter. Identification and quantification of diadenosine polyphosphate concentrations in human plasma. Arteriosclerosis, thrombosis, and vascular biology. 2003 Jul; 23(7):1231-8. doi: 10.1161/01.atv.0000075913.00428.fd. [PMID: 12738682]
  • Michael Kron, Michael Petridis, Youli Milev, Joseph Leykam, Michael Härtlein. Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi. Molecular and biochemical parasitology. 2003 Jun; 129(1):33-9. doi: 10.1016/s0166-6851(03)00080-x. [PMID: 12798504]
  • A Minelli, L Liguori, I Bellezza, T Renieri, C Castellini. Effects of diadenosine polyphosphates and seminal fluid vesicles on rabbit sperm cells. Reproduction (Cambridge, England). 2003 Jun; 125(6):827-35. doi: 10.1530/rep.0.1250827. [PMID: 12773105]
  • Sang-Han Lee, Tae-Jung Kim, Ho-Young Kim, Jin-Gook Kim, Mi-Kyoung Park, Kee-Min Woo, Sung-Ho Kim, Kyu-Yoon Hwang, Hae-Seon Nam, Young-Ki Min, Man-Hee Cho. Expression of the fragile histidine triad gene in normal rat tissues and human kidney cancer cell lines. Research communications in molecular pathology and pharmacology. 2002; 112(1-4):145-57. doi: . [PMID: 15080505]
  • H M Abdelghany, L Gasmi, J L Cartwright, S Bailey, J B Rafferty, A G McLennan. Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. Biochimica et biophysica acta. 2001 Nov; 1550(1):27-36. doi: 10.1016/s0167-4838(01)00263-1. [PMID: 11738085]
  • G Gabriëls, K Endlich, K H Rahn, E Schlatter, M Steinhausen. In vivo effects of diadenosine polyphosphates on rat renal microcirculation. Kidney international. 2000 Jun; 57(6):2476-84. doi: 10.1046/j.1523-1755.2000.00106.x. [PMID: 10844616]
  • A Minelli, M Moroni, I Mezzasoma. Human seminal plasma soluble 5'-nucleotidase: regulatory aspects of the dephosphorylation of nucleoside 5'-monophosphates. Biochemical and molecular medicine. 1997 Jun; 61(1):95-101. doi: 10.1006/bmme.1997.2589. [PMID: 9232203]
  • J Mateo, P Rotllan, E Marti, I Gomez De Aranda, C Solsona, M T Miras-Portugal. Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ. The Biochemical journal. 1997 May; 323 ( Pt 3)(?):677-84. doi: 10.1042/bj3230677. [PMID: 9169600]
  • A Ogilvie, R Bläsius, E Schulze-Lohoff, R B Sterzel. Adenine dinucleotides: a novel class of signalling molecules. Journal of autonomic pharmacology. 1996 Dec; 16(6):325-8. doi: 10.1111/j.1474-8673.1996.tb00045.x. [PMID: 9131408]
  • H Hohage, C Reinhardt, U Borucki, G Enck, H Schlüter, E Schlatter, W Zidek. Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats. Journal of the American Society of Nephrology : JASN. 1996 Aug; 7(8):1216-22. doi: 10.1681/asn.v781216. [PMID: 8866415]
  • E Schlatter, I Ankorina, S Haxelmans, R Kleta. Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells. Pflugers Archiv : European journal of physiology. 1995 Sep; 430(5):721-8. doi: 10.1007/bf00386167. [PMID: 7478924]
  • E Busshardt, W Gerok, D Häussinger. Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. Biochimica et biophysica acta. 1989 Feb; 1010(2):151-9. doi: 10.1016/0167-4889(89)90155-9. [PMID: 2563228]
  • J Lüthje, A Ogilvie. Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes. European journal of biochemistry. 1988 Apr; 173(1):241-5. doi: 10.1111/j.1432-1033.1988.tb13990.x. [PMID: 3356191]
  • J Lüthje, A Ogilvie. Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization. European journal of biochemistry. 1987 Dec; 169(2):385-8. doi: 10.1111/j.1432-1033.1987.tb13624.x. [PMID: 2826143]
  • J Lüthje, D Miller, A Ogilvie. Unproportionally high concentrations of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) in heavy platelets. Consequences for in vitro studies with human platelets. Blut. 1987 Apr; 54(4):193-200. doi: 10.1007/bf00594193. [PMID: 3030468]
  • J Lüthje, J Baringer, A Ogilvie. Effects of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) on platelet aggregation in unfractionated human blood. Blut. 1985 Dec; 51(6):405-13. doi: 10.1007/bf00320727. [PMID: 3852686]
  • J Lüthje, J Baringer, A Ogilvie. Highly efficient induction of human platelet aggregation in heparinized platelet-rich plasma by diadenosine triphosphate (Ap3A). Thrombosis and haemostasis. 1985 Aug; 54(2):469-71. doi: . [PMID: 4082083]
  • J Lüthje, A Ogilvie. Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity. European journal of biochemistry. 1985 May; 149(1):119-27. doi: 10.1111/j.1432-1033.1985.tb08901.x. [PMID: 2986968]
  • J Lüthje, A Ogilvie. Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. Biochemical and biophysical research communications. 1984 Feb; 118(3):704-9. doi: 10.1016/0006-291x(84)91451-7. [PMID: 6704102]