D-Citrulline (BioDeep_00000177884)

Main id: BioDeep_00000002963

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


2-amino-5-[(C-hydroxycarbonimidoyl)amino]pentanoic acid

化学式: C6H13N3O3 (175.0957)
中文名称: DL-瓜氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CC(C(=O)O)N)CNC(=O)N
InChI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)

描述信息

Citrullin, also known as cit or 2-amino-5-uredovaleric acid, is a member of the class of compounds known as alpha amino acids. Alpha amino acids are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Citrullin is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Citrullin can be found in a number of food items such as cow milk, sesame, orange bell pepper, and pepper (c. frutescens), which makes citrullin a potential biomarker for the consumption of these food products.
2-Amino-5-ureidopentanoic acid is an endogenous metabolite.
2-Amino-5-ureidopentanoic acid is an endogenous metabolite.

同义名列表

16 个代谢物同义名

2-amino-5-[(C-hydroxycarbonimidoyl)amino]pentanoic acid; 2-amino-5-(C-hydroxycarbonimidoylamino)pentanoic acid; N(5)-(Aminocarbonyl)-DL-ornithine; DL-2-Amino-5-ureidovaleric acid; N(5)-(Aminocarbonyl)ornithine; 2-Amino-5-uredovaleric acid; N(5)-Carbamoyl-DL-ornithine; DL-2-Amino-5-ureidovalerate; 2-Amino-5-uredovalerate; DL-Citrulline; D-Citrulline; Citrullin; Citrulina; Cit; 2-Amino-5-ureidopentanoic acid; DL-Citrulline



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

40 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ASS1, CAT, CD36, CHI3L1, MMUT, NOS3, PIK3C2A, VIM
Endosome membrane 1 HLA-DRB1
Endoplasmic reticulum membrane 2 HLA-DRB1, HMGCR
Nucleus 4 FLG, MAFF, NOS3, PIK3C2A
cytosol 9 ASS1, AVP, CAT, FLG, GPT, MB, NOS3, PIK3C2A, VIM
dendrite 1 AVP
phagocytic vesicle 2 CD36, VIM
trans-Golgi network 1 PIK3C2A
nucleoplasm 5 ASS1, MAFF, NOS3, OLR1, PIK3C2A
RNA polymerase II transcription regulator complex 1 MAFF
Cell membrane 6 CD36, HLA-DRB1, OLR1, PIK3C2A, SELP, VIM
Lipid-anchor 1 OLR1
Cytoplasmic granule 1 FLG
Early endosome membrane 1 HLA-DRB1
Multi-pass membrane protein 2 CD36, HMGCR
cell surface 2 CD36, HLA-DRB1
glutamatergic synapse 1 FLG
Golgi apparatus 2 CD36, NOS3
Golgi membrane 2 HLA-DRB1, NOS3
lysosomal membrane 1 HLA-DRB1
mitochondrial inner membrane 1 OTC
postsynapse 1 FLG
Cytoplasm, cytosol 1 ASS1
plasma membrane 9 CD36, F2, FLG, HLA-DRB1, NOS3, OLR1, PIK3C2A, SELP, VIM
Membrane 7 CAT, CD36, FLG, HLA-DRB1, HMGCR, OLR1, PIK3C2A
apical plasma membrane 1 CD36
axon 1 VIM
caveola 2 CD36, NOS3
extracellular exosome 10 ASS1, CAT, CHI3L1, F2, GPT, HLA-DRB1, MB, PIK3C2A, SELP, VIM
Lysosome membrane 1 HLA-DRB1
endoplasmic reticulum 2 CHI3L1, HMGCR
extracellular space 7 AVP, CD36, CHI3L1, CRP, F2, HLA-DRB1, SELP
perinuclear region of cytoplasm 2 CHI3L1, NOS3
mitochondrion 4 CAT, MAFF, MMUT, OTC
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 3 CAT, OLR1, PIK3C2A
Single-pass type I membrane protein 2 HLA-DRB1, SELP
Secreted 5 AVP, CRP, F2, OLR1, SELP
extracellular region 8 AVP, CAT, CHI3L1, CRP, F2, FLG, OLR1, SELP
Single-pass membrane protein 1 HLA-DRB1
mitochondrial outer membrane 1 ASS1
Mitochondrion matrix 2 MMUT, OTC
mitochondrial matrix 3 CAT, MMUT, OTC
external side of plasma membrane 3 CD36, HLA-DRB1, SELP
perikaryon 1 ASS1
cytoplasmic vesicle 1 FLG
sarcoplasm 1 MB
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Single-pass type II membrane protein 1 OLR1
vesicle 1 PIK3C2A
Apical cell membrane 1 CD36
Cytoplasm, perinuclear region 1 CHI3L1
Membrane raft 2 CD36, OLR1
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 2 CAT, VIM
extracellular matrix 1 CHI3L1
Peroxisome 2 CAT, VIM
collagen trimer 1 CD36
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
collagen-containing extracellular matrix 2 F2, FLG
secretory granule 1 AVP
intermediate filament 2 HLA-DRB1, VIM
receptor complex 3 CD36, FLG, OLR1
neuron projection 1 VIM
chromatin 1 MAFF
cell leading edge 1 VIM
Late endosome membrane 1 HLA-DRB1
phagocytic vesicle membrane 1 HLA-DRB1
cell periphery 1 CD36
cytoskeleton 2 NOS3, VIM
cytoplasmic ribonucleoprotein granule 1 FLG
Secreted, extracellular space 1 CHI3L1
brush border membrane 1 CD36
Golgi apparatus, trans-Golgi network 1 PIK3C2A
blood microparticle 1 F2
Recycling endosome membrane 1 HLA-DRB1
Cornified envelope 1 FLG
microtubule organizing center 1 VIM
cell body fiber 1 ASS1
specific granule membrane 2 CD36, OLR1
tertiary granule membrane 1 OLR1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
intermediate filament cytoskeleton 1 VIM
Peroxisome membrane 1 HMGCR
clathrin-coated vesicle 1 PIK3C2A
trans-Golgi network membrane 1 HLA-DRB1
platelet dense granule membrane 1 SELP
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
Golgi lumen 1 F2
endoplasmic reticulum lumen 1 F2
nuclear matrix 1 VIM
phosphatidylinositol 3-kinase complex 1 PIK3C2A
specific granule lumen 1 CHI3L1
endocytic vesicle membrane 3 CD36, HLA-DRB1, NOS3
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
immunological synapse 1 HLA-DRB1
neuronal dense core vesicle 1 AVP
ER to Golgi transport vesicle membrane 1 HLA-DRB1
Nucleus matrix 1 VIM
clathrin-coated endocytic vesicle membrane 2 AVP, HLA-DRB1
lumenal side of endoplasmic reticulum membrane 1 HLA-DRB1
platelet alpha granule membrane 2 CD36, SELP
Autolysosome membrane 1 HLA-DRB1
MHC class II protein complex 1 HLA-DRB1
transport vesicle membrane 1 HLA-DRB1
Cytoplasm, sarcoplasm 1 MB
platelet dense granule lumen 1 SELP
catalase complex 1 CAT
keratohyalin granule 1 FLG


文献列表

  • L Puccetti, F Bruni, A L Pasqui, M Pastorelli, F Ciani, A Palazzuoli, M Acampa, A Auteri. Genetic influence in antithrombotic actions of atorvastatin in hypercholesterolaemia. European journal of clinical investigation. 2008 Jan; 38(1):11-6. doi: 10.1111/j.1365-2362.2007.01891.x. [PMID: 18173546]
  • Fulvio Bruni, Anna Laura Pasqui, Marcello Pastorelli, Giovanni Bova, Michela Cercignani, Alberto Palazzuoli, Tatsuya Sawamura, W R Gioffre, Alberto Auteri, Luca Puccetti. Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2005 Oct; 11(4):417-28. doi: 10.1177/107602960501100408. [PMID: 16244767]
  • L Puccetti, T Sawamura, A L Pasqui, M Pastorelli, A Auteri, F Bruni. Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients. European journal of clinical investigation. 2005 Jan; 35(1):47-51. doi: 10.1111/j.1365-2362.2005.01446.x. [PMID: 15638819]