ethionamide (BioDeep_00001867780)
Main id: BioDeep_00000002720
Chemicals and Drugs
代谢物信息卡片
ethionamide
化学式: C8H10N2S (166.0565)
中文名称: 乙硫异酰胺, 乙硫异烟胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=NC=CC(=C1)C(=S)N
InChI: InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)
描述信息
J - Antiinfectives for systemic use > J04 - Antimycobacterials > J04A - Drugs for treatment of tuberculosis > J04AD - Thiocarbamide derivatives
D000963 - Antimetabolites > D000960 - Hypolipidemic Agents > D054872 - Fatty Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic.
同义名列表
4 个代谢物同义名
ethionamide; 2-Ethylthioisonicotinamide; Ethionamide; Ethionamide
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:4885
- KEGG: C07665
- KEGGdrug: D00591
- PubChem: 2761171
- DrugBank: DB00609
- ChEMBL: CHEMBL1441
- MeSH: Ethionamide
- CAS: 536-33-4
- PubChem: 9867
- PDB-CCD: 1JA
- NIKKAJI: J2.066D
- medchemexpress: HY-B0276
- KNApSAcK: 4885
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ronald Rodriguez, Nick Campbell-Kruger, Jesus Gonzalez Camba, John Berude, Rachel Fetterman, Sarah Stanley. MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus.
Antimicrobial agents and chemotherapy.
2023 Mar; ?(?):e0135022. doi:
10.1128/aac.01350-22. [PMID: 36988462] - Kyotaka Muta, Kosuke Saito, Yusuke Kemmochi, Taku Masuyama, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai. Phosphatidylcholine (18:0/20:4), a potential biomarker to predict ethionamide-induced hepatic steatosis in rats.
Journal of applied toxicology : JAT.
2022 09; 42(9):1533-1547. doi:
10.1002/jat.4324. [PMID: 35315511] - Pradeep Kumar Anand, Arbind Kumar, Amrit Saini, Jagdeep Kaur. Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc2155.
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10.1128/aac.00099-19. [PMID: 30962335] - Agibothu Kupparam Hemanth Kumar, Alok Kumar, Thiruvengadam Kannan, Rakesh Bhatia, Dipti Agarwal, Santosh Kumar, Rajeshwar Dayal, Sheo Pratap Singh, Geetha Ramachandran. Pharmacokinetics of Second-Line Antituberculosis Drugs in Children with Multidrug-Resistant Tuberculosis in India.
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