3,5-Dihydroxyphenylglycine (BioDeep_00000172067)

   

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-amino-2-(3,5-dihydroxyphenyl)acetic acid

化学式: C8H9NO4 (183.0531554)
中文名称: 人体重组型神经营养蛋白-4
谱图信息: 最多检出来源 Homo sapiens(blood) 9.45%

分子结构信息

SMILES: C1=C(C=C(C=C1O)O)C(C(=O)O)N
InChI: InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
DHPG ((RS)-3,5-DHPG) is an amino acid, which acts as a selective and potent agonist of group I mGluR (mGluR 1 and mGluR 5), shows no effect on Group II or Group III mGluRs[1]. DHPG ((RS)-3,5-DHPG) is also an effective antagonist of mGluRs linked to phospholipase D[2].

同义名列表

7 个代谢物同义名

2-amino-2-(3,5-dihydroxyphenyl)acetic acid; 2-Amino-2-(3,5-dihydroxyphenyl)acetate; 3,5-Dihydroxyphenylglycine; Dihydroxyphenylglycine; (RS)-3,5-DHPG; DHPG; 3,5-Dihydroxy-phenylglycine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Andrea Ferrigno, Clarissa Berardo, Laura Giuseppina Di Pasqua, Marta Cagna, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti. The selective blockade of metabotropic glutamate receptor-5 attenuates fat accumulation in an in vitro model of benign steatosis. European journal of histochemistry : EJH. 2020 Nov; 64(4):. doi: 10.4081/ejh.2020.3175. [PMID: 33207858]
  • Jason S Yang, Steven Symington, John M Clark, Yeonhwa Park. Permethrin, a pyrethroid insecticide, regulates ERK1/2 activation through membrane depolarization-mediated pathway in HepG2 hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Nov; 121(?):387-395. doi: 10.1016/j.fct.2018.09.009. [PMID: 30205134]
  • Nik Nasihah Nik Ramli, Nursyazwani Omar, Andrean Husin, Zalina Ismail, Rosfaiizah Siran. Preconditioning effect of (S)-3,5-dihydroxyphenylglycine on ischemic injury in middle cerebral artery occluded Sprague-Dawley rats. Neuroscience letters. 2015 Feb; 588(?):137-41. doi: 10.1016/j.neulet.2014.12.062. [PMID: 25562631]
  • Leyi Gu, Xinyue Liang, Lihua Wang, Yucheng Yan, Zhaohui Ni, Huili Dai, Jiayuan Gao, Shan Mou, Qin Wang, Xinyu Chen, Liming Wang, Jiaqi Qian. Functional metabotropic glutamate receptors 1 and 5 are expressed in murine podocytes. Kidney international. 2012 Mar; 81(5):458-68. doi: 10.1038/ki.2011.406. [PMID: 22166849]
  • Valentina De Chiara, Francesco Angelucci, Silvia Rossi, Alessandra Musella, Francesca Cavasinni, Cristina Cantarella, Giorgia Mataluni, Lucia Sacchetti, Francesco Napolitano, Maura Castelli, Carlo Caltagirone, Giorgio Bernardi, Mauro Maccarrone, Alessandro Usiello, Diego Centonze. Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Jun; 30(24):8127-37. doi: 10.1523/jneurosci.1683-10.2010. [PMID: 20554863]
  • Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P Huynh, Stefan M Pulst, Ilya Bezprozvanny. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Jul; 29(29):9148-62. doi: 10.1523/jneurosci.0660-09.2009. [PMID: 19625506]
  • Gentaroh Suzuki, Hiroko Kawagoe-Takaki, Takao Inoue, Toshifumi Kimura, Hirohiko Hikichi, Takashi Murai, Akio Satow, Mikiko Hata, Shunsuke Maehara, Satoru Ito, Hiroshi Kawamoto, Satoshi Ozaki, Hisashi Ohta. Correlation of receptor occupancy of metabotropic glutamate receptor subtype 1 (mGluR1) in mouse brain with in vivo activity of allosteric mGluR1 antagonists. Journal of pharmacological sciences. 2009 Jul; 110(3):315-25. doi: 10.1254/jphs.09011fp. [PMID: 19542684]
  • Allison P Berg, Neil Sen, Douglas A Bayliss. TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Aug; 27(33):8845-56. doi: 10.1523/jneurosci.0551-07.2007. [PMID: 17699666]
  • Antje Lindecke, Martin Korte, Marta Zagrebelsky, Volker Horejschi, Margitta Elvers, Darius Widera, Maria Prüllage, Julia Pfeiffer, Barbara Kaltschmidt, Christian Kaltschmidt. Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1. The European journal of neuroscience. 2006 Jul; 24(2):555-63. doi: 10.1111/j.1460-9568.2006.04909.x. [PMID: 16903857]
  • Eleonora Aronica, Jan A Gorter, Annemieke J Rozemuller, Bulent Yankaya, Dirk Troost. Interleukin-1 beta down-regulates the expression of metabotropic glutamate receptor 5 in cultured human astrocytes. Journal of neuroimmunology. 2005 Mar; 160(1-2):188-94. doi: 10.1016/j.jneuroim.2004.11.015. [PMID: 15710472]
  • Valerie J Collett, Graham L Collingridge. Interactions between NMDA receptors and mGlu5 receptors expressed in HEK293 cells. British journal of pharmacology. 2004 Jul; 142(6):991-1001. doi: 10.1038/sj.bjp.0705861. [PMID: 15210575]
  • Meir Aridor, Amy K Guzik, Anna Bielli, Kenneth N Fish. Endoplasmic reticulum export site formation and function in dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Apr; 24(15):3770-6. doi: 10.1523/jneurosci.4775-03.2004. [PMID: 15084657]
  • Sang Jeong Kim, Yu Shin Kim, Joseph P Yuan, Ronald S Petralia, Paul F Worley, David J Linden. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature. 2003 Nov; 426(6964):285-91. doi: 10.1038/nature02162. [PMID: 14614461]
  • Hui Zhang, David Sulzer. Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Nov; 23(33):10585-92. doi: 10.1523/jneurosci.23-33-10585.2003. [PMID: 14627643]
  • Itsunari Minami, Mineko Kengaku, Peter Sillevis Smitt, Ryuichi Shigemoto, Tomoo Hirano. Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons. The European journal of neuroscience. 2003 Mar; 17(5):1023-32. doi: 10.1046/j.1460-9568.2003.02499.x. [PMID: 12653978]
  • Valerie Heidinger, Pat Manzerra, Xue Qing Wang, Uta Strasser, Shan-Ping Yu, Dennis W Choi, M Margarita Behrens. Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Jul; 22(13):5452-61. doi: 20026565. [PMID: 12097497]
  • V Pfeifer, G J Nicholson, J Ries, J Recktenwald, A B Schefer, R M Shawky, J Schröder, W Wohlleben, S Pelzer. A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. The Journal of biological chemistry. 2001 Oct; 276(42):38370-7. doi: 10.1074/jbc.m106580200. [PMID: 11495926]
  • M P Johnson, G Kelly, M Chamberlain. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. Journal of neuroendocrinology. 2001 Aug; 13(8):670-7. doi: 10.1046/j.1365-2826.2001.00678.x. [PMID: 11489083]
  • M J Croucher, L S Thomas, H Ahmadi, V Lawrence, J R Harris. Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system. British journal of pharmacology. 2001 Jul; 133(6):815-24. doi: 10.1038/sj.bjp.0704138. [PMID: 11454654]
  • G Page, M Peeters, M Najimi, J M Maloteaux, E Hermans. Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. Journal of neurochemistry. 2001 Mar; 76(5):1282-90. doi: 10.1046/j.1471-4159.2001.00179.x. [PMID: 11238713]
  • R Balázs, S Miller, Y Chun, J O'Toole, C W Cotman. Metabotropic glutamate receptor agonists potentiate cyclic AMP formation induced by forskolin or beta-adrenergic receptor activation in cerebral cortical astrocytes in culture. Journal of neurochemistry. 1998 Jun; 70(6):2446-58. doi: 10.1046/j.1471-4159.1998.70062446.x. [PMID: 9603209]
  • R Ciccarelli, F X Sureda, G Casabona, P Di Iorio, A Caruso, F Spinella, D F Condorelli, F Nicoletti, F Caciagli. Opposite influence of the metabotropic glutamate receptor subtypes mGlu3 and -5 on astrocyte proliferation in culture. Glia. 1997 Dec; 21(4):390-8. doi: 10.1002/(sici)1098-1136(199712)21:4<390::aid-glia6>3.0.co;2-7. [PMID: 9419014]
  • M R Young, S M Fleetwood-Walker, T Dickinson, G Blackburn-Munro, H Sparrow, P J Birch, C Bountra. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord. Brain research. 1997 Nov; 777(1-2):161-9. doi: . [PMID: 9449425]
  • E M Blanc, J F Kelly, R J Mark, G Waeg, M P Mattson. 4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors: possible action on G alpha(q/11). Journal of neurochemistry. 1997 Aug; 69(2):570-80. doi: 10.1046/j.1471-4159.1997.69020570.x. [PMID: 9231714]
  • I Berlin, S Said, O Spreux-Varoquaux, R Olivares, J M Launay, A J Puech. Monoamine oxidase A and B activities in heavy smokers. Biological psychiatry. 1995 Dec; 38(11):756-61. doi: 10.1016/0006-3223(95)00084-4. [PMID: 8580230]
  • C Forster, G Naik, P W Armstrong. Noradrenaline biosynthesis and metabolism during development and recovery from pacing-induced heart failure in the dog. Canadian journal of physiology and pharmacology. 1994 Jan; 72(1):45-9. doi: 10.1139/y94-008. [PMID: 8012897]
  • B Rundquist, G Eisenhofer, N A Dakak, M Elam, F Waagstein, P Friberg. Cardiac noradrenergic function one year following cardiac transplantation. Blood pressure. 1993 Dec; 2(4):252-61. doi: 10.3109/08037059309077165. [PMID: 8173693]