palmitoyl-CoA (BioDeep_00001868767)
Main id: BioDeep_00000004146
代谢物信息卡片
化学式: C37H66N7O17P3S (1005.3449)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)O
InChI: InChI=1S/C37H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/t26-,30-,31-,32+,36-/m1/s1
描述信息
A long-chain fatty acyl-CoA resulting from the formal condensation of the carboxy group of hexadecanoic acid with the thiol group of coenzyme A.
COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:15525
- KEGG: C00154
- PubChem: 644109
- MeSH: Palmitoyl Coenzyme A
- MetaboLights: MTBLC15525
- PubChem: 3454
- LipidMAPS: LMFA07050360
- KNApSAcK: C00007462
- CAS: 1763-10-6
- PDB-CCD: PKZ
- 3DMET: B04641
- NIKKAJI: J207.891K
- RefMet: Palmitoyl-CoA
- KNApSAcK: 15525
分类词条
相关代谢途径
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- M Kerr, K M J H Dennis, C A Carr, W Fuller, G Berridge, S Rohling, C L Aitken, C Lopez, R Fischer, J J Miller, K Clarke, D J Tyler, L C Heather. Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.
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The Biochemical journal.
2021 07; 478(13):2539-2553. doi:
10.1042/bcj20210264
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International journal of molecular sciences.
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Nucleic acids research.
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Journal of applied physiology (Bethesda, Md. : 1985).
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PloS one.
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PLoS computational biology.
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The Biochemical journal.
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The Journal of biological chemistry.
2016 Feb; 291(7):3520-30. doi:
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Journal of lipid research.
2016 Feb; 57(2):288-98. doi:
10.1194/jlr.m065003
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Proteomics.
2015 Jun; 15(12):2066-77. doi:
10.1002/pmic.201500063
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Metabolism: clinical and experimental.
2015 May; 64(5):580-7. doi:
10.1016/j.metabol.2015.01.002
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Biochimica et biophysica acta.
2015 May; 1851(5):549-65. doi:
10.1016/j.bbalip.2015.01.004
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The Journal of biological chemistry.
2014 Sep; 289(39):26895-26903. doi:
10.1074/jbc.m114.591354
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The Journal of biological chemistry.
2014 Aug; 289(32):21984-94. doi:
10.1074/jbc.m114.579318
. [PMID: 24917677] - Marie-Soleil Beaudoin, Christopher G R Perry, Alicia M Arkell, Adrian Chabowski, Jeremy A Simpson, David C Wright, Graham P Holloway. Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats.
The Journal of physiology.
2014 Jun; 592(12):2519-33. doi:
10.1113/jphysiol.2013.270538
. [PMID: 24639481] - Madhumitha Balanarasimha, Andrea M Davis, Frances L Soman, S Dean Rider, Heather A Hostetler. Ligand-regulated heterodimerization of peroxisome proliferator-activated receptor α with liver X receptor α.
Biochemistry.
2014 Apr; 53(16):2632-43. doi:
10.1021/bi401679y
. [PMID: 24713062] - Janos Kerner, Paul E Minkler, Edward J Lesnefsky, Charles L Hoppel. Fatty acid chain elongation in palmitate-perfused working rat heart: mitochondrial acetyl-CoA is the source of two-carbon units for chain elongation.
The Journal of biological chemistry.
2014 Apr; 289(14):10223-34. doi:
10.1074/jbc.m113.524314
. [PMID: 24558043] - Yi Yu, Chris R J Carter, Nermeen Youssef, Jason R B Dyck, Peter E Light. Intracellular long-chain acyl CoAs activate TRPV1 channels.
PloS one.
2014; 9(5):e96597. doi:
10.1371/journal.pone.0096597
. [PMID: 24798548] - Sarah Brice Russo, Rotem Tidhar, Anthony H Futerman, L Ashley Cowart. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.
The Journal of biological chemistry.
2013 May; 288(19):13397-409. doi:
10.1074/jbc.m112.428185
. [PMID: 23530041] - E Alefishat, S P H Alexander, V Ralevic. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate.
British journal of pharmacology.
2013 Apr; 168(8):1911-22. doi:
10.1111/bph.12086
. [PMID: 23215951] - Xiao-jun Zhang, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Noe A Rodriguez, David N Herndon, Robert R Wolfe. Acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis.
Metabolism: clinical and experimental.
2013 Jan; 62(1):44-51. doi:
10.1016/j.metabol.2012.06.002
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The Journal of biological chemistry.
2012 Aug; 287(35):29837-50. doi:
10.1074/jbc.m112.373654
. [PMID: 22778252] - Benjamin C Jennings, Maurine E Linder. DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities.
The Journal of biological chemistry.
2012 Mar; 287(10):7236-45. doi:
10.1074/jbc.m111.337246
. [PMID: 22247542] - Xiao-Jun Zhang, Noe A Rodriguez, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Alai Tan, David N Herndon, Robert R Wolfe. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate.
Journal of lipid research.
2012 Jan; 53(1):119-25. doi:
10.1194/jlr.m019901
. [PMID: 21934122] - Eri Oyanagi, Hiromi Yano, Masataka Uchida, Kozo Utsumi, Junzo Sasaki. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acid stress.
Biochemical and biophysical research communications.
2011 Aug; 412(1):61-7. doi:
10.1016/j.bbrc.2011.07.039
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Journal of lipid research.
2011 Aug; 52(8):1583-94. doi:
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The Journal of biological chemistry.
2011 Jul; 286(28):25352-62. doi:
10.1074/jbc.m110.214866
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The Journal of biological chemistry.
2011 Apr; 286(14):11937-50. doi:
10.1074/jbc.m110.203661
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Circulation research.
2010 Jul; 107(2):233-41. doi:
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Metabolism: clinical and experimental.
2009 Nov; 58(11):1649-56. doi:
10.1016/j.metabol.2009.05.021
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Pediatric neurology.
2009 Aug; 41(2):151-3. doi:
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Journal of lipid research.
2009 Jun; 50(6):1237-44. doi:
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Pediatric research.
2008 Dec; 64(6):667-72. doi:
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Journal of biomolecular screening.
2008 Oct; 13(9):855-61. doi:
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American journal of physiology. Endocrinology and metabolism.
2008 Sep; 295(3):E678-85. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2008 Aug; 46(8):2616-28. doi:
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American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H105-12. doi:
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. [PMID: 18469143] - Sonja Primassin, Frank Ter Veld, Ertan Mayatepek, Ute Spiekerkoetter. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine.
Pediatric research.
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International journal of biological macromolecules.
2008 Apr; 42(3):271-7. doi:
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Journal of molecular and cellular cardiology.
2008 Jan; 44(1):201-9. doi:
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The Journal of clinical investigation.
2007 Dec; 117(12):3979-87. doi:
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Toxicology.
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Journal of pharmacological sciences.
2007 Jun; 104(2):137-45. doi:
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American journal of physiology. Endocrinology and metabolism.
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American journal of physiology. Endocrinology and metabolism.
2006 Dec; 291(6):E1341-50. doi:
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Pediatrics.
2006 Sep; 118(3):1065-9. doi:
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Microbiology (Reading, England).
2006 Aug; 152(Pt 8):2355-2363. doi:
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Obesity (Silver Spring, Md.).
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The British journal of nutrition.
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American journal of physiology. Endocrinology and metabolism.
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Diabetologia.
2005 Dec; 48(12):2622-30. doi:
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Biochemistry.
2005 Sep; 44(35):11903-12. doi:
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Journal of applied physiology (Bethesda, Md. : 1985).
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Lipids.
2005 Jan; 40(1):39-47. doi:
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