Difenidol (BioDeep_00001868278)
Main id: BioDeep_00000006386
代谢物信息卡片
化学式: C21H27NO (309.2093)
中文名称: 地芬尼多, 二苯并吲哚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCN(CC1)CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O
InChI: InChI=1S/C21H27NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1-2,4-7,11-14,23H,3,8-10,15-18H2
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
同义名列表
4 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liu Yang, Junbo Zhao, Mengxi Liu, Le Li, Huan Yang, Caixia Guo, Jing Hu, Ping Xiang, Baohua Shen, Zheng Qiao, Yonghui Dang, Yan Shi. Identifying metabolites of diphenidol by liquid chromatography-quadrupole/orbitrap mass spectrometry using rat liver microsomes, human blood, and urine samples.
Drug testing and analysis.
2021 Jun; 13(6):1127-1135. doi:
10.1002/dta.3012. [PMID: 33554459] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ute Wölfle, Floriana A Elsholz, Astrid Kersten, Birgit Haarhaus, Walter E Müller, Christoph M Schempp. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
Skin pharmacology and physiology.
2015; 28(3):137-46. doi:
10.1159/000367631. [PMID: 25573083] - Shun-wen Luo, Feng Wang, Zhi-yuan Xie, Xiao-ke Huang, Yi-ping Lu. [Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2011 Aug; 43(4):514-8. doi:
. [PMID: 21844956] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Guangming Cao, Qian Liu, Yan Huang, Wang Li, Shouzhuo Yao. Generation of gold nanostructures at the surface of platinum electrode by electrodeposition for ECL detection for CE.
Electrophoresis.
2010 Mar; 31(6):1055-62. doi:
10.1002/elps.200900433. [PMID: 20309916] - Gabriel Marcelín-Jiménez, Miriam Morales-Martínez, Alionka P Angeles-Moreno, Luís Mendoza-Morales. Ultra-fast chromatographic micro-assay for quantification of diphenidol in plasma: application in an oral multi-dose switchability trial.
Biomedical chromatography : BMC.
2008 Oct; 22(10):1143-8. doi:
10.1002/bmc.1037. [PMID: 18506741] - Yan Huang, Wen Pan, Manli Guo, Shouzhuo Yao. Capillary electrophoresis with end-column electrochemiluminescence for the analysis of chloroquine phosphate and the study on its interaction with human serum albumin.
Journal of chromatography. A.
2007 Jun; 1154(1-2):373-8. doi:
10.1016/j.chroma.2007.02.029. [PMID: 17498727] - José Hernández, G Marcelín-Jiménez, L Rivera, P Angeles Alionka, L Contreras, M Hinojosa, L Martínez-Rossier, O Amancio, A Fernández. Development of an HPLC method for determination of diphenidol in plasma and its application in an oral multi-dose bioequivalence study in a healthy female Mexican population.
Journal of pharmaceutical and biomedical analysis.
2005 Jul; 38(4):746-50. doi:
10.1016/j.jpba.2005.01.037. [PMID: 15967303] - V Cápka, Y Xu. Simultaneous determination of enantiomers of structurally related anticholinergic analogs in human serum by liquid chromatography-electrospray ionization mass spectrometry with on-line sample cleanup.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Oct; 762(2):181-92. doi:
10.1016/s0378-4347(01)00364-4. [PMID: 11678378]
