(4-Chloro-2-methylphenoxy)acetic acid (BioDeep_00000001804)

 

Secondary id: BioDeep_00000397723

human metabolite blood metabolite Industrial Pollutants


代谢物信息卡片


2-(4-chloro-2-methylphenoxy)acetic acid

化学式: C9H9ClO3 (200.024)
中文名称: 2-甲基-4-氯苯氧乙酸, （4-氯-2-甲基苯氧基）乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 7.22%

分子结构信息

SMILES: CC1=C(C=CC(=C1)Cl)OCC(=O)O
InChI: InChI=1S/C9H9ClO3/c1-6-4-7(10)2-3-8(6)13-5-9(11)12/h2-4H,5H2,1H3,(H,11,12)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4601; ORIGINAL_PRECURSOR_SCAN_NO 4597
CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4590; ORIGINAL_PRECURSOR_SCAN_NO 4587
CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4578; ORIGINAL_PRECURSOR_SCAN_NO 4576
CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4593; ORIGINAL_PRECURSOR_SCAN_NO 4590
CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4563; ORIGINAL_PRECURSOR_SCAN_NO 4559
CONFIDENCE standard compound; INTERNAL_ID 579; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4587; ORIGINAL_PRECURSOR_SCAN_NO 4585
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8421
D010575 - Pesticides > D006540 - Herbicides
CONFIDENCE standard compound; ML_ID 2
D016573 - Agrochemicals

同义名列表

20 个代谢物同义名

2-(4-chloro-2-methylphenoxy)acetic acid; (2-Methyl-4-chlorophenoxy)acetic acid; (4-Chloro-2-methylphenoxy)acetic acid; 2 Methyl 4 chlorophenoxyacetic acid; ((4-Chloro-O-tolyl)oxy)acetic acid; [(4-Chloro-O-tolyl)oxy]acetic acid; 2-Methyl-4-chlorphenoxyessigsaeure; (2-Methyl-4-chlorophenoxy)acetate; 2-Methyl-4-chlorophenoxyacetate; ((4-Chloro-O-tolyl)oxy)acetate; [(4-Chloro-O-tolyl)oxy]acetate; Methoxone; 2,4-MCPA; Agroxone; zelan; MCPA; MCP; MCPA; MCPA; (4-Chloro-2-methylphenoxy)acetic acid



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, ARHGAP45, CAT, CNP, CST3, CYP1A1, FTO, HPGDS, IGF2BP3, PPM1G, TFF3
Peripheral membrane protein 2 CRAT, CYP1A1
Endoplasmic reticulum membrane 2 CYP1A1, SPP1
Nucleus 5 ALB, CHD7, FTO, IGF2BP3, PPM1G
cytosol 9 ALB, ARHGAP45, CAT, CLPX, CRAT, FTO, GSR, HPGDS, IGF2BP3
centrosome 1 ALB
nucleoplasm 5 CHD7, CLPX, FTO, HPGDS, PPM1G
Cell membrane 3 CD8A, HAVCR1, SPP1
Lipid-anchor 2 CNP, PPM1G
ruffle membrane 1 ARHGAP45
Multi-pass membrane protein 1 SPP1
Synapse 1 CNP
cell surface 1 HAVCR1
Golgi apparatus 3 ALB, CST3, SPP1
lysosomal membrane 1 GAA
mitochondrial inner membrane 4 CLPX, CNP, CRAT, CYP1A1
Lysosome 1 GAA
plasma membrane 7 ARHGAP45, CD8A, CST3, FTO, GAA, HAVCR1, SPP1
Membrane 5 ARHGAP45, CAT, CNP, GAA, PPM1G
extracellular exosome 7 ALB, CAT, CNP, CST3, GAA, GSR, SPP1
Lysosome membrane 1 GAA
endoplasmic reticulum 3 ALB, CRAT, CST3
extracellular space 5 ALB, CNP, CST3, SPP1, TFF3
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 CNP, SPP1
mitochondrion 5 CAT, CLPX, CRAT, CYP1A1, GSR
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 5 CAT, CYP1A1, FTO, GAA, HPGDS
Microsome membrane 1 CYP1A1
Single-pass type I membrane protein 2 CD8A, HAVCR1
Secreted 4 ALB, CST3, GAA, SPP1
extracellular region 8 ALB, ARHGAP45, CAT, CD8A, CST3, GAA, SPP1, TFF3
mitochondrial outer membrane 1 CNP
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 3 CAT, CLPX, GSR
anchoring junction 1 ALB
motile cilium 1 HAVCR1
external side of plasma membrane 2 CD8A, GSR
Secreted, extracellular space, extracellular matrix 1 TFF3
nucleolus 1 CHD7
Cytoplasm, P-body 1 IGF2BP3
P-body 1 IGF2BP3
vesicle 1 CST3
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 2 CRAT, CYP1A1
Matrix side 1 CRAT
focal adhesion 1 CAT
microtubule 1 CNP
mitochondrial nucleoid 1 CLPX
Peroxisome 2 CAT, CRAT
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, CRAT
peroxisomal membrane 1 CAT
secretory granule 1 TFF3
nuclear speck 1 FTO
receptor complex 1 CD8A
ciliary basal body 1 ALB
chromatin 1 CHD7
cell projection 1 SPP1
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 CRAT
spindle pole 1 ALB
blood microparticle 1 ALB
microvillus 1 CNP
tertiary granule membrane 1 GAA
Melanosome 1 CNP
Cytoplasm, Stress granule 1 IGF2BP3
cytoplasmic stress granule 1 IGF2BP3
Nucleus speckle 1 FTO
pseudopodium 1 CNP
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 2 CAT, CST3
secretory granule lumen 2 ARHGAP45, CAT
endoplasmic reticulum lumen 3 ALB, CST3, SPP1
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 CST3
azurophil granule membrane 1 GAA
azurophil granule lumen 1 ARHGAP45
[Isoform 1]: Nucleus 1 CHD7
ficolin-1-rich granule membrane 1 GAA
[Isoform 1]: Cell membrane 1 CD8A
endopeptidase Clp complex 1 CLPX
mitochondrial endopeptidase Clp complex 1 CLPX
T cell receptor complex 1 CD8A
catalase complex 1 CAT
myelin sheath abaxonal region 1 CNP
myelin sheath adaxonal region 1 CNP
autolysosome lumen 1 GAA
[Isoform 2]: Peroxisome 1 CRAT
ciliary transition fiber 1 ALB
[Isoform 3]: Nucleus, nucleolus 1 CHD7


文献列表

  • Xianyan Chen, Yonglin Ma, Mengge Huang, Weisheng Li, Dongqiang Zeng, Jingbo Li, Yanhui Wang. Multiple herbicide resistance in a Cyperus difformis population in rice field from China. Pesticide biochemistry and physiology. 2023 Sep; 195(?):105576. doi: 10.1016/j.pestbp.2023.105576. [PMID: 37666602]
  • Fitri Widhiastuti, William Rajendram, Biplob Kumar Pramanik. Understanding the risk of using herbicides for tree root removal into wastewater treatment plant performance. Chemosphere. 2023 Jun; 337(?):139345. doi: 10.1016/j.chemosphere.2023.139345. [PMID: 37379978]
  • Xuan Zhang, Keke Geng, Ningning Wu, Gang Hu, Ben Fan, Jian He, Wenjing Qiao. Sustained anaerobic degradation of 4-chloro-2-methylphenoxyacetic acid by acclimated sludge in a continuous-flow reactor. Chemosphere. 2023 Apr; 330(?):138749. doi: 10.1016/j.chemosphere.2023.138749. [PMID: 37086982]
  • Elżbieta Mierzejewska, Wojciech Tołoczko, Magdalena Urbaniak. Behind the plant-bacteria system: The role of zucchini and its secondary metabolite in shaping functional microbial diversity in MCPA-contaminated soil. The Science of the total environment. 2023 Apr; 867(?):161312. doi: 10.1016/j.scitotenv.2022.161312. [PMID: 36603641]
  • Jūratė Žaltauskaitė, Austra Dikšaitytė, Diana Miškelytė, Giedrė Kacienė, Gintarė Sujetovienė, Irena Januškaitienė, Romualdas Juknys. Effects of elevated CO2 concentration and temperature on the mixed-culture grown wild mustard (Sinapis arvensis L.) response to auxin herbicide. Environmental science and pollution research international. 2023 Jan; 30(5):13711-13725. doi: 10.1007/s11356-022-23134-1. [PMID: 36136189]
  • Quan-Cheng Zhang, Jing Wang, Jun-Gang Wang. Use of plant growth regulators to reduce 2-methyl-4-chlorophenoxy acetic acid-Na (MPCA-Na) damage in cotton (Gossypium hirsutum). BMC plant biology. 2022 Nov; 22(1):533. doi: 10.1186/s12870-022-03917-x. [PMID: 36380296]
  • Dongming Wu, Dong Ren, Qinfen Li, Anhong Zhu, Yike Song, Wenfang Yin, Chunyuan Wu. Molecular linkages between chemodiversity and MCPA complexation behavior of dissolved organic matter in paddy soil: Effects of land conversion. Environmental pollution (Barking, Essex : 1987). 2022 Oct; 311(?):119949. doi: 10.1016/j.envpol.2022.119949. [PMID: 35970345]
  • Elżbieta Mierzejewska, Wojciech Tołoczko, Magdalena Urbaniak. The effects of syringic acid on the properties of MCPA-contaminated soil and the growth of two cucurbit species. International journal of phytoremediation. 2022; 24(2):205-214. doi: 10.1080/15226514.2021.1932727. [PMID: 34126809]
  • Alireza Hasanfard, Mehdi Rastgoo, Ebrahim Izadi Darbandi, Ahmad Nezami, Bhagirath Singh Chauhan. Freezing stress affects the efficacy of clodinafop-propargyl and 2,4-D plus MCPA on wild oat (Avena ludoviciana Durieu) and turnipweed [Rapistrum rugosum (L.) All.] in wheat (Triticum aestivum L.). PloS one. 2022; 17(10):e0274945. doi: 10.1371/journal.pone.0274945. [PMID: 36201477]
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  • Dongming Wu, Changqi Ren, Chunyuan Wu, Yi Li, Xiao Deng, Qinfen Li. Mechanisms by which different polar fractions of dissolved organic matter affect sorption of the herbicide MCPA in ferralsol. Journal of hazardous materials. 2021 08; 416(?):125774. doi: 10.1016/j.jhazmat.2021.125774. [PMID: 33857809]
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  • Anna Parus, Jan Homa, Dariusz Radoński, Grzegorz Framski, Marta Woźniak-Karczewska, Anna Syguda, Łukasz Ławniczak, Łukasz Chrzanowski. Novel esterquat-based herbicidal ionic liquids incorporating MCPA and MCPP for simultaneous stimulation of maize growth and fighting cornflower. Ecotoxicology and environmental safety. 2021 Jan; 208(?):111595. doi: 10.1016/j.ecoenv.2020.111595. [PMID: 33396116]
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  • Daria Pęziak-Kowalska, Anna Syguda, Łukasz Ławniczak, Andrzej Borkowski, Florence Fourcade, Hermann J Heipieper, Grzegorz Lota, Łukasz Chrzanowski. Hybrid electrochemical and biological treatment of herbicidal ionic liquids comprising the MCPA anion. Ecotoxicology and environmental safety. 2019 Oct; 181(?):172-179. doi: 10.1016/j.ecoenv.2019.05.084. [PMID: 31185431]
  • Shi-Wei Liu, Mohammed Esmail Abdalla Elzaki, Christian Staehelin, Zhi-Hui Ma, Zhong Qin, Rui-Long Wang. Exposure to herbicides reduces larval sensitivity to insecticides in Spodoptera litura (Lepidoptera: Noctuidae). Insect science. 2019 Aug; 26(4):711-720. doi: 10.1111/1744-7917.12642. [PMID: 30239122]
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  • Roger Holten, Frederik Norheim Bøe, Marit Almvik, Sheela Katuwal, Marianne Stenrød, Mats Larsbo, Nicholas Jarvis, Ole Martin Eklo. The effect of freezing and thawing on water flow and MCPA leaching in partially frozen soil. Journal of contaminant hydrology. 2018 12; 219(?):72-85. doi: 10.1016/j.jconhyd.2018.11.003. [PMID: 30466740]
  • Hewa Pathirannahelage Athri Thathsarani Weerakoon, Keerthi Sri Senarathna Atapaththu, Hewa Bandulage Asanthi. Toxicity evaluation and environmental risk assessment of 2-methyl-4-chlorophenoxy acetic acid (MCPA) on non-target aquatic macrophyte Hydrilla verticillata. Environmental science and pollution research international. 2018 Oct; 25(30):30463-30474. doi: 10.1007/s11356-018-3013-z. [PMID: 30168109]
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  • Nanna Bygvraa Svenningsen, Mette Damgaard, Maria Rasmussen, Danilo Pérez-Pantoja, Ole Nybroe, Mette Haubjerg Nicolaisen. Cupriavidus pinatubonensis AEO106 deals with copper-induced oxidative stress before engaging in biodegradation of the herbicide 4-chloro-2-methylphenoxyacetic acid. BMC microbiology. 2017 Oct; 17(1):211. doi: 10.1186/s12866-017-1119-y. [PMID: 29084513]
  • Mònica Escolà Casas, Tue Kjærgaard Nielsen, Witold Kot, Lars Hestbjerg Hansen, Anders Johansen, Kai Bester. Degradation of mecoprop in polluted landfill leachate and waste water in a moving bed biofilm reactor. Water research. 2017 09; 121(?):213-220. doi: 10.1016/j.watres.2017.05.031. [PMID: 28544990]
  • Zhen-Yuan Xia, Long Zhang, Yan Zhao, Xin Yan, Shun-Peng Li, Tao Gu, Jian-Dong Jiang. Biodegradation of the Herbicide 2,4-Dichlorophenoxyacetic Acid by a New Isolated Strain of Achromobacter sp. LZ35. Current microbiology. 2017 Feb; 74(2):193-202. doi: 10.1007/s00284-016-1173-y. [PMID: 27933337]
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  • Elżbieta Skiba, Joanna Kobyłecka, Wojciech M Wolf. Influence of 2,4-D and MCPA herbicides on uptake and translocation of heavy metals in wheat (Triticum aestivum L.). Environmental pollution (Barking, Essex : 1987). 2017 Jan; 220(Pt B):882-890. doi: 10.1016/j.envpol.2016.10.072. [PMID: 27836479]
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