3-Hydroxy-alpha-methyl-DL-tyrosine (BioDeep_00000178469)

   

human metabolite blood metabolite


代谢物信息卡片


2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

化学式: C10H13NO4 (211.0844538)
中文名称: α-甲基-DL-β-3,4-二羟基苯丙氨酸, DL-甲基多巴
谱图信息: 最多检出来源 Homo sapiens(blood) 80%

分子结构信息

SMILES: CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)N
InChI: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AB - Methyldopa
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

25 个代谢物同义名

2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; 3-Hydroxy-alpha-methyl-DL-tyrosine; 3-Hydroxy-α-methyl-DL-tyrosine; 3-Hydroxy-a-methyl-DL-tyrosine; alpha Methyl L Dopa; alpha-Methyl-L-dopa; alpha Methyldopa; alpha-Methyldopa; Alphamethyldopa; Apo Methyldopa; Apo-Methyldopa; L-Methyldopa; α methyldopa; Methyldopate; Methyldopa; Nu-Medopa; Nu Medopa; Dopergit; Sembrina; Dopegyt; Aldomet; Meldopa; Dopegit; Dopamet; Hydopa



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yasser H Habib, Mennatallah A Gowayed, Sherien A Abdelhady, Nevine M El-Deeb, Inas E Darwish, Mahmoud M El-Mas. Modulation by antenatal therapies of cardiovascular and renal programming in male and female offspring of preeclamptic rats. Naunyn-Schmiedeberg's archives of pharmacology. 2021 11; 394(11):2273-2287. doi: 10.1007/s00210-021-02146-7. [PMID: 34468816]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122125. doi: 10.1016/j.jchromb.2020.122125. [PMID: 32371329]
  • Nagalakshmamma Vadabingi, Vijaya Kumar Reddy Avula, Grigory V Zyryanov, Swetha Vallela, Jaya Shree Anireddy, Visweswara Rao Pasupuleti, Venkataswamy Mallepogu, Naga Raju Chamarthi, Venkata Chalapathi Ponne. Multiple molecular targets mediated antioxidant activity, molecular docking, ADMET, QSAR and bioactivity studies of halo substituted urea derivatives of α-Methyl-l-DOPA. Bioorganic chemistry. 2020 04; 97(?):103708. doi: 10.1016/j.bioorg.2020.103708. [PMID: 32146177]
  • Xuemin Huang, Huanan Zhao, Wen Qiu, Jian Wang, Longhua Guo, Zhenyu Lin, Wei Pan, Yong Wu, Bin Qiu. A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters. Mikrochimica acta. 2020 03; 187(4):240. doi: 10.1007/s00604-020-4186-y. [PMID: 32198661]
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  • Berit Woetmann Pedersen, Lene Ringholm, Peter Damm, Ann Tabor, Kirsten Søgaard, Ellinor Hellmuth, Elisabeth R Mathiesen. Stable fetal hemodynamics measured by Doppler flow after initiation of anti-hypertensive treatment with methyldopa in pregnant women with diabetes. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2016; 29(4):550-3. doi: 10.3109/14767058.2015.1010198. [PMID: 25655528]
  • Samy Emara, Tsutomu Masujima, Walaa Zarad, Maha Kamal, Marwa Fouad, Ramzia El-Bagary. An Eco-Friendly Direct Injection HPLC Method for Methyldopa Determination in Serum by Mixed-Mode Chromatography Using a Single Protein-Coated Column. Journal of chromatographic science. 2015 Sep; 53(8):1353-60. doi: 10.1093/chromsci/bmv024. [PMID: 25834172]
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  • Sikiru Lamina. Comparative effect of interval and continuous training programs on serum uric acid in management of hypertension: a randomized controlled trial. Journal of strength and conditioning research. 2011 Mar; 25(3):719-26. doi: 10.1519/jsc.0b013e3181d09edf. [PMID: 20574413]
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  • Shu-Fang Li, Hai-Long Wu, Yong-Jie Yu, Yuan-Na Li, Jin-Fang Nie, Hai-Yan Fu, Ru-Qin Yu. Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm. Talanta. 2010 May; 81(3):805-12. doi: 10.1016/j.talanta.2010.01.019. [PMID: 20298857]
  • Zsófia Ozsvár, Zsuzsa Solymossi, Katalin Monostory. [Methyldopa-induced acute reactive hepatitis in pregnancy, drug-metabolizing capacity of the liver]. Orvosi hetilap. 2010 Mar; 151(11):457-61. doi: 10.1556/oh.2010.28736. [PMID: 20211808]
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  • Thomas Y K Chan, Charles D Gomersall, Claudia A Y Cheng, Jean Woo. Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient. Pharmacoepidemiology and drug safety. 2009 Oct; 18(10):977-9. doi: 10.1002/pds.1807. [PMID: 19623566]
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