thiotepa (BioDeep_00001867808)
Main id: BioDeep_00000006560
代谢物信息卡片
Thio-TEPA
化学式: C6H12N3PS (189.049)
中文名称: 塞替派, 噻替帕
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN1P(=S)(N1CC1)N1CC1
InChI: InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AC - Ethylene imines
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents > D019653 - Myeloablative Agonists
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:9570
- KEGG: C07641
- KEGGdrug: D00583
- PubChem: 5453
- DrugBank: DB04572
- ChEMBL: CHEMBL671
- MeSH: Thiotepa
- CAS: 1631739-26-8
- CAS: 52-24-4
- PubChem: 9843
- NIKKAJI: J2.307H
- RefMet: Thiotepa
- KNApSAcK: 9570
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Theresa Vilsmaier, Helene Hildegard Heidegger, Lennard Schröder, Elisabeth Trapp, Alaleh Zati Zehni, Brigitte Rack, Wolfgang Janni, Sven Mahner, Tobias Weissenbacher, Udo Jeschke, Jan-Niclas Mumm. Interleukin 15 and Eotaxin correlate with the outcome of breast cancer patients vice versa independent of CTC status.
Archives of gynecology and obstetrics.
2021 01; 303(1):217-230. doi:
10.1007/s00404-020-05793-y. [PMID: 32929618] - Adrian Martuszewski, Patrycja Paluszkiewicz, Katarzyna Sierżęga-Staykov, Elżbieta Wawrzyniak-Dzierżek, Małgorzata Salamonowicz-Bodzioch, Jowita Frączkiewicz, Małgorzata Janeczko-Czarnecka, Monika Mielcarek-Siedziuk, Mateusz Nowak, Nel Dąbrowska-Leonik, Beata Wolska-Kuśnierz, Katarzyna Gul, Katarzyna Bąbol-Pokora, Wojciech Młynarski, Krzysztof Kałwak, Marek Ussowicz. Successful Allogeneic Stem Cell Transplantation in Nuclear Factor-Kappa B Essential Modulator Deficiency Syndrome After Treosulfan-Based Conditioning: A Case Report.
Transplantation proceedings.
2020 Mar; 52(2):647-652. doi:
10.1016/j.transproceed.2019.11.033. [PMID: 32035679] - Yasser Elborai, Mohammad Almutereen, Ossama M Maher, Hanafy Hafez, Michelle A Lee, Leslie Lehmann. Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation.
Journal of the Egyptian National Cancer Institute.
2020 Feb; 32(1):9. doi:
10.1186/s43046-020-00024-6. [PMID: 32372349] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Daniel Wegener, Peter Lang, Frank Paulsen, Nicola Weidner, Daniel Zips, Martin Ebinger, Ursula Holzer, Michaela Döring, Oliver Basu, Bernd Gruhn, Andrea Wittig, Heiko-Manuel Teltschik, Rupert Handgretinger, Frank Heinzelmann. Immunosuppressive Total Nodal Irradiation-Based Reconditioning Regimens After Graft Rejection or Graft Failure in Pediatric Patients Treated With Myeloablative Allogeneic Hematopoietic Cell Transplantation.
International journal of radiation oncology, biology, physics.
2019 05; 104(1):137-143. doi:
10.1016/j.ijrobp.2018.12.031. [PMID: 30593907] - Nicolas Simon, Valérie Coiteux, Bénédicte Bruno, Sophie Taque, Amandine Charbonnier, Laetitia Souchet, Laure Vincent, Ibrahim Yakoub-Agha, Yves Chalandon. [Dose adaptation of the drugs used for hematopoietic stem-cell transplantation in patients with comorbidity: Obesity, chronic renal disease or hepatopathy: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Bulletin du cancer.
2017 Dec; 104(12S):S99-S105. doi:
10.1016/j.bulcan.2017.07.010. [PMID: 29173979] - Diane D Lu, Stephen A Boorjian, Jay D Raman. Intravesical chemotherapy use after radical nephroureterectomy: A national survey of urologic oncologists.
Urologic oncology.
2017 03; 35(3):113.e1-113.e7. doi:
10.1016/j.urolonc.2016.10.016. [PMID: 27884539] - George B McDonald, Ashley T Evans, Jeannine S McCune, Gary Schoch, J Donald Ostrow, Ted A Gooley. Mortality outcomes after busulfan-containing conditioning treatment and haemopoietic cell transplantation in patients with Gilbert's syndrome: a retrospective cohort study.
The Lancet. Haematology.
2016 Nov; 3(11):e516-e525. doi:
10.1016/s2352-3026(16)30149-1. [PMID: 27968820] - Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Valter Torri, Christopher P Fox, Paul La Rosée, Elisabeth Schorb, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Angela Ferrari, Kim M Linton, Roberta Rudà, Mascha Binder, Tobias Pukrop, Monica Balzarotti, Alberto Fabbri, Peter Johnson, Jette Sønderskov Gørløv, Georg Hess, Jens Panse, Francesco Pisani, Alessandra Tucci, Stephan Stilgenbauer, Bernd Hertenstein, Ulrich Keller, Stefan W Krause, Alessandro Levis, Hans J Schmoll, Franco Cavalli, Jürgen Finke, Michele Reni, Emanuele Zucca, Gerald Illerhaus. Chemoimmunotherapy with methotrexate, cytarabine, thiotepa, and rituximab (MATRix regimen) in patients with primary CNS lymphoma: results of the first randomisation of the International Extranodal Lymphoma Study Group-32 (IELSG32) phase 2 trial.
The Lancet. Haematology.
2016 May; 3(5):e217-27. doi:
10.1016/s2352-3026(16)00036-3. [PMID: 27132696] - Doh Yu Hwang, Soo-Jeong Kim, June-Won Cheong, Yundeok Kim, Ji Eun Jang, Jung Yeon Lee, Yoo Hong Min, Woo Ick Yang, Jin Seok Kim. High pre-transplant serum ferritin and busulfan-thiotepa conditioning regimen as risk factors for hepatic sinusoidal obstructive syndrome after autologous stem cell transplantation in patients with malignant lymphoma.
Leukemia & lymphoma.
2016; 57(1):51-7. doi:
10.3109/10428194.2015.1041387. [PMID: 25899401] - Stewart Goldman, Eric Bouffet, Paul G Fisher, Jeffrey C Allen, Patricia L Robertson, Paul J Chuba, Bernadine Donahue, Cynthia S Kretschmar, Tianni Zhou, Allen B Buxton, Ian F Pollack. Phase II Trial Assessing the Ability of Neoadjuvant Chemotherapy With or Without Second-Look Surgery to Eliminate Measurable Disease for Nongerminomatous Germ Cell Tumors: A Children's Oncology Group Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2015 Aug; 33(22):2464-71. doi:
10.1200/jco.2014.59.5132. [PMID: 26101244] - Venkata V V R Marada, Saskia Flörl, Annett Kühne, Gerhard Burckhardt, Yohannes Hagos. Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.
European journal of medicinal chemistry.
2015 Mar; 92(?):723-31. doi:
10.1016/j.ejmech.2015.01.011. [PMID: 25618019] - Shuichiro Uehara, Takaharu Oue, Kengo Nakahata, Keigo Nara, Takehisa Ueno, Mitsugu Owari, Noriaki Usui, Takako Miyamura, Yoshiko Hashii. Perioperative management after high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell transplantation for pediatric solid tumors.
European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie.
2015 Feb; 25(1):118-22. doi:
10.1055/s-0034-1386638. [PMID: 25111275] - G Milone, S Leotta, A Cupri, A L Fauci, P Spina, M Parisi, D Berritta, G Tripepi. Palifermin reduces infection rate and hyperfibrinogenemia in patients treated with high-dose chemotherapy based on beam or BU-thiothepa.
Bone marrow transplantation.
2014 Sep; 49(9):1193-7. doi:
10.1038/bmt.2014.140. [PMID: 25000456] - F Selle, S Wittnebel, P Biron, G Gravis, G Roubaud, B N Bui, R Delva, J O Bay, A Fléchon, L Geoffrois, A Caty, D G Soares, T de Revel, K Fizazi, J Gligorov, J M Micléa, C Dubot, S Provent, I Temby, M Gaulet, E Horn, I Brindel, J P Lotz. A phase II trial of high-dose chemotherapy (HDCT) supported by hematopoietic stem-cell transplantation (HSCT) in germ-cell tumors (GCTs) patients failing cisplatin-based chemotherapy: the Multicentric TAXIF II study.
Annals of oncology : official journal of the European Society for Medical Oncology.
2014 Sep; 25(9):1775-1782. doi:
10.1093/annonc/mdu198. [PMID: 24894084] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - J Sanz, J C H Boluda, C Martín, M González, C Ferrá, D Serrano, C D de Heredia, C Barrenetxea, A M Martinez, C Solano, M A Sanz, G F Sanz. Single-unit umbilical cord blood transplantation from unrelated donors in patients with hematological malignancy using busulfan, thiotepa, fludarabine and ATG as myeloablative conditioning regimen.
Bone marrow transplantation.
2012 Oct; 47(10):1287-93. doi:
10.1038/bmt.2012.13. [PMID: 22327127] - Daniel Weisdorf, Sarah Cooley, Steven Devine, Todd A Fehniger, John DiPersio, Claudio Anasetti, Edmund K Waller, David Porter, Sherif Farag, William Drobyski, Todd Defor, Michael Haagenson, Julie Curtsinger, Jeffrey Miller. T cell-depleted partial matched unrelated donor transplant for advanced myeloid malignancy: KIR ligand mismatch and outcome.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2012 Jun; 18(6):937-43. doi:
10.1016/j.bbmt.2011.11.024. [PMID: 22155505] - Stefan O Ciurea, Rima M Saliba, Nelson Hamerschlak, Amado J Karduss Aurueta, Roland Bassett, Marcelo Fernandez-Vina, Demetrios Petropoulos, Laura L Worth, Ka Wah Chan, Daniel R Couriel, Gabriela Rondon, Manish Sharma, Muzaffar Qazilbash, Roy B Jones, Partow Kebriaei, John McMannis, Chitra M Hosing, Yago Nieto, Richard E Champlin, Elizabeth J Shpall, Marcos de Lima. Fludarabine, melphalan, thiotepa and anti-thymocyte globulin conditioning for unrelated cord blood transplant.
Leukemia & lymphoma.
2012 May; 53(5):901-6. doi:
10.3109/10428194.2011.631159. [PMID: 21988645] - Fei Li, Andrew D Patterson, Constance C Höfer, Kristopher W Krausz, Frank J Gonzalez, Jeffrey R Idle. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics.
Biochemical pharmacology.
2011 Apr; 81(8):1043-53. doi:
10.1016/j.bcp.2011.01.024. [PMID: 21300029] - Aurore Fraix, Tristan Montier, Nathalie Carmoy, Damien Loizeau, Laure Burel-Deschamps, Tony Le Gall, Philippe Giamarchi, Hélène Couthon-Gourvès, Jean-Pierre Haelters, Pierre Lehn, Paul-Alain Jaffrès. Cationic lipo-thiophosphoramidates for gene delivery: synthesis, physico-chemical characterization and gene transfection activity--comparison with lipo-phosphoramidates.
Organic & biomolecular chemistry.
2011 Apr; 9(7):2422-32. doi:
10.1039/c0ob00981d. [PMID: 21321786] - Stefan Weigt, Nicole Huebler, Ruben Strecker, Thomas Braunbeck, Thomas H Broschard. Zebrafish (Danio rerio) embryos as a model for testing proteratogens.
Toxicology.
2011 Mar; 281(1-3):25-36. doi:
10.1016/j.tox.2011.01.004. [PMID: 21237239] - Jian-Ping Cheng, Ying Yan, Xiang-Yi Wang, Yuan-Li Lu, Yan-Hua Yuan, Jun Jia, Jun Ren. MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer.
Chinese journal of cancer.
2011 Jan; 30(1):54-61. doi:
10.5732/cjc.010.10239. [PMID: 21192844] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Ciska Buijs, Pax H B Willemse, E G E de Vries, Klase A Ten Hoor, H M Boezen, Harry Hollema, Marian J E Mourits. Effect of tamoxifen on the endometrium and the menstrual cycle of premenopausal breast cancer patients.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2009 May; 19(4):677-81. doi:
10.1111/igc.0b013e3181a47cbe. [PMID: 19509569] - Corine Ekhart, Sjoerd Rodenhuis, Jos H Beijnen, Alwin D R Huitema. Pharmacokinetics of cyclophosphamide and thiotepa in a conventional fractionated high-dose regimen compared with a novel simplified unfractionated regimen.
Therapeutic drug monitoring.
2009 Feb; 31(1):95-103. doi:
10.1097/ftd.0b013e318194e484. [PMID: 19155964] - Corine Ekhart, J Martijn Kerst, Sjoerd Rodenhuis, Jos H Beijnen, Alwin D R Huitema. Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency.
Cancer chemotherapy and pharmacology.
2009 Jan; 63(2):375-9. doi:
10.1007/s00280-008-0757-z. [PMID: 18431571] - Corine Ekhart, Valerie D Doodeman, Sjoerd Rodenhuis, Paul H M Smits, Jos H Beijnen, Alwin D R Huitema. Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
British journal of clinical pharmacology.
2009 Jan; 67(1):50-60. doi:
10.1111/j.1365-2125.2008.03321.x. [PMID: 19076156] - Farid S Haddad. The FISH test for the diagnosis, surveillance, and prognosis of transitional cell carcinoma of the bladder.
Le Journal medical libanais. The Lebanese medical journal.
2008 Oct; 56(4):230-2. doi:
NULL. [PMID: 19115598] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - J Bouligand, A Le Maitre, D Valteau-Couanet, J Grill, L Drouard-Troalen, A Paci, O Hartmann, E Benhamou, G Vassal. Elevated plasma ferritin and busulfan pharmacodynamics during high-dose chemotherapy regimens in children with malignant solid tumors.
Clinical pharmacology and therapeutics.
2007 Oct; 82(4):402-9. doi:
10.1038/sj.clpt.6100168. [PMID: 17392724] - Koji Izumi, Hitomi Kanno, Susumu Umemoto, Hisashi Hasumi, Yutaka Osada, Junichi Otai, Kunihisa Mikata, Futoshi Tsuchiya, Yoji Nagashima. [A case of recurrent renal cell carcinoma which recurred after fourth surgical resection and survived for about 2 years by medroxyporgesterone acetate administration].
Hinyokika kiyo. Acta urologica Japonica.
2007 Sep; 53(9):623-6. doi:
. [PMID: 17933137] - Amanda M Termuhlen, Alfred Grovas, Kathryn Klopfenstein, Robin Rosselet, Thomas G Gross. Autologous hematopoietic stem cell transplant with melphalan and thiotepa is safe and feasible in pediatric patients with low normalized glomerular filtration rate.
Pediatric transplantation.
2006 Nov; 10(7):830-4. doi:
10.1111/j.1399-3046.2006.00589.x. [PMID: 17032431] - Claudia Lanvers-Kaminsky, Dorothea-Maria Nolting, Julia Köster, Anke Schröder, Julia Sandkötter, Joachim Boos. In-vitro toxicity of Ukrain against human Ewing tumor cell lines.
Anti-cancer drugs.
2006 Oct; 17(9):1025-30. doi:
10.1097/01.cad.0000231467.61911.50. [PMID: 17001175] - M E de Jonge, A D R Huitema, J H Beijnen, S Rodenhuis. High exposures to bioactivated cyclophosphamide are related to the occurrence of veno-occlusive disease of the liver following high-dose chemotherapy.
British journal of cancer.
2006 May; 94(9):1226-30. doi:
10.1038/sj.bjc.6603097. [PMID: 16622453] - Milly E de Jonge, Alwin D R Huitema, Selma M van Dam, Sjoerd Rodenhuis, Jos H Beijnen. Population pharmacokinetics of cyclophosphamide and its metabolites 4-hydroxycyclophosphamide, 2-dechloroethylcyclophosphamide, and phosphoramide mustard in a high-dose combination with Thiotepa and Carboplatin.
Therapeutic drug monitoring.
2005 Dec; 27(6):756-65. doi:
10.1097/01.ftd.0000177224.19294.92. [PMID: 16306851] - E B Kruglova, E L Ermak, T P Soloshchuk, A I Potopal'skiĭ, Iu A Potopal'skaia. [Berberine and amitozine binding with calf thymus DNA].
Ukrains'kyi biokhimichnyi zhurnal (1999 ).
2005 Jul; 77(4):70-6. doi:
". [PMID: 16568606] - Milly E de Jonge, Alwin D R Huitema, Sjoerd Rodenhuis, Jos H Beijnen. Sparse sampling design for therapeutic drug monitoring of sequentially administered cyclophosphamide, thiotepa, and carboplatin (CTC).
Therapeutic drug monitoring.
2005 Jun; 27(3):393-402. doi:
10.1097/01.ftd.0000158081.38330.5e. [PMID: 15905813] - Milly E de Jonge, Alwin D R Huitema, Selma M van Dam, Jos H Beijnen, Sjoerd Rodenhuis. Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin.
Cancer chemotherapy and pharmacology.
2005 May; 55(5):507-10. doi:
10.1007/s00280-004-0922-y. [PMID: 15685452] - Milly E de Jonge, Alwin D R Huitema, Annemarie C Tukker, Selma M van Dam, Sjoerd Rodenhuis, Jos H Beijnen. Accuracy, feasibility, and clinical impact of prospective Bayesian pharmacokinetically guided dosing of cyclophosphamide, thiotepa, and carboplatin in high-dose chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Jan; 11(1):273-83. doi:
. [PMID: 15671556] - E P Alessandrino, P Bernasconi, A A Colombo, D Caldera, L Malcovati, D Troletti, L Vanelli, M Varettoni, F Montanari, M Lazzarino. Reduced-intensity conditioning regimen with thiotepa and fludarabine followed by allogeneic blood stem cell transplantation in haematological malignancies.
Bone marrow transplantation.
2004 Dec; 34(12):1039-45. doi:
10.1038/sj.bmt.1704717. [PMID: 15516936] - Andrew D Campbell, Susan L Cohn, Marleta Reynolds, Roopa Seshadri, Elaine Morgan, Grant Geissler, Alfred Rademaker, Maryann Marymount, John Kalapurakal, Paul R Haut, Reggie Duerst, Morris Kletzel. Treatment of relapsed Wilms' tumor with high-dose therapy and autologous hematopoietic stem-cell rescue: the experience at Children's Memorial Hospital.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2004 Jul; 22(14):2885-90. doi:
10.1200/jco.2004.09.073. [PMID: 15254057] - Franca Fagioli, Eleonora Biasin, Luana Mastrodicasa, Alessandro Sandri, Ivana Ferrero, Massimo Berger, Elena Vassallo, Enrico Madon. High-dose thiotepa and etoposide in children with poor-prognosis brain tumors.
Cancer.
2004 May; 100(10):2215-21. doi:
10.1002/cncr.20227. [PMID: 15139067] - Milly E de Jonge, Alwin D R Huitema, Sjoerd Rodenhuis, Jos H Beijnen. Integrated Population Pharmacokinetic Model of both cyclophosphamide and thiotepa suggesting a mutual drug-drug interaction.
Journal of pharmacokinetics and pharmacodynamics.
2004 Apr; 31(2):135-56. doi:
10.1023/b:jopa.0000034405.03895.c2. [PMID: 15379382] - Milly E de Jonge, Selma M van Dam, Michel J X Hillebrand, Hilde Rosing, Alwin D R Huitema, Sjoerd Rodenhuis, Jos H Beijnen. Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS.
2004 Mar; 39(3):262-71. doi:
10.1002/jms.570. [PMID: 15039933] - J G Schrama, M J Holtkamp, J W Baars, J H Schornagel, S Rodenhuis. Toxicity of the high-dose chemotherapy CTC regimen (cyclophosphamide, thiotepa, carboplatin): the Netherlands Cancer Institute experience.
British journal of cancer.
2003 Jun; 88(12):1831-8. doi:
10.1038/sj.bjc.6601001. [PMID: 12799623] - Milly E de Jonge, Ron A A Mathôt, Selma M van Dam, Sjoerd Rodenhuis, Jos H Beijnen. Sorption of thiotepa to polyurethane catheter causes falsely elevated plasma levels.
Therapeutic drug monitoring.
2003 Jun; 25(3):261-3. doi:
10.1097/00007691-200306000-00002. [PMID: 12766550] - Lin-jie Guo, Zhong-yao Wu, Sheng Zhang, Jian-liang Zheng, Hu-ling Zheng. [Effect of bcl-2 antisense oligonucleotides on multidrug resistance of cultured uveal melanoma cells].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology.
2003 Feb; 39(2):73-6. doi:
". [PMID: 12783683] - Simone Cesaro, Maria Vittoria Gazzola, Piero Marson, Elisabetta Calore, Luciana Caenazzo, Roberta Destro, Giustina De Silvestro, Stefania Varotto, Marta Pillon, Luigi Zanesco, Chiara Messina. Successful engraftment and stable full donor chimerism after myeloablation with thiotepa, fludarabine, and melphalan and CD34-selected peripheral allogeneic stem cell transplantation in hemophagocytic lymphohistiocytosis.
American journal of hematology.
2003 Feb; 72(2):143-6. doi:
10.1002/ajh.10266. [PMID: 12555220] - R P Nelson, T F Logan, R Abonour. Nonablative hematopoietic cell transplantation for the treatment of metastatic renal cell carcinoma.
Bone marrow transplantation.
2002 Dec; 30(12):805-12. doi:
10.1038/sj.bmt.1703740. [PMID: 12476272] - B Kremens, B Gruhn, T Klingebiel, C Hasan, H-J Laws, E Koscielniak, B Hero, B Selle, C Niemeyer, F G Finckenstein, A Schulz, A Wawer, F Zintl, N Graf. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma.
Bone marrow transplantation.
2002 Dec; 30(12):893-8. doi:
10.1038/sj.bmt.1703771. [PMID: 12476282] - M E de Jonge, R A A Mathôt, O Dalesio, A D R Huitema, S Rodenhuis, J H Beijnen. Relationship between irreversible alopecia and exposure to cyclophosphamide, thiotepa and carboplatin (CTC) in high-dose chemotherapy.
Bone marrow transplantation.
2002 Nov; 30(9):593-7. doi:
10.1038/sj.bmt.1703695. [PMID: 12407434] - Milly E De Jonge, Ron A A Mathôt, Selma M Van Dam, Jos H Beijnen, Sjoerd Rodenhuis. Extremely high exposures in an obese patient receiving high-dose cyclophosphamide, thiotepa and carboplatin.
Cancer chemotherapy and pharmacology.
2002 Sep; 50(3):251-5. doi:
10.1007/s00280-002-0494-7. [PMID: 12203108] - Charlotte Kloft, Wolfgang Siegert, Joerg Beyer, Ulrich Jaehde. Toxicity of high-dose carboplatin: ultrafiltered and not total plasma pharmacokinetics is of clinical relevance.
Journal of clinical pharmacology.
2002 Jul; 42(7):762-73. doi:
10.1177/009127002401102704. [PMID: 12092743] - James M Rae, Nadia V Soukhova, David A Flockhart, Zeruesenay Desta. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2002 May; 30(5):525-30. doi:
10.1124/dmd.30.5.525. [PMID: 11950782] - Ugo De Giorgi, Giovanni Rosti, Giorgio Papiani, Maurizio Marangolo. The status of high-dose chemotherapy with hematopoietic stem cell transplantation in germ cell tumor patients.
Haematologica.
2002 Jan; 87(1):95-104. doi:
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Blood.
2001 Oct; 98(8):2332-8. doi:
10.1182/blood.v98.8.2332. [PMID: 11588027] - M Sanchez-Carbayo, M Urrutia, R Romani, M Herrero, J M Gonzalez de Buitrago, J A Navajo. Serial urinary IL-2, IL-6, IL-8, TNFalpha, UBC, CYFRA 21-1 and NMP22 during follow-up of patients with bladder cancer receiving intravesical BCG.
Anticancer research.
2001 Jul; 21(4B):3041-7. doi:
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Anti-cancer drugs.
2001 Jul; 12(6):519-24. doi:
10.1097/00001813-200107000-00005. [PMID: 11459998] - A D Huitema, R A Mathôt, M M Tibben, S Rodenhuis, J H Beijnen. A mechanism-based pharmacokinetic model for the cytochrome P450 drug-drug interaction between cyclophosphamide and thioTEPA and the autoinduction of cyclophosphamide.
Journal of pharmacokinetics and pharmacodynamics.
2001 Jun; 28(3):211-30. doi:
10.1023/a:1011543508731. [PMID: 11468938] - A D Huitema, R A Mathôt, M M Tibben, J H Schellens, S Rodenhuis, J H Beijnen. Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.
British journal of clinical pharmacology.
2001 Jan; 51(1):61-70. doi:
10.1046/j.1365-2125.2001.01301.x. [PMID: 11167666] - A Ruggiero, V Conter, M Milani, E Biagi, I Lazzareschi, P Sparano, R Riccardi. Intrathecal chemotherapy with antineoplastic agents in children.
Paediatric drugs.
2001; 3(4):237-46. doi:
10.2165/00128072-200103040-00001. [PMID: 11354696] - K P Papadopoulos, M J Egorin, M Huang, A B Troxel, E Kaufman, C M Balmaceda, L T Vahdat, C S Hesdorffer. The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m2 continuous infusion over 24 h) with hematopoietic support in women with metastatic breast cancer.
Cancer chemotherapy and pharmacology.
2001; 47(1):45-50. doi:
10.1007/s002800000193. [PMID: 11221961] - T Lamparelli, M T van Lint, F Gualandi, A M Raiola, M Barbanti, N Sacchi, G Ficai, C Ghinatti, S Bregante, G Berisso, A Dominietto, C Di Grazia, B Bruno, M Sessarego, L Casarino, S Verdiani, A Bacigalupo. Alternative donor transplants for patients with advanced hematologic malignancies, conditioned with thiotepa, cyclophosphamide and antithymocyte globulin.
Bone marrow transplantation.
2000 Dec; 26(12):1305-11. doi:
10.1038/sj.bmt.1702719. [PMID: 11223970] - V Papadakis, I J Dunkel, L D Cramer, E Kramer, E Papadopoulos, S Goldman, R J Packer, M Willoughby, D Baker, J Garvin, S Strandjord, P Coccia, A M Kaplan, M Klemperer, J L Finlay. High-dose carmustine, thiotepa and etoposide followed by autologous bone marrow rescue for the treatment of high risk central nervous system tumors.
Bone marrow transplantation.
2000 Jul; 26(2):153-60. doi:
10.1038/sj.bmt.1702475. [PMID: 10918425] - X Zhang, H Yang, G Lu. [Establishment of MRP-overexpression subline of bladder carcinoma and its MDR phenotype].
Zhonghua zhong liu za zhi [Chinese journal of oncology].
2000 Jul; 22(4):273-5. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
2000 Jun; 742(2):335-43. doi:
10.1016/s0378-4347(00)00181-x. [PMID: 10901138] - M J van Maanen, K Doesburg Smits, J M Damen, A J Heck, J H Beijnen. Stability of thioTEPA and its metabolites, TEPA, monochloroTEPA and thioTEPA-mercapturate, in plasma and urine.
International journal of pharmaceutics.
2000 May; 200(2):187-94. doi:
10.1016/s0378-5173(00)00370-7. [PMID: 10867248] - H A Hahm, D K Armstrong, T L Chen, L Grochow, J Passos-Coelho, S N Goodman, N E Davidson, M J Kennedy. Novobiocin in combination with high-dose chemotherapy for the treatment of advanced breast cancer: a phase 2 study.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2000; 6(3A):335-43. doi:
10.1016/s1083-8791(00)70059-0. [PMID: 10905771] - D G Izhogin, V K Boiarshinov, I S Dolgonolov, M Ia Iankelevich, E A Ptushkina, G L Mentkevich. [High-dose thiotepa chemotherapy in children].
Voprosy onkologii.
2000; 46(4):401-6. doi:
NULL. [PMID: 11147412] - M J van Maanen, I M Tijhof, J M Damen, C Versluis, J J van den Bosch, A J Heck, S Rodenhuis, J H Beijnen. A search for new metabolites of N,N',N''-triethylenethiophosphoramide.
Cancer research.
1999 Sep; 59(18):4720-4. doi:
NULL. [PMID: 10493531] - M J van Maanen, J H Beijnen. Liquid chromatographic-mass spectrometric determination of the novel, recently identified thioTEPA metabolite, thioTEPA-mercapturate, in urine.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Sep; 732(1):73-9. doi:
10.1016/s0378-4347(99)00268-6. [PMID: 10517224] - L G Feun, K R Reddy, T Scagnelli, J M Yrizarry, J J Guerra, E Russell, M Schwartz, N Savaraj, A S Livingstone, J U Levi, L J Jeffers, B Ardalan, E R Schiff. A phase I study of chemoembolization with cisplatin, thiotepa, and lipiodol for primary and metastatic liver cancer.
American journal of clinical oncology.
1999 Aug; 22(4):375-80. doi:
10.1097/00000421-199908000-00010. [PMID: 10440193] - B Bolwell, B Pohlman, M Kalaycio, K Wise, M Goormastic, S Andresen. LDH elevation after autologous stem cell transplantation.
Bone marrow transplantation.
1999 Jul; 24(1):53-5. doi:
10.1038/sj.bmt.1701812. [PMID: 10435735] - V R Panday, L J van Warmerdam, M T Huizing, S Rodenhuis, J H Schellens, J H Beijnen. A single 24-hour plasma sample does not predict the carboplatin AUC from carboplatin-paclitaxel combinations or from a high-dose carboplatin-thiotepa-cyclophosphamide regimen.
Cancer chemotherapy and pharmacology.
1999; 43(5):435-8. doi:
10.1007/s002800050919. [PMID: 10100601] - R J van Maanen, R D van Ooijen, J W Zwikker, A D Huitema, S Rodenhuis, J H Beijnen. Determination of N,N',N'-triethylenethiophosphoramide and its active metabolite N,N',N'-triethylenephosphoramide in plasma and urine using capillary gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Nov; 719(1-2):103-12. doi:
10.1016/s0378-4347(98)00381-8. [PMID: 9869370] - A D Huitema, M M Tibben, T Kerbusch, J W Zwikker, S Rodenhuis, J H Beijnen. Simultaneous determination of N,N',N"-triethylenethiophosphoramide, cyclophosphamide and some of their metabolites in plasma using capillary gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Sep; 716(1-2):177-86. doi:
10.1016/s0378-4347(98)00300-4. [PMID: 9824231] - A Mäkipernaa, P L Lähde. Elevated levels of serum CA-125 and NSE in a patient with desmoplastic tumor.
Pediatric hematology and oncology.
1998 Jan; 15(1):91-2. doi:
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Journal of neurosurgery.
1997 Nov; 87(5):694-9. doi:
10.3171/jns.1997.87.5.0694. [PMID: 9347977] - B A Teicher, M Ikebe, G Ara, S R Keyes, R S Herbst. Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin.
In vivo (Athens, Greece).
1997 Nov; 11(6):463-72. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1997 Sep; 698(1-2):111-21. doi:
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Revista de medicina de la Universidad de Navarra.
1997 Jul; 41(3):143-51. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1997 May; 25(5):544-51. doi:
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Bone marrow transplantation.
1996 Apr; 17(4):503-7. doi:
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Bone marrow transplantation.
1996 Apr; 17(4):497-501. doi:
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British journal of cancer.
1996 Apr; 73(8):979-84. doi:
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Blood.
1996 Mar; 87(5):1687-91. doi:
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Cancer chemotherapy and pharmacology.
1996; 38(1):59-64. doi:
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Cancer.
1995 Dec; 76(11):2338-42. doi:
10.1002/1097-0142(19951201)76:11<2338::aid-cncr2820761123>3.0.co;2-p. [PMID: 8635040] - C L Shapiro, B J Dezube, O Tretyakov, J Wright, B Cap, I C Henderson, D F Hayes. Dose escalation of N,N',N'-triethylenethiophosphoramide combined with pentoxifylline for advanced breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1995 Aug; 1(8):791-6. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1995 May; 13(5):1136-43. doi:
10.1200/jco.1995.13.5.1136. [PMID: 7738619] - T L Chen, J L Passos-Coelho, D A Noe, M J Kennedy, K C Black, O M Colvin, L B Grochow. Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation.
Cancer research.
1995 Feb; 55(4):810-6. doi:
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Cancer chemotherapy and pharmacology.
1995; 37(1-2):155-60. doi:
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Blood.
1994 Aug; 84(3):950-6. doi:
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Cancer research.
1994 Apr; 54(8):2228-33. doi:
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Cancer chemotherapy and pharmacology.
1994; 35(2):179-81. doi:
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Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.
1993 Dec; 3(6):979-87. doi:
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The Journal of urology.
1993 Sep; 150(3):1034-7. doi:
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