Albendazole (BioDeep_00000001867)

 

Secondary id: BioDeep_00000397471

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester

化学式: C12H15N3O2S (265.0885)
中文名称: 阿苯达唑
谱图信息: 最多检出来源 Mus musculus(blood) 5.48%

分子结构信息

SMILES: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
InChI: InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

描述信息

Albendazole is only found in individuals that have used or taken this drug. It is a benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CA - Benzimidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3580
KEIO_ID A082; [MS3] KO008867
KEIO_ID A082; [MS2] KO008866
KEIO_ID A082
Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

同义名列表

53 个代谢物同义名

(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester; methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate; (5-(Propylthio)-1H-benzimidazol-2-yl)carbamate methyl ester; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamic acid; O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate; 5-(Propylthio)-2-carbomethoxyaminobenzimidazole; SmithKline beecham brand OF albendazole; Noé-socopharm brand OF albendazole; Noé socopharm brand OF albendazole; Albendazole noé-socopharm brand; Valdecasas brand OF albendazole; Monohydrochloride, albendazole; Sanicoopa brand OF albendazole; Armstrong brand OF albendazole; Albendazole monohydrochloride; Liferpal brand OF albendazole; Hormona brand OF albendazole; Fustery brand OF albendazole; Albendazole valdecasas brand; Albendazole sanicoopa brand; Pfizer brand OF albendazole; Albendazole armstrong brand; Albendazole liferpal brand; Albendazole hormona brand; Diba brand OF albendazole; Albendazole fustery brand; Albendazole pfizer brand; Albendazole diba brand; V Disthelm, mediamix; Disthelm, mediamix V; Mediamix V disthelm; SK And F 62979; SK And F-62979; SK And F62979; albendazole; Albendoral; albendazol; Digezanol; Bendapar; Metiazol; Disthelm; Eskazole; Valbazen; Proftril; Endoplus; Albenza; Andazol; Bilutac; Gascop; Lurdex; Zentel; SKF-62979; Albendazole



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, ANG, CASP3, CAT, CYP3A4, HPGDS, TUBB4B, VEGFA
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 4 CD4, CYP1A2, CYP1B1, CYP3A4
Nucleus 5 ALB, ANG, CASP3, TUBB4B, VEGFA
cytosol 7 ALB, ANG, CASP3, CAT, GPT, HPGDS, TUBB4B
centrosome 1 ALB
nucleoplasm 2 CASP3, HPGDS
Cell membrane 3 CD4, CD8A, TNF
cell surface 2 TNF, VEGFA
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ALB, VEGFA
growth cone 1 ANG
neuronal cell body 3 ANG, CASP3, TNF
plasma membrane 5 CD4, CD8A, IFNLR1, IGHE, TNF
Membrane 5 CAT, CYP1B1, CYP3A4, IFNLR1, VEGFA
extracellular exosome 4 ALB, CAT, GPT, TUBB4B
endoplasmic reticulum 2 ALB, VEGFA
extracellular space 9 ALB, ANG, IGHE, IL10, IL2, IL4, IL5, TNF, VEGFA
adherens junction 1 VEGFA
mitochondrion 2 CAT, CYP1B1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 5 CAT, CYP1A2, CYP1B1, CYP3A4, HPGDS
Microsome membrane 3 CYP1A2, CYP1B1, CYP3A4
postsynaptic density 1 CASP3
Single-pass type I membrane protein 4 CD4, CD8A, IFNLR1, IGHE
Secreted 7 ALB, ANG, IL10, IL2, IL4, IL5, VEGFA
extracellular region 12 ALB, ANG, CAT, CD8A, IGHE, IL10, IL2, IL4, IL5, TNF, TUBB4B, VEGFA
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 3 CD4, CD8A, TNF
Extracellular vesicle 1 TUBB4B
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 TUBB4B
nucleolus 1 ANG
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 2 CD4, TNF
Cytoplasm, cytoskeleton 1 TUBB4B
focal adhesion 1 CAT
microtubule 1 TUBB4B
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
receptor complex 1 CD8A
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
phagocytic cup 1 TNF
mitotic spindle 1 TUBB4B
Chromosome 1 ANG
cytoskeleton 1 TUBB4B
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 1 ALB
[Isoform 2]: Cell membrane 1 IGHE
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 2 ALB, CD4
platelet alpha granule lumen 2 ALB, VEGFA
endocytic vesicle 1 ANG
azurophil granule lumen 1 TUBB4B
clathrin-coated endocytic vesicle membrane 1 CD4
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Nashaat E Nassef, Sawsan S Shendi, Abdel-Gawad E Saad, Nancy M Harba, Engy V N Beshay, Asmaa Shams El-Dein Mohamed, Marwa A Gouda. An in vivo appraisal of Punica granatum peel extract's ultrastructural effect on cystic echinococcosis in mice. Journal of helminthology. 2024 May; 98(?):e40. doi: 10.1017/s0022149x24000300. [PMID: 38738533]
  • Asmaa F Ibrahim, Sahar M Selim, Dalia A Shafey, Dina M Sweed, Shaimaa A Farag, Marwa A Gouda. Appraisal of Chitosan-Coated Lipid Nano-Combination with Miltefosine and Albendazole in the Treatment of Murine Trichinellosis: Experimental Study with Evaluation of Immunological and Immunohistochemical Parameters. Acta parasitologica. 2024 Mar; 69(1):929-950. doi: 10.1007/s11686-024-00799-x. [PMID: 38489009]
  • Q Chen, C Liu, C Li, B Zhang, H Fan. [Traditional Chinese medicine for treatment of echinococcosis: a review]. Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control. 2023 Sep; 35(4):398-406. doi: 10.16250/j.32.1374.2022266. [PMID: 37926477]
  • Sunidhi Sharma, Vanshita Goel, Pawandeep Kaur, Kundlik Gadhave, Neha Garg, Lachhman Das Singla, Diptiman Choudhury. Targeted drug delivery using beeswax-derived albendazole-loaded solid lipid nanoparticles in Haemonchus contortus, an albendazole-tolerant nematode. Experimental parasitology. 2023 Aug; 253(?):108593. doi: 10.1016/j.exppara.2023.108593. [PMID: 37595879]
  • Cynthia Guzmán, Nelly Villalobos, Anabel Ortiz Caltempa, Marisela Hernández, Guadalupe Núñez, Juan Salazar, Raúl José Bobes, Gladis Fragoso, Edda Sciutto, María Luisa Villarreal. In Vitro and In Vivo Cysticidal Effects of Carica Papaya Cell Suspensions. Infection and immunity. 2023 Jun; ?(?):e0051722. doi: 10.1128/iai.00517-22. [PMID: 37341599]
  • Eleni Gkimprixi, Stathis Lagos, Christina N Nikolaou, Dimitrios G Karpouzas, Daniela Tsikou. Veterinary drug albendazole inhibits root colonization and symbiotic function of the arbuscular mycorrhizal fungus Rhizophagus irregularis. FEMS microbiology ecology. 2023 May; ?(?):. doi: 10.1093/femsec/fiad048. [PMID: 37156498]
  • Eman S El-Wakil, Shimaa Shaker, Tarek Aboushousha, El-Sayed S Abdel-Hameed, Ezzat E A Osman. In vitro and in vivo anthelmintic and chemical studies of Cyperus rotundus L. extracts. BMC complementary medicine and therapies. 2023 Jan; 23(1):15. doi: 10.1186/s12906-023-03839-7. [PMID: 36658562]
  • Yiting Wen, Yujia Zhang, Xiaoli Zhang, Linjun Wang, Qiuxia Pan, Qiuhan Bai, Du Zhu, Weiming Chai. Inhibition of albendazole and 2-(2-aminophenyl)-1H-benzimidazole against tyrosinase: mechanism, structure-activity relationship, and anti-browning effect. Journal of the science of food and agriculture. 2023 Jan; ?(?):. doi: 10.1002/jsfa.12450. [PMID: 36641547]
  • Stathis Lagos, Kalliopi Koutroutsiou, Dimitrios G Karpouzas. Isolation of soil bacteria able to degrade the anthelminthic compound albendazole. PeerJ. 2023; 11(?):e16127. doi: 10.7717/peerj.16127. [PMID: 37953781]
  • Soheila Fotoohi, Mohammad Hossein Radfar, Ali Afgar, Majid Fasihi Harandi. Anti-echinococcal effects of sumac, Rhus coriaria, in a murine model of cystic echinococcosis: Parasitological and molecular evaluation. Experimental parasitology. 2022 Dec; 243(?):108406. doi: 10.1016/j.exppara.2022.108406. [PMID: 36244447]
  • Stahis Lagos, Chrysovalantou Moutzoureli, Ifigenia Spiropoulou, Aggeliki Alexandropoulou, Panagiotis A Karas, Anastasios Saratsis, Smaragda Sotiraki, Dimitrios G Karpouzas. Biodegradation of anthelmintics in soils: does prior exposure of soils to anthelmintics accelerate their dissipation?. Environmental science and pollution research international. 2022 Sep; 29(41):62404-62422. doi: 10.1007/s11356-022-19964-8. [PMID: 35397025]
  • Esther Blanco-Paniagua, Laura Álvarez-Fernández, Alba M Garcia-Lino, Ana I Álvarez, Gracia Merino. Secretion into Milk of the Main Metabolites of the Anthelmintic Albendazole Is Mediated by the ABCG2/BCRP Transporter. Antimicrobial agents and chemotherapy. 2022 07; 66(7):e0006222. doi: 10.1128/aac.00062-22. [PMID: 35736132]
  • Felipe Romano, José Guilherme Xavier, Ronalda Silva DE Araújo, Selene Dall'Acqua Coutinho, Maria Anete Lallo. Successful use of albendazole and fenbendazole therapy in a cat with persistent diarrhea due Enterocytozoon bieneusi. The Journal of veterinary medical science. 2022 Jun; 84(6):869-871. doi: 10.1292/jvms.22-0045. [PMID: 35491092]
  • Greisi Curico, Paul García-Bardales, Tackeshy Pinedo, Wagner Shapiama, Miguel Moncada-Yaicate, Lucero Romaina, Pablo P Yori, Maribel Paredes-Olortegui, Graciela Meza-Sánchez, Andrés G Lescano, Valerie A Paz-Soldan, Francesca Schiaffino, Richard A Oberhelman, Margaret N Kosek. Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol. BMC infectious diseases. 2022 Jun; 22(1):528. doi: 10.1186/s12879-022-07494-0. [PMID: 35672751]
  • Yun-Ting He, Xiao-Hong Huang, Yue-Yi Fang, Qing-Sheng Zeng, Lai-De Li, Le Luo, Ying-Si Lai. Cost-effectiveness evaluation of different control strategies for Clonorchis sinensis infection in a high endemic area of China: A modelling study. PLoS neglected tropical diseases. 2022 05; 16(5):e0010429. doi: 10.1371/journal.pntd.0010429. [PMID: 35605030]
  • Ramzi Shawahna, Lina Zaid. Concentrations of antiseizure medications in breast milk of lactating women with epilepsy: A systematic review with qualitative synthesis. Seizure. 2022 May; 98(?):57-70. doi: 10.1016/j.seizure.2022.03.017. [PMID: 35427849]
  • Youran Cai, Ye Yang, Xin Zhong. A Case Report of Intravitreal Dexamethasone Implant with Exudative Retinal Detachment for Ocular Toxocariasis Treatment. The Korean journal of parasitology. 2022 Apr; 60(2):133-137. doi: 10.3347/kjp.2022.60.2.133. [PMID: 35500895]
  • Daniela Hofmann, Janneke M Brussee, Jessica D Schulz, Jean T Coulibaly, Marc Pfister, Jennifer Keiser. Pharmacokinetic modelling and simulation to optimize albendazole dosing in hookworm- or Trichuris trichiura-infected infants to adults. The Journal of antimicrobial chemotherapy. 2022 03; 77(4):1082-1093. doi: 10.1093/jac/dkac020. [PMID: 35152279]
  • Pierre H H Schneeberger, Morgan Gueuning, Sophie Welsche, Eveline Hürlimann, Julian Dommann, Cécile Häberli, Jürg E Frey, Somphou Sayasone, Jennifer Keiser. Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases. Nature communications. 2022 02; 13(1):1063. doi: 10.1038/s41467-022-28658-1. [PMID: 35217670]
  • Abdul Jabbar, Muhammad Zahid Iqbal, Muhammad Ashraf, Aneela Zameer Durrani, Hira Sajjad, Mohammed Nasiru Wana, Asad Ullah, Muhammad Imran, Muhammad Shair Zaman Ghauri, Hafiz Ishfaq Ahmad. Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep. Tropical animal health and production. 2022 Feb; 54(2):107. doi: 10.1007/s11250-022-03111-z. [PMID: 35187616]
  • Caroline Rodrigues de Almeida, Renata Coltro Bezagio, Cristiane Maria Colli, Liara Izabela Lopes Romera, Ariana Ferrari, Mônica Lúcia Gomes. Elimination of Giardia duodenalis BIV in vivo using natural extracts in microbiome and dietary supplements. Parasitology international. 2022 Feb; 86(?):102484. doi: 10.1016/j.parint.2021.102484. [PMID: 34688884]
  • Sibo Wang, Yibo Ma, Weishan Wang, Yi Dai, Haohao Sun, Jing Li, Shan Wang, Feng Li. Status and prospect of novel treatment options toward alveolar and cystic echinococcosis. Acta tropica. 2022 Feb; 226(?):106252. doi: 10.1016/j.actatropica.2021.106252. [PMID: 34808118]
  • Shengli Liu, Honglian Liu, Hao Sun, Shengming Deng, Ling Yue, Zhen Weng, Jianfeng Yang, Bin Zuo, Yang He, Bin Zhang. (cRGD)2 peptides modified nanoparticles increase tumor-targeting therapeutic effects by co-delivery of albendazole and iodine-131. Anti-cancer drugs. 2022 01; 33(1):19-29. doi: 10.1097/cad.0000000000001135. [PMID: 34261920]
  • Saravanakumar Kaliappan, Karthikeyan Ramanujam, Malathi Manuel, Jasmine Farzana, Venkateshprabhu Janagaraj, Selvi Laxmanan, Jayaprakash Muliyil, Rajiv Sarkar, Gagandeep Kang, Judd Walson, Sitara Ajjampur. Soil-transmitted helminth infections after mass drug administration for lymphatic filariasis in rural southern India. Tropical medicine & international health : TM & IH. 2022 01; 27(1):81-91. doi: 10.1111/tmi.13697. [PMID: 34704320]
  • Eveline Hürlimann, Ladina Keller, Chandni Patel, Sophie Welsche, Jan Hattendorf, Said M Ali, Shaali M Ame, Somphou Sayasone, Jean T Coulibaly, Jennifer Keiser. Efficacy and safety of co-administered ivermectin and albendazole in school-aged children and adults infected with Trichuris trichiura in Côte d'Ivoire, Laos, and Pemba Island, Tanzania: a double-blind, parallel-group, phase 3, randomised controlled trial. The Lancet. Infectious diseases. 2022 01; 22(1):123-135. doi: 10.1016/s1473-3099(21)00421-7. [PMID: 34856181]
  • Vipin Kumar, Ayushi Mishra, Awadehesh Kumar Yadav, Sushma Rathaur, Anchal Singh. Lymphatic filarial serum proteome profiling for identification and characterization of diagnostic biomarkers. PloS one. 2022; 17(7):e0270635. doi: 10.1371/journal.pone.0270635. [PMID: 35793325]
  • Sooji Hong, Bong-Kwang Jung, Hyemi Song, Jaeeun Cho, Woon-Mok Sohn, Sung-Jong Hong, Jin-Youp Ryu, Hyun-Seung Kim, Mun-Hyoo Jeong, Thi Thi Htoon, Htay Htay Tin, Jong-Yil Chai. Failure of Repeated MDA with Albendazole for Trichuriasis Control in Schoolchildren of the Yangon Region, Myanmar. The Korean journal of parasitology. 2021 Dec; 59(6):607-613. doi: 10.3347/kjp.2021.59.6.607. [PMID: 34974667]
  • Mehdi Farhadi, Ali Haniloo, Kobra Rostamizadeh, Nahid Ahmadi. In vitro evaluation of albendazole-loaded nanostructured lipid carriers on Echinococcus granulosus microcysts and their prophylactic efficacy on experimental secondary hydatidosis. Parasitology research. 2021 Dec; 120(12):4049-4060. doi: 10.1007/s00436-021-07343-0. [PMID: 34669034]
  • C J Opperman, J M N Enslin, J Nuttall, A J Brink, S P Da Fonseca, H D Tootla. Hydatid brain cyst: A delayed diagnosis in a rural setting during COVID-19. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2021 11; 111(11):1050-1054. doi: 10.7196/samj.2021.v111i11.16043. [PMID: 34949267]
  • Hui Yi, Long Liang, Haiqin Wang, Saiqun Luo, Lei Hu, Yanpeng Wang, Xiaokai Shen, Ling Xiao, Yibin Zhang, Hongling Peng, Chongwen Dai, Lingli Yuan, Ruijuan Li, Fanjie Gong, Zhenzhen Li, Mao Ye, Jing Liu, Hui Zhou, Ji Zhang, Xiaojuan Xiao. Albendazole inhibits NF-κB signaling pathway to overcome tumor stemness and bortezomib resistance in multiple myeloma. Cancer letters. 2021 11; 520(?):307-320. doi: 10.1016/j.canlet.2021.08.009. [PMID: 34390764]
  • Jules N Kouadio, Jennifer Giovanoli Evack, Louise Y Achi, Oliver Balmer, Jürg Utzinger, Eliézer K N'Goran, Bassirou Bonfoh, Jan Hattendorf, Jakob Zinsstag. Efficacy of triclabendazole and albendazole against Fasciola spp. infection in cattle in Côte d'Ivoire: a randomised blinded trial. Acta tropica. 2021 Oct; 222(?):106039. doi: 10.1016/j.actatropica.2021.106039. [PMID: 34252386]
  • Martina Navrátilová, Lucie Raisová Stuchlíková, Petra Matoušková, Martin Ambrož, Jiří Lamka, Ivan Vokřál, Barbora Szotáková, Lenka Skálová. Proof of the environmental circulation of veterinary drug albendazole in real farm conditions. Environmental pollution (Barking, Essex : 1987). 2021 Oct; 286(?):117590. doi: 10.1016/j.envpol.2021.117590. [PMID: 34438501]
  • Martin Walker, Piet Cools, Marco Albonico, Shaali M Ame, Mio Ayana, Daniel Dana, Jennifer Keiser, Leonardo F Matoso, Antonio Montresor, Zeleke Mekonnen, Rodrigo Corrêa-Oliveira, Simone A Pinto, Somphou Sayasone, Jozef Vercruysse, Johnny Vlaminck, Bruno Levecke. Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure. PLoS neglected tropical diseases. 2021 10; 15(10):e0009888. doi: 10.1371/journal.pntd.0009888. [PMID: 34665810]
  • Cengiz Gokbulut, Veli Y Cirak, Suleyman Aypak, Hamdi Avci, Selim Sekkin, Hande S Yalinkilinc, Buket Boga, Erol Ayaz. In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):799-807. doi: 10.1111/jvp.12974. [PMID: 33893651]
  • Shigehiro Enkai, Hirokazu Kouguchi, Daniel Ken Inaoka, Takao Irie, Kinpei Yagi, Kiyoshi Kita. In vivo efficacy of combination therapy with albendazole and atovaquone against primary hydatid cysts in mice. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Sep; 40(9):1815-1820. doi: 10.1007/s10096-021-04230-5. [PMID: 33770336]
  • L Ceballos, E Nieves, M Juárez, R Aveldaño, M Travacio, J Martos, R Cimino, J L Walson, A Krolewiecki, C Lanusse, L Alvarez. Assessment of Diet-Related Changes on Albendazole Absorption, Systemic Exposure, and Pattern of Urinary Excretion in Treated Human Volunteers. Antimicrobial agents and chemotherapy. 2021 08; 65(9):e0043221. doi: 10.1128/aac.00432-21. [PMID: 34152813]
  • Linda Petrone, Francesca Tamarozzi, Ambra Vola, Maria Angeles Gomez Morales, Alessandra Ludovisi, Saeid Najafi Fard, Mara Mariconti, Enrico Brunetti, Delia Goletti. Accuracy of an experimental whole-blood test for detecting reactivation of echinococcal cysts. PLoS neglected tropical diseases. 2021 08; 15(8):e0009648. doi: 10.1371/journal.pntd.0009648. [PMID: 34415898]
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