Wortmannin (BioDeep_00000001645)
natural product Volatile Flavor Compounds
代谢物信息卡片
11-(acetyloxy)-1S,6bR,7,8,9aS,10,11R,11bR-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione
化学式: C23H24O8 (428.1471104)
中文名称: 渥曼青霉素
谱图信息:
最多检出来源 Mentha canadensis(plant) 93.94%
分子结构信息
SMILES: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
InChI: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D007329 - Insulin Antagonists
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2152 - Phosphatidylinositide 3-Kinase Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
D011838 - Radiation-Sensitizing Agents
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:52289
- KEGG: C15181
- PubChem: 312145
- Metlin: METLIN45282
- DrugBank: DB08059
- ChEMBL: CHEMBL428496
- MeSH: Wortmannin
- CAS: 19545-26-7
- PMhub: MS000000906
- MetaboLights: MTBLC52289
- PubChem: 17396178
- KNApSAcK: C00023672
- PDB-CCD: KWT
- NIKKAJI: J13.549F
- RefMet: Wortmannin
- LOTUS: LTS0256688
- KNApSAcK: 52289
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 4890 - Ascomycota: LTS0256688
- 4751 - Fungi: LTS0256688
- 5506 - Fusarium: LTS0256688
- 5507 - Fusarium oxysporum:
- 5507 - Fusarium oxysporum: LTS0256688
- 110618 - Nectriaceae: LTS0256688
- 147550 - Sordariomycetes: LTS0256688
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Journal of plant physiology.
2023 Dec; 291(?):154137. doi:
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Frontiers in bioscience (Landmark edition).
2023 Nov; 28(11):282. doi:
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PloS one.
2023; 18(2):e0281668. doi:
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Nanoscale.
2022 Sep; 14(36):13098-13112. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Aug; 103(?):154204. doi:
10.1016/j.phymed.2022.154204. [PMID: 35671635] - Larissa Smulders, Rachel Altman, Carolina Briseno, Alireza Saatchi, Leslie Wallace, Maha AlSebaye, Robert V Stahelin, Nikolas Nikolaidis. Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein.
Biomolecules.
2022 06; 12(6):. doi:
10.3390/biom12060856. [PMID: 35740982] - Junli Luo, Dongdong Li, Song Chen, Hong Zhang, Huijun Cai. Sevoflurane Postconditioning Inhibits Pulmonary Apoptosis via PI3K/AKT in Dog Cardiopulmonary Bypass Model.
The heart surgery forum.
2022 May; 25(3):E374-E380. doi:
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Bioorganic & medicinal chemistry.
2021 09; 46(?):116346. doi:
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Aging.
2021 08; 13(16):20246-20257. doi:
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American journal of physiology. Cell physiology.
2021 07; 321(1):C82-C93. doi:
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The protein journal.
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Cell proliferation.
2021 Apr; 54(4):e13005. doi:
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The Plant cell.
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2020 03; 318(3):E371-E380. doi:
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International journal of medical sciences.
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Neuroscience letters.
2020 01; 714(?):134545. doi:
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Frontiers in immunology.
2020; 11(?):621148. doi:
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Chemico-biological interactions.
2019 Sep; 310(?):108688. doi:
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Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2019 Aug; 28(8):1059-1066. doi:
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BMC neuroscience.
2019 07; 20(1):36. doi:
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African health sciences.
2019 Jun; 19(2):2219-2229. doi:
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The Journal of biological chemistry.
2019 04; 294(16):6405-6415. doi:
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The Journal of surgical research.
2019 04; 236(?):311-318. doi:
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Lipids in health and disease.
2019 Mar; 18(1):70. doi:
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Journal of cellular biochemistry.
2019 03; 120(3):3082-3090. doi:
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International journal of pharmaceutics.
2019 Jan; 555(?):165-174. doi:
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The International journal of developmental biology.
2019; 63(6-7):259-270. doi:
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Chemico-biological interactions.
2018 Dec; 296(?):26-33. doi:
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Open biology.
2018 10; 8(10):. doi:
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Pharmacological reports : PR.
2018 Aug; 70(4):789-795. doi:
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Biomaterials.
2018 07; 169(?):1-10. doi:
10.1016/j.biomaterials.2018.03.055. [PMID: 29631163] - Peng Wang, Chang Gao, Wei Wang, Li-Ping Yao, Jing Zhang, Sun-Dong Zhang, Ji Li, Shao-Hong Fang, Yu-Jie Fu. Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells.
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2018 Jun; 116(Pt B):40-50. doi:
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Journal of medicinal food.
2018 May; 21(5):462-468. doi:
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Chemico-biological interactions.
2018 Mar; 284(?):80-89. doi:
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Archives of virology.
2018 Mar; 163(3):623-632. doi:
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2017 11; 493(3):1304-1310. doi:
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2017 Nov; 31(21):2527-2530. doi:
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Molecular medicine reports.
2017 Nov; 16(5):7569-7576. doi:
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Molecules (Basel, Switzerland).
2017 Oct; 22(10):. doi:
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International journal of molecular medicine.
2017 Oct; 40(4):1277-1284. doi:
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Plant signaling & behavior.
2017 09; 12(9):e1362518. doi:
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The Journal of physiology.
2017 07; 595(14):4927-4946. doi:
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Fish physiology and biochemistry.
2017 Jun; 43(3):719-730. doi:
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General and comparative endocrinology.
2017 06; 247(?):34-45. doi:
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Shock (Augusta, Ga.).
2017 03; 47(3):346-351. doi:
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American journal of physiology. Endocrinology and metabolism.
2017 01; 312(1):E27-E36. doi:
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Current cancer drug targets.
2017; 17(8):722-734. doi:
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PloS one.
2017; 12(5):e0177862. doi:
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Journal of experimental botany.
2016 12; 67(22):6459-6472. doi:
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The New phytologist.
2016 08; 211(3):886-98. doi:
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Bulletin of experimental biology and medicine.
2016 Aug; 161(4):495-500. doi:
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Archives of toxicology.
2016 Mar; 90(3):589-601. doi:
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Oxidative medicine and cellular longevity.
2016; 2016(?):3849087. doi:
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Neuroscience letters.
2016 Jan; 610(?):79-85. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(4):1333-42. doi:
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Experimental physiology.
2016 Jan; 101(1):113-23. doi:
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Journal of virology.
2015 Nov; 89(22):11420-37. doi:
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The Journal of nutrition.
2015 Nov; 145(11):2440-7. doi:
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Biochemical and biophysical research communications.
2015 Oct; 466(3):438-43. doi:
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Drug metabolism and pharmacokinetics.
2015 Oct; 30(5):341-6. doi:
10.1016/j.dmpk.2015.06.002. [PMID: 26403086] - Zeynep Özcan, Gizem Gül, Ibrahim Yaman. Ochratoxin A activates opposing c-MET/PI3K/Akt and MAPK/ERK 1-2 pathways in human proximal tubule HK-2 cells.
Archives of toxicology.
2015 Aug; 89(8):1313-27. doi:
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Journal of the American Society of Nephrology : JASN.
2015 Aug; 26(8):1839-54. doi:
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Biochemical and biophysical research communications.
2015 Jul; 463(3):205-10. doi:
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Chemical research in toxicology.
2015 May; 28(5):897-906. doi:
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Molecular psychiatry.
2015 May; 20(5):551-2. doi:
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Shock (Augusta, Ga.).
2015 May; 43(5):470-4. doi:
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The Journal of biological chemistry.
2015 May; 290(18):11526-36. doi:
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Neuroscience letters.
2015 Apr; 593(?):83-9. doi:
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Free radical biology & medicine.
2015 Apr; 81(?):170-82. doi:
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Phytotherapy research : PTR.
2015 Apr; 29(4):607-16. doi:
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BMC cell biology.
2015 Feb; 16(?):5. doi:
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Cellular signalling.
2015 Feb; 27(2):340-52. doi:
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Zhonghua wei zhong bing ji jiu yi xue.
2015 Feb; 27(2):86-91. doi:
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Biochemical and biophysical research communications.
2015 Jan; 456(1):238-44. doi:
10.1016/j.bbrc.2014.11.065. [PMID: 25462567] - Pooja Sharma, Aparna Shukla, Komal Kalani, Vijaya Dubey, Santosh Kumar Srivastava, Suaib Luqman, Feroz Khan. Water Molecules Increases Binding Affinity of Natural PI3Kγ Inhibitors Against Cancer.
Current computer-aided drug design.
2015; 11(4):304-20. doi:
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The American journal of Chinese medicine.
2015; 43(1):71-85. doi:
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International journal of clinical and experimental pathology.
2015; 8(11):13821-33. doi:
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British journal of pharmacology.
2014 Dec; 171(23):5237-51. doi:
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Cancer science.
2014 Nov; 105(11):1472-9. doi:
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Life sciences.
2014 Oct; 114(2):62-9. doi:
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Veterinary journal (London, England : 1997).
2014 Oct; 202(1):188-90. doi:
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International journal of molecular sciences.
2014 Aug; 15(8):13738-54. doi:
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Molecular medicine reports.
2014 Jul; 10(1):536-42. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2014 Jun; 111(22):E2281-90. doi:
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Apoptosis : an international journal on programmed cell death.
2014 Jun; 19(6):946-57. doi:
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Molecular plant.
2014 Jun; 7(6):1026-1040. doi:
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Experimental neurology.
2014 May; 255(?):71-82. doi:
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Clinical science (London, England : 1979).
2014 Apr; 126(8):545-56. doi:
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Plant & cell physiology.
2014 Apr; 55(4):727-36. doi:
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Canadian journal of physiology and pharmacology.
2014 Apr; 92(4):338-49. doi:
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Plant & cell physiology.
2014 Apr; 55(4):715-26. doi:
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The international journal of biochemistry & cell biology.
2014 Apr; 49(?):26-31. doi:
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