1,4-Dihydroxy-2-naphthoic acid (BioDeep_00001868545)

Main id: BioDeep_00000001709

 

natural product


代谢物信息卡片


1,4-Dihydroxy-2-naphthoic acid

化学式: C11H8O4 (204.0423)
中文名称: 1,4-二羟基-2-萘甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CC(=C2O)C(=O)O)O
InChI: InChI=1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

描述信息

A naphthoic acid that is 2-naphthoic acid substituted by hydroxy groups at positions 1 and 4.

同义名列表

2 个代谢物同义名

1,4-Dihydroxy-2-naphthoic acid; 1,4-Dihydroxy-2-naphthoate



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AHR, BGLAP, CRYZ, CYP1A1, FANCA, FDPS, MAPKAPK3, MVK
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP27A1, HSD17B6
Endoplasmic reticulum membrane 2 CYP1A1, CYP1B1
Mitochondrion membrane 1 CYP27A1
Nucleus 4 AHR, FANCA, MAPKAPK3, PNKD
cytosol 6 AHR, CRYZ, FANCA, FDPS, MAPKAPK3, MVK
dendrite 1 BGLAP
nucleoplasm 4 AHR, FANCA, FDPS, MAPKAPK3
Cell membrane 1 TNF
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 ATP4A
cell surface 1 TNF
glutamatergic synapse 1 C1QL3
mitochondrial inner membrane 3 ATP5ME, CYP1A1, CYP27A1
neuronal cell body 1 TNF
plasma membrane 4 ATP4A, MADCAM1, ME3, TNF
Membrane 6 ATP4A, CYP1B1, FDPS, MADCAM1, ME3, PNKD
apical plasma membrane 1 ATP4A
extracellular exosome 2 CRYZ, LYZ
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 5 ATP4A, BGLAP, IL10, LYZ, TNF
mitochondrion 7 ATP5ME, CRYZ, CYP1A1, CYP1B1, CYP27A1, ME3, PNKD
protein-containing complex 1 AHR
intracellular membrane-bounded organelle 4 CYP1A1, CYP1B1, HSD17B6, MVK
Microsome membrane 3 CYP1A1, CYP1B1, HSD17B6
Secreted 3 BGLAP, C1QL3, IL10
extracellular region 4 BGLAP, IL10, LYZ, TNF
Single-pass membrane protein 1 ME3
hippocampal mossy fiber to CA3 synapse 1 C1QL3
mitochondrial matrix 3 CYP27A1, FDPS, ME3
transcription regulator complex 1 AHR
external side of plasma membrane 1 TNF
perikaryon 1 BGLAP
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 BGLAP
Apical cell membrane 1 ATP4A
Mitochondrion inner membrane 2 CYP1A1, CYP27A1
Membrane raft 1 TNF
Peroxisome 2 FDPS, MVK
collagen trimer 1 C1QL3
chromatin 2 AHR, FANCA
phagocytic cup 1 TNF
Fanconi anaemia nuclear complex 1 FANCA
aryl hydrocarbon receptor complex 1 AHR
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 1 BGLAP
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
azurophil granule lumen 1 LYZ
synaptic cleft 1 C1QL3
presynaptic cytosol 1 PNKD
proton-transporting ATP synthase complex 1 ATP5ME
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
potassium:proton exchanging ATPase complex 1 ATP4A
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fabienne Furt, William J Allen, Joshua R Widhalm, Peter Madzelan, Robert C Rizzo, Gilles Basset, Mark A Wilson. Functional convergence of structurally distinct thioesterases from cyanobacteria and plants involved in phylloquinone biosynthesis. Acta crystallographica. Section D, Biological crystallography. 2013 Oct; 69(Pt 10):1876-88. doi: 10.1107/s0907444913015771. [PMID: 24100308]
  • Masayuki Uchida, Hiroshi Tsuboi, Masayo Takahashi Arita, Atsushi Nemoto, Keisuke Seki, Hajime Tsunoo, Stephanie Martyres, Ashley Roberts. Safety of high doses of Propionibacterium freudenreichii ET-3 culture in healthy adult subjects. Regulatory toxicology and pharmacology : RTP. 2011 Jul; 60(2):262-7. doi: 10.1016/j.yrtph.2010.12.005. [PMID: 21172397]
  • M Matsubara, E Yamachika, H Tsujigiwa, N Mizukawa, T Ueno, J Murakami, N Ishida, Y Kaneda, N Shirasu, S Takagi. Suppressive effects of 1,4-dihydroxy-2-naphthoic acid administration on bone resorption. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2010 Aug; 21(8):1437-47. doi: 10.1007/s00198-009-1075-y. [PMID: 19813044]
  • Hyun Uk Kim, Chloë van Oostende, Gilles J C Basset, John Browse. The AAE14 gene encodes the Arabidopsis o-succinylbenzoyl-CoA ligase that is essential for phylloquinone synthesis and photosystem-I function. The Plant journal : for cell and molecular biology. 2008 Apr; 54(2):272-83. doi: 10.1111/j.1365-313x.2008.03416.x. [PMID: 18208520]
  • Y Okada, Y Tsuzuki, J Miyazaki, K Matsuzaki, R Hokari, S Komoto, S Kato, A Kawaguchi, S Nagao, K Itoh, T Watanabe, S Miura. Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing. Gut. 2006 May; 55(5):681-8. doi: 10.1136/gut.2005.070490. [PMID: 16299037]
  • O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse. Immunology. 1978 Jan; 34(1):167-73. doi: NULL. [PMID: 23994]
  • . . . . doi: . [PMID: 19321747]