Eprosartan (BioDeep_00001868003)
Main id: BioDeep_00000001540
代谢物信息卡片
Eprosartan
化学式: C23H24N2O4S (424.1457)
中文名称: 依普罗沙坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O
InChI: InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29)/b18-12+
描述信息
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09C - Angiotensin ii receptor blockers (arbs), plain > C09CA - Angiotensin ii receptor blockers (arbs), plain
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C66930 - Angiotensin II Receptor Antagonist
D057911 - Angiotensin Receptor Antagonists > D057912 - Angiotensin II Type 2 Receptor Blockers
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC50s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively [1].
同义名列表
3 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:94094
- ChEBI: CHEBI:4814
- KEGG: C07467
- KEGGdrug: D04040
- PubChem: 5281037
- DrugBank: DB00876
- ChEMBL: CHEMBL813
- CAS: 133040-01-4
- PubChem: 9670
- NIKKAJI: J380.264G
- RefMet: Eprosartan
- medchemexpress: HY-117743
- KNApSAcK: 4814
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Anna Masajtis-Zagajewska, Jacek Majer, Michał Nowicki. Losartan and Eprosartan Induce a Similar Effect on the Acute Rise in Serum Uric Acid Concentration after an Oral Fructose Load in Patients with Metabolic Syndrome.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):2214978. doi:
10.1155/2021/2214978. [PMID: 34527078] - G N Leonova, O S Maistrovskaya, V A Lubova. Molecular and Genetic Bases of Inhibition of Tick-Borne Encephalitis Virus Replication by Eprosartan and Ribavirin.
Bulletin of experimental biology and medicine.
2020 Nov; 170(1):53-57. doi:
10.1007/s10517-020-05003-4. [PMID: 33222083] - Daan J L van Twist, Alfons J H M Houben, Peter W de Leeuw, Abraham A Kroon. Acute eprosartan-induced intrarenal vasodilation in hypertensive humans is not influenced by dietary sodium intake or angiotensin II co-infusion.
Journal of hypertension.
2016 08; 34(8):1607-14. doi:
10.1097/hjh.0000000000000974. [PMID: 27214088] - Mohamed A Morsy, Gehan H Heeba, Magda E Mahmoud. Ameliorative effect of eprosartan on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats.
European journal of pharmacology.
2015 Mar; 750(?):90-7. doi:
10.1016/j.ejphar.2015.01.027. [PMID: 25625658] - Pengyuan Sun, Changyuan Wang, Qi Liu, Qiang Meng, Aijie Zhang, Xiaokui Huo, Huijun Sun, Kexin Liu. OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human.
Pharmacological reports : PR.
2014 Apr; 66(2):311-9. doi:
10.1016/j.pharep.2014.02.013. [PMID: 24911086] - Petra C van Rijn-Bikker, Oliver Ackaert, Nelleke Snelder, Reinier M van Hest, Bart A Ploeger, Richard P Koopmans, Ron A A Mathôt. Pharmacokinetic-pharmacodynamic modeling of the antihypertensive effect of eprosartan in Black and White hypertensive patients.
Clinical pharmacokinetics.
2013 Sep; 52(9):793-803. doi:
10.1007/s40262-013-0073-6. [PMID: 23696281] - V V Kaliuzhin, O F Sibireva, O I Urazova, L M Tkalich, L I Zibnitskaia, E V Kaliuzhina, É A Sazonov, V Iu Grankina. [Effect of eprosartan on the hemostatic system in patients with chronic kidney disease associated with hereditary thrombophilia].
Terapevticheskii arkhiv.
2013; 85(9):77-81. doi:
. [PMID: 24261234] - Henrik Vase, Thomas G Lauridsen, Carolina C Graffe, Erling B Pedersen. The effect of eprosartan on reflex sympathetic activation in sodium restricted patients with essential hypertension.
Journal of the American Society of Hypertension : JASH.
2011 Sep; 5(5):385-94. doi:
10.1016/j.jash.2011.03.007. [PMID: 21640689] - Fathalla Belal, Amina M El-Brashy, Nahed El-Enany, Manar M Tolba. Liquid chromatographic method for the simultaneous determination of eprosartan and hydrochlorothiazide in tablets and human plasma.
Journal of AOAC International.
2011 May; 94(3):823-32. doi:
. [PMID: 21797010] - Jasper W L Hartog, Ruud M van de Wal, Casper G Schalkwijk, Toshio Miyata, Wybren Jaarsma, H W Thijs Plokker, Leen M van Wijk, Andries J Smit, Dirk J van Veldhuisen, Adriaan A Voors. Advanced glycation end-products, anti-hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction.
European journal of heart failure.
2010 Apr; 12(4):397-403. doi:
10.1093/eurjhf/hfq001. [PMID: 20154337] - R Fogari, A Zoppi, I Ferrari, A Mugellini, P Preti, P Lazzari, G Derosa. Comparative effects of telmisartan and eprosartan on insulin sensitivity in the treatment of overweight hypertensive patients.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2009 Dec; 41(12):893-8. doi:
10.1055/s-0029-1237359. [PMID: 19708000] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Greg L Plosker. Eprosartan: a review of its use in hypertension.
Drugs.
2009; 69(17):2477-99. doi:
10.2165/11203980-000000000-00000. [PMID: 19911859] - P J Blankestijn, H Rupp. Clinical profile of eprosartan: a different angiotensin II receptor blocker.
Cardiovascular & hematological agents in medicinal chemistry.
2008 Oct; 6(4):253-7. doi:
10.2174/187152508785909500. [PMID: 18855637] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Henrik Vase, Thomas G Lauridsen, Jesper N Bech, Erling B Pedersen. Eprosartan modulates the reflex activation of the sympathetic nervous system in sodium restricted healthy humans.
British journal of clinical pharmacology.
2008 Jun; 65(6):822-32. doi:
10.1111/j.1365-2125.2008.03149.x. [PMID: 18341678] - Nerea Ferreirós, Gorka Iriarte, Rosa María Alonso, Rosa María Jiménez, Eduardo Ortíz. Separation and quantitation of several angiotensin II receptor antagonist drugs in human urine by a SPE-HPLC-DAD method.
Journal of separation science.
2008 Mar; 31(4):667-76. doi:
10.1002/jssc.200700442. [PMID: 18307163] - V B Simonenko, I N Medvedev, T A Kumova. [Effect of eprosartan on thrombocytes aggregative capacity in patients with arterial hypertension and metabolic syndrome].
Klinicheskaia meditsina.
2008; 86(4):19-21. doi:
NULL. [PMID: 18494280] - C Venkata S Ram. Angiotensin blockade with eprosartan: vascular and functional implications.
Current medical research and opinion.
2007 Nov; 23 Suppl 5(?):S5-11. doi:
10.1185/030079907x260700. [PMID: 18093408] - H R Xu, W L Chen, X N Li, G Y Liu, N N Chu, C Yu. Pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers of different gender.
Die Pharmazie.
2007 Oct; 62(10):782-4. doi:
NULL. [PMID: 18236785] - Xue-Ning Li, Hong-Rong Xu, Wei-Li Chen, Gang-Yi Liu, Nan-Nan Chu, Chen Yu. Determination of eprosartan in human plasma and urine by LC/MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):47-53. doi:
10.1016/j.jchromb.2007.02.049. [PMID: 17409033] - Evangelos C Rizos, Athanasia Spyrou, Evangelos N Liberopoulos, Eleni C Papavasiliou, Vasilis Saougos, Alexandros D Tselepis, Moses Elisaf. Effects of eprosartan on serum metabolic parameters in patients with essential hypertension.
The open cardiovascular medicine journal.
2007; 1(?):22-6. doi:
10.2174/1874192400701010022. [PMID: 18949087] - N Ferreirós, G Iriarte, R M Alonso, R M Jiménez, E Ortíz. Validation of a solid phase extraction-high performance liquid chromatographic method for the determination of eprosartan in human plasma.
Journal of chromatography. A.
2006 Jun; 1119(1-2):309-14. doi:
10.1016/j.chroma.2006.02.055. [PMID: 16542666] - Henry Krum, Elisabeth Lambert, Emma Windebank, Duncan J Campbell, Murray Esler. Effect of angiotensin II receptor blockade on autonomic nervous system function in patients with essential hypertension.
American journal of physiology. Heart and circulatory physiology.
2006 Apr; 290(4):H1706-12. doi:
10.1152/ajpheart.00885.2005. [PMID: 16284232] - A S Ametov, T Iu Demidova, S A Kosykh. [An AT-II blocker in patients with type II diabetes and arterial hypertension].
Klinicheskaia meditsina.
2006; 84(2):50-5. doi:
. [PMID: 16613007] - Stella-Maria G Kyvelou, Gregory P Vyssoulis, Eva A Karpanou, Dionysios N Adamopoulos, Alexandra I Zervoudaki, Panagiota G Pietri, Christodoulos I Stefanadis. Effects of antihypertensive treatment with angiotensin II receptor blockers on lipid profile: an open multi-drug comparison trial.
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.
2006 Jan; 47(1):21-8. doi:
NULL. [PMID: 16532712] - Tony Karram, Anan Abbasi, Shlomo Keidar, Eliahu Golomb, Irit Hochberg, Joseph Winaver, Aaron Hoffman, Zaid Abassi. Effects of spironolactone and eprosartan on cardiac remodeling and angiotensin-converting enzyme isoforms in rats with experimental heart failure.
American journal of physiology. Heart and circulatory physiology.
2005 Oct; 289(4):H1351-8. doi:
10.1152/ajpheart.01186.2004. [PMID: 15894569] - Jorge P van Kats, Wenxia Chai, Dirk J Duncker, Maarten A D H Schalekamp, A H Jan Danser. Adrenal angiotensin: origin and site of generation.
American journal of hypertension.
2005 Aug; 18(8):1104-10. doi:
10.1016/j.amjhyper.2005.02.005. [PMID: 16109325] - Jay P Garg, Renee Ellis, William J Elliott, Nahla Hasabou, Dave Chua, Glenn M Chertow, George L Bakris. Angiotensin receptor blockade and arterial compliance in chronic kidney disease: a pilot study.
American journal of nephrology.
2005 Jul; 25(4):393-9. doi:
10.1159/000087211. [PMID: 16088080] - Marina Christensen, Hans Ibsen, René Worck. Effect of eprosartan on catecholamines and peripheral haemodynamics in subjects with insulin-induced hypoglycaemia.
Clinical science (London, England : 1979).
2005 Feb; 108(2):113-9. doi:
10.1042/cs20040094. [PMID: 15383007] - Duncan J Campbell, Henry Krum, Murray D Esler. Losartan increases bradykinin levels in hypertensive humans.
Circulation.
2005 Jan; 111(3):315-20. doi:
10.1161/01.cir.0000153269.07762.3b. [PMID: 15655136] - P L Lip, S Chatterjee, G J Caine, M Hope-Ross, J Gibson, A D Blann, G Y H Lip. Plasma vascular endothelial growth factor, angiopoietin-2, and soluble angiopoietin receptor tie-2 in diabetic retinopathy: effects of laser photocoagulation and angiotensin receptor blockade.
The British journal of ophthalmology.
2004 Dec; 88(12):1543-6. doi:
10.1136/bjo.2004.048587. [PMID: 15548809] - Jutta Neumann, Gerry Ligtenberg, Liam Oey, Hein A Koomans, Peter J Blankestijn. Moxonidine normalizes sympathetic hyperactivity in patients with eprosartan-treated chronic renal failure.
Journal of the American Society of Nephrology : JASN.
2004 Nov; 15(11):2902-7. doi:
10.1097/01.asn.0000143471.10750.8c. [PMID: 15504943] - Hsin-Bang Leu, Ming-Ji Charng, Philip Yu-An Ding. A double blind randomized trial to compare the effects of eprosartan and enalapril on blood pressure, platelets, and endothelium function in patients with essential hypertension.
Japanese heart journal.
2004 Jul; 45(4):623-35. doi:
10.1536/jhj.45.623. [PMID: 15353873] - Giuseppe Derosa, Pietro D Ragonesi, Amedeo Mugellini, Leonardina Ciccarelli, Roberto Fogari. Effects of telmisartan compared with eprosartan on blood pressure control, glucose metabolism and lipid profile in hypertensive, type 2 diabetic patients: a randomized, double-blind, placebo-controlled 12-month study.
Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jul; 27(7):457-64. doi:
10.1291/hypres.27.457. [PMID: 15302981] - B Rayner, B Jaeger, C N Verboom, M Pascoe. Potential renoprotective effects of the angiotensin receptor blocker eprosartan: a review of preliminary renal studies.
Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners.
2004 Jan; 15(1):32-7. doi:
. [PMID: 14997235] - T K Makris, G Stavroulakis, D P Papadopoulos, P Krespi, A Hatzizacharias, A Zilidis, C Tsoukala, V E Votteas. Eprosartan effect on fibrinolytic/hemostatic variables in arterial hypertension: a comparative study to losartan.
Drugs under experimental and clinical research.
2004; 30(3):125-32. doi:
. [PMID: 15366789] - Lars Rothermund, Peter Kossmehl, Hans-H Neumayer, Martin Paul, Reinhold Kreutz. Renal damage is not improved by blockade of endothelin receptors in primary renin-dependent hypertension.
Journal of hypertension.
2003 Dec; 21(12):2389-97. doi:
10.1097/00004872-200312000-00028. [PMID: 14654760] - Karsten Heusser, Jan Vitkovsky, Walter Raasch, Roland E Schmieder, Hans P Schobel. Elevation of sympathetic activity by eprosartan in young male subjects.
American journal of hypertension.
2003 Aug; 16(8):658-64. doi:
10.1016/s0895-7061(03)00917-8. [PMID: 12878372] - Steven G Terra. Cardiology patient page. Angiotensin receptor blockers.
Circulation.
2003 Jun; 107(24):e215-6. doi:
10.1161/01.cir.0000072344.12827.13. [PMID: 12821593] - Helga Frank, Hans-Paul Schobel, Jan Vitkowsky, Roland E Schmieder, Karsten Heusser. Effects of angiotensin II receptor antagonism on the renal hemodynamic response to cardiovascular stress.
Kidney international.
2003 Feb; 63(2):617-23. doi:
10.1046/j.1523-1755.2003.00760.x. [PMID: 12631126] - Juan G Puig, Rosa Torres, Luis Miguel Ruilope. AT1 blockers and uric acid metabolism: are there relevant differences?.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
2002 Jun; 20(5):S29-31. doi:
NULL. [PMID: 12184060] - Christian Delles, Johannes Jacobi, Stefan John, Ingrid Fleischmann, Roland E Schmieder. Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension.
Kidney international.
2002 Apr; 61(4):1462-8. doi:
10.1046/j.1523-1755.2002.00260.x. [PMID: 11918753] - Christian T Abrahamsen, Frank C Barone, Wallace G Campbell, Allen H Nelson, Lisa C Contino, Mark A Pullen, Eugene T Grygielko, Richard M Edwards, Nicholas J Laping, David P Brooks. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension.
The Journal of pharmacology and experimental therapeutics.
2002 Apr; 301(1):21-8. doi:
10.1124/jpet.301.1.21. [PMID: 11907153] - J P van Kats, M A Schalekamp, P D Verdouw, D J Duncker, A H Danser. Intrarenal angiotensin II: interstitial and cellular levels and site of production.
Kidney international.
2001 Dec; 60(6):2311-7. doi:
10.1046/j.1523-1755.2001.00049.x. [PMID: 11737604] - W B White, Y A Anwar, G A Mansoor, D A Sica. Evaluation of the 24-hour blood pressure effects of eprosartan in patients with systemic hypertension.
American journal of hypertension.
2001 Dec; 14(12):1248-55. doi:
10.1016/s0895-7061(01)02201-4. [PMID: 11775134] - N K Hollenberg. Potential of the angiotensin II receptor 1 blocker eprosartan in the management of patients with hypertension or heart failure.
Current hypertension reports.
2001 Sep; 3 Suppl 1(?):S25-8. doi:
. [PMID: 11580885] - H P Gavras. Issues in hypertension: drug tolerability and special populations.
American journal of hypertension.
2001 Jul; 14(7 Pt 2):231S-236S. doi:
10.1016/s0895-7061(01)02132-x. [PMID: 11459211] - F C Barone, R W Coatney, S Chandra, S K Sarkar, A H Nelson, L C Contino, D P Brooks, W G Campbell, E H Ohlstein, R N Willette. Eprosartan reduces cardiac hypertrophy, protects heart and kidney, and prevents early mortality in severely hypertensive stroke-prone rats.
Cardiovascular research.
2001 Jun; 50(3):525-37. doi:
10.1016/s0008-6363(01)00257-7. [PMID: 11376628] - D R Murdoch, T A McDonagh, R Farmer, J J Morton, J J McMurray, H J Dargie. ADEPT: Addition of the AT1 receptor antagonist eprosartan to ACE inhibitor therapy in chronic heart failure trial: hemodynamic and neurohormonal effects.
American heart journal.
2001 May; 141(5):800-7. doi:
10.1067/mhj.2001.114802. [PMID: 11320369] - T M Ramahi. Expanded role for ARBs in cardiovascular and renal disease? Recent observations have far-reaching implications.
Postgraduate medicine.
2001 Apr; 109(4):115-22; quiz 9. doi:
10.3810/pgm.2001.04.911. [PMID: 11317462] - F Muders, M Palkovits, U Bahner, I Kirst, D Elsner, K Jandeleit-Dahm. Central inhibition of AT1receptors by eprosartan--in vitro autoradiography in the brain.
Pharmacological research.
2001 Mar; 43(3):251-5. doi:
10.1006/phrs.2000.0767. [PMID: 11401417] - J P van Kats, J R van Meegen, P D Verdouw, D J Duncker, M A Schalekamp, A H Danser. Subcellular localization of angiotensin II in kidney and adrenal.
Journal of hypertension.
2001 Mar; 19(3 Pt 2):583-9. doi:
10.1097/00004872-200103001-00010. [PMID: 11327633] - V Y Wong, N J Laping, L C Contino, B A Olson, E Grygielko, D P Brooks. Gene expression in rats with renal disease treated with the angiotensin II receptor antagonist, eprosartan.
Physiological genomics.
2000 Nov; 4(1):35-42. doi:
10.1152/physiolgenomics.2000.4.1.35. [PMID: 11074011] - E Grossman, F H Messerli, J M Neutel. Angiotensin II receptor blockers: equal or preferred substitutes for ACE inhibitors?.
Archives of internal medicine.
2000 Jul; 160(13):1905-11. doi:
10.1001/archinte.160.13.1905. [PMID: 10888965] - S Y Osei, D A Price, L M Laffel, M C Lansang, N K Hollenberg. Effect of angiotensin II antagonist eprosartan on hyperglycemia-induced activation of intrarenal renin-angiotensin system in healthy humans.
Hypertension (Dallas, Tex. : 1979).
2000 Jul; 36(1):122-6. doi:
10.1161/01.hyp.36.1.122. [PMID: 10904023] - J G Puig, F Mateos, A Buño, R Ortega, F Rodriguez, R Dal-Ré. Effect of eprosartan and losartan on uric acid metabolism in patients with essential hypertension.
Journal of hypertension.
1999 Jul; 17(7):1033-9. doi:
10.1097/00004872-199917070-00021. [PMID: 10419078] - S J Kovacs, D M Tenero, D E Martin, B E Ilson, D K Jorkasky. Pharmacokinetics and protein binding of eprosartan in hemodialysis-dependent patients with end-stage renal disease.
Pharmacotherapy.
1999 May; 19(5):612-9. doi:
10.1592/phco.19.8.612.31518. [PMID: 10331824] - M B Bottorff, D M Tenero. Pharmacokinetics of eprosartan in healthy subjects, patients with hypertension, and special populations.
Pharmacotherapy.
1999 Apr; 19(4 Pt 2):73S-78S. doi:
10.1592/phco.19.7.73s.30946. [PMID: 10213525] - D A Sica, N K Hollenberg. The renal profile of eprosartan.
Pharmacotherapy.
1999 Apr; 19(4 Pt 2):86S-94S. doi:
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Pharmacotherapy.
1999 Apr; 19(4 Pt 2):108S-109S. doi:
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Journal of human hypertension.
1999 Jan; 13 Suppl 1(?):S11-20; discussion S33. doi:
10.1038/sj.jhh.1000744. [PMID: 10076916] - I Gavras, H Gavras. Effects of eprosartan versus enalapril in hypertensive patients on the renin-angiotensin-aldosterone system and safety parameters: results from a 26-week, double-blind, multicentre study. Eprosartan Multinational Study Group.
Current medical research and opinion.
1999; 15(1):15-24. doi:
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Hypertension (Dallas, Tex. : 1979).
1998 Oct; 32(4):746-52. doi:
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British journal of clinical pharmacology.
1998 Sep; 46(3):267-70. doi:
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Biopharmaceutics & drug disposition.
1998 Sep; 19(6):351-6. doi:
10.1002/(sici)1099-081x(199809)19:6<351::aid-bdd115>3.0.co;2-v. [PMID: 9737815] - B E Ilson, D E Martin, S C Boike, D K Jorkasky. The effects of eprosartan, an angiotensin II AT1 receptor antagonist, on uric acid excretion in patients with mild to moderate essential hypertension.
Journal of clinical pharmacology.
1998 May; 38(5):437-41. doi:
10.1002/j.1552-4604.1998.tb04450.x. [PMID: 9602957] - D E Lundberg, C R Person, S Knox, M J Cyronak. Determination of SK&F 108566 (Teveten) in human plasma by reversed-phase high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Apr; 707(1-2):328-33. doi:
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