Coelenterazine (BioDeep_00000177613)

   

human metabolite blood metabolite natural product


代谢物信息卡片


2-(4-Hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one

化学式: C26H21N3O3 (423.1583)
中文名称: 腔肠素
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: C1=CC=C(C=C1)CC2=NC(=CN3C2=NC(=C3O)CC4=CC=C(C=C4)O)C5=CC=C(C=C5)O
InChI: InChI=1S/C26H21N3O3/c30-20-10-6-18(7-11-20)15-23-26(32)29-16-24(19-8-12-21(31)13-9-19)27-22(25(29)28-23)14-17-4-2-1-3-5-17/h1-13,16,30-32H,14-15H2

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents

同义名列表

4 个代谢物同义名

2-(4-Hydroxybenzyl)-6-(4-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazo(1,2-a)pyrazin-3-one; 8-benzyl-6-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]imidazo[1,2-a]pyrazin-3-ol; coelenterazine; Oplophorus luciferin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

52 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ALB, AXIN2, BLVRB, CAT, ELMO3, LMO3, NFKB1, NOS2, NPAT, SULT1A1, XDH
Peripheral membrane protein 2 GBA1, HSD17B6
Nucleus 7 ALB, AXIN2, FOS, LMO3, NFKB1, NOS2, NPAT
cytosol 9 ALB, AXIN2, BLVRB, CAT, FOS, NFKB1, NOS2, SULT1A1, XDH
trans-Golgi network 1 GBA1
centrosome 2 ALB, AXIN2
nucleoplasm 5 BLVRB, FOS, NFKB1, NOS2, NPAT
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 3 ABCB1, ABCC1, GPRC5A
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 ABCB1, ABCC1, GPRC5A
cell surface 1 ABCB1
Golgi apparatus 2 ALB, GBA1
Golgi membrane 2 C1GALT1, INS
lysosomal membrane 1 GBA1
Cytoplasm, cytosol 1 NOS2
Lysosome 1 GBA1
plasma membrane 6 ABCB1, ABCC1, AXIN2, BLVRB, GPRC5A, NOS2
Membrane 4 ABCB1, ABCC1, C1GALT1, CAT
apical plasma membrane 2 ABCB1, ABCC1
basolateral plasma membrane 1 ABCC1
extracellular exosome 8 ABCB1, ABCC1, ALB, BLVRB, CAT, GBA1, GPRC5A, SOD2
Lysosome membrane 1 GBA1
Lumenal side 2 GBA1, HSD17B6
endoplasmic reticulum 4 ALB, FOS, GBA1, HSD17B6
extracellular space 3 ALB, INS, XDH
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 1 NOS2
mitochondrion 3 CAT, NFKB1, SOD2
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 4 BLVRB, CAT, GPRC5A, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 2 ALB, INS
extracellular region 4 ALB, CAT, INS, NFKB1
Mitochondrion matrix 1 SOD2
mitochondrial matrix 2 CAT, SOD2
anchoring junction 1 ALB
transcription regulator complex 1 NFKB1
beta-catenin destruction complex 1 AXIN2
nucleolus 1 GPRC5A
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Single-pass type II membrane protein 1 C1GALT1
vesicle 1 GPRC5A
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 NOS2
focal adhesion 1 CAT
mitochondrial nucleoid 1 SOD2
Peroxisome 3 CAT, NOS2, XDH
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ABCC1
receptor complex 1 GPRC5A
ciliary basal body 1 ALB
chromatin 2 FOS, NFKB1
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 GPRC5A
basal plasma membrane 1 ABCC1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
nuclear matrix 1 FOS
platelet alpha granule lumen 1 ALB
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Gemini of coiled bodies 1 NPAT
Cajal body 1 NPAT
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
transcription factor AP-1 complex 1 FOS
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
ciliary transition fiber 1 ALB


文献列表

  • Ryo Nishihara, Ryoji Kurita. Mix-and-read bioluminescent copper detection platform using a caged coelenterazine analogue. The Analyst. 2021 Oct; 146(20):6139-6144. doi: 10.1039/d1an01292d. [PMID: 34486602]
  • Masahiro Abe, Ryo Nishihara, Sung-Bae Kim, Koji Suzuki. Near-Infrared Bioluminescence Imaging of Animal Cells with Through-Bond Energy Transfer Cassette. Methods in molecular biology (Clifton, N.J.). 2021; 2274(?):103-110. doi: 10.1007/978-1-0716-1258-3_10. [PMID: 34050466]
  • Ryo Nishihara, Kazuki Niwa, Tatsunosuke Tomita, Ryoji Kurita. Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence. Bioconjugate chemistry. 2020 12; 31(12):2679-2684. doi: 10.1021/acs.bioconjchem.0c00536. [PMID: 33236887]
  • Hossein Rahmani, Fahimeh Ghavamipour, Reza H Sajedi. Bioluminescence Detection of Superoxide Anion Using Aequorin. Analytical chemistry. 2019 10; 91(20):12768-12774. doi: 10.1021/acs.analchem.9b02293. [PMID: 31500415]
  • Masahiro Abe, Ryo Nishihara, Yuma Ikeda, Takahiro Nakajima, Moritoshi Sato, Naoko Iwasawa, Shigeru Nishiyama, Ramasamy Paulmurugan, Daniel Citterio, Sung Bae Kim, Koji Suzuki. Near-Infrared Bioluminescence Imaging with a through-Bond Energy Transfer Cassette. Chembiochem : a European journal of chemical biology. 2019 08; 20(15):1919-1923. doi: 10.1002/cbic.201900149. [PMID: 30957352]
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  • Jutta Walstab, Sandra Combrink, Michael Brüss, Manfred Göthert, Beate Niesler, Heinz Bönisch. Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization. Analytical biochemistry. 2007 Sep; 368(2):185-92. doi: 10.1016/j.ab.2007.06.007. [PMID: 17617370]
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  • Markus Fuhrmann, Amparo Hausherr, Lars Ferbitz, Thomas Schödl, Markus Heitzer, Peter Hegemann. Monitoring dynamic expression of nuclear genes in Chlamydomonas reinhardtii by using a synthetic luciferase reporter gene. Plant molecular biology. 2004 Aug; 55(6):869-81. doi: 10.1007/s11103-004-2150-6. [PMID: 15604722]
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