Acotiamide (BioDeep_00001868900)
Main id: BioDeep_00000009711
代谢物信息卡片
化学式: C21H30N4O5S (450.1937)
中文名称: 阿考替胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
InChI: InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03F - Propulsives > A03FA - Propulsives
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D005765 - Gastrointestinal Agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:34523
- KEGG: C14127
- PubChem: 5282338
- DrugBank: DB12482
- ChEMBL: CHEMBL2107723
- CAS: 185106-16-5
- PubChem: 7846941
- NIKKAJI: J1.360.929B
- KNApSAcK: 34523
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.
Journal of pharmacological sciences.
2021 Jan; 145(1):122-129. doi:
10.1016/j.jphs.2020.10.006. [PMID: 33357770] - Nishant Singh, Shinsuke Mizoguchi, Takahisa Suzuki, Irina Zabbarova, Youko Ikeda, Anthony Kanai, Christopher Chermansky, Naoki Yoshimura, Pradeep Tyagi. Excitatory effect of acotiamide on rat and human bladder: Implications for underactive bladder treatment.
Life sciences.
2020 Oct; 258(?):118179. doi:
10.1016/j.lfs.2020.118179. [PMID: 32758626] - Masamichi Hirayama, Yusuke Hoshino, Kazuyoshi Yoshii, Ryoko Toda, Yoshihiro Kawabata, Takeo Nakanishi, Ikumi Tamai. Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue.
Molecular pharmaceutics.
2020 04; 17(4):1071-1078. doi:
10.1021/acs.molpharmaceut.9b00894. [PMID: 32105080] - Yukio Maezawa, Toru Aoyama, Junya Morita, Kazuki Kano, Shinya Amano, Sho Sawazaki, Masakatsu Numata, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Ohshima, Norio Yukawa, Takaki Yoshikawa, Munetaka Masuda, Yasushi Rino. [A Case in Which Acotiamide Hydrochloride Was Effective for Reflux Esophagitis after Distal Gastrectomy with Billroth Ⅰ Reconstruction for Gastric Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2019 Mar; 46(3):595-597. doi:
NULL. [PMID: 30914625] - Prinesh N Patel, Pradipbhai D Kalariya, Mohit Thummar, S Gananadhamu, R Srinivas. In vivo metabolite identification of acotiamide in rats using ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry.
Biomedical chromatography : BMC.
2017 Jul; 31(7):. doi:
10.1002/bmc.3915. [PMID: 27943342] - Jing Li, Rui Huang, Zhi Wang, Haijun Qu, Meijuan Sun, Zhenhuan Zhao. Development and Validation of a Sensitive and Specific LC-MS-MS Method for the Determination of Acotiamide in Rat Plasma.
Journal of chromatographic science.
2016 Jul; 54(6):1004-9. doi:
10.1093/chromsci/bmw035. [PMID: 26980723] - Prinesh N Patel, Pradipbhai D Kalariya, Challa Veerabhadra Swamy, S Gananadhamu, R Srinivas. Quantitation of acotiamide in rat plasma by UHPLC-Q-TOF-MS: method development, validation and application to pharmacokinetics.
Biomedical chromatography : BMC.
2016 Mar; 30(3):363-8. doi:
10.1002/bmc.3555. [PMID: 26153099] - Kazuyoshi Yoshii, Masamichi Hirayama, Toshifumi Nakamura, Ryoko Toda, Junko Hasegawa, Mineo Takei, Yukinori Mera, Yoshihiro Kawabata. Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach.
Journal of pharmaceutical sciences.
2011 Nov; 100(11):4965-73. doi:
10.1002/jps.22649. [PMID: 21630282] - Shigeru Furuta, Emiko Kamada, Takeshi Omata, Tohru Sugimoto, Yoshihiro Kawabata, Keiko Yonezawa, Xiaochun Cheryl Wu, Tadashi Kurimoto. Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.
European journal of pharmacology.
2004 Aug; 497(2):223-31. doi:
10.1016/j.ejphar.2004.06.040. [PMID: 15306208] - S Furuta, H Miyahara, T Sugimoto, H Sano. LC determination of Z-338, novel gastroprokinetic agent in dog plasma by SCX solid phase extraction.
Journal of pharmaceutical and biomedical analysis.
2001 Jun; 25(3-4):599-603. doi:
10.1016/s0731-7085(00)00593-8. [PMID: 11377040]
