dihydropteroate (BioDeep_00001868979)

Main id: BioDeep_00000004519

 

natural product


代谢物信息卡片


7,8-Dihydropteroic acid

化学式: C14H14N6O3 (314.1127)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)O
InChI: InChI=1S/C14H14N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,16H,5-6H2,(H,22,23)(H4,15,17,19,20,21)

描述信息

A pteroic acid derivative arising from formal hydrogenation of the 7,8-double bond of pteroic acid.

同义名列表

2 个代谢物同义名

7,8-Dihydropteroic acid; dihydropteroate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CLEC7A, DHFR, DHPS, FASN, FST, GCH1, SPR
Peripheral membrane protein 2 CYP27A1, PPOX
Mitochondrion membrane 1 CYP27A1
Nucleus 2 FST, GCH1
cytosol 5 DHFR, DHPS, FASN, GCH1, SPR
mitochondrial membrane 1 PPOX
nucleoplasm 2 GCH1, SPR
Cell membrane 2 CLEC7A, TNF
Synapse 1 PPOX
cell surface 2 CLEC7A, TNF
Golgi apparatus 1 FASN
mitochondrial inner membrane 2 CYP27A1, PPOX
neuronal cell body 1 TNF
postsynapse 1 PPOX
synaptic vesicle 1 PPOX
plasma membrane 3 CLEC7A, FASN, TNF
Membrane 3 CLEC7A, FASN, TMPRSS15
brush border 1 TMPRSS15
extracellular exosome 2 FASN, SPR
extracellular space 4 CXCL8, FST, IL10, TNF
perinuclear region of cytoplasm 1 PPOX
mitochondrion 5 CYP27A1, DHFR, GCH1, PPOX, SPR
protein-containing complex 1 GCH1
Secreted 3 CXCL8, IL10, IL23A
extracellular region 6 CXCL8, FST, IL10, IL23A, PPOX, TNF
mitochondrial matrix 1 CYP27A1
nuclear membrane 1 GCH1
external side of plasma membrane 1 TNF
neuronal dense core vesicle lumen 1 PPOX
cytoplasmic vesicle 2 GCH1, PPOX
recycling endosome 1 TNF
Single-pass type II membrane protein 3 CLEC7A, TMPRSS15, TNF
Mitochondrion inner membrane 2 CYP27A1, PPOX
Membrane raft 1 TNF
mitochondrial intermembrane space 1 PPOX
phagocytic cup 1 TNF
[Isoform 5]: Cytoplasm 1 CLEC7A
Melanosome 1 FASN
endoplasmic reticulum lumen 1 IL23A
Rough endoplasmic reticulum 1 PPOX
Intermembrane side 1 PPOX
[Isoform 7]: Cytoplasm 1 CLEC7A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
neuron projection terminus 1 GCH1
[Isoform 6]: Cytoplasm 1 CLEC7A
interleukin-23 complex 1 IL23A
glycogen granule 1 FASN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tzu-Chieh Hung, Kuen-Bao Chen, Wen-Yuan Lee, Calvin Yu-Chian Chen. The inhibition of folylpolyglutamate synthetase (folC) in the prevention of drug resistance in Mycobacterium tuberculosis by traditional Chinese medicine. BioMed research international. 2014; 2014(?):635152. doi: 10.1155/2014/635152. [PMID: 25050369]
  • J Enrique Salcedo-Sora, Edwin Ochong, Susan Beveridge, David Johnson, Alexis Nzila, Giancarlo A Biagini, Paul A Stocks, Paul M O'Neill, Sanjeev Krishna, Patrick G Bray, Stephen A Ward. The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. The Journal of biological chemistry. 2011 Dec; 286(52):44659-68. doi: 10.1074/jbc.m111.286054. [PMID: 21998306]
  • Maddalena Rossi, Alberto Amaretti, Stefano Raimondi. Folate production by probiotic bacteria. Nutrients. 2011 01; 3(1):118-34. doi: 10.3390/nu3010118. [PMID: 22254078]
  • Paul Francis Morris, Laura Rose Schlosser, Katherine Diane Onasch, Tom Wittenschlaeger, Ryan Austin, Nicholas Provart. Multiple horizontal gene transfer events and domain fusions have created novel regulatory and metabolic networks in the oomycete genome. PloS one. 2009 Jul; 4(7):e6133. doi: 10.1371/journal.pone.0006133. [PMID: 19582169]
  • Valérie de Crécy-Lagard, Basma El Yacoubi, Rocío Díaz de la Garza, Alexandre Noiriel, Andrew D Hanson. Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC genomics. 2007 Jul; 8(?):245. doi: 10.1186/1471-2164-8-245. [PMID: 17645794]
  • Ping Wang, Qi Wang, Paul F G Sims, John E Hyde. Characterisation of exogenous folate transport in Plasmodium falciparum. Molecular and biochemical parasitology. 2007 Jul; 154(1):40-51. doi: 10.1016/j.molbiopara.2007.04.002. [PMID: 17509698]
  • Ralf Stracke, Hirofumi Ishihara, Gunnar Huep, Aiko Barsch, Frank Mehrtens, Karsten Niehaus, Bernd Weisshaar. Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling. The Plant journal : for cell and molecular biology. 2007 May; 50(4):660-77. doi: 10.1111/j.1365-313x.2007.03078.x. [PMID: 17419845]
  • Sungano Mharakurwa, Christopher Simoloka, Philip E Thuma, Clive J Shiff, David J Sullivan. PCR detection of Plasmodium falciparum in human urine and saliva samples. Malaria journal. 2006 Nov; 5(?):103. doi: 10.1186/1475-2875-5-103. [PMID: 17092335]
  • Samuel Jabrin, Stéphane Ravanel, Bernadette Gambonnet, Roland Douce, Fabrice Rébeillé. One-carbon metabolism in plants. Regulation of tetrahydrofolate synthesis during germination and seedling development. Plant physiology. 2003 Mar; 131(3):1431-9. doi: 10.1104/pp.016915. [PMID: 12644692]
  • Jean-Marie Mouillon, Stéphane Ravanel, Roland Douce, Fabrice Rébeillé. Folate synthesis in higher-plant mitochondria: coupling between the dihydropterin pyrophosphokinase and the dihydropteroate synthase activities. The Biochemical journal. 2002 Apr; 363(Pt 2):313-9. doi: 10.1042/0264-6021:3630313. [PMID: 11931659]
  • L M Iyer, L Aravind, P Bork, K Hofmann, A R Mushegian, I B Zhulin, E V Koonin. Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences. Genome biology. 2001; 2(12):RESEARCH0051. doi: 10.1186/gb-2001-2-12-research0051. [PMID: 11790254]
  • F Rébeillé, D Macherel, J M Mouillon, J Garin, R Douce. Folate biosynthesis in higher plants: purification and molecular cloning of a bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase localized in mitochondria. The EMBO journal. 1997 Mar; 16(5):947-57. doi: 10.1093/emboj/16.5.947. [PMID: 9118956]
  • J K Seydel, W Butte. P-Aminobenzoic acid derivatives. Mode of action and structure-activity relationships in a cell-free system (Escherichia coli). Journal of medicinal chemistry. 1977 Mar; 20(3):439-47. doi: 10.1021/jm00213a023. [PMID: 321779]