urethane (BioDeep_00001867619)

Main id: BioDeep_00000004706

 

PANOMIX_OTCML-2023


代谢物信息卡片


urethane

化学式: C3H7NO2 (89.0476762)
中文名称: 氨基甲酸乙酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)N
InChI: InChI=1S/C3H7NO2/c1-2-6-3(4)5/h2H2,1H3,(H2,4,5)

描述信息

A carbamate ester obtained by the formal condensation of ethanol with carbamic acid. It has been found in alcoholic beverages.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D009676 - Noxae > D002273 - Carcinogens
D000970 - Antineoplastic Agents
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].

同义名列表

4 个代谢物同义名

urethane; Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Gaofeng Fang, Shengquan Wang, Qianyao Chen, Han Luo, Xuemei Lian, Dan Shi. Time-restricted feeding affects the fecal microbiome metabolome and its diurnal oscillations in lung cancer mice. Neoplasia (New York, N.Y.). 2023 11; 45(?):100943. doi: 10.1016/j.neo.2023.100943. [PMID: 37852131]
  • Tao Bao, Naymul Karim, Huihui Ke, Jitbanjong Tangpong, Wei Chen. Polysaccharide isolated from wax apple suppresses ethyl carbamate-induced oxidative damage in human hepatocytes. Journal of Zhejiang University. Science. B. 2023 Jul; 24(7):574-586. doi: 10.1631/jzus.b2200629. [PMID: 37455135]
  • Heba A Sahyon, Nagi M El-Shafai, Noha Elnajjar, Fayez Althobaiti, Adil Aldhahrani, Nadaa S Alharbi, Abdel Ghany F Shoair, Ibrahim M El-Mehasseb. Avocado peel extract loaded on chitosan nanoparticles alleviates urethane toxicity that causes lung cancer in a mouse model. International journal of biological macromolecules. 2023 Feb; 234(?):123633. doi: 10.1016/j.ijbiomac.2023.123633. [PMID: 36791938]
  • Mona A Ibrahim, Sherif R Mohamed, Mohamed A Dkhil, Felwa A Thagfan, Rewaida Abdel-Gaber, Doaa Soliman. The effect of Moringa oleifera leaf extracts against urethane-induced lung cancer in rat model. Environmental science and pollution research international. 2022 Dec; ?(?):. doi: 10.1007/s11356-022-24813-9. [PMID: 36567388]
  • M A Hamzawy, A M Abo-Youssef, M N Malak, M M Khalaf. Multiple targets of Nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cGMP and limitation of cyclin D1 and Bcl2. European review for medical and pharmacological sciences. 2022 12; 26(24):9393-9408. doi: 10.26355/eurrev_202212_30690. [PMID: 36591848]
  • Luis Vázquez, Mario Sánchez-Moyano, Lorena de la Iglesia, Guillermo Reglero, Carlos F Torres. A new urea adducts method for PUFA concentration using green food grade solvents and avoiding ethyl carbamate formation. Food chemistry. 2022 Oct; 392(?):133197. doi: 10.1016/j.foodchem.2022.133197. [PMID: 35659697]
  • Yang Xu, Yuting Li, Jiaxin Li, Wei Chen. Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation. Redox biology. 2022 07; 53(?):102349. doi: 10.1016/j.redox.2022.102349. [PMID: 35623314]
  • Marwa A Mahmoud, Mona A El-Bana, Sfaa M Morsy, Ehsan A Badawy, Abd-Elrazik Farrag, Ahmed M Badawy, Mosaad A Abdel-Wahhab, Mohamed A El-Dosoky. Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer. International journal of pharmaceutics. 2022 Apr; 618(?):121652. doi: 10.1016/j.ijpharm.2022.121652. [PMID: 35278602]
  • X Yu, Y Q Zou, Y Wang, Z K Chen, D F Ma. [Equol and its enantiomers inhibited urethane-induced lung cancer in mice]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2022 Apr; 54(2):244-248. doi: . [PMID: 35435186]
  • Jun Fang, Song Li. End-Point Immobilization of Heparin on Electrospun Polycarbonate-Urethane Vascular Graft. Methods in molecular biology (Clifton, N.J.). 2022; 2375(?):47-59. doi: 10.1007/978-1-0716-1708-3_5. [PMID: 34591298]
  • Leon J DeLalio, Sean D Stocker. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli. Journal of neurophysiology. 2021 08; 126(2):668-679. doi: 10.1152/jn.00277.2021. [PMID: 34259043]
  • Huihui Ke, Tao Bao, Wei Chen. New function of polysaccharide from Rubus chingii Hu: protective effect against ethyl carbamate induced cytotoxicity. Journal of the science of food and agriculture. 2021 Jun; 101(8):3156-3164. doi: 10.1002/jsfa.10944. [PMID: 33211321]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Leon J DeLalio, Sean D Stocker. Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity. American journal of physiology. Heart and circulatory physiology. 2021 01; 320(1):H117-H132. doi: 10.1152/ajpheart.00675.2020. [PMID: 33216622]
  • Kimio Sugaya, Saori Nishijima, Katsumi Kadekawa, Katsuhiko Noguchi, Je T Woo, Hideyuki Yamamoto, Seiji Matsumoto. Vanilla scent reduces frequency of urination in urethane-anesthetized rats. Lower urinary tract symptoms. 2021 Jan; 13(1):189-193. doi: 10.1111/luts.12346. [PMID: 32871621]
  • Yang Lv, Hongyu Liang, Jun Li, Xiuxiu Li, Xiaohui Tang, Songyu Gao, Hao Zou, Jing Zhang, Mei Wang, Liang Xiao. Central inhibition prevents the in vivo acute toxicity of harmine in mice. The Journal of toxicological sciences. 2021; 46(6):289-301. doi: 10.2131/jts.46.289. [PMID: 34078836]
  • Hui-Juan Zhang, Wen-Jing Chang, Cai-Yun Jia, Ling Qiao, Jing Zhou, Qing Chen, Xiao-Wei Zheng, Jian-Hua Zhang, Hong-Chao Li, Zheng-Yan Yang, Zhong-Hua Liu, Guang-Chao Liu, Shao-Ping Ji, Feng Lu. Destrin Contributes to Lung Adenocarcinoma Progression by Activating Wnt/β-Catenin Signaling Pathway. Molecular cancer research : MCR. 2020 12; 18(12):1789-1802. doi: 10.1158/1541-7786.mcr-20-0187. [PMID: 32878967]
  • Weihua Wang, ZhanJiang Han, Dongqi Guo, Yanju Xiang. UHPLC-QTOFMS-based metabolomic analysis of serum and urine in rats treated with musalais containing varying ethyl carbamate content. Analytical and bioanalytical chemistry. 2020 Nov; 412(27):7627-7637. doi: 10.1007/s00216-020-02900-5. [PMID: 32897411]
  • Linxing Yao, Kaitlyn Maloley, Corey Broeckling, Steve Ensley, Scott Crain, Robert Coffey. Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by Gas Chromatography-Mass Spectrometry. Journal of agricultural and food chemistry. 2020 Sep; 68(39):10984-10991. doi: 10.1021/acs.jafc.0c03535. [PMID: 32833443]
  • Wanyi Zhou, Jingjin Hu, Xinglin Zhang, Qihe Chen. Application of bamboo leaves extract to Chinese yellow rice wine brewing for ethyl carbamate regulation and its mitigation mechanism. Food chemistry. 2020 Jul; 319(?):126554. doi: 10.1016/j.foodchem.2020.126554. [PMID: 32169766]
  • Hoshyar Gholami, Hamid Yeganeh. Vegetable oil-based polyurethanes as antimicrobial wound dressings: in vitro and in vivo evaluation. Biomedical materials (Bristol, England). 2020 05; 15(4):045001. doi: 10.1088/1748-605x/ab7387. [PMID: 32031994]
  • Victor Constante Oliveira, Maria Paula Carvalho Naves, Cássio Resende de Morais, Sarah Alves Rodrigues Constante, Priscila Capelari Orsolin, Bianca Silva Alves, Francisco Rinaldi Neto, Lucas Henrique Domingos da Silva, Lucas Teixeira Souza de Oliveira, Natália Helen Ferreira, Tábata Rodrigues Esperandim, Wilson Roberto Cunha, Denise Crispim Tavares, Mário Antônio Spanó. Betulinic acid modulates urethane-induced genotoxicity and mutagenicity in mice and Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2020 Apr; 138(?):111228. doi: 10.1016/j.fct.2020.111228. [PMID: 32112866]
  • Jianbo Zheng, Xin Guo, Yuka Nakamura, Xiaolei Zhou, Reimon Yamaguchi, Jing Zhang, Yasuhito Ishigaki, Hidetaka Uramoto, Sohsuke Yamada. Overexpression of PRDX4 Modulates Tumor Microenvironment and Promotes Urethane-Induced Lung Tumorigenesis. Oxidative medicine and cellular longevity. 2020; 2020(?):8262730. doi: 10.1155/2020/8262730. [PMID: 33456675]
  • Julien Peyrton, Clémence Chambaretaud, Luc Avérous. New Insight on the Study of the Kinetic of Biobased Polyurethanes Synthesis Based on Oleo-Chemistry. Molecules (Basel, Switzerland). 2019 Nov; 24(23):. doi: 10.3390/molecules24234332. [PMID: 31783536]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Christian A Reynolds, Donal S O'Leary, Cheng Ly, Scott A Smith, Zeljka Minic. Development of a decerebrate model for investigating mechanisms mediating viscero-sympathetic reflexes in the spinalized rat. American journal of physiology. Heart and circulatory physiology. 2019 06; 316(6):H1332-H1340. doi: 10.1152/ajpheart.00724.2018. [PMID: 30875256]
  • Yong Sun Lee, In Jun Yeo, Ki Cheon Kim, Sang-Bae Han, Jin Tae Hong. Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity. Frontiers in immunology. 2019; 10(?):1379. doi: 10.3389/fimmu.2019.01379. [PMID: 31275318]
  • Yiming Jiang, Aman Khan, Haiying Huang, Yanrong Tian, Xuan Yu, Qiang Xu, Lichao Mou, Jianguo Lv, Pengyun Zhang, Pu Liu, Li Deng, Xiangkai Li. Using nano-attapulgite clay compounded hydrophilic urethane foams (AT/HUFs) as biofilm support enhances oil-refinery wastewater treatment in a biofilm membrane bioreactor. The Science of the total environment. 2019 Jan; 646(?):606-617. doi: 10.1016/j.scitotenv.2018.07.149. [PMID: 30059921]
  • Gaofeng Chen, Hairuo Wen, Zhihui Mao, Jie Song, Hua Jiang, Weifan Wang, Ying Yang, Yufa Miao, Chao Wang, Zhiying Huang, Xue Wang. Assessment of the Pig-a, micronucleus, and comet assay endpoints in rats treated by acute or repeated dosing protocols with procarbazine hydrochloride and ethyl carbamate. Environmental and molecular mutagenesis. 2019 01; 60(1):56-71. doi: 10.1002/em.22227. [PMID: 30240497]
  • Atsuyoshi Okada, Keiichiro Suzuki, Keisuke Hara, Moeko Kojina, Tetsuya Aiba. In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure. Biological & pharmaceutical bulletin. 2019; 42(3):501-506. doi: 10.1248/bpb.b18-00659. [PMID: 30828081]
  • Ryu Kimura, Minoru Miyazato, Asuka Ashikari, Takuma Oshiro, Seiichi Saito. Age-associated urethral dysfunction in urethane-anesthetized rats. Neurourology and urodynamics. 2018 04; 37(4):1313-1319. doi: 10.1002/nau.23481. [PMID: 29333618]
  • Yuting Li, Tao Bao, Wei Chen. Comparison of the protective effect of black and white mulberry against ethyl carbamate-induced cytotoxicity and oxidative damage. Food chemistry. 2018 Mar; 243(?):65-73. doi: 10.1016/j.foodchem.2017.09.106. [PMID: 29146371]
  • Luis Vázquez, Elena Ortego, Marta Corzo-Martínez, Guillermo Reglero, Carlos F Torres. Stearidonic Acid Concentration by Urea Complexation from Echium Oil. Journal of oleo science. 2018; 67(9):1091-1099. doi: 10.5650/jos.ess18025. [PMID: 30175765]
  • Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Amit Kumar, Anupam Guleria, Shubhini A Saraf. Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup3):S598-S610. doi: 10.1080/21691401.2018.1505738. [PMID: 30322263]
  • Ting Chen, Lei Lu, Cai Xu, Xiaojing Lin, Yuet-Kin Leung, Shuk-Mei Ho, Xiong Z Ruan, Xuemei Lian. Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice. Scientific reports. 2017 07; 7(1):4723. doi: 10.1038/s41598-017-05053-1. [PMID: 28680122]
  • Isha Nagpal, Suresh K Abraham. Ameliorative effects of gallic acid, quercetin and limonene on urethane-induced genotoxicity and oxidative stress in Drosophila melanogaster. Toxicology mechanisms and methods. 2017 May; 27(4):286-292. doi: 10.1080/15376516.2016.1278294. [PMID: 28043195]
  • Xuefeng Qiu, Benjamin Li-Ping Lee, Xinghai Ning, Niren Murthy, Nianguo Dong, Song Li. End-point immobilization of heparin on plasma-treated surface of electrospun polycarbonate-urethane vascular graft. Acta biomaterialia. 2017 03; 51(?):138-147. doi: 10.1016/j.actbio.2017.01.012. [PMID: 28069505]
  • Shoshiro Okada, Naoko Yamaguchi. Possible role of adrenoceptors in the hypothalamic paraventricular nucleus in corticotropin-releasing factor-induced sympatho-adrenomedullary outflow in rats. Autonomic neuroscience : basic & clinical. 2017 Mar; 203(?):74-80. doi: 10.1016/j.autneu.2017.01.008. [PMID: 28202248]
  • Peng Zhang, Guocheng Du, Huijun Zou, Guangfa Xie, Jian Chen, Zhongping Shi, Jingwen Zhou. Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System. Journal of agricultural and food chemistry. 2017 Mar; 65(8):1641-1648. doi: 10.1021/acs.jafc.6b05348. [PMID: 28185458]
  • Wei Chen, Yuting Li, Tao Bao, Vemana Gowd. Mulberry Fruit Extract Affords Protection against Ethyl Carbamate-Induced Cytotoxicity and Oxidative Stress. Oxidative medicine and cellular longevity. 2017; 2017(?):1594963. doi: 10.1155/2017/1594963. [PMID: 28819542]
  • Wei Chen, Yang Xu, Lingxia Zhang, Hongming Su, Xiaodong Zheng. Blackberry subjected to in vitro gastrointestinal digestion affords protection against Ethyl Carbamate-induced cytotoxicity. Food chemistry. 2016 Dec; 212(?):620-7. doi: 10.1016/j.foodchem.2016.06.031. [PMID: 27374576]
  • Bogyoung Choi, Eunmi Koh. Changes of ethyl carbamate and its precursors in maesil (Prunus mume) extract during one-year fermentation. Food chemistry. 2016 Oct; 209(?):318-22. doi: 10.1016/j.foodchem.2016.04.040. [PMID: 27173569]
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  • Hironori Satoh, Takashi Moriguchi, Daisuke Saigusa, Liam Baird, Lei Yu, Hirofumi Rokutan, Keiko Igarashi, Masahito Ebina, Tatsuhiro Shibata, Masayuki Yamamoto. NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth. Cancer research. 2016 05; 76(10):3088-96. doi: 10.1158/0008-5472.can-15-1584. [PMID: 27020858]
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