Ibutilide (BioDeep_00001868052)
Main id: BioDeep_00000006591
Volatile Flavor Compounds
代谢物信息卡片
Ibutilide
化学式: C20H36N2O3S (384.2446506)
中文名称: 伊布利特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
InChI: InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C93038 - Cation Channel Blocker
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:5856
- KEGG: C07753
- KEGGdrug: D08060
- PubChem: 60753
- DrugBank: DB00308
- ChEMBL: CHEMBL533
- CAS: 122647-31-8
- CAS: 100632-81-3
- CAS: 130350-52-6
- PubChem: 9955
- NIKKAJI: J362.100F
- RefMet: Ibutilide
- KNApSAcK: 5856
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- James E Tisdale, Heather A Jaynes, Brian R Overholser, Kevin M Sowinski, Mark D Fisch, Jo E Rodgers, Ahmed Aldemerdash, Chia-Chi Hsu, Nan Wang, Elena Tomaselli Muensterman, Vijay U Rao, Richard J Kovacs. Enhanced Response to Drug-Induced QT Interval Lengthening in Patients with Heart Failure with Preserved Ejection Fraction.
Journal of cardiac failure.
2020 Sep; 26(9):781-785. doi:
10.1016/j.cardfail.2020.06.008. [PMID: 32592895] - Amit Malviya, Manish Kapoor, Rondeep Kumar Nath Sivam, Shakeel Ahamad Khan, Ruchi Pandey, Utpal Kumar, Tony Ete, Animesh Mishra. Ibutilide with magnesium for conversion of atrial fibrillation or flutter in rheumatic heart disease patients: Ibutilide with magnesium for chemical cardioversion of atrial fibrillation or flutter.
Indian heart journal.
2020 Jul; 72(4):283-288. doi:
10.1016/j.ihj.2020.07.008. [PMID: 32861384] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - James E Tisdale, Brian R Overholser, Kevin M Sowinski, Heather A Wroblewski, Kwadwo Amankwa, Steven Borzak, Joanna R Kingery, Rita Coram, Douglas P Zipes, David A Flockhart, Richard J Kovacs. Pharmacokinetics of ibutilide in patients with heart failure due to left ventricular systolic dysfunction.
Pharmacotherapy.
2008 Dec; 28(12):1461-70. doi:
10.1592/phco.28.12.1461. [PMID: 19025427] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Yishi Li, Lei Tian, Yiling Huang, Lu Hua. Pharmacokinetic and pharmacodynamic properties of a single intravenous dose of ibutilide fumarate: a phase I, randomized, open-label, increasing-dose study in healthy Chinese men.
Clinical therapeutics.
2007 Sep; 29(9):1957-66. doi:
10.1016/j.clinthera.2007.09.010. [PMID: 18035195] - Charles M Beasley, Malcolm I Mitchell, Alex A Dmitrienko, Jeffrey T Emmick, Wei Shen, Timothy M Costigan, Alun W Bedding, Michael A Turik, Arash Bakhtyari, Margaret R Warner, Jeremy N Ruskin, Louis R Cantilena, Robert A Kloner. The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval.
Journal of the American College of Cardiology.
2005 Aug; 46(4):678-87. doi:
10.1016/j.jacc.2005.05.036. [PMID: 16098435] - Lei Tian, Yishi Li, Yiling Huang, Fuhua Kuang, Feiou Li, Lu Hua. Sensitive method for the determination of ibutilide in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Feb; 816(1-2):81-5. doi:
10.1016/j.jchromb.2004.11.015. [PMID: 15664337] - Johann Reisinger, Edmund Gatterer, Wolfgang Lang, Thetis Vanicek, Geza Eisserer, Theresia Bachleitner, Christopher Niemeth, Friedrich Aicher, Wilhelm Grander, Georg Heinze, Peter Kühn, Peter Siostrzonek. Flecainide versus ibutilide for immediate cardioversion of atrial fibrillation of recent onset.
European heart journal.
2004 Aug; 25(15):1318-24. doi:
10.1016/j.ehj.2004.04.030. [PMID: 15288159] - Ramesh M Gowda, Gopikrishna Punukollu, Ijaz A Khan, Sabrina L Wilbur, Balendu C Vasavada, Terrence J Sacchi. Ibutilide for pharmacological cardioversion of atrial fibrillation and flutter: impact of race on efficacy and safety.
American journal of therapeutics.
2003 Jul; 10(4):259-63. doi:
10.1097/00045391-200307000-00005. [PMID: 12845389] - Michael F Caron, Jeffrey Kluger, James P Tsikouris, Arnold Ritvo, James S Kalus, C Michael White. Effects of intravenous magnesium sulfate on the QT interval in patients receiving ibutilide.
Pharmacotherapy.
2003 Mar; 23(3):296-300. doi:
10.1592/phco.23.3.296.32109. [PMID: 12627926] - Weeranuj Yamreudeewong, Michael DeBisschop, Linda G Martin, Dennis L Lower. Potentially significant drug interactions of class III antiarrhythmic drugs.
Drug safety.
2003; 26(6):421-38. doi:
10.2165/00002018-200326060-00004. [PMID: 12688833] - Anil Yadav, Melvin Scheinman. Atrial fibrillation in the elderly.
The American journal of geriatric cardiology.
2003 Jan; 12(1):49-56. doi:
10.1111/j.1076-7460.2003.01754.x. [PMID: 12502916] - Marcus G Hennersdorf, Stefan M Perings, Christian Zühlke, Ulrich E Heidland, Christian Perings, Matthias P Heintzen, Bodo E Strauer. Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed.
Intensive care medicine.
2002 Jul; 28(7):925-9. doi:
10.1007/s00134-002-1317-3. [PMID: 12122531] - S J Humphrey, M P Smith, C Y Hsu, R R Walters. Cardiovascular effects of the R- and S-enantiomers of ibutilide in conscious beagle dogs.
Methods and findings in experimental and clinical pharmacology.
2001 Oct; 23(8):449-55. doi:
10.1358/mf.2001.23.8.662135. [PMID: 11838320] - A Eversole, W Hancock, T Johns, L M Lopez, C R Conti. Ibutilide: efficacy and safety in atrial fibrillation and atrial flutter in a general cardiology practice.
Clinical cardiology.
2001 Jul; 24(7):521-5. doi:
10.1002/clc.4960240709. [PMID: 11444644] - A Vereckei, E Warman, R Mehra, D P Zipes. Comparison of the effects on drug concentrations, electrophysiologic parameters, and termination of atrial fibrillation in dogs when procainamide and ibutilide are delivered into the right atrium versus intravenously.
Journal of cardiovascular electrophysiology.
2001 Mar; 12(3):330-6. doi:
10.1046/j.1540-8167.2001.00330.x. [PMID: 11291807] - S S Chugh, S B Johnson, D L Packer. Altered response to ibutilide in a heart failure model.
Cardiovascular research.
2001 Jan; 49(1):94-102. doi:
10.1016/s0008-6363(00)00235-2. [PMID: 11121800] - M Franz, A Geppert, R Kain, W H Hörl, E Pohanka. Acute renal failure after ibutilide.
Lancet (London, England).
1999 Feb; 353(9151):467. doi:
10.1016/s0140-6736(98)04237-8. [PMID: 9989724] - V Labhasetwar, S A Strickberger, T Underwood, J Davis, R J Levy. Prevention of acute inducible atrial flutter in dogs by using an ibutilide-polymer-coated pacing electrode.
Journal of cardiovascular pharmacology.
1998 Mar; 31(3):449-55. doi:
10.1097/00005344-199803000-00017. [PMID: 9514191] - J S Cropp, E G Antal, R L Talbert. Ibutilide: a new class III antiarrhythmic agent.
Pharmacotherapy.
1997 Jan; 17(1):1-9. doi:
. [PMID: 9017761] - K A Ellenbogen, H F Clemo, B S Stambler, M A Wood, J T VanderLugt. Efficacy of ibutilide for termination of atrial fibrillation and flutter.
The American journal of cardiology.
1996 Oct; 78(8A):42-5. doi:
10.1016/s0002-9149(96)00565-6. [PMID: 8903275] - K A Ellenbogen, B S Stambler, M A Wood, P T Sager, R C Wesley, M C Meissner, R G Zoble, L K Wakefield, K T Perry, J T Vanderlugt. Efficacy of intravenous ibutilide for rapid termination of atrial fibrillation and atrial flutter: a dose-response study.
Journal of the American College of Cardiology.
1996 Jul; 28(1):130-6. doi:
10.1016/0735-1097(96)00121-0. [PMID: 8752805] - L V Buchanan, R J LeMay, R R Walters, C Y Hsu, M N Brunden, J K Gibson. Antiarrhythmic and electrophysiologic effects of intravenous ibutilide and sotalol in the canine sterile pericarditis model.
Journal of cardiovascular electrophysiology.
1996 Feb; 7(2):113-9. doi:
10.1111/j.1540-8167.1996.tb00506.x. [PMID: 8853021] - C L Hsu, R R Walters. Assay of the enantiomers of ibutilide and artilide using solid-phase extraction, derivatization, and achiral-chiral column-switching high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications.
1995 May; 667(1):115-28. doi:
10.1016/0378-4347(95)00005-4. [PMID: 7663674]