Moxisylyte (BioDeep_00000181109)

   

human metabolite blood metabolite


代谢物信息卡片


4-[2-(Dimethylamino)ethoxy]-2-methyl-5-(propan-2-yl)phenyl acetic acid

化学式: C16H25NO3 (279.18343400000003)
中文名称: 莫西赛利
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1=C(OCCN(C)C)C=C(C)C(OC(C)=O)=C1
InChI: InChI=1S/C16H25NO3/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6/h9-11H,7-8H2,1-6H3

描述信息

G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals > G04BE - Drugs used in erectile dysfunction
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

15 个代谢物同义名

4-[2-(Dimethylamino)ethoxy]-2-methyl-5-(propan-2-yl)phenyl acetic acid; 4-[2-(dimethylamino)ethoxy]-2-methyl-5-(propan-2-yl)phenyl acetate; Arkopharma brand OF moxisylyte hydrochloride; Viatris brand OF moxisylyte hydrochloride; Hansam brand OF moxisylyte hydrochloride; Opilon brand OF moxisylyte hydrochloride; Hydrochloride, moxisylyte; Moxisylyte hydrochloride; Acetoxythymoxamine; Thymoxyalcylamine; Thymoxamine; moxisylyte; Carlytene; Carlytène; Icavex



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Naida Yin, Xia Jin, Jiangyan He, Zhan Yin. Effects of adrenergic agents on the expression of zebrafish (Danio rerio) vitellogenin Ao1. Toxicology and applied pharmacology. 2009 Jul; 238(1):20-6. doi: 10.1016/j.taap.2009.04.004. [PMID: 19371759]
  • N Chapuis, C Brühlmann, M Reist, P A Carrupt, J M Mayer, B Testa. The esterase-like activity of serum albumin may be due to cholinesterase contamination. Pharmaceutical research. 2001 Oct; 18(10):1435-9. doi: 10.1023/a:1012204906502. [PMID: 11697469]
  • R Sakakibara, T Hattori, T Uchiyama, T Suenaga, H Takahashi, T Yamanishi, K Egoshi, N Sekita. Are alpha-blockers involved in lower urinary tract dysfunction in multiple system atrophy? A comparison of prazosin and moxisylyte. Journal of the autonomic nervous system. 2000 Mar; 79(2-3):191-5. doi: 10.1016/s0165-1838(99)00105-8. [PMID: 10699651]
  • C Marquer, F Bressolle. Moxisylyte: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in impotence. Fundamental & clinical pharmacology. 1998; 12(4):377-87. doi: 10.1111/j.1472-8206.1998.tb00961.x. [PMID: 9711459]
  • B Neau, J Roux, J P Marty. Metabolism of 14C-moxisylyte after percutaneous application in hairless rat. Arzneimittel-Forschung. 1998 Jan; 48(1):34-8. doi: NULL. [PMID: 9522028]
  • C Marquer, F Bressolle. High-performance liquid chromatographic determination of the conjugate metabolites of moxisylyte in human plasma and urine. Journal of chromatography. B, Biomedical sciences and applications. 1997 Apr; 691(2):389-96. doi: 10.1016/s0378-4347(96)00468-9. [PMID: 9174276]
  • P M Bouloux, S Corsello, M Besser, A Grossman. The acute cardiovascular actions of intravenous thyrotrophin releasing hormone (TRH) in man are mediated by non-catecholaminergic mechanisms. British journal of clinical pharmacology. 1996 Aug; 42(2):225-32. doi: 10.1046/j.1365-2125.1996.41421.x. [PMID: 8864322]
  • P Costa, F Bressolle, N Mottet, R Rouzier-Panis, H Navratil, C Marquer. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous infusion and intracavernous administration with and without a penile tourniquet. Therapeutic drug monitoring. 1996 Apr; 18(2):135-44. doi: 10.1097/00007691-199604000-00005. [PMID: 8721275]
  • F Bressolle, P Costa, R Rouzier-Panis, C Marquer. Pharmacokinetics of moxisylyte in healthy volunteers after intracavernous injection of increasing doses. European journal of clinical pharmacology. 1996; 49(5):411-5. doi: 10.1007/bf00203788. [PMID: 8866639]
  • K Kumano, M Go, H Ning, T Sakai. Effects of vasodilators on peritoneal solute and fluid transport in rat peritoneal dialysis. Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 1996; 12(?):27-32. doi: NULL. [PMID: 8865867]
  • B Neau, J Roux, C Courtiol, B Lambrey, J P Marty. Pharmacokinetics study of 14C-moxisylyte after percutaneous application to hairless rat. Arzneimittel-Forschung. 1995 Nov; 45(11):1161-5. doi: NULL. [PMID: 8929231]
  • B Neau, J Roux, B Lambrey, C Courtiol, J P Marty, L Grislain. Metabolism of 14C-moxisylyte in hairless rat. Comparison between intravenous and oral route. Arzneimittel-Forschung. 1995 Jan; 45(1):10-4. doi: NULL. [PMID: 7893260]
  • I Aldana, E González-Peñas, D Fos, L Bruseghini, A Esteras, N Ceppi Monti, V Gianesello. Pharmacokinetics of thymoxamine in rabbits after ophthalmic and intravenous administration. European journal of drug metabolism and pharmacokinetics. 1994 Apr; 19(2):79-83. doi: 10.1007/bf03188827. [PMID: 8001598]
  • P Costa, F Bressolle, E Jarroux, B Sarrazin, J Mosser, H Navratil, M Galtier. Multiple-dose pharmacokinetics of moxisylyte after oral administration to healthy volunteers. Journal of pharmaceutical sciences. 1993 Sep; 82(9):968-71. doi: 10.1002/jps.2600820920. [PMID: 8229699]
  • P Costa, F Bressolle, B Sarrazin, J Mosser, M Galtier. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous and intracavernous administration. Journal of pharmaceutical sciences. 1993 Jul; 82(7):729-33. doi: 10.1002/jps.2600820711. [PMID: 8103112]
  • P Costa, F Bressolle, B Sarrazin, J Mosser, H Navratil, M Galtier. Moxisylyte plasma kinetics in humans after intracavernous administration. Biopharmaceutics & drug disposition. 1992 Dec; 13(9):671-9. doi: 10.1002/bdd.2510130905. [PMID: 1467454]
  • P Costa, F Bressolle, M Bromet-Petit, J Mosser, B Sarrazin. Pharmacokinetics of moxisylyte in healthy volunteers after intravenous and oral administration. Journal of pharmaceutical sciences. 1992 Dec; 81(12):1223-6. doi: 10.1002/jps.2600811220. [PMID: 1491345]
  • C Marquer, J H Trouvin, J Y Lacolle, C Dupont, C Jacquot. Pharmacokinetics of a prodrug thymoxamine: dose-dependence of the metabolite ratio in healthy subjects. European journal of drug metabolism and pharmacokinetics. 1991 Jul; 16(3):183-8. doi: 10.1007/bf03189957. [PMID: 1839981]
  • H Izumi, S Kudo, A Fuino, E Yokoyama, A Ishibashi. [The effect of moxisylyte hydrochloride in the symptomatic treatment of benign prostatic hyperplasia]. Hinyokika kiyo. Acta urologica Japonica. 1989 Mar; 35(3):541-9. doi: NULL. [PMID: 2472054]
  • P Duchene, C Bernouillet, M Bromet-Petit, J Mosser, C Feniou, D Gaudin, H Virelizier. Metabolism of 14C-thymoxamine in rat and man. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Aug; 18(8):919-28. doi: 10.3109/00498258809167515. [PMID: 2973182]
  • R Paradisi, S Venturoli, M Capelli, M Spada, M E Giambiasi, O Magrini, E Porcu, R Fabbri, C Flamigni. Effects of alpha 1-adrenergic blockade on pulsatile luteinizing hormone, follicle-stimulating hormone, and prolactin secretion in polycystic ovary syndrome. The Journal of clinical endocrinology and metabolism. 1987 Nov; 65(5):841-6. doi: 10.1210/jcem-65-5-841. [PMID: 2889749]
  • R J Unwin, C J Mathias, W S Peart, H L Frankel. Renal vascular responses to saralasin in conscious chemically denervated rabbits and patients with tetraplegia. Clinical and experimental hypertension. Part A, Theory and practice. 1986; 8(6):919-39. doi: 10.3109/10641968609044078. [PMID: 2944679]
  • M R Lucey, J A Wass, P Fairclough, J Webb, S Webb, S Medbak, L H Rees. Autonomic regulation of postprandial plasma somatostatin, gastrin, and insulin. Gut. 1985 Jul; 26(7):683-8. doi: 10.1136/gut.26.7.683. [PMID: 2862095]
  • H Hengy, A Von Hodenberg, K O Vollmer. GLC method for the quantification of metabolites of thymoxamine in human plasma. European journal of drug metabolism and pharmacokinetics. 1985 Jul; 10(3):203-8. doi: 10.1007/bf03189743. [PMID: 2935399]
  • K O Vollmer, A von Hodenberg. Metabolism of thymoxamine. III. Structure elucidation of the metabolites and interspecies comparison. European journal of drug metabolism and pharmacokinetics. 1985 Apr; 10(2):139-45. doi: 10.1007/bf03189708. [PMID: 2931278]
  • K O Vollmer, B Liedtke, A Poisson, A von Hodenberg, W Steinbrecher. Metabolism of thymoxamine. I. Studies with 14C-thymoxamine in rats. European journal of drug metabolism and pharmacokinetics. 1985 Jan; 10(1):61-9. doi: 10.1007/bf03189698. [PMID: 3161738]
  • K O Vollmer, A Poisson. Metabolism of thymoxamine. II. Studies with 14C-thymoxamine in man. European journal of drug metabolism and pharmacokinetics. 1985 Jan; 10(1):71-6. doi: 10.1007/bf03189699. [PMID: 3161739]
  • C J Mathias, R J Unwin, F A Pike, H L Frankel, P S Sever, W S Peart. The immediate pressor response to saralasin in man: evidence against sympathetic activation and for intrinsic angiotensin II-like myotropism. Clinical science (London, England : 1979). 1984 May; 66(5):517-24. doi: 10.1042/cs0660517. [PMID: 6231156]
  • J I Nurnberger, S Simmons-Alling, L Kessler, S Jimerson, J Schreiber, E Hollander, C A Tamminga, N S Nadi, D S Goldstein, E S Gershon. Separate mechanisms for behavioral, cardiovascular, and hormonal responses to dextroamphetamine in man. Psychopharmacology. 1984; 84(2):200-4. doi: 10.1007/bf00427446. [PMID: 6239300]
  • M Aylward, P A Bater, D E Davies, P M Dewland, P A Lewis, J Maddock. Long-term monitoring of the effects of thymoxamine hydrochloride tablets in the management of patients with Raynaud's disease. Current medical research and opinion. 1982; 8(3):158-70. doi: 10.1185/03007998209112378. [PMID: 6215212]
  • P Kessar, E D Saggerson. Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor. The Biochemical journal. 1980 Jul; 190(1):119-23. doi: 10.1042/bj1900119. [PMID: 6255939]
  • F Nielsen-Kudsk, P Jakobsen, I Magnussen. Plasma induced biotransformation of thymoxamine and its kinetics. Acta pharmacologica et toxicologica. 1980 Jul; 47(1):11-6. doi: 10.1111/j.1600-0773.1980.tb02018.x. [PMID: 6446831]
  • A E Geahchan, P L Chambon. Determination of metabolites of thymoxamine in plasma by high performance liquid chromatography. Analytical chemistry. 1980 May; 52(6):999-1001. doi: 10.1021/ac50056a057. [PMID: 6446865]
  • C Feniou, B Neau, G Prat, C Cheze, F Fauran, J Roquebert. Metabolism of thymoxamine: identification of metabolites in rat. The Journal of pharmacy and pharmacology. 1980 Feb; 32(2):104-7. doi: 10.1111/j.2042-7158.1980.tb12862.x. [PMID: 6103028]
  • K Ghose, A Coppen, P Turner. Autonomic actions and interactions of mianserin hydrochloride (Org. GB 94) and amitriptyline in patients with depressive illness. Psychopharmacology. 1976 Sep; 49(2):201-4. doi: 10.1007/bf00427291. [PMID: 136668]
  • R C Turner, N W Oakley, J D Nabarro. Changes in plasma insulin during ethanol-induced hypoglycemia. Metabolism: clinical and experimental. 1973 Feb; 22(2):111-21. doi: 10.1016/0026-0495(73)90261-8. [PMID: 4345838]