pyridostigmine (BioDeep_00001868399)

Main id: BioDeep_00000002991

 


代谢物信息卡片


pyridostigmine

化学式: C9H13N2O2+ (181.09769780000002)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C(=O)Oc1ccc[n+](C)c1
InChI: InChI=1S/C9H13N2O2/c1-10(2)9(12)13-8-5-4-6-11(3)7-8/h4-7H,1-3H3/q+1

描述信息

N - Nervous system > N07 - Other nervous system drugs > N07A - Parasympathomimetics > N07AA - Anticholinesterases
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

pyridostigmine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Runqing Xue, Qing Wu, Lulu Guo, Dan Ye, Qing Cao, Meng Zhang, Yushan Xian, Minchun Chen, Kangkang Yan, Jie Zheng. Pyridostigmine attenuated high-fat-diet induced liver injury by the reduction of mitochondrial damage and oxidative stress via α7nAChR and M3AChR. Journal of biochemical and molecular toxicology. 2024 Mar; 38(3):e23671. doi: 10.1002/jbt.23671. [PMID: 38454809]
  • M Zeng, A Issotina Zibrila, X Li, X Liu, X Wang, Z Zeng, Z Wang, Y He, L Meng, J Liu. Pyridostigmine ameliorates pristane-induced arthritis symptoms in Dark Agouti rats. Scandinavian journal of rheumatology. 2023 Nov; 52(6):627-636. doi: 10.1080/03009742.2023.2196783. [PMID: 37339380]
  • Shan Caifeng, Zhang Jingsheng, Lin Yi, Huang Xueshi, Wang Zhanyou, Pan Haiou, Qiao Wenjun. Effect of treatment with Fufang Huangqi decoction on dose reductions and discontinuation of pyridostigmine bromide tablets, prednisone, and tacrolimus in patients with type I or II myasthenia gravis. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 10; 42(5):810-817. doi: 10.19852/j.cnki.jtcm.20220719.004. [PMID: 36083490]
  • Ewa Sobieszczuk, Łukasz Napiórkowski, Piotr Szczudlik, Anna Kostera-Pruszczyk. Myasthenia gravis-treatment and severity in nationwide cohort. Acta neurologica Scandinavica. 2022 Apr; 145(4):471-478. doi: 10.1111/ane.13576. [PMID: 34981830]
  • Elena V Kozlova, Bruno Carabelli, Anthony E Bishay, Maximillian E Denys, Devi B Chinthirla, Jasmin D Tran, Ansel Hsiao, Nicole I Zur Nieden, Margarita C Currás-Collazo. Persistent exercise fatigue and associative learning deficits in combination with transient glucose dyshomeostasis in a mouse model of Gulf War Illness. Life sciences. 2022 Jan; 289(?):120094. doi: 10.1016/j.lfs.2021.120094. [PMID: 34710444]
  • Giuliana Galassi, Vittorio Rispoli, Erika Iori, Alessandra Ariatti, Alessandro Marchioni. Coincidental Onset of Ocular Myasthenia Gravis Following ChAdOx1 n-CoV-19 Vaccine against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The Israel Medical Association journal : IMAJ. 2022 Jan; 24(1):9-10. doi: NULL. [PMID: 35077038]
  • Elena V Kozlova, Bruno Carabelli, Anthony E Bishay, Rui Liu, Maximillian E Denys, John C Macbeth, Varadh Piamthai, Meli'sa S Crawford, Declan F McCole, Nicole I Zur Nieden, Ansel Hsiao, Margarita C Curras-Collazo. Induction of distinct neuroinflammatory markers and gut dysbiosis by differential pyridostigmine bromide dosing in a chronic mouse model of GWI showing persistent exercise fatigue and cognitive impairment. Life sciences. 2022 Jan; 288(?):120153. doi: 10.1016/j.lfs.2021.120153. [PMID: 34801513]
  • Hunter Sheckley, Kunal Malhotra, Nakul Katyal, Naureen Narula, Raghav Govindarajan. Clinical experience with maintenance therapeutic plasma exchange in refractory generalized myasthenia gravis. Journal of clinical apheresis. 2021 Oct; 36(5):727-736. doi: 10.1002/jca.21923. [PMID: 34241920]
  • Y Muralidhar Reddy, Santhosh Kumar B, Syed Osman, Jagarlapudi M K Murthy. Temporal association between SARS-CoV-2 and new-onset myasthenia gravis: is it causal or coincidental?. BMJ case reports. 2021 Jul; 14(7):. doi: 10.1136/bcr-2021-244146. [PMID: 34290032]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sergio Fragoso-Saavedra, David A Iruegas-Nunez, Alejandro Quintero-Villegas, H Benjamín García-González, Isaac Nuñez, Sergio L Carbajal-Morelos, Belem M Audelo-Cruz, Sarahi Arias-Martínez, Yanink Caro-Vega, Juan José Calva, Verónica Luqueño-Martínez, Alejandra González-Duarte, Brenda Crabtree-Ramírez, José C Crispín, Juan Sierra-Madero, Pablo F Belaunzarán-Zamudio, Sergio I Valdés-Ferrer. A parallel-group, multicenter randomized, double-blinded, placebo-controlled, phase 2/3, clinical trial to test the efficacy of pyridostigmine bromide at low doses to reduce mortality or invasive mechanical ventilation in adults with severe SARS-CoV-2 infection: the Pyridostigmine In Severe COvid-19 (PISCO) trial protocol. BMC infectious diseases. 2020 Oct; 20(1):765. doi: 10.1186/s12879-020-05485-7. [PMID: 33066761]
  • Shivangi Singh, Raghav Govindarajan. COVID-19 and generalized Myasthenia Gravis exacerbation: A case report. Clinical neurology and neurosurgery. 2020 09; 196(?):106045. doi: 10.1016/j.clineuro.2020.106045. [PMID: 32634699]
  • Guray Koc, Zeki Odabasi, Ersin Tan. Myasthenic Syndrome Caused by Hydroxychloroquine Used for COVID-19 Prophylaxis. Journal of clinical neuromuscular disease. 2020 Sep; 22(1):60-62. doi: 10.1097/cnd.0000000000000316. [PMID: 32833728]
  • Masaru Yanagihashi, Ryuichi Okamoto, Harumi Morioka, Masahiro Sawada, Shingo Matsumoto, Takanori Ikeda, Osamu Kano. Coronary spastic angina after the administration of intravenous immunoglobulin in myasthenia gravis: a case report. BMC neurology. 2020 Aug; 20(1):319. doi: 10.1186/s12883-020-01901-2. [PMID: 32859168]
  • Zeynab Alshelh, Daniel S Albrecht, Courtney Bergan, Oluwaseun Akeju, Daniel J Clauw, Lisa Conboy, Robert R Edwards, Minhae Kim, Yvonne C Lee, Ekaterina Protsenko, Vitaly Napadow, Kimberly Sullivan, Marco L Loggia. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain, behavior, and immunity. 2020 07; 87(?):498-507. doi: 10.1016/j.bbi.2020.01.020. [PMID: 32027960]
  • Cheng-Yuan Lin, Wei-Cheng Liu, Min-Hsien Chiang, I-Ting Tsai, Jen-Yin Chen, Wan-Jung Cheng, Chun-Ning Ho, Shu-Wei Liao, Chin-Chen Chu, Cheuk-Kwan Sun, Kuo-Chuan Hung. Myasthenic crisis and late deep vein thrombosis following thymectomy in a patient with myasthenia gravis: A case report. Medicine. 2020 Apr; 99(15):e19781. doi: 10.1097/md.0000000000019781. [PMID: 32282741]
  • Gary Cutter, Haichang Xin, Inmaculada Aban, Ted M Burns, Phillip H Allman, Ramin Farzaneh-Far, Petra W Duda, Henry J Kaminski. Cross-sectional analysis of the Myasthenia Gravis Patient Registry: Disability and treatment. Muscle & nerve. 2019 12; 60(6):707-715. doi: 10.1002/mus.26695. [PMID: 31487038]
  • Utsav Joshi, Andrew Pearson, James E Evans, Heather Langlois, Nicole Saltiel, Joseph Ojo, Nancy Klimas, Kimberly Sullivan, Andrew P Keegan, Sarah Oberlin, Teresa Darcey, Adam Cseresznye, Balaram Raya, Daniel Paris, Bruce Hammock, Natalia Vasylieva, Surat Hongsibsong, Lawrence J Stern, Fiona Crawford, Michael Mullan, Laila Abdullah. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain, behavior, and immunity. 2019 10; 81(?):545-559. doi: 10.1016/j.bbi.2019.07.015. [PMID: 31325531]
  • Ibrahim A Naguib, Eglal A Abdelaleem, Aml A Emam, Fatma F Abdallah. Green Simultaneous Chromatographic Separation of Pyridostigmine Bromide and Its Related Substances in Pure Form, Tablets and Spiked Human Plasma. Journal of chromatographic science. 2019 Aug; 57(7):653-661. doi: 10.1093/chromsci/bmz043. [PMID: 31204433]
  • Jessica Robinson-Papp, Alexandra Nmashie, Elizabeth Pedowitz, Mary Catherine George, Sandeep Sharma, Jacinta Murray, Emma K T Benn, Steven A Lawrence, Josef Machac, Sherif Heiba, Seunghee Kim-Schulze, Allison Navis, Bani Chander Roland, Susan Morgello. The effect of pyridostigmine on small intestinal bacterial overgrowth (SIBO) and plasma inflammatory biomarkers in HIV-associated autonomic neuropathies. Journal of neurovirology. 2019 08; 25(4):551-559. doi: 10.1007/s13365-019-00756-9. [PMID: 31098925]
  • Run-Qing Xue, Xiao-Jiang Yu, Ming Zhao, Man Xu, Qing Wu, Yan-Ling Cui, Si Yang, Dong-Ling Li, Wei-Jin Zang. Pyridostigmine alleviates cardiac dysfunction via improving mitochondrial cristae shape in a mouse model of metabolic syndrome. Free radical biology & medicine. 2019 04; 134(?):119-132. doi: 10.1016/j.freeradbiomed.2019.01.011. [PMID: 30633969]
  • Lindsay T Michalovicz, Alicia R Locker, Kimberly A Kelly, Julie V Miller, Zachary Barnes, Mary Ann Fletcher, Diane B Miller, Nancy G Klimas, Mariana Morris, Stephen M Lasley, James P O'Callaghan. Corticosterone and pyridostigmine/DEET exposure attenuate peripheral cytokine expression: Supporting a dominant role for neuroinflammation in a mouse model of Gulf War Illness. Neurotoxicology. 2019 01; 70(?):26-32. doi: 10.1016/j.neuro.2018.10.006. [PMID: 30339781]
  • N E Gilhus, Y Hong. Maternal myasthenia gravis represents a risk for the child through autoantibody transfer, immunosuppressive therapy and genetic influence. European journal of neurology. 2018 12; 25(12):1402-1409. doi: 10.1111/ene.13788. [PMID: 30133097]
  • Yi Lu, Qing Wu, Long-Zhu Liu, Xiao-Jiang Yu, Jin-Jun Liu, Man-Xiang Li, Wei-Jin Zang. Pyridostigmine protects against cardiomyopathy associated with adipose tissue browning and improvement of vagal activity in high-fat diet rats. Biochimica et biophysica acta. Molecular basis of disease. 2018 Apr; 1864(4 Pt A):1037-1050. doi: 10.1016/j.bbadis.2018.01.006. [PMID: 29309922]
  • Ferdos Nazari, Siamak Abdi. Pyridostigmine-Induced Bradycardia in Patient With MuSK-Ab-Positive Myasthenia Gravis and Alopecia Universalis. Journal of clinical neuromuscular disease. 2017 09; 19(1):49-50. doi: 10.1097/cnd.0000000000000162. [PMID: 28827491]
  • Manushree Bharadwaj, Carey Pope, Michael Davis, Stuart Katz, Christian Cook, Lara Maxwell. Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats. Clinical and experimental pharmacology & physiology. 2017 Aug; 44(8):872-879. doi: 10.1111/1440-1681.12773. [PMID: 28440910]
  • Daniele J Feriani, Gabriel I H Souza, Nicolle M Carrozzi, Cristiano Mostarda, Paulo M M Dourado, Fernanda M Consolim-Colombo, Kátia De Angelis, Heitor Moreno, Maria Cláudia Irigoyen, Bruno Rodrigues. Impact of exercise training associated to pyridostigmine treatment on autonomic function and inflammatory profile after myocardial infarction in rats. International journal of cardiology. 2017 Jan; 227(?):757-765. doi: 10.1016/j.ijcard.2016.10.061. [PMID: 27823896]
  • Lisa M Pierce, Wendy E Kurata, Karen W Matsumoto, Margaret E Clark, Douglas M Farmer. Long-term epigenetic alterations in a rat model of Gulf War Illness. Neurotoxicology. 2016 07; 55(?):20-32. doi: 10.1016/j.neuro.2016.05.007. [PMID: 27179617]
  • Feng Gao, Xue Zhao, Jing Zhang, Xinzheng Cui, Yingna Zhang, Qianru Li, Pingping Liu, Hua Fang, Ying Du, Qingyong Zhang, Junhong Yang, Yunke Zhang. Clinical features of patients with Myasthenia gravis from the Henan province, China. Muscle & nerve. 2016 May; 53(5):711-6. doi: 10.1002/mus.24920. [PMID: 26403759]
  • Renata M Lataro, Carlos A A Silva, Cristiane Tefé-Silva, Cibele M Prado, Helio C Salgado. Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats. American journal of hypertension. 2015 Oct; 28(10):1201-8. doi: 10.1093/ajh/hpv017. [PMID: 25758777]
  • Jens Jordan, Cyndya Shibao, Italo Biaggioni. Multiple system atrophy: using clinical pharmacology to reveal pathophysiology. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 Feb; 25(1):53-9. doi: 10.1007/s10286-015-0271-4. [PMID: 25757803]
  • M Nagappa, M Netravathi, A B Taly, S Sinha, P S Bindu, A Mahadevan. Long-term efficacy and limitations of cyclophosphamide in myasthenia gravis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2014 Nov; 21(11):1909-14. doi: 10.1016/j.jocn.2014.03.019. [PMID: 25043165]
  • J B Andersen, J F Owe, A Engeland, N E Gilhus. Total drug treatment and comorbidity in myasthenia gravis: a population-based cohort study. European journal of neurology. 2014 Jul; 21(7):948-55. doi: 10.1111/ene.12439. [PMID: 24712740]
  • Marília Beatriz de Cuba, Marcus Paulo Ribeiro Machado, Thais Soares Farnesi, Angelica Cristina Alves, Livia Alves Martins, Lucas Felipe de Oliveira, Caroline Santos Capitelli, Camila Ferreira Leite, Marcos Vinícius Silva, Juliana Reis Machado, Henrique Borges Kappel, Helioswilton Sales de Campos, Luciano Paiva, Natália Lins da Silva Gomes, Ana Carolina Guimarães Faleiros, Constança Felicia de Paoli de Carvalho Britto, Wilson Savino, Otacílio Cruz Moreira, Virmondes Rodrigues, Nicola Montano, Eliane Lages-Silva, Luis Eduardo Ramirez, Valdo Jose Dias da Silva. Effects of cholinergic stimulation with pyridostigmine bromide on chronic chagasic cardiomyopathic mice. Mediators of inflammation. 2014; 2014(?):475946. doi: 10.1155/2014/475946. [PMID: 25221388]
  • Laila Abdullah, James E Evans, Hannah Montague, Jon M Reed, Ann Moser, Gogce Crynen, Ariel Gonzalez, Zuchra Zakirova, Ivan Ross, Chris Mullan, Michael Mullan, Ghania Ait-Ghezala, Fiona Crawford. Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin. Neurotoxicology and teratology. 2013 Nov; 40(?):74-84. doi: 10.1016/j.ntt.2013.10.002. [PMID: 24140745]
  • Qunyou Tan, Li Zhang, Guodong Liu, Dan He, Huafeng Yin, Hong Wang, Jianyong Wu, Hong Liao, Jingqing Zhang. Novel taste-masked orally disintegrating tablets for a highly soluble drug with an extremely bitter taste: design rationale and evaluation. Drug development and industrial pharmacy. 2013 Sep; 39(9):1364-71. doi: 10.3109/03639045.2012.718784. [PMID: 22994163]
  • Martina Richtsfeld, Shingo Yasuhara, Heidrun Fink, Manfred Blobner, J A Jeevendra Martyn. Prolonged administration of pyridostigmine impairs neuromuscular function with and without down-regulation of acetylcholine receptors. Anesthesiology. 2013 Aug; 119(2):412-21. doi: 10.1097/aln.0b013e318291c02e. [PMID: 23563362]
  • Laila Abdullah, James E Evans, Alex Bishop, Jon M Reed, Gogce Crynen, John Phillips, Robert Pelot, Myles A Mullan, Austin Ferro, Christopher M Mullan, Michael J Mullan, Ghania Ait-Ghezala, Fiona C Crawford. Lipidomic profiling of phosphocholine-containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents. Neuromolecular medicine. 2012 Dec; 14(4):349-61. doi: 10.1007/s12017-012-8192-z. [PMID: 22798222]
  • Ni-Ni Hu, Qun-You Tan, Li Zhang, Hua-Feng Yin, Jing-Qing Zhang. [Pharmacokinetics of mestinon-phospholipid complex in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2012 Nov; 43(6):873-6. doi: NULL. [PMID: 23387217]
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