2-methylcrotonoyl-CoA (BioDeep_00001869045)

Main id: BioDeep_00000630310

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-methylcrotonoyl-CoA

化学式: C26H42N7O17P3S (849.1571)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C(\C)/C(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)OP(=O)(O)O)O
InChI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/b14-5+/t15-,18-,19-,20+,24-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

2-methylcrotonoyl-CoA



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ACADL, DHX58, EIF2AK2, GLUD1, HADH, HLCS, HPGDS, HSD17B4, IRF3, MAPK14, PC, PFDN5, RIGI, TRAF6
Endosome membrane 2 OCA2, TRAF6
Endoplasmic reticulum membrane 1 OCA2
Nucleus 5 EIF2AK2, IRF3, MAPK14, PFDN5, TRAF6
cytosol 12 EIF2AK2, HLCS, HPGDS, HSD17B4, IRF3, MAPK14, MCCC1, MCCC2, PC, PFDN5, RIGI, TRAF6
mitochondrial membrane 1 ACADL
nucleoplasm 5 EIF2AK2, HADH, HPGDS, IRF3, MAPK14
ruffle membrane 1 RIGI
Multi-pass membrane protein 1 OCA2
cell cortex 1 TRAF6
glutamatergic synapse 2 MAPK14, TRAF6
lysosomal membrane 1 OCA2
mitochondrial inner membrane 1 HADH
plasma membrane 1 TRAF6
Membrane 3 EIF2AK2, HSD17B4, OCA2
axon 1 CCK
endoplasmic reticulum 1 GLUD1
extracellular space 1 CCK
perinuclear region of cytoplasm 2 EIF2AK2, TRAF6
bicellular tight junction 1 RIGI
mitochondrion 10 ACADL, ECHS1, GLUD1, HADH, HLCS, IRF3, MAPK14, MCCC1, MCCC2, PC
protein-containing complex 1 TRAF6
intracellular membrane-bounded organelle 2 HPGDS, HSD17B4
Secreted 1 CCK
extracellular region 2 CCK, MAPK14
cytoplasmic side of plasma membrane 1 TRAF6
Mitochondrion matrix 5 ACADL, HADH, MCCC1, MCCC2, PC
mitochondrial matrix 7 ACADL, ECHS1, GLUD1, HADH, MCCC1, MCCC2, PC
CD40 receptor complex 1 TRAF6
actin cytoskeleton 1 RIGI
Melanosome membrane 1 OCA2
Cytoplasm, perinuclear region 1 EIF2AK2
Mitochondrion inner membrane 1 HADH
mitochondrial nucleoid 1 HADH
Peroxisome 1 HSD17B4
peroxisomal matrix 1 HSD17B4
peroxisomal membrane 1 HSD17B4
nuclear speck 1 MAPK14
chromatin 2 HLCS, IRF3
spindle pole 1 MAPK14
Cytoplasm, cell cortex 1 TRAF6
Lipid droplet 1 TRAF6
intermediate filament cytoskeleton 1 PFDN5
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
nuclear matrix 1 HLCS
mitochondrial fatty acid beta-oxidation multienzyme complex 1 HADH
nuclear lamina 1 HLCS
ribonucleoprotein complex 1 RIGI
extrinsic component of cytoplasmic side of plasma membrane 1 TRAF6
prefoldin complex 1 PFDN5
ribosome 1 EIF2AK2
3-methylcrotonyl-CoA carboxylase complex, mitochondrial 2 MCCC1, MCCC2
methylcrotonoyl-CoA carboxylase complex 2 MCCC1, MCCC2


文献列表

  • Kenichiro Yamada, Kaori Aiba, Yasuyuki Kitaura, Yusuke Kondo, Noriko Nomura, Yuji Nakamura, Daisuke Fukushi, Kei Murayama, Yoshiharu Shimomura, James Pitt, Seiji Yamaguchi, Kenji Yokochi, Nobuaki Wakamatsu. Clinical, biochemical and metabolic characterisation of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. Journal of medical genetics. 2015 Oct; 52(10):691-8. doi: 10.1136/jmedgenet-2015-103231. [PMID: 26251176]
  • Geng Ding, Ping Che, Hilal Ilarslan, Eve S Wurtele, Basil J Nikolau. Genetic dissection of methylcrotonyl CoA carboxylase indicates a complex role for mitochondrial leucine catabolism during seed development and germination. The Plant journal : for cell and molecular biology. 2012 May; 70(4):562-77. doi: 10.1111/j.1365-313x.2011.04893.x. [PMID: 22211474]
  • M Duran, L Bruinvis, D Ketting, J P Kamerling, S K Wadman, R B Schutgens. The identification of (E)-2-methylglutaconic acid, a new isoleucine metabolite, in the urine of patients with beta-ketothiolase deficiency, propionic acidaemia and methylmalonic acidaemia. Biomedical mass spectrometry. 1982 Jan; 9(1):1-5. doi: 10.1002/bms.1200090102. [PMID: 7059658]