1-Hydroxypyrene (BioDeep_00000001745)

 

Secondary id: BioDeep_00000032838, BioDeep_00001873808

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


1-HYDROXYPYRENE

化学式: C16H10O (218.0732)
中文名称: 1-羟基芘
谱图信息: 最多检出来源 Homo sapiens(blood) 14.88%

分子结构信息

SMILES: C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)O
InChI: InChI=1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H

描述信息

1-Hydroxypyrene is a metabolite of the noncarcinogen pyrene found in urine that is always a component of PAH mixtures. 1-hydroxypyrene is an accepted biomarker of carcinogenic Polycyclic aromatic hydrocarbons (PAH) dose(PMID: 15159317). PAH are a diverse group of environmental carcinogens formed during the incomplete combustion of organic matter. PAHs are believed to play an important role as causes of human cancer, particularly in certain occupational settings and in cigarette smokers. (PMID: 15247141) [HMDB]
1-Hydroxypyrene is a metabolite of the noncarcinogen pyrene found in urine that is always a component of PAH mixtures. 1-Hydroxypyrene is an accepted biomarker of carcinogenic polycyclic aromatic hydrocarbons (PAHs) dose (PMID: 15159317). PAHs are a diverse group of environmental carcinogens formed during the incomplete combustion of organic matter. PAHs are believed to play an important role as causes of human cancer, particularly in certain occupational settings and in cigarette smokers (PMID: 15247141).
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5366; ORIGINAL_PRECURSOR_SCAN_NO 5365
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5365; ORIGINAL_PRECURSOR_SCAN_NO 5363
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5373; ORIGINAL_PRECURSOR_SCAN_NO 5371
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5353; ORIGINAL_PRECURSOR_SCAN_NO 5351
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5367; ORIGINAL_PRECURSOR_SCAN_NO 5365
CONFIDENCE standard compound; INTERNAL_ID 500; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5334; ORIGINAL_PRECURSOR_SCAN_NO 5333
CONFIDENCE standard compound; INTERNAL_ID 44
D009676 - Noxae > D009153 - Mutagens
1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes[1].

同义名列表

7 个代谢物同义名

1-HYDROXYPYRENE; 3-Hydroxypyrene; pyren-1-ol; 1-Pyrenol; 3-Pyrenol; 1-Hydroxypyrene; 1-Hydroxypyrene



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AHR, ALB, CYP1A1, CYP2E1, GSTM1, GSTP1, GSTT1, HPGDS, NAT2, NQO1
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP2E1, GBA1
Endoplasmic reticulum membrane 6 CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1, UGT1A6
Nucleus 6 AHR, ALB, GSTP1, NAT2, NQO1, XRCC1
cytosol 8 AHR, ALB, GSTM1, GSTP1, GSTT1, HPGDS, NAT2, NQO1
dendrite 1 NQO1
trans-Golgi network 1 GBA1
centrosome 1 ALB
nucleoplasm 3 AHR, HPGDS, XRCC1
Cell membrane 1 NAT2
Multi-pass membrane protein 2 NAT2, SLC45A2
Synapse 1 NQO1
Golgi apparatus 2 ALB, GBA1
lysosomal membrane 1 GBA1
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuronal cell body 2 NAT2, NQO1
Cytoplasm, cytosol 1 NQO1
Lysosome 1 GBA1
plasma membrane 1 NAT2
Membrane 5 CYP1B1, NAT2, NQO1, SLC45A2, UGT1A6
axon 1 NAT2
basolateral plasma membrane 1 NAT2
extracellular exosome 5 ALB, GBA1, GSTP1, GSTT1, NAT2
Lysosome membrane 1 GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 3 ALB, GBA1, UGT1A6
extracellular space 5 ALB, CRP, GSTP1, IL10, IL6
lysosomal lumen 1 GBA1
mitochondrion 3 CYP1A1, CYP1B1, GSTP1
protein-containing complex 2 AHR, ALB
intracellular membrane-bounded organelle 6 CYP1A1, CYP1A2, CYP1B1, CYP2E1, HPGDS, UGT1A6
Microsome membrane 5 CYP1A1, CYP1A2, CYP1B1, CYP2E1, EPHX1
Secreted 4 ALB, CRP, IL10, IL6
extracellular region 5 ALB, CRP, GSTP1, IL10, IL6
Single-pass membrane protein 1 UGT1A6
anchoring junction 1 ALB
transcription regulator complex 2 AHR, NAT2
nucleolus 1 XRCC1
Melanosome membrane 1 SLC45A2
vesicle 1 GSTP1
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
ciliary basal body 1 ALB
chromatin 2 AHR, XRCC1
Chromosome 1 XRCC1
centriole 1 ALB
spindle pole 1 ALB
chromosome, telomeric region 1 XRCC1
blood microparticle 1 ALB
intercellular bridge 1 GSTM1
aryl hydrocarbon receptor complex 1 AHR
ficolin-1-rich granule lumen 1 GSTP1
secretory granule lumen 1 GSTP1
endoplasmic reticulum lumen 2 ALB, IL6
platelet alpha granule lumen 1 ALB
Single-pass type III membrane protein 1 EPHX1
external side of apical plasma membrane 1 NAT2
site of DNA damage 1 XRCC1
interleukin-6 receptor complex 1 IL6
ERCC4-ERCC1 complex 1 XRCC1
TRAF2-GSTP1 complex 1 GSTP1
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
NatA complex 1 NAT2
ciliary transition fiber 1 ALB


文献列表

  • Ye Fu, Xuejing Li, Baolong Pan, Yingying Niu, Bin Zhang, Xinyu Zhao, Jisheng Nie, Jin Yang. Effects of H19/SAHH/DNMT1 on the oxidative DNA damage related to benzo[a]pyrene exposure. Environmental science and pollution research international. 2023 Jan; 30(5):11706-11718. doi: 10.1007/s11356-022-22936-7. [PMID: 36098921]
  • Shi-Wen Yue, Yi-Lian Zhou, Xi-Tian Peng, Qin Zhao. Application of a novel nylon needle filter-based solid-phase extraction device to determination of 1-hydroxypyrene in urine. Journal of separation science. 2022 Mar; 45(6):1262-1272. doi: 10.1002/jssc.202100830. [PMID: 35029014]
  • Jinye Hu, Yuling Bao, Hui Huang, Zhan Zhang, Feng Chen, Lei Li, Qian Wu. The preliminary investigation of potential response biomarkers to PAHs exposure on childhood asthma. Journal of exposure science & environmental epidemiology. 2022 01; 32(1):82-93. doi: 10.1038/s41370-021-00334-4. [PMID: 33972693]
  • Hua Miao, Xia-Qing Wu, Yan-Ni Wang, Dan-Qian Chen, Lin Chen, Nosratola D Vaziri, Shougang Zhuang, Yan Guo, Wei Su, Shi-Xing Ma, Huan-Qiao Zhang, You-Quan Shang, Xiao-Yong Yu, Yan-Long Zhao, Jia-Rong Mao, Ming Gao, Jin-Hua Zhang, Jin Zhao, Yuan Zhang, Li Zhang, Ying-Yong Zhao, Gang Cao. 1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway. British journal of pharmacology. 2022 01; 179(1):103-124. doi: 10.1111/bph.15705. [PMID: 34625952]
  • Jing Zhang, Yaxian Zhu, Yong Zhang. Potential ability of different types of cyclodextrins to modulate the interaction between bovine serum albumin and 1-hydroxypyrene. Food chemistry. 2021 May; 343(?):128516. doi: 10.1016/j.foodchem.2020.128516. [PMID: 33183870]
  • Kanika Miglani, Sunil Kumar, Anita Yadav, Neeraj Aggarwal, Ranjan Gupta. OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage. Iranian biomedical journal. 2021 01; 25(1):47-53. doi: 10.29252/ibj.25.1.47. [PMID: 33129239]
  • Tae-Woo Lee, Dae Hwan Kim, Ji Young Ryu. Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012-2014). Scientific reports. 2020 10; 10(1):17142. doi: 10.1038/s41598-020-74353-w. [PMID: 33051516]
  • Antoine Netter, Elena Siri, Virginie Tassitro, Noémie Resseguier, Nicolas Beauval, Irène Sari-Minodier, Blandine Courbiere, Jeanne Perrin. Influence of polycyclic aromatic hydrocarbon exposure on IVF: now is the time to focus on women. Reproductive biomedicine online. 2020 Aug; 41(2):161-169. doi: 10.1016/j.rbmo.2020.03.022. [PMID: 32532665]
  • Fariborz Omidi, Monireh Khadem, Fatemeh Dehghani, Mirghani Seyedsomeah, Seyed Jamaleddin Shahtaheri. Ultrasound-assisted dispersive micro-solid-phase extraction based on N-doped mesoporous carbon and high-performance liquid chromatographic determination of 1-hydroxypyrene in urine samples. Journal of separation science. 2020 Jul; 43(13):2602-2609. doi: 10.1002/jssc.202000172. [PMID: 32223065]
  • Jin-Hua Xue, Ke-Ping Xiao, Yong-Sheng Wang, Ling Liu, Jia-Qian Li, Mei Li, Yue-Ning Qu, Xi-Lin Xiao. Aggregation-induced photoluminescence enhancement of protamine-templated gold nanoclusters for 1-hydroxypyrene detection using 9-hydroxyphenanthrene as a sensitizer. Colloids and surfaces. B, Biointerfaces. 2020 May; 189(?):110873. doi: 10.1016/j.colsurfb.2020.110873. [PMID: 32113085]
  • Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Donguk Park. Comparison of Polycyclic Aromatic Hydrocarbons Exposure Across Occupations Using Urinary Metabolite 1-Hydroxypyrene. Annals of work exposures and health. 2020 04; 64(4):445-454. doi: 10.1093/annweh/wxaa014. [PMID: 32064494]
  • Violet Kayamba, Paul Kelly. Estimated 24-hour urinary sodium excretion as a risk factor for oxidative stress in Zambian adults: A cross-sectional study. PloS one. 2020; 15(11):e0242144. doi: 10.1371/journal.pone.0242144. [PMID: 33180810]
  • Tzu-Hsuen Yuan, Deng-Yuan Ke, Joyce En-Hua Wang, Chang-Chuan Chan. Associations between renal functions and exposure of arsenic and polycyclic aromatic hydrocarbon in adults living near a petrochemical complex. Environmental pollution (Barking, Essex : 1987). 2020 Jan; 256(?):113457. doi: 10.1016/j.envpol.2019.113457. [PMID: 31785941]
  • Liren Yang, Li Shang, Shanshan Wang, Wenfang Yang, Liyan Huang, Cuifang Qi, Anil Gurcan, Zixuan Yang, Mei Chun Chung. The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis. PloS one. 2020; 15(8):e0236708. doi: 10.1371/journal.pone.0236708. [PMID: 32790684]
  • Mengran Du, Benjamin J Mullins, Peter Franklin, A W Musk, Novak S J Elliot, Nita Sodhi-Berry, Edwin Junaldi, Nicholas de Klerk, Alison Reid. Measurement of urinary 1-aminopyrene and 1-hydroxypyrene as biomarkers of exposure to diesel particulate matter in gold miners. The Science of the total environment. 2019 Oct; 685(?):723-728. doi: 10.1016/j.scitotenv.2019.06.242. [PMID: 31234134]
  • Niels Hadrup, Danuta Mielżyńska-Švach, Agnieszka Kozłowska, Manuela Campisi, Sofia Pavanello, Ulla Vogel. Association between a urinary biomarker for exposure to PAH and blood level of the acute phase protein serum amyloid A in coke oven workers. Environmental health : a global access science source. 2019 09; 18(1):81. doi: 10.1186/s12940-019-0523-1. [PMID: 31477116]
  • Aisha Mohamed Samir, Dalia Abdel-Hamid Shaker, Mona Mohamed Fathy, Salwa Farouk Hafez, Mona Mohsen Abdullatif, Laila Ahmed Rashed, Hany Ahmed Fouad Alghobary. Urinary and Genetic Biomonitoring of Polycyclic Aromatic Hydrocarbons in Egyptian Coke Oven Workers: Associations between Exposure, Effect, and Carcinogenic Risk Assessment. The international journal of occupational and environmental medicine. 2019 07; 10(3):124-136. doi: 10.15171/ijoem.2019.1541. [PMID: 31325295]
  • Ayman Alhamdow, Christian Lindh, Maria Albin, Per Gustavsson, Håkan Tinnerberg, Karin Broberg. Cardiovascular disease-related serum proteins in workers occupationally exposed to polycyclic aromatic hydrocarbons. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Jun; ?(?):. doi: 10.1093/toxsci/kfz142. [PMID: 31228248]
  • Iván N Pérez-Maldonado, Ángeles C Ochoa-Martínez, Myrna L López-Ramírez, José A Varela-Silva. Urinary levels of 1-hydroxypyrene and health risk assessment in children living in Mexican communities with a high risk of contamination by polycyclic aromatic hydrocarbons (PAHs). International journal of environmental health research. 2019 Jun; 29(3):348-357. doi: 10.1080/09603123.2018.1549727. [PMID: 30468079]
  • Yueli Yao, Dong Wang, Haitao Ma, Chengyun Li, Xiaoru Chang, Patrick Low, S Katharine Hammond, Mary Ellen Turyk, Junling Wang, Sa Liu. The impact on T-regulatory cell related immune responses in rural women exposed to polycyclic aromatic hydrocarbons (PAHs) in household air pollution in Gansu, China: A pilot investigation. Environmental research. 2019 06; 173(?):306-317. doi: 10.1016/j.envres.2019.03.053. [PMID: 30951957]
  • Jing Han, Wei Liu, Rui Su, Lixue Zhu, Debo Wu, Jiaquan Xu, Aiying Liu, Hua Zhang, Wei Kou, Xiaoping Zhang, Shuiping Yang. Coupling of micro-solid-phase extraction and internal extractive electrospray ionization mass spectrometry for ultra-sensitive detection of 1-hydroxypyrene and papaverine in human urine samples. Analytical and bioanalytical chemistry. 2019 Jun; 411(15):3281-3290. doi: 10.1007/s00216-019-01794-2. [PMID: 30989270]
  • Dan Chen, Hui Xu. Simultaneous HPLC-MS determination of 8-hydroxy-2'-deoxyguanosine, 3-hydroxyphenanthrene and 1-hydroxypyrene after online in-tube solid phase microextraction using a graphene oxide/poly(3,4-ethylenedioxythiophene)/polypyrrole composite. Mikrochimica acta. 2019 04; 186(5):300. doi: 10.1007/s00604-019-3429-2. [PMID: 31025201]
  • Nicola Cherry, Yayne-Abeba Aklilu, Jeremy Beach, Philip Britz-McKibbin, Rebecca Elbourne, Jean-Michel Galarneau, Biban Gill, David Kinniburgh, Xu Zhang. Urinary 1-hydroxypyrene and Skin Contamination in Firefighters Deployed to the Fort McMurray Fire. Annals of work exposures and health. 2019 04; 63(4):448-458. doi: 10.1093/annweh/wxz006. [PMID: 30753267]
  • Biban Gill, Alicia Mell, Meera Shanmuganathan, Karl Jobst, Xu Zhang, David Kinniburgh, Nicola Cherry, Philip Britz-McKibbin. Urinary hydroxypyrene determination for biomonitoring of firefighters deployed at the Fort McMurray wildfire: an inter-laboratory method comparison. Analytical and bioanalytical chemistry. 2019 Mar; 411(7):1397-1407. doi: 10.1007/s00216-018-01569-1. [PMID: 30683964]
  • Anna M Adetona, W. Kyle Martin, Sarah H Warren, Nancy M Hanley, Olorunfemi Adetona, Junfeng Jim Zhang, Christopher Simpson, Mike Paulsen, Stephen Rathbun, Jia-Sheng Wang, David M DeMarini, Luke P Naeher. Urinary mutagenicity and other biomarkers of occupational smoke exposure of wildland firefighters and oxidative stress. Inhalation toxicology. 2019 02; 31(2):73-87. doi: 10.1080/08958378.2019.1600079. [PMID: 30985217]
  • Joanna Zając, Ewa Gomółka, Wojciech Szot. Urinary 1-hydroxypyrene in occupationally-exposed and non-exposed individuals in Silesia, Poland. Annals of agricultural and environmental medicine : AAEM. 2018 Dec; 25(4):625-629. doi: 10.26444/aaem/75940. [PMID: 30586979]
  • Aksorn Saengtienchai, Yoshinori Ikenaka, Minami Kawata, Yusuke Kawai, Kazuki Takeda, Mitsuki Kondo, Nesta Bortey-Sam, Shouta M M Nakayama, Hazuki Mizukawa, Mayumi Ishizuka. Comparison of xenobiotic metabolism in phase I oxidation and phase II conjugation between rats and bird species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2018 12; 214(?):28-35. doi: 10.1016/j.cbpc.2018.08.007. [PMID: 30176376]
  • Yanli Liu, Hongjie Zhang, Huitao Zhang, Yingying Niu, Ye Fu, Jisheng Nie, Aimin Yang, Jinzhu Zhao, Jin Yang. Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers. Environmental pollution (Barking, Essex : 1987). 2018 Dec; 243(Pt B):972-977. doi: 10.1016/j.envpol.2018.09.014. [PMID: 30248604]
  • Jacopo Fostinelli, Egidio Madeo, Emanuele Toraldo, Michela Sarnico, Giorgio Luzzana, Cesare Tomasi, Giuseppe De Palma. Environmental and biological monitoring of occupational exposure to polynuclear aromatic hydrocarbons during highway pavement construction in Italy. Toxicology letters. 2018 Dec; 298(?):134-140. doi: 10.1016/j.toxlet.2018.06.005. [PMID: 29894843]
  • Denise Bohrer, Marcia M Barichello, Carine Viana, Paulo C Nascimento, Leandro M Carvalho. Newborn Exposure to Polycyclic Aromatic Hydrocarbons Through Parenteral Nutrition. Journal of pediatric gastroenterology and nutrition. 2018 11; 67(5):671-676. doi: 10.1097/mpg.0000000000002083. [PMID: 29985872]
  • Wenshan Fu, Zhuowang Chen, Yansen Bai, Xiulong Wu, Guyanan Li, Weilin Chen, Gege Wang, Suhan Wang, Xiaoliang Li, Meian He, Xiaomin Zhang, Tangchun Wu, Huan Guo. The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study. Environmental pollution (Barking, Essex : 1987). 2018 Nov; 242(Pt B):2100-2110. doi: 10.1016/j.envpol.2018.05.026. [PMID: 30097281]
  • Ingrid Gjesteland, Bjørg Eli Hollund, Jorunn Kirkeleit, Per Daling, Magne Bråtveit. Biomonitoring of Benzene and Effect of Wearing Respirators during an Oil Spill Field Trial at Sea. Annals of work exposures and health. 2018 10; 62(8):1033-1039. doi: 10.1093/annweh/wxy067. [PMID: 30010761]
  • Jing Zhang, Linfeng Chen, Dan Liu, Yaxian Zhu, Yong Zhang. Interactions of pyrene and/or 1-hydroxypyrene with bovine serum albumin based on EEM-PARAFAC combined with molecular docking. Talanta. 2018 Aug; 186(?):497-505. doi: 10.1016/j.talanta.2018.04.066. [PMID: 29784393]
  • Rogelio Recio-Vega, Edgar Olivas-Calderon, Gladis Michel-Ramirez, Rebeca Isabel Martinez-Salinas, Martha Patricia Gallegos-Arreola, Guadalupe Leticia Ocampo-Gomez, Rebeca Perez-Morales. Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. International archives of occupational and environmental health. 2018 08; 91(6):725-734. doi: 10.1007/s00420-018-1320-9. [PMID: 29845565]
  • You Zhou, Qian Yang, Jing Cuan, Yanan Wang, Ning Gan, Yuting Cao, Tianhua Li. A pyrene-involved luminescent MOF for monitoring 1-hydroxypyrene, a biomarker for human intoxication of PAH carcinogens. The Analyst. 2018 Jul; 143(15):3628-3634. doi: 10.1039/c8an00909k. [PMID: 29969119]
  • Jun Li, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Yizhi Zhang, Biqi Wang, Xuezhen Liu, Siyun Deng, Jie Hu, Qifei Deng, Huizhen Sun, Huan Guo, Xiaomin Zhang, Weihong Chen, Jing Yuan, Meian He, Yansen Bai, Xu Han, Bing Liu, Chuanyao Liu, Yanjun Guo, Bing Zhang, Zhihong Zhang, Frank B Hu, Wenjing Gao, Liming Li, Mark Lathrop, Catherine Laprise, Liming Liang, Tangchun Wu. Exposure to Polycyclic Aromatic Hydrocarbons and Accelerated DNA Methylation Aging. Environmental health perspectives. 2018 06; 126(6):067005. doi: 10.1289/ehp2773. [PMID: 29906262]
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  • Tzu-Hsuan Wong, Chon-Lin Lee, Hsiang-Han Su, Chin-Lai Lee, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Chien-Jen Wang, Yu-Chun Lin, Hua-Ling Chen, Ming-Shyan Huang, Jeng-Hsien Yen, Shau-Ku Huang, Jau-Ling Suen. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. Scientific reports. 2018 03; 8(1):5198. doi: 10.1038/s41598-018-23542-9. [PMID: 29581487]
  • J Yang, H Zhang, H Zhang, B Pan, W Wang, Y Fan, Y Liu. S phase arrest in lymphocytes induced by urinary 1-hydroxypyrene and alcohol drinking in coke oven workers. Human & experimental toxicology. 2018 Mar; 37(3):229-239. doi: 10.1177/0960327116678296. [PMID: 29357763]
  • Jin Yang, Yanli Liu, Huitao Zhang, Hongjie Zhang, Wubin Wang, Yanfeng Fan. Urinary 1-hydroxypyrene and smoking are determinants of LINE-1 and AhRR promoter methylation in coke oven workers. Mutation research. Genetic toxicology and environmental mutagenesis. 2018 Feb; 826(?):33-40. doi: 10.1016/j.mrgentox.2018.01.001. [PMID: 29412867]
  • Jena Webb, Oliver T Coomes, Donna Mergler, Nancy A Ross. Levels of 1-hydroxypyrene in urine of people living in an oil producing region of the Andean Amazon (Ecuador and Peru). International archives of occupational and environmental health. 2018 01; 91(1):105-115. doi: 10.1007/s00420-017-1258-3. [PMID: 28939924]
  • Donald C Hilton, Debra A Trinidad, Kendra Hubbard, Zheng Li, Andreas Sjödin. Measurement of urinary Benzo[a]pyrene tetrols and their relationship to other polycyclic aromatic hydrocarbon metabolites and cotinine in humans. Chemosphere. 2017 Dec; 189(?):365-372. doi: 10.1016/j.chemosphere.2017.09.077. [PMID: 28946070]
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