15-Hydroxy-5,8,11,13-eicosatetraenoic acid (BioDeep_00000172877)
human metabolite blood metabolite
代谢物信息卡片
15-Hydroxy-5,8,11,13-eicosatetraenoic acid, (S-(e,Z,Z,Z))-isomer
化学式: C20H32O3 (320.2351)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(O)C=CC=CCC=CCC=CCCCC(O)=O
InChI: InChI=1S/C20H32O3/c1-2-3-13-16-19(21)17-14-11-9-7-5-4-6-8-10-12-15-18-20(22)23/h4-5,8-11,14,17,19,21H,2-3,6-7,12-13,15-16,18H2,1H3,(H,22,23)
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sasikumar J Soumya, Sheela Binu, A Helen, K Anil Kumar, P Reddanna, Perumana R Sudhakaran. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
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10.1007/s00011-012-0463-5. [PMID: 22450700] - Jun Yang, Jason P Eiserich, Carroll E Cross, Brian M Morrissey, Bruce D Hammock. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients.
Free radical biology & medicine.
2012 Jul; 53(1):160-71. doi:
10.1016/j.freeradbiomed.2012.05.001. [PMID: 22580336] - Lei Yu, Yun Liu, Zhaoping Qiu, Shulin Liu, Xu Gao, Daling Zhu. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE.
Journal of receptor and signal transduction research.
2012 Apr; 32(2):87-95. doi:
10.3109/10799893.2012.660530. [PMID: 22390281] - Mohamad Navab, Srinivasa T Reddy, G M Anantharamaiah, Greg Hough, Georgette M Buga, Jan Danciger, Alan M Fogelman. D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice.
Journal of lipid research.
2012 Mar; 53(3):437-445. doi:
10.1194/jlr.m023523. [PMID: 22167743] - Peter Hoffman, Mária Cupáková, Drahomíra Rauová, Renáta Kollárová, Mária Pekárová, Marek Oblozinský, Lýdia Bezáková. [Identification of lipoxygenase expressing omega-6 dioxygenase activity by means of liquid chromatography].
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Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
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10.1039/c1pp05272a. [PMID: 22173231] - Jonathan Bertin, Corinne Barat, Sylvie Méthot, Michel J Tremblay. Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system.
Retrovirology.
2012 Jan; 9(?):4. doi:
10.1186/1742-4690-9-4. [PMID: 22236409] - Xiaowei Nie, Shasha Song, Lei Zhang, Zhaoping Qiu, Shuai Shi, Yun Liu, Lan Yao, Daling Zhu. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway.
Prostaglandins & other lipid mediators.
2012 Jan; 97(1-2):50-9. doi:
10.1016/j.prostaglandins.2011.11.003. [PMID: 22101001] - Dirk Schäfer, Steffen Maune. Pathogenic Mechanisms and In Vitro Diagnosis of AERD.
Journal of allergy.
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PloS one.
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Cancer prevention research (Philadelphia, Pa.).
2011 Nov; 4(11):1929-37. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Nov; 26(11):3465-73. doi:
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Journal of lipid research.
2011 Oct; 52(10):1795-809. doi:
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Lipids.
2011 Oct; 46(10):893-906. doi:
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Molecules (Basel, Switzerland).
2011 Sep; 16(10):8198-208. doi:
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American journal of physiology. Renal physiology.
2011 Sep; 301(3):F672-81. doi:
10.1152/ajprenal.00597.2010. [PMID: 21697242] - Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochimica et biophysica acta.
2011 Aug; 1812(8):1007-22. doi:
10.1016/j.bbadis.2011.02.014. [PMID: 21382489] - Janny C de Grauw, Chris H A van de Lest, Paul René van Weeren. A targeted lipidomics approach to the study of eicosanoid release in synovial joints.
Arthritis research & therapy.
2011 Jul; 13(4):R123. doi:
10.1186/ar3427. [PMID: 21794148] - Charles B Stephensen, Patrice Armstrong, John W Newman, Theresa L Pedersen, Jillian Legault, Gertrud U Schuster, Darshan Kelley, Susanna Vikman, Jaana Hartiala, Rami Nassir, Michael F Seldin, Hooman Allayee. ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation.
Journal of lipid research.
2011 May; 52(5):991-1003. doi:
10.1194/jlr.p012864. [PMID: 21296957] - Jérôme Bellenger, Sandrine Bellenger, Amandine Bataille, Karen A Massey, Anna Nicolaou, Mickaël Rialland, Christian Tessier, Jing X Kang, Michel Narce. High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition.
Diabetes.
2011 Apr; 60(4):1090-9. doi:
10.2337/db10-0901. [PMID: 21330635] - Jing Jiang, Shuang Wang, Zhigang Wang, Jun Ma, Shulin Liu, Weiyang Li, Daling Zhu. The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells.
Journal of receptor and signal transduction research.
2011 Feb; 31(1):45-52. doi:
10.3109/10799893.2010.512013. [PMID: 20822476] - Till Adhikary, Kerstin Kaddatz, Florian Finkernagel, Anne Schönbauer, Wolfgang Meissner, Maren Scharfe, Michael Jarek, Helmut Blöcker, Sabine Müller-Brüsselbach, Rolf Müller. Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ).
PloS one.
2011 Jan; 6(1):e16344. doi:
10.1371/journal.pone.0016344. [PMID: 21283829] - Joan Clària, Ana González-Périz, Cristina López-Vicario, Bibiana Rius, Esther Titos. New insights into the role of macrophages in adipose tissue inflammation and Fatty liver disease: modulation by endogenous omega-3 Fatty Acid-derived lipid mediators.
Frontiers in immunology.
2011; 2(?):49. doi:
10.3389/fimmu.2011.00049. [PMID: 22566839] - Gabrielle Fredman, Sungwhan F Oh, Srinivas Ayilavarapu, Hatice Hasturk, Charles N Serhan, Thomas E Van Dyke. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1.
PloS one.
2011; 6(9):e24422. doi:
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PloS one.
2011; 6(8):e23864. doi:
10.1371/journal.pone.0023864. [PMID: 21897859] - Etsuo Niki. Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited.
Journal of clinical biochemistry and nutrition.
2011 Jan; 48(1):3-7. doi:
10.3164/jcbn.11-007fr. [PMID: 21297905] - Rémi Fiancette, Christelle Vincent-Fabert, Estelle Guerin, Franck Trimoreau, Yves Denizot. Lipid mediators and human leukemic blasts.
Journal of oncology.
2011; 2011(?):. doi:
10.1155/2011/389021. [PMID: 20953410] - Barbara Dolegowska, Wojciech Blogowski, Krzysztof Safranow, Leszek Domanski, Katarzyna Jakubowska, Maria Olszewska. Lipoxygenase-derived hydroxyeicosatetraenoic acids--novel perioperative markers of early post-transplant allograft function?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Dec; 25(12):4061-7. doi:
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American journal of respiratory cell and molecular biology.
2010 Dec; 43(6):674-83. doi:
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Diabetes.
2010 Dec; 59(12):3223-8. doi:
10.2337/db10-0844. [PMID: 20826564] - Xiaohong Li, Cui Ma, Daling Zhu, Liwei Meng, Lei Guo, Yali Wang, Lei Zhang, Zhixue Li, Enyou Li. Increased expression and altered subcellular distribution of PKC-δ and PKC-ɛ in pulmonary arteries exposed to hypoxia and 15-HETE.
Prostaglandins & other lipid mediators.
2010 Nov; 93(3-4):84-92. doi:
10.1016/j.prostaglandins.2010.06.008. [PMID: 20615477] - Andrea Comba, Damian M Maestri, María A Berra, Carolina Paola Garcia, Undurti N Das, Aldo R Eynard, María E Pasqualini. Effect of ω-3 and ω-9 fatty acid rich oils on lipoxygenases and cyclooxygenases enzymes and on the growth of a mammary adenocarcinoma model.
Lipids in health and disease.
2010 Oct; 9(?):112. doi:
10.1186/1476-511x-9-112. [PMID: 20932327] - Jenny T Mao, Wen-Xian Nie, I-Hsien Tsu, Yu-Sheng Jin, Jian Yu Rao, Qing-Yi Lu, Zuo-Feng Zhang, Vay Liang W Go, Kenneth J Serio. White tea extract induces apoptosis in non-small cell lung cancer cells: the role of peroxisome proliferator-activated receptor-{gamma} and 15-lipoxygenases.
Cancer prevention research (Philadelphia, Pa.).
2010 Sep; 3(9):1132-40. doi:
10.1158/1940-6207.capr-09-0264. [PMID: 20668019] - Shanshan Li, Yajuan Ran, Xiaodong Zheng, Xiaoping Pang, Zhigang Wang, Rong Zhang, Daling Zhu. 15-HETE mediates sub-acute hypoxia-induced TRPC1 expression and enhanced capacitative calcium entry in rat distal pulmonary arterial myocytes.
Prostaglandins & other lipid mediators.
2010 Sep; 93(1-2):60-74. doi:
10.1016/j.prostaglandins.2010.06.007. [PMID: 20599518] - Nirav G Shah, Mohan E Tulapurkar, Ishwar S Singh, James H Shelhamer, Mark J Cowan, Jeffrey D Hasday. Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.
Prostaglandins & other lipid mediators.
2010 Sep; 93(1-2):1-7. doi:
10.1016/j.prostaglandins.2010.03.006. [PMID: 20382255] - Lei Zhang, Jun Ma, Yaqian Li, Lei Guo, Yajuan Ran, Shulin Liu, Chun Jiang, Daling Zhu. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90.
Life sciences.
2010 Aug; 87(7-8):223-31. doi:
10.1016/j.lfs.2010.06.019. [PMID: 20619278] - Oliver Jung, Felix Jansen, Anja Mieth, Eduardo Barbosa-Sicard, Rainer U Pliquett, Andrea Babelova, Christophe Morisseau, Sung H Hwang, Cindy Tsai, Bruce D Hammock, Liliana Schaefer, Gerd Geisslinger, Kerstin Amann, Ralf P Brandes. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease.
PloS one.
2010 Aug; 5(8):e11979. doi:
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Drug metabolism letters.
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Malaria journal.
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Diabetes.
2010 Jul; 59(7):1780-8. doi:
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Journal of lipid research.
2010 May; 51(5):1049-56. doi:
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Lipids in health and disease.
2010 Apr; 9(?):41. doi:
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Diabetes.
2010 Apr; 59(4):808-18. doi:
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The Journal of biological chemistry.
2010 Mar; 285(10):6891-903. doi:
10.1074/jbc.m109.078428. [PMID: 20061396] - Shuang Wang, Yali Wang, Jing Jiang, Ruifang Wang, Lisa Li, Zhaoping Qiu, Hong Wu, Daling Zhu. 15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway.
Prostaglandins & other lipid mediators.
2010 Feb; 91(1-2):51-60. doi:
10.1016/j.prostaglandins.2009.12.007. [PMID: 20060487] - Monica Ottaviani, Emanuela Camera, Mauro Picardo. Lipid mediators in acne.
Mediators of inflammation.
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Journal of cellular physiology.
2010 Jan; 222(1):82-94. doi:
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Hepatology (Baltimore, Md.).
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Malaria journal.
2009 Aug; 8(?):195. doi:
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The Journal of biological chemistry.
2009 Aug; 284(32):21185-91. doi:
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The Journal of biological chemistry.
2009 Jul; 284(31):21077-89. doi:
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The Journal of biological chemistry.
2009 Jun; 284(25):16799-16807. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2009 Jun; 29(6):837-42. doi:
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Arteriosclerosis, thrombosis, and vascular biology.
2009 Jun; 29(6):809-15. doi:
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Journal of inflammation (London, England).
2009 Jan; 6(?):2. doi:
10.1186/1476-9255-6-2. [PMID: 19133137] - Dong Won Lee, Ihm Soo Kwak, Soo Bong Lee, Sang Heon Song, Eun Young Seong, Hyun Chul Chung, Byeong Yun Yang, Min Young Lee, Mee Young Sol. Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.
Journal of Korean medical science.
2009 Jan; 24 Suppl(?):S183-8. doi:
10.3346/jkms.2009.24.s1.s183. [PMID: 19194550] - Xiaojie Chu, Xiaobo Tang, Lei Guo, Hongxia Bao, Shuang Zhang, Jianing Zhang, Daling Zhu. Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery.
Prostaglandins & other lipid mediators.
2009 Jan; 88(1-2):42-50. doi:
10.1016/j.prostaglandins.2008.09.005. [PMID: 18984061] - Diana Nieves, Juan J Moreno. Enantioselective effect of 12(S)-hydroxyeicosatetraenoic acid on 3T6 fibroblast growth through ERK 1/2 and p38 MAPK pathways and cyclin D1 activation.
Biochemical pharmacology.
2008 Sep; 76(5):654-61. doi:
10.1016/j.bcp.2008.06.013. [PMID: 18640102] - Mauro Prato, Valentina Gallo, Giuliana Giribaldi, Paolo Arese. Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE.
Malaria journal.
2008 Aug; 7(?):157. doi:
10.1186/1475-2875-7-157. [PMID: 18710562] - Yeshao Wen, Jiali Gu, George E Vandenhoff, Xiaoping Liu, Jerry L Nadler. Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages.
American journal of physiology. Heart and circulatory physiology.
2008 Apr; 294(4):H1933-8. doi:
10.1152/ajpheart.00260.2007. [PMID: 18296557] - Rona Limor, Orly Sharon, Esther Knoll, Ariel Many, Gary Weisinger, Naftali Stern. Lipoxygenase-derived metabolites are regulators of peroxisome proliferator-activated receptor gamma-2 expression in human vascular smooth muscle cells.
American journal of hypertension.
2008 Feb; 21(2):219-23. doi:
10.1038/ajh.2007.39. [PMID: 18202670] - Lorraine M Sordillo, Katie L Streicher, Isis K Mullarky, Jeffery C Gandy, Wendy Trigona, Chris M Corl. Selenium inhibits 15-hydroperoxyoctadecadienoic acid-induced intracellular adhesion molecule expression in aortic endothelial cells.
Free radical biology & medicine.
2008 Jan; 44(1):34-43. doi:
10.1016/j.freeradbiomed.2007.09.002. [PMID: 18045545] - Seon Hwa Lee, Kannan Rangiah, Michelle V Williams, Angela Y Wehr, Raymond N DuBois, Ian A Blair. Cyclooxygenase-2-mediated metabolism of arachidonic acid to 15-oxo-eicosatetraenoic acid by rat intestinal epithelial cells.
Chemical research in toxicology.
2007 Nov; 20(11):1665-75. doi:
10.1021/tx700130p. [PMID: 17910482] - Maria Cristina Belfiore, Alessandro Natoni, Roberta Barzellotti, Nicolo' Merendino, Gloria Pessina, Lina Ghibelli, Giampiero Gualandi. Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells.
Cancer letters.
2007 Sep; 254(2):236-43. doi:
10.1016/j.canlet.2007.03.010. [PMID: 17467166] - Hui-Chun Yeh, Ah-Lim Tsai, Lee-Ho Wang. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.
Archives of biochemistry and biophysics.
2007 May; 461(2):159-68. doi:
10.1016/j.abb.2007.03.012. [PMID: 17459323] - George B Lenon, Charlie C L Xue, David F Story, Frank C K Thien, Sarah McPhee, Chun G Li. Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis.
Chinese medicine.
2007 Feb; 2(?):2. doi:
10.1186/1749-8546-2-2. [PMID: 17302969] - Dean G Tang, Bobby Bhatia, Shaohua Tang, Robin Schneider-Broussard. 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
Prostaglandins & other lipid mediators.
2007 Jan; 82(1-4):135-46. doi:
10.1016/j.prostaglandins.2006.05.022. [PMID: 17164141] - Jane Elizabeth Ward, Xiahui Tan. Peroxisome proliferator activated receptor ligands as regulators of airway inflammation and remodelling in chronic lung disease.
PPAR research.
2007; 2007(?):14983. doi:
10.1155/2007/14983. [PMID: 18000530] - Jacek Dobryniewski, Sławomir Dariusz Szajda, Napoleon Waszkiewicz, Krzysztof Zwierz. [Biology of essential fatty acids (EFA)].
Przeglad lekarski.
2007; 64(2):91-9. doi:
NULL. [PMID: 17892040] - Erik Andersson, Frida Schain, Märta Svedling, Hans-Erik Claesson, Pontus K A Forsell. Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.
Biochimica et biophysica acta.
2006 Dec; 1761(12):1498-505. doi:
10.1016/j.bbalip.2006.09.007. [PMID: 17052953] - B Dołegowska, E Pikuła, K Safranow, M Olszewska, K Jakubowska, D Chlubek, P Gutowski. Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil.
Prostaglandins, leukotrienes, and essential fatty acids.
2006 Dec; 75(6):403-11. doi:
10.1016/j.plefa.2006.07.016. [PMID: 17011760] - P Manini, S Briganti, C Fabbri, M Picardo, A Napolitano, M d'Ischia. Free radical oxidation of 15-(S)-hydroxyeicosatetraenoic acid with the Fenton reagent: characterization of an epoxy-alcohol and cytotoxic 4-hydroxy-2E-nonenal from the heptatrienyl radical pathway.
Chemistry and physics of lipids.
2006 Jul; 142(1-2):14-22. doi:
10.1016/j.chemphyslip.2006.02.015. [PMID: 16581048] - M Peters-Golden, M M Gleason, A Togias. Cysteinyl leukotrienes: multi-functional mediators in allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2006 Jun; 36(6):689-703. doi:
10.1111/j.1365-2222.2006.02498.x. [PMID: 16776669] - Otylia Kowal-Bielecka, Krzysztof Kowal, Oliver Distler, Joanna Rojewska, Anna Bodzenta-Lukaszyk, Beat A Michel, Renate E Gay, Steffen Gay, Stanislaw Sierakowski. Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators.
Arthritis and rheumatism.
2005 Dec; 52(12):3783-91. doi:
10.1002/art.21432. [PMID: 16320329] - Joo-Heon Yoon, Seung Joon Baek. Molecular targets of dietary polyphenols with anti-inflammatory properties.
Yonsei medical journal.
2005 Oct; 46(5):585-96. doi:
10.3349/ymj.2005.46.5.585. [PMID: 16259055] - Yuemang Yao, Christopher M Clark, John Q Trojanowski, Virginia M-Y Lee, Domenico Praticò. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.
Annals of neurology.
2005 Oct; 58(4):623-6. doi:
10.1002/ana.20558. [PMID: 16037976] - Joanna M Little, Mika Kurkela, Julia Sonka, Sirkku Jäntti, Raimo Ketola, Stacie Bratton, Moshe Finel, Anna Radominska-Pandya. Glucuronidation of oxidized fatty acids and prostaglandins B1 and E2 by human hepatic and recombinant UDP-glucuronosyltransferases.
Journal of lipid research.
2004 Sep; 45(9):1694-703. doi:
10.1194/jlr.m400103-jlr200. [PMID: 15231852] - Frédéric Coutant, Sophie Agaugué, Laure Perrin-Cocon, Patrice André, Vincent Lotteau. Sensing environmental lipids by dendritic cell modulates its function.
Journal of immunology (Baltimore, Md. : 1950).
2004 Jan; 172(1):54-60. doi:
10.4049/jimmunol.172.1.54. [PMID: 14688309] - Charles N Serhan, Ashish Jain, Sylvie Marleau, Clary Clish, Alpdogan Kantarci, Balsam Behbehani, Sean P Colgan, Gregory L Stahl, Aksam Merched, Nicos A Petasis, Lawrence Chan, Thomas E Van Dyke. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.
Journal of immunology (Baltimore, Md. : 1950).
2003 Dec; 171(12):6856-65. doi:
10.4049/jimmunol.171.12.6856. [PMID: 14662892] - George G Chen, Hu Xu, Janet F Y Lee, Malayannan Subramaniam, Ka L Leung, Su H Wang, Ursula P F Chan, Thomas C Spelsberg. 15-hydroxy-eicosatetraenoic acid arrests growth of colorectal cancer cells via a peroxisome proliferator-activated receptor gamma-dependent pathway.
International journal of cancer.
2003 Dec; 107(5):837-43. doi:
10.1002/ijc.11447. [PMID: 14566836] - David Turgeon, Sarah Chouinard, Patrick Belanger, Serge Picard, Jean-Francois Labbe, Pierre Borgeat, Alain Belanger. Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases.
Journal of lipid research.
2003 Jun; 44(6):1182-91. doi:
10.1194/jlr.m300010-jlr200. [PMID: 12639971] - Pattabhiraman Shankaranarayanan, Santosh Nigam. IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor.
Journal of immunology (Baltimore, Md. : 1950).
2003 Jan; 170(2):887-94. doi:
10.4049/jimmunol.170.2.887. [PMID: 12517954] - Evelin Schwarzer, Hartmut Kuhn, Elena Valente, Paolo Arese. Malaria-parasitized erythrocytes and hemozoin nonenzymatically generate large amounts of hydroxy fatty acids that inhibit monocyte functions.
Blood.
2003 Jan; 101(2):722-8. doi:
10.1182/blood-2002-03-0979. [PMID: 12393662] - Linda C Hsi, Leigh C Wilson, Thomas E Eling. Opposing effects of 15-lipoxygenase-1 and -2 metabolites on MAPK signaling in prostate. Alteration in peroxisome proliferator-activated receptor gamma.
The Journal of biological chemistry.
2002 Oct; 277(43):40549-56. doi:
10.1074/jbc.m203522200. [PMID: 12189136] - Xiao Han, Songyuan Chen, Yujie Sun, Jerry L Nadler, David Bleich. Induction of cyclooxygenase-2 gene in pancreatic beta-cells by 12-lipoxygenase pathway product 12-hydroxyeicosatetraenoic acid.
Molecular endocrinology (Baltimore, Md.).
2002 Sep; 16(9):2145-54. doi:
10.1210/me.2001-0300. [PMID: 12198250] - I A Kudryavtsev, O D Golenko, M V Gudkova, N V Myasishcheva. Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells.
Biochemistry. Biokhimiia.
2002 Sep; 67(9):1021-6. doi:
10.1023/a:1020526119866. [PMID: 12387716] - Carola Buccellati, Francesca Fumagalli, Serena Viappiani, Giancarlo Folco. Leukotriene modifiers: novel therapeutic opportunities in asthma.
Farmaco (Societa chimica italiana : 1989).
2002 Mar; 57(3):235-42. doi:
10.1016/s0014-827x(02)01209-0. [PMID: 11989802] - Peter Jeffery, Jie Zhu. Mucin-producing elements and inflammatory cells.
Novartis Foundation symposium.
2002; 248(?):51-68; discussion 68. doi:
. [PMID: 12568488] - Hiroaki Taniguchi, Yoshihisa Uenoyama, Yoko Miyamoto, Kiyoshi Okuda. The lipoxygenase pathways are involved in LH-stimulated progesterone production in bovine corpus luteum.
Prostaglandins & other lipid mediators.
2002 Jan; 67(1):49-60. doi:
10.1016/s0090-6980(01)00174-5. [PMID: 11789897] - T Schewe, C Sadik, L O Klotz, T Yoshimoto, H Kühn, H Sies. Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase.
Biological chemistry.
2001 Dec; 382(12):1687-96. doi:
10.1515/bc.2001.204. [PMID: 11843182] - T D Foley. The cyclooxygenase hydroperoxide product PGG(2) activates synaptic nitric oxide synthase: a possible antioxidant response to membrane lipid peroxidation.
Biochemical and biophysical research communications.
2001 Aug; 286(2):235-8. doi:
10.1006/bbrc.2001.5378. [PMID: 11500026] - B A Ek-Von Mentzer, F Zhang, J A Hamilton. Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation.
The Journal of biological chemistry.
2001 May; 276(19):15575-80. doi:
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