Leukotriene B4 (BioDeep_00000018516)
Secondary id: BioDeep_00000003312, BioDeep_00000028041
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C20H32O4 (336.2300472)
中文名称: [5S,12R]-二羟基-[6Z,8E,10E,14Z]-二十碳四烯酸, 白三烯B4
谱图信息:
最多检出来源 Macaca mulatta(otcml) 0.32%
分子结构信息
SMILES: CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O
InChI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1
描述信息
Leukotriene B4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region, and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by omega-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the omega-carboxy position and after CoA ester formation. Other specific pathways of leukotriene metabolism include the 12-hydroxydehydrogenase/15-oxo-prostaglandin-13-reductase that form a series of conjugated diene metabolites that have been observed to be excreted in human urine. Metabolism of LTC4 occurs by sequential peptide cleavage reactions involving a gamma-glutamyl transpeptidase that forms LTD4 (leukotriene D4) and a membrane-bound dipeptidase that converts LTD4 into LTE4 (leukotriene E4) before omega-oxidation. These metabolic transformations of the primary leukotrienes are critical for termination of their biological activity, and defects in expression of participating enzymes may be involved in specific genetic disease. The term leukotriene was coined to indicate the presence of three conjugated double bonds within the 20-carbon structure of arachidonic acid as well as the fact that these compounds were derived from leucocytes such as PMNNs or transformed mast cells. Interestingly, most of the cells known to express 5-LO are of myeloid origin, which includes neutrophils, eosinophils, mast cells, macrophages, basophils, and monocytes. Leukotriene biosynthesis begins with the specific oxidation of arachidonic acid by a free radical mechanism as a consequence of interaction with 5-LO. The first enzymatic step involves the abstraction of a hydrogen atom from C-7 of arachidonate followed by the addition of molecular oxygen to form 5-HpETE (5-hydroperoxyeicosatetraenoic acid). A second enzymatic step is also catalyzed by 5-LO and involves removal of a hydrogen atom from C-10, resulting in the formation of the conjugated triene epoxide LTA4. LTA4 must then be released by 5-LO and encounter either LTA4-H (LTA4 hydrolase) or LTC4-S [LTC4 (leukotriene C4) synthase]. LTA4-H can stereospecifically add water to C-12 while retaining a specific double-bond geometry, leading to LTB4 [leukotriene B4, 5(S),12(R)-dihydroxy-6,8,10,14-(Z,E,E,Z)-eicosatetraenoic acid]. If LTA4 encounters LTC4-S, then the reactive epoxide is opened at C-6 by the thiol anion of glutathione to form the product LTC4 [5(S)-hydroxy-6(R)-S-glutathyionyl-7,9,11,14- (E,E,Z,Z)-eicosatetraenoic acid], essentially a glutathionyl adduct of oxidized arachidonic acid. Both of these terminal leukotrienes are biologically active in that specific GPCRs recognize these chemical structures and receptor recognition initiates complex intracellular signalling cascades. In order for these molecules to serve as lipid mediators, however, they must be released from the biosynthetic cell into the extracellular milieu so that they can encounter the corresponding GPCRs. Surprising features of this cascade include the recognition of the assembly of critical enzymes at the perinuclear region of the cell and even localization of 5-LO within the nucleus of some cells. Under some situations, the budding phagosome has been found to assemble these proteins. Non-enzymatic proteins such as FLAP are now known as critical partners of this protein-machine assembly. An unexpected pathway of leukotriene biosynthesis involves the transfer of the chemically reactive intermediate, LTA4, from the biosynthetic cell followed by conversion into LTB4 or LTC4 by other cells that do not express ...
同义名列表
37 个代谢物同义名
(6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoic acid; (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid; (5S,12R,6Z,8E,10E,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoic acid; (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoic acid; (S-(R*,s*-(e,Z,e,Z)))-5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid; (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid; (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate; (6Z,8E,10E,14Z)-(5S,12R)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoate; 5(S),12(R)-Dihydroxy-6-cis,8,10-trans,14-cis-eicosatetraenoic acid; (5S,12R,6Z,8E,10E,14Z)-5,12-Dihydroxy-6,8,10,14-eicosatetraenoate; (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyeicosa-6,8,10,14-tetraenoate; (S-(R*,s*-(e,Z,e,Z)))-5,12-dihydroxy-6,8,10,14-eicosatetraenoate; 5(S),12(R)-Dihydroxy-6(Z),8(e),10(e),14(Z)-eicosatetraenoic acid; 5(S),12(R)-Dihydroxy-6(Z),8(e),10(e),14(Z)-icosatetraenoic acid; 5(S),12(R)-Dihydroxy-6(Z),8(e),10(e),14(Z)-eicosatetraenoate; 5(S),12(R)-Dihydroxy-6(Z),8(e),10(e),14(Z)-icosatetraenoate; 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid; 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate; 5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 5S,12R-Dihydroxy-6Z,8E,10E,14Z-eicosatetraenoate; 5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid; Leukotriene b4 ethanol solution; (5S,12R)-Leukotriene b4; (+)-Leukotriene b4; cis-Leukotriene b4; b-4, Leukotriene; Leukotriene b 4; Leukotriene b-4; Leukotriene B4; Leukotrienes b; Leucotriene b4; Leukotriene b; 5,12 DiHETE; 5,12-DiHETE; 5,12 HETE; 5,12-Hete; LTB4
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:15647
- KEGG: C02165
- PubChem: 5280492
- PubChem: 169
- HMDB: HMDB0001085
- DrugBank: DB12961
- ChEMBL: CHEMBL65061
- Wikipedia: Leukotriene_B4
- MeSH: Leukotriene B4
- CAS: 101759-15-3
- CAS: 71160-24-2
- PMhub: MS000008774
- PubChem: 5240
- LipidMAPS: LMFA03020001
- PDB-CCD: LTB
- 3DMET: B01542
- NIKKAJI: J240.041C
- RefMet: LTB4
分类词条
相关代谢途径
Reactome(13)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of lipids
- Cytochrome P450 - arranged by substrate type
- Signaling Pathways
- Fatty acid metabolism
- Arachidonic acid metabolism
- Signaling by GPCR
- GPCR ligand binding
- Class A/1 (Rhodopsin-like receptors)
- GPCR downstream signalling
- Eicosanoids
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 9606 Homo sapiens: 10.1007/S11306-016-1051-4
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Larisse Ricardo Gadelha, Maria Juliana Bezerra Costa, João Paulo Alecrim de Abreu, Larissa Paola Rodrigues Venancio, Mary Hellen Fabres-Klein, Raphael Contelli Klein, Jonilson Berlink Lima, Théo Araújo-Santos. Prostaglandin E2/Leukotriene B4 balance and viral load in distinct clinical stages of COVID-19: A cross-sectional study.
Prostaglandins & other lipid mediators.
2024 Jun; 172(?):106820. doi:
10.1016/j.prostaglandins.2024.106820
. [PMID: 38346573] - Zumer Naeem, Sven Zukunft, Arnaud Huard, Jiong Hu, Bruce D Hammock, Andreas Weigert, Timo Frömel, Ingrid Fleming. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Jan; 171(?):116127. doi:
10.1016/j.biopha.2024.116127
. [PMID: 38198951] - Amanda Brady, Katelyn R Sheneman, Amanda R Pulsifer, Sarah L Price, Taylor M Garrison, Krishna Rao Maddipati, Sobha R Bodduluri, Jianmin Pan, Nolan L Boyd, Jing-Juan Zheng, Shesh N Rai, Jason Hellmann, Bodduluri Haribabu, Silvia M Uriarte, Matthew B Lawrenz. Type 3 secretion system induced leukotriene B4 synthesis by leukocytes is actively inhibited by Yersinia pestis to evade early immune recognition.
PLoS pathogens.
2024 Jan; 20(1):e1011280. doi:
10.1371/journal.ppat.1011280
. [PMID: 38271464] - Jialu Chen, Yue Tang, Delong Qin, Xiaopeng Yu, Huanjun Tong, Chengwei Tang, Zhaohui Tang. ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway.
Journal of translational medicine.
2023 Dec; 21(1):923. doi:
10.1186/s12967-023-04804-1
. [PMID: 38124204] - Riko Tatsumi, Saki Aihara, Seiya Matsune, Junken Aoki, Asuka Inoue, Takao Shimizu, Motonao Nakamura. Stepwise phosphorylation of BLT1 defines complex assemblies with β-arrestin serving distinct functions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 Nov; 37(11):e23213. doi:
10.1096/fj.202301440r
. [PMID: 37795742] - Mohsen Molaei, Ramin Lotfi, Reza Heidarymoghadam, Alireza Rezaiemanesh, Ali Gorgin Karaji, Farhad Salari. Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) may contribute to the pathogenesis of atherosclerosis.
Prostaglandins & other lipid mediators.
2023 Sep; ?(?):106781. doi:
10.1016/j.prostaglandins.2023.106781
. [PMID: 37704124] - Szimonetta Xénia Tamás, Benoit Thomas Roux, Boldizsár Vámosi, Fabian Gregor Dehne, Anna Török, László Fazekas, Balázs Enyedi. A genetically encoded sensor for visualizing leukotriene B4 gradients in vivo.
Nature communications.
2023 08; 14(1):4610. doi:
10.1038/s41467-023-40326-6
. [PMID: 37528073] - Motonao Nakamura, Takao Shimizu. Therapeutic target of leukotriene B4 receptors, BLT1 and BLT2: Insights from basic research.
Biochimie.
2023 Jul; ?(?):. doi:
10.1016/j.biochi.2023.06.014
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The Journal of steroid biochemistry and molecular biology.
2023 Jun; 232(?):106345. doi:
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. [PMID: 37286110] - Jie Tang, Ping Wu, Ze-Yun Yu, Xue Wang, Si-Yu Tao, Nan-Nan Jiang, Guan-Hua Chen, Rou-Xian Shuai. [Regulatory effect of moxibustion on LTB4/MMP-9 in serum of patients with rheumatoid arthritis].
Zhen ci yan jiu = Acupuncture research.
2023 May; 48(5):488-93. doi:
10.13702/j.1000-0607.20220088
. [PMID: 37247863] - Chol Seung Lim, Brandon Veltri, Michael Kashon, Dale W Porter, Qiang Ma. Multi-walled carbon nanotubes induce arachidonate 5-lipoxygenase expression and enhance the polarization and function of M1 macrophages in vitro.
Nanotoxicology.
2023 Apr; ?(?):1-21. doi:
10.1080/17435390.2023.2204161
. [PMID: 37115655] - Xiaoxin Wu, Antonia RuJia Sun, Ross Crawford, Yin Xiao, Yanping Wang, Indira Prasadam, Xinzhan Mao. Inhibition of Leukotriene A4 Hydrolase Suppressed Cartilage Degradation and Synovial Inflammation in a Mouse Model of Experimental Osteoarthritis.
Cartilage.
2023 Apr; ?(?):19476035231169940. doi:
10.1177/19476035231169940
. [PMID: 37086004] - Takehiko Yokomizo, Takao Shimizu. The leukotriene B4 receptors BLT1 and BLT2 as potential therapeutic targets.
Immunological reviews.
2023 Mar; ?(?):. doi:
10.1111/imr.13196
. [PMID: 36908237] - Cristina Salinas-Nolasco, Gabriela Soledad Barragán-Zarate, Luicita Lagunez-Rivera, Rodolfo Solano, Liliana Favari, Juan Miguel Jiménez-Andrade, Aracely Evangelina Chávez-Piña. Role of LTB4 and nitric oxide in the gastroprotective effect of Prosthechea karwinskii leaves extract in the indomethacin-induced gastric injury in the rat.
Natural product research.
2023 Mar; 37(5):819-822. doi:
10.1080/14786419.2022.2089880
. [PMID: 35722687] - Ryotaro Shioda, Airi Jo-Watanabe, Toshiaki Okuno, Kazuko Saeki, Maiko Nakayama, Yusuke Suzuki, Takehiko Yokomizo. The leukotriene B4 /BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 02; 37(2):e22789. doi:
10.1096/fj.202201936r
. [PMID: 36692419] - Changqing Sun, Wuyang Zheng, Ling Liang, Ziguan Zhang, Zuheng Liu, Wenchao Sun, Jianwei Zhou, Weitong Qiao, Qiang Xie, Rong Tang. Acute Coronary Syndrome May be Associated with Decreased Resolvin D1-to-Leukotriene B4 Ratio.
International heart journal.
2023 Jan; ?(?):. doi:
10.1536/ihj.22-361
. [PMID: 36682769] - Amir A Razmjou, Jennifer M Wang, Ani Shahbazian, Srinivasa Reddy, Christina Charles-Schoeman. Suppressed paraoxonase-1 activity associates with elevated oxylipins and the presence of small airways disease in patients with rheumatoid arthritis.
Clinical rheumatology.
2023 Jan; 42(1):75-82. doi:
10.1007/s10067-022-06375-w
. [PMID: 36138190] - Letícia Paula Trajano Noronha, Monique Daiane Andrade Martins, Archimedes Barbosa Castro-Junior, Maria Luiza Thorstenberg, Laís Costa-Soares, Thuany Prado Rangel, Felipe Carvalho-Gondim, Bartira Rossi-Bergmann, Luiz Eduardo Baggio Savio, Claudio de Azevedo Canetti, Robson Coutinho-Silva. Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control.
Frontiers in cellular and infection microbiology.
2023; 13(?):1192800. doi:
10.3389/fcimb.2023.1192800
. [PMID: 37377641] - Lauren E Hein, Shuvasree SenGupta, Gaurie Gunasekaran, Craig N Johnson, Carole A Parent. TGF-β1 activates neutrophil signaling and gene expression but not migration.
PloS one.
2023; 18(9):e0290886. doi:
10.1371/journal.pone.0290886
. [PMID: 37682817] - Sourbh Suren Garg, Jeena Gupta, Debasis Sahu, Chuan-Ju Liu. Pharmacological and Therapeutic Applications of Esculetin.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012643
. [PMID: 36293500] - Berend Gagestein, Johannes H von Hegedus, Joanneke C Kwekkeboom, Marieke Heijink, Niek Blomberg, Tom van der Wel, Bogdan I Florea, Hans van den Elst, Kim Wals, Herman S Overkleeft, Martin Giera, René E M Toes, Andreea Ioan-Facsinay, Mario van der Stelt. Comparative Photoaffinity Profiling of Omega-3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages.
Journal of the American Chemical Society.
2022 10; 144(41):18938-18947. doi:
10.1021/jacs.2c06827
. [PMID: 36197299] - Motonao Nakamura, Takao Shimizu. Recent advances in function and structure of two leukotriene B4 receptors: BLT1 and BLT2.
Biochemical pharmacology.
2022 09; 203(?):115178. doi:
10.1016/j.bcp.2022.115178
. [PMID: 35850310] - Louise Ménégaut, Aline Laubriet, Valentin Crespy, Maxime Nguyen, Jean-Michel Petit, Georges Tarris, Thomas Pilot, Alexis Varin, Hélène Choubley, Victoria Bergas, Jean-Paul Pais de Barros, Charles Thomas, Eric Steinmetz, David Masson. Profiling of lipid mediators in atherosclerotic carotid plaques from type 2 diabetic and non-diabetic patients.
Prostaglandins, leukotrienes, and essential fatty acids.
2022 09; 184(?):102477. doi:
10.1016/j.plefa.2022.102477
. [PMID: 35952424] - Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing, Qian Jiang, Qijin Zhao, Bing Cui, Zhifeng Huang, Pingping Li. Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity.
Hepatology (Baltimore, Md.).
2022 Aug; ?(?):. doi:
10.1002/hep.32708
. [PMID: 35931467] - Subhash B Arya, Song Chen, Fatima Jordan-Javed, Carole A Parent. Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation.
Nature cell biology.
2022 07; 24(7):1019-1028. doi:
10.1038/s41556-022-00934-8
. [PMID: 35739317] - Shu-Heng Jiang, Dejun Liu, Li-Peng Hu, Shan Zhang, Yanqiu Yu, Yong-Wei Sun, Jianguang Ji, Zhi-Gang Zhang. Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer.
EBioMedicine.
2022 Jun; 80(?):104050. doi:
10.1016/j.ebiom.2022.104050
. [PMID: 35561453] - Yanfeng Li, Miaomiao Li, Rui Wang, Biyu Wang, Seyyed Shamsadin Athari, Jinli Wang. Ganoderma modulates allergic asthma pathologic features via anti-inflammatory effects.
Respiratory physiology & neurobiology.
2022 05; 299(?):103843. doi:
10.1016/j.resp.2022.103843
. [PMID: 35026480] - Jing Ruan, Chen Yang, Yali Du, Miao Chen, Bing Han. Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Clinical and experimental medicine.
2022 Apr; ?(?):. doi:
10.1007/s10238-022-00826-z
. [PMID: 35445952] - Claudia Carranza, Laura Elena Carreto-Binaghi, Silvia Guzmán-Beltrán, Marcela Muñoz-Torrico, Martha Torres, Yolanda González, Esmeralda Juárez. Sex-Dependent Differential Expression of Lipidic Mediators Associated with Inflammation Resolution in Patients with Pulmonary Tuberculosis.
Biomolecules.
2022 03; 12(4):. doi:
10.3390/biom12040490
. [PMID: 35454079] - Francine Lorencetti da Silva, Giuliana de Campos Chaves Lamarque, Fernanda Maria Machado Pereira Cabral de Oliveira, Paulo Nelson-Filho, Léa Assed Bezerra da Silva, Raquel Assed Bezerra Segato, Lúcia Helena Faccioli, Francisco Wanderley Garcia Paula-Silva. Leukotriene B4 loaded in microspheres regulate the expression of genes related to odontoblastic differentiation and biomineralization by dental pulp stem cells.
BMC oral health.
2022 02; 22(1):45. doi:
10.1186/s12903-022-02083-8
. [PMID: 35197043] - Miho Asahara, Nobuko Ito, Yoko Hoshino, Takaharu Sasaki, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada. Role of leukotriene B4 (LTB4)-LTB4 receptor 1 signaling in post-incisional nociceptive sensitization and local inflammation in mice.
PloS one.
2022; 17(10):e0276135. doi:
10.1371/journal.pone.0276135
. [PMID: 36264904] - Olga V Belyaeva, Samuel E Wirth, William E Boeglin, Suman Karki, Kelli R Goggans, Stacy G Wendell, Kirill M Popov, Alan R Brash, Natalia Y Kedishvili. Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates.
The Journal of biological chemistry.
2022 01; 298(1):101527. doi:
10.1016/j.jbc.2021.101527
. [PMID: 34953854] - Jiheng Hao, Yao Feng, Xin Xu, Long Li, Kun Yang, Gaolei Dai, Weiwei Gao, Meng Zhang, Yaming Fan, Tengkun Yin, Jiyue Wang, Bin Yang, Liqun Jiao, Liyong Zhang. Plasma Lipid Mediators Associate With Clinical Outcome After Successful Endovascular Thrombectomy in Patients With Acute Ischemic Stroke.
Frontiers in immunology.
2022; 13(?):917974. doi:
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. [PMID: 35865524] - Undurti N Das. Essential Fatty Acids and Their Metabolites in the Pathobiology of Inflammation and Its Resolution.
Biomolecules.
2021 12; 11(12):. doi:
10.3390/biom11121873
. [PMID: 34944517] - Luiza Oliveira Perucci, Kelerson Mauro de Castro Pinto, Sirlaine Pio Gomes da Silva, Eura Martins Lage, Patrícia Gonçalves Teixeira, Alexandre Simões Barbosa, Patrícia Nessralla Alpoim, Lirlândia Pires de Sousa, André Talvani, Luci Maria SantAna Dusse. Longitudinal assessment of leukotriene B4, lipoxin A4, and resolvin D1 plasma levels in pregnant women with risk factors for preeclampsia.
Clinical biochemistry.
2021 Dec; 98(?):24-28. doi:
10.1016/j.clinbiochem.2021.09.002
. [PMID: 34492288] - Pallavi Bedi, Kerstin Ziegler, Phil D Whitfield, Donald Davidson, Adriano Giorgio Rossi, Adam T Hill. Dysregulation of prostaglandins, leukotrienes and lipoxin A4 in bronchiectasis.
Thorax.
2021 Nov; ?(?):. doi:
10.1136/thoraxjnl-2020-216475
. [PMID: 34789559] - Jun Cao, Hui Liu, Xiao-Jie Ding. Effect of halometasone cream combined with Simiao pill on the therapeutic effect and expression of serum leukotriene B4 (LTB4) and thymic stromal lymphopoietin (TSLP) in patients with eczema, and the factors influencing its clinical efficacy.
Annals of palliative medicine.
2021 Nov; 10(11):11643-11652. doi:
10.21037/apm-21-2685
. [PMID: 34872289] - Mélissa Simard, Geneviève Rioux, Sophie Morin, Cyril Martin, Sylvain L Guérin, Nicolas Flamand, Pierre Julien, Julie Fradette, Roxane Pouliot. Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells.
The Journal of investigative dermatology.
2021 10; 141(10):2391-2401.e13. doi:
10.1016/j.jid.2021.02.755
. [PMID: 33857488] - Anne Barden, Michael Phillips, Sujata Shinde, Tomas Corcoran, Trevor A Mori. The effects of perioperative dexamethasone on eicosanoids and mediators of inflammation resolution: A sub-study of the PADDAG trial.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 10; 173(?):102334. doi:
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Nutrients.
2021 Sep; 13(9):. doi:
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Diabetes.
2021 09; 70(9):2120-2130. doi:
10.2337/db20-1260
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Journal of pharmacological sciences.
2021 Sep; 147(1):126-131. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 06; 35(6):e21666. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 04; 35(4):e21448. doi:
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Clinical nutrition (Edinburgh, Scotland).
2021 02; 40(2):445-459. doi:
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Prostaglandins & other lipid mediators.
2021 02; 152(?):106502. doi:
10.1016/j.prostaglandins.2020.106502
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BioMed research international.
2021; 2021(?):6657646. doi:
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Oxidative medicine and cellular longevity.
2021; 2021(?):4475968. doi:
10.1155/2021/4475968
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Journal of natural medicines.
2021 Jan; 75(1):28-36. doi:
10.1007/s11418-020-01439-0
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Placenta.
2021 01; 103(?):76-81. doi:
10.1016/j.placenta.2020.10.007
. [PMID: 33099202] - Ana Carolina Guerta Salina, Stephanie L Brandt, Nathan Klopfenstein, Amondrea Blackman, Júlia Miranda Ribeiro Bazzano, Anderson Sá-Nunes, Nicole Byers-Glosson, Claudia Brodskyn, Natalia Machado Tavares, Icaro Bonyek Santos Da Silva, Alexandra I Medeiros, C Henrique Serezani. Leukotriene B4 licenses inflammasome activation to enhance skin host defense.
Proceedings of the National Academy of Sciences of the United States of America.
2020 12; 117(48):30619-30627. doi:
10.1073/pnas.2002732117
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The Journal of investigative dermatology.
2020 12; 140(12):2421-2432.e10. doi:
10.1016/j.jid.2020.04.011
. [PMID: 32387270] - Ramin Lotfi, Akram Davoodi, Seyed Hamidreza Mortazavi, Ali Gorgin Karaji, Hanieh Tarokhian, Alireza Rezaiemanesh, Farhad Salari. Imbalanced serum levels of resolvin E1 (RvE1) and leukotriene B4 (LTB4) in patients with allergic rhinitis.
Molecular biology reports.
2020 Oct; 47(10):7745-7754. doi:
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Biomolecules.
2020 09; 10(9):. doi:
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 09; 1865(9):158756. doi:
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Pharmacological research.
2020 08; 158(?):104857. doi:
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The Journal of endocrinology.
2020 08; 246(2):175-187. doi:
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. [PMID: 32485676] - Liu Tang, Xiao-Lei Li, Zi-Xin Deng, Yao Xiao, Ya-Hong Cheng, Jing Li, Hong Ding. Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling.
The Journal of nutritional biochemistry.
2020 07; 81(?):108379. doi:
10.1016/j.jnutbio.2020.108379
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Nature chemical biology.
2020 07; 16(7):783-790. doi:
10.1038/s41589-020-0544-7
. [PMID: 32393899] - Minrui Liang, Jiaoyan Lv, Zhixing Jiang, Hang He, Chen Chen, Yinluo Xiong, Xiaoxia Zhu, Yu Xue, Yiyun Yu, Sen Yang, Lingbiao Wang, Wenjing Li, Ming Guan, Weiguo Wan, Rui He, Hejian Zou. Promotion of Myofibroblast Differentiation and Tissue Fibrosis by the Leukotriene B4 -Leukotriene B4 Receptor Axis in Systemic Sclerosis.
Arthritis & rheumatology (Hoboken, N.J.).
2020 06; 72(6):1013-1025. doi:
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Molecular nutrition & food research.
2020 06; 64(11):e2000129. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2020 05; 117(21):11674-11684. doi:
10.1073/pnas.1921015117
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Journal of ethnopharmacology.
2020 May; 253(?):112655. doi:
10.1016/j.jep.2020.112655
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Journal of ethnopharmacology.
2020 May; 253(?):112673. doi:
10.1016/j.jep.2020.112673
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Medecine sciences : M/S.
2020 May; 36(5):528-530. doi:
10.1051/medsci/2020087
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Molecules (Basel, Switzerland).
2020 Apr; 25(9):. doi:
10.3390/molecules25092033
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Lymphatic research and biology.
2020 04; 18(2):136-145. doi:
10.1089/lrb.2019.0008
. [PMID: 31429621] - Carlos Arterio Sorgi, Elyara Maria Soares, Rogério Silva Rosada, Claudia Silva Bitencourt, Karina Furlani Zoccal, Priscilla Aparecida Tartari Pereira, Caroline Fontanari, Izaíra Brandão, Ana Paula Masson, Simone Gusmão Ramos, Célio Lopes Silva, Fabiani Gai Frantz, Lúcia Helena Faccioli. Eicosanoid pathway on host resistance and inflammation during Mycobacterium tuberculosis infection is comprised by LTB4 reduction but not PGE2 increment.
Biochimica et biophysica acta. Molecular basis of disease.
2020 03; 1866(3):165574. doi:
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Journal of pharmaceutical and biomedical analysis.
2020 Feb; 180(?):113078. doi:
10.1016/j.jpba.2019.113078
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Infection and immunity.
2020 02; 88(3):. doi:
10.1128/iai.00909-19
. [PMID: 31871100] - Luiza Oliveira Perucci, Talita Adriana Pereira Santos, Patrícia Campi Santos, Lívia Cristina Ribeiro Teixeira, Patrícia Nessralla Alpoim, Karina Braga Gomes, Lirlândia Pires Sousa, Luci Maria Sant'Ana Dusse, André Talvani. Pre-eclampsia is associated with reduced resolvin D1 and maresin 1 to leukotriene B4 ratios in the plasma.
American journal of reproductive immunology (New York, N.Y. : 1989).
2020 02; 83(2):e13206. doi:
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. [PMID: 31679164] - Matteo Bertelli, Aysha Karim Kiani, Stefano Paolacci, Elena Manara, Astrit Dautaj, Tommaso Beccari, Sandro Michelini. Molecular pathways involved in lymphedema: Hydroxytyrosol as a candidate natural compound for treating the effects of lymph accumulation.
Journal of biotechnology.
2020 Jan; 308(?):82-86. doi:
10.1016/j.jbiotec.2019.11.017
. [PMID: 31794783] - Francisco Wanderley Garcia Paula-Silva, Fernanda Regina Ribeiro-Santos, Igor Bassi Ferreira Petean, Maya Fernanda Manfrin Arnez, Luciano Aparecido de Almeida-Junior, Fabrício Kitazono de Carvalho, Léa Assed Bezerra da Silva, Lúcia Helena Faccioli. Root canal contamination or exposure to lipopolysaccharide differentially modulate prostaglandin E 2 and leukotriene B 4 signaling in apical periodontitis.
Journal of applied oral science : revista FOB.
2020; 28(?):e20190699. doi:
10.1590/1678-7757-2019-0699
. [PMID: 32401938] - Marcin Surmiak, Anna Gielicz, Darko Stojkov, Rafał Szatanek, Katarzyna Wawrzycka-Adamczyk, Shida Yousefi, Hans-Uwe Simon, Marek Sanak. LTB4 and 5-oxo-ETE from extracellular vesicles stimulate neutrophils in granulomatosis with polyangiitis.
Journal of lipid research.
2020 01; 61(1):1-9. doi:
10.1194/jlr.m092072
. [PMID: 31740445] - Kristin Grotle Nore, Marthe Jøntvedt Jørgensen, Anne Ma Dyrhol-Riise, Synne Jenum, Kristian Tonby. Elevated Levels of Anti-Inflammatory Eicosanoids and Monocyte Heterogeneity in Mycobacterium tuberculosis Infection and Disease.
Frontiers in immunology.
2020; 11(?):579849. doi:
10.3389/fimmu.2020.579849
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Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2020 01; 17(1):282-293. doi:
10.1007/s13311-019-00787-4
. [PMID: 31520306] - Elias El-Mafarjeh, Gisele Henrique Cardoso Martins, Jessica Jorge Probst, Alana Santos-Dias, Manoel Carneiro Oliveira-Junior, Marcelo Paes de Barros, Luis Vicente Franco de Oliveira, Leandro Damas de Andrade, Renata Kelly da Palma, Renilson Moraes-Ferreira, Deborah de Camargo Hizume-Kunzler, André Luis Lacerda Bachi, Rodolfo P Vieira. Exercise Improves Lung Inflammation, but Not Lung Remodeling and Mechanics in a Model of Bleomycin-Induced Lung Fibrosis.
Oxidative medicine and cellular longevity.
2020; 2020(?):4302608. doi:
10.1155/2020/4302608
. [PMID: 33123311] - Danilo Giusepponi, Roberta Galarini, Carolina Barola, Pierangelo Torquato, Desirée Bartolini, Simone Moretti, Giorgio Saluti, Antimo Gioiello, Carmelo Libetta, Francesco Galli. LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum.
Free radical biology & medicine.
2019 11; 144(?):134-143. doi:
10.1016/j.freeradbiomed.2019.04.017
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Proceedings of the National Academy of Sciences of the United States of America.
2019 11; 116(46):23254-23263. doi:
10.1073/pnas.1907490116
. [PMID: 31570601] - Makiko Sato, Haruka Aoki-Saito, Hayato Fukuda, Hiroyuki Ikeda, Yasuhiko Koga, Masakiyo Yatomi, Hiroaki Tsurumaki, Toshitaka Maeno, Tsugumichi Saito, Takashi Nakakura, Tetsuya Mori, Masataka Yanagawa, Mitsuhiro Abe, Yasushi Sako, Kunio Dobashi, Tamotsu Ishizuka, Masanobu Yamada, Satoshi Shuto, Takeshi Hisada. Resolvin E3 attenuates allergic airway inflammation via the interleukin-23-interleukin-17A pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 11; 33(11):12750-12759. doi:
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Journal of leukocyte biology.
2019 09; 106(3):665-675. doi:
10.1002/jlb.ma1218-477rr
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Animal science journal = Nihon chikusan Gakkaiho.
2019 Aug; 90(8):999-1007. doi:
10.1111/asj.13222
. [PMID: 31148331] - Prabha Tiwari, Takahiro Nagatake, So-Ichiro Hirata, Kento Sawane, Azusa Saika, Yuki Shibata, Sakiko Morimoto, Tetsuya Honda, Jun Adachi, Yuichi Abe, Junko Isoyama, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Jun Kunisawa. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice.
Allergy.
2019 08; 74(8):1522-1532. doi:
10.1111/all.13762
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Prostaglandins & other lipid mediators.
2019 08; 143(?):106336. doi:
10.1016/j.prostaglandins.2019.106336
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Journal of helminthology.
2019 Jul; 94(?):e67. doi:
10.1017/s0022149x19000464
. [PMID: 31339092] - Zhenxiao Zheng, Zhiyuan Dai, Yalun Cao, Qing Shen, Yiqi Zhang. Docosapentaenoic acid (DPA, 22:5n-3) ameliorates inflammation in an ulcerative colitis model.
Food & function.
2019 Jul; 10(7):4199-4209. doi:
10.1039/c8fo02338g
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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2019 Jun; 24(4):352-359. doi:
10.1080/1354750x.2019.1581840
. [PMID: 30744430] - Maria Bhat, Anna Lindgren, Susanna Eketjäll, Rabia Hidi, Philipp Schatz, Carl Whatling, Mark Fidock. Highly sensitive and specific LC-MS/MS method to determine endogenous leukotriene B4 levels in human plasma.
Bioanalysis.
2019 Jun; 11(11):1055-1066. doi:
10.4155/bio-2019-0021
. [PMID: 31251101] - Manlio Barbarisi, Alfonso Barbarisi, Gabriele De Sena, Emilia Armenia, Caterina Aurilio, Michele Libutti, Rosario Vincenzo Iaffaioli, Gerardo Botti, Nicola Maurea, Vincenzo Quagliariello. Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.
Phytotherapy research : PTR.
2019 06; 33(6):1670-1682. doi:
10.1002/ptr.6354
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Scientific reports.
2019 04; 9(1):5936. doi:
10.1038/s41598-019-42410-8
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Prostaglandins & other lipid mediators.
2019 04; 141(?):34-39. doi:
10.1016/j.prostaglandins.2019.02.001
. [PMID: 30738873] - Sikai Li, Tsugunobu Andoh, Qun Zhang, Daisuke Uta, Yasushi Kuraishi. β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4 and thromboxane A2) are involved in chronic renal failure-associated itch-associated responses in mice.
European journal of pharmacology.
2019 Mar; 847(?):19-25. doi:
10.1016/j.ejphar.2019.01.017
. [PMID: 30659825] - JaeIn Park, Jae-Hyun Jang, Jae-Hong Kim. Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
Biochimica et biophysica acta. Molecular cell research.
2019 03; 1866(3):329-336. doi:
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. [PMID: 30553812] - Jessica Wei, Karsten Gronert. Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells.
Trends in biochemical sciences.
2019 03; 44(3):214-225. doi:
10.1016/j.tibs.2018.10.007
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Rheumatology (Oxford, England).
2019 02; 58(2):345-351. doi:
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. [PMID: 30247644] - Yilan Li, Xueming Xu, Dandan Zhang, Wei Cheng, Yanan Zhang, Bo Yu, Yao Zhang. Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.
Lipids in health and disease.
2019 Jan; 18(1):25. doi:
10.1186/s12944-019-0968-9
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Multiple sclerosis and related disorders.
2019 Jan; 27(?):34-41. doi:
10.1016/j.msard.2018.09.040
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PloS one.
2019; 14(2):e0202842. doi:
10.1371/journal.pone.0202842
. [PMID: 30818366] - Chun-Yu Chen, Ying-Hsuan Lee, Shih-Hsin Chang, Yung-Fong Tsai, Jia-You Fang, Tsong-Long Hwang. Oleic acid-loaded nanostructured lipid carrier inhibit neutrophil activities in the presence of albumin and alleviates skin inflammation.
International journal of nanomedicine.
2019; 14(?):6539-6553. doi:
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