Thiopental (BioDeep_00000001771)

 

Secondary id: BioDeep_00000408814

human metabolite blood metabolite


代谢物信息卡片


5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione

化学式: C11H18N2O2S (242.1089)
中文名称: 戊硫代巴比妥
谱图信息: 最多检出来源 Homo sapiens(blood) 7.49%

分子结构信息

SMILES: C1([C@@](C(N=C(N1)S)=O)([C@@H](CCC)C)CC)=O
InChI: InChI=1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

描述信息

A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CA - Barbiturates, plain
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AF - Barbiturates, plain
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
EAWAG_UCHEM_ID 2742; CONFIDENCE standard compound
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2742

同义名列表

36 个代谢物同义名

5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione; 5-ethyl-5-(pentan-2-yl)-2-sulfanylidene-1,3-diazinane-4,6-dione; 2-Thio-5-ethyl-5-sec-pentylbarbituric acid; Rhone merieux brand OF thiopental sodium; 2-Thio-5-ethyl-5-sec-pentylbarbitic acid; Altana pharma brand OF thiopental sodium; 2-Thio-5-ethyl-5-sec-pentylbarbitate; Pharmtech brand OF thiopental sodium; Nycomed brand OF thiopental sodium; Abbott brand OF thiopental sodium; Merial brand OF thiopental sodium; Braun brand OF thiopental sodium; Pisa brand OF thiopental sodium; Thiopentobarbituric acid; Thiopentobarbitic acid; Thiopentobarbitone; Thiopental nycomed; Thiopentobarbitate; Tiobarbital braun; Thiopentobarbital; thiopental sodium; Pentothiobarbital; Pentothal sodico; (+-)-Thiopental; Penthiobarbital; Thionembutal; Thiomebumal; Thiopentone; Sodipental; thiopental; Pentothal; Bomathal; Nesdonal; Trapanal; Thiopental; Thiopental



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, AXIN2, CA1, CASP3, CAT, POMC, PRL
Peripheral membrane protein 1 ACHE
Nucleus 5 ACHE, ALB, AXIN2, CASP3, PRL
cytosol 8 ALB, AVP, AXIN2, CA1, CASP3, CAT, GPT, PRKCQ
dendrite 1 AVP
centrosome 2 ALB, AXIN2
nucleoplasm 2 CASP3, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 3 ACHE, GLRA2, TNF
Multi-pass membrane protein 2 CACNA1I, GLRA2
Synapse 2 ACHE, GLRA2
cell surface 2 ACHE, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ACHE, ALB
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
plasma membrane 9 ACHE, AXIN2, BCHE, CACNA1I, GLRA2, IGHE, PRKCQ, REN, TNF
Membrane 5 ACHE, CACNA1I, CAT, GLRA2, REN
extracellular exosome 4 ALB, CA1, CAT, GPT
endoplasmic reticulum 1 ALB
extracellular space 12 ACHE, ALB, AVP, BCHE, IGHE, IL2, IL6, INS, POMC, PRL, REN, TNF
perinuclear region of cytoplasm 1 ACHE
mitochondrion 1 CAT
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 2 CAT, GLRA2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 IGHE
Secreted 10 ACHE, ALB, AVP, BCHE, IL2, IL6, INS, POMC, PRL, REN
extracellular region 13 ACHE, ALB, AVP, BCHE, CAT, IGHE, IL2, IL6, INS, POMC, PRL, REN, TNF
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 TNF
beta-catenin destruction complex 1 AXIN2
apical part of cell 1 REN
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 CAT
GABA-ergic synapse 1 GLRA2
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 2 AVP, POMC
Postsynaptic cell membrane 1 GLRA2
neuron projection 1 GLRA2
ciliary basal body 1 ALB
chromatin 1 PRL
IgE immunoglobulin complex 1 IGHE
cell projection 1 GLRA2
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 2 ALB, BCHE
transmembrane transporter complex 1 GLRA2
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 2 INS, PRL
chloride channel complex 1 GLRA2
side of membrane 1 ACHE
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, IL6, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 AVP
aggresome 1 PRKCQ
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 AVP
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 GLRA2
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
catalase complex 1 CAT
glycinergic synapse 1 GLRA2
interleukin-6 receptor complex 1 IL6
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • F Islam, A Akter, A A Mimi, H Urmee, Md R Islam, Md S Rahaman, A A Mamun, Md M Rahman, K Dhama, T B Emran. Neuropharmacological Effects of Chassalia curviflora (Rubiaceae) Leaves in Swiss Albino Mice Model. Archives of Razi Institute. 2022 Apr; 77(2):881-890. doi: 10.22092/ari.2021.356880.1937. [PMID: 36284956]
  • Md Mominur Rahman, Fahadul Islam, Anwar Parvez, Md A K Azad, Ghulam Md Ashraf, Mohammad Fahad Ullah, Muniruddin Ahmed. Citrus limon L. (lemon) seed extract shows neuro-modulatory activity in an in vivo thiopental-sodium sleep model by reducing the sleep onset and enhancing the sleep duration. Journal of integrative neuroscience. 2022 Jan; 21(1):42. doi: 10.31083/j.jin2101042. [PMID: 35164478]
  • V Jean-Michel, T Caulier, P-Y Delannoy, A Meybeck, H Georges. Thiopental as substitute therapy for critically ill patients with COVID-19 requiring mechanical ventilation and prolonged sedation. Medicina intensiva. 2022 01; 46(1):58-61. doi: 10.1016/j.medine.2020.07.004. [PMID: 34991875]
  • Asher Orkaby, Sukumar P Desai. The Death of Sodium Pentothal: The Rise and Fall of an Anesthetic Turned Lethal. Journal of the history of medicine and allied sciences. 2021 Sep; 76(3):294-318. doi: 10.1093/jhmas/jrab016. [PMID: 34198331]
  • Leon J DeLalio, Sean D Stocker. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli. Journal of neurophysiology. 2021 08; 126(2):668-679. doi: 10.1152/jn.00277.2021. [PMID: 34259043]
  • Leon J DeLalio, Sean D Stocker. Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity. American journal of physiology. Heart and circulatory physiology. 2021 01; 320(1):H117-H132. doi: 10.1152/ajpheart.00675.2020. [PMID: 33216622]
  • Canzhan Zhu, Wanjing Li, Xinhong Wang, Jiahong Xue, Ling Zhao, Yafan Song, Tian Zhou, Mingjuan Zhang. Thiopental sodium loaded solid lipid nano-particles attenuates obesity-induced cardiac dysfunction and cardiac hypertrophy via inactivation of inflammatory pathway. Drug delivery. 2020 Dec; 27(1):1188-1200. doi: 10.1080/10717544.2020.1803449. [PMID: 32762480]
  • Toshiko Tanaka, Hiroaki Sato, Kentaro Kasai. [An Autopsy Case of Death After Deep Sedation of Thiopental]. Journal of UOEH. 2019; 41(2):217-223. doi: 10.7888/juoeh.41.217. [PMID: 31292367]
  • Haiyun Qi, Christian Østergaard Mariager, Jakob Lindhardt, Per Mose Nielsen, Hans Stødkilde-Jørgensen, Christoffer Laustsen. Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI. Magnetic resonance in medicine. 2018 11; 80(5):2073-2080. doi: 10.1002/mrm.27165. [PMID: 29520870]
  • Tomas A Schiffer, Michael Christensen, Håkan Gustafsson, Fredrik Palm. The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. PloS one. 2018; 13(11):e0207728. doi: 10.1371/journal.pone.0207728. [PMID: 30475856]
  • Sarah Sonnay, João M N Duarte, Nathalie Just, Rolf Gruetter. Energy metabolism in the rat cortex under thiopental anaesthesia measured In Vivo by 13 C MRS. Journal of neuroscience research. 2017 11; 95(11):2297-2306. doi: 10.1002/jnr.24032. [PMID: 28316083]
  • Osbourne Quaye, Precious Cramer, Mark Ofosuhene, Laud K N Okine, Alexander K Nyarko. Acute and Subchronic Toxicity Studies of Aqueous Extract of Desmodium adscendens (Sw) DC. Journal of evidence-based complementary & alternative medicine. 2017 10; 22(4):753-759. doi: 10.1177/2156587217736587. [PMID: 29228815]
  • Mohammad H Abou-Arab, Morten Rostrup, Tom Heier. Dose requirements of alfentanil to eliminate autonomic responses during rapid-sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg. Journal of clinical anesthesia. 2016 Dec; 35(?):465-474. doi: 10.1016/j.jclinane.2016.09.026. [PMID: 27871575]
  • Seyed Mojtaba Moosavi, Kiran Shekar, John Fraser, Maree T Smith, Sussan Ghassabian. High-throughput assay for quantification of the plasma concentrations of thiopental using automated solid phase extraction (SPE) directly coupled to LC-MS/MS instrumentation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Dec; 1038(?):80-87. doi: 10.1016/j.jchromb.2016.10.038. [PMID: 27802918]
  • Marcin Możański, Dariusz Tomaszewski, Zbigniew Rybicki, Jolanta Bejm, Mariusz Bałkota. Etomidate, but not thiopental, decreases serum cortisol concentration in morbidly obese patients. A randomized controlled trial. Anaesthesiology intensive therapy. 2016; 48(1):7-12. doi: 10.5603/ait.2016.0002. [PMID: 26966106]
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  • Sinan Hatipoglu, Huseyin Yildiz, Ertan Bulbuloglu, Ismail Coskuner, Ergul Belge Kurutas, Filiz Hatipoglu, Harun Ciralik, Mehmet Sait Berhuni. Protective effects of intravenous anesthetics on kidney tissue in obstructive jaundice. World journal of gastroenterology. 2014 Mar; 20(12):3320-6. doi: 10.3748/wjg.v20.i12.3320. [PMID: 24695809]
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  • Bart F E Feyen, Dries Coenen, Philippe G Jorens, Kristien Wouters, Andrew I R Maas, Viviane Van Hoof, Walter Verbrugghe. Falsely elevated sodium levels during thiopental treatment in the ICU: technical interference on a laboratory device with important clinical relevance. Neurocritical care. 2013 Feb; 18(1):64-9. doi: 10.1007/s12028-012-9794-x. [PMID: 23104171]
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  • Norio Sogawa, Yuri Hazehara, Muneyoshi Kunitomo, Yuya Morita, Bupsang Yoo, Kazumi Ohyama, Chiharu Sogawa, Shigeo Kitayama. Age-dependent changes in the susceptibility to thiopental anesthesia in mice: analysis of the relationship to the functional expression of GABA transporter. Pharmacology, biochemistry, and behavior. 2012 Dec; 103(2):267-72. doi: 10.1016/j.pbb.2012.08.027. [PMID: 22963929]
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  • Ferhat Harman, Askin Esen Hasturk, Mehmet Yaman, Turkan Arca, Kamer Kilinc, Mustafa Fevzi Sargon, Erkan Kaptanoglu. Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2012 Jul; 28(7):1055-62. doi: 10.1007/s00381-012-1782-0. [PMID: 22562195]
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  • Jae Yeon Lee. Oxidative stress due to anesthesia and surgical trauma and comparison of the effects of propofol and thiopental in dogs. The Journal of veterinary medical science. 2012 May; 74(5):663-5. doi: 10.1292/jvms.11-0221. [PMID: 22198056]
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  • Jinhwa Chang, Sujin Kim, Joohyun Jung, Heechun Lee, Dongwoo Chang, Youngwon Lee, Inhyung Lee, Junghee Yoon, Mincheol Choi. Evaluation of the effects of thiopental, propofol, and etomidate on glomerular filtration rate measured by the use of dynamic computed tomography in dogs. American journal of veterinary research. 2011 Jan; 72(1):146-51. doi: 10.2460/ajvr.72.1.146. [PMID: 21194347]
  • Michal Zorniak, Katarzyna Mitrega, Szymon Bialka, Maurycy Porc, Tadeusz F Krzeminski. Comparison of thiopental, urethane, and pentobarbital in the study of experimental cardiology in rats in vivo. Journal of cardiovascular pharmacology. 2010 Jul; 56(1):38-44. doi: 10.1097/fjc.0b013e3181dd502c. [PMID: 20351562]
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