Nifedipine (BioDeep_00000001629)

 

Secondary id: BioDeep_00000398974

human metabolite blood metabolite natural product


代谢物信息卡片


3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

化学式: C17H18N2O6 (346.1165)
中文名称: 硝苯地平
谱图信息: 最多检出来源 Homo sapiens(natural_products) 11.65%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

描述信息

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

38 个代谢物同义名

3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester; Adcock ingram brand OF nifedipine; AWD pharma brand OF nifedipine; Monohydrochloride, nifedipine; Nifedipine monohydrochloride; Pfizer brand OF nifedipine; Orion brand OF nifedipine; Bayer brand OF nifedipine; KRKA brand OF nifedipine; Nifedipine pfizer brand; Nifedipine orion brand; Nifedipine bayer brand; Nifedipine krka brand; Nifedipine-gtis; Nifedipine gtis; Procardia XL; Nifedipinum; Afeditab CR; BAY-a-1040; nifedipine; Nifedipres; Nifedipino; BAY a 1040; Fenigidin; Procardia; Cordipine; Korinfar; Coracten; Cordipin; Corinfar; Nifecard; Nifangin; Adapine; Vascard; Nifecor; Adalat; Nifedipine



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, AXIN2, CA1, CACNA1C, CYP2B6, CYP2C19, DHPS, MYLK, PRL
Peripheral membrane protein 1 CYP2B6
Endoplasmic reticulum membrane 2 CYP2B6, CYP2C19
Nucleus 2 AXIN2, PRL
cytosol 5 AXIN2, CA1, DHPS, MYLK, PRKCQ
dendrite 1 CACNA1C
centrosome 1 AXIN2
nucleoplasm 2 ATP2B1, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 6 ACE, ADRB3, AGTR1, AGTR2, ATP2B1, CACNA1C
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 6 ADRB3, AGTR1, AGTR2, ATP2B1, CACNA1C, KCNA3
Synapse 3 ATP2B1, MYLK, TAC1
glutamatergic synapse 2 ATP2B1, KCNA3
Golgi membrane 1 INS
neuronal cell body 1 TAC1
presynaptic membrane 2 ATP2B1, KCNA3
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 14 ACE, ADRB3, AGTR1, AGTR2, ATP2B1, AXIN2, CACNA1C, CYP2C19, GCG, KCNA3, KNG1, MYLK, PRKCQ, REN
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ACE, AGTR1, ATP2B1, CACNA1C, KCNA3, REN
axon 2 KCNA3, TAC1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 ACE, ATP2B1, CA1, KNG1
extracellular space 7 ACE, GCG, INS, KNG1, PRL, REN, TAC1
perinuclear region of cytoplasm 1 KCNA3
intracellular membrane-bounded organelle 3 ATP2B1, CYP2B6, CYP2C19
Microsome membrane 1 CYP2B6
postsynaptic density 1 CACNA1C
Single-pass type I membrane protein 1 ACE
Secreted 5 ACE, GCG, INS, PRL, REN
extracellular region 7 ACE, GCG, INS, KNG1, PRL, REN, TAC1
centriolar satellite 1 PRKCQ
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 1 ACE
actin cytoskeleton 1 MYLK
T-tubule 1 CACNA1C
perikaryon 1 CACNA1C
Z disc 1 CACNA1C
beta-catenin destruction complex 1 AXIN2
apical part of cell 1 REN
postsynaptic membrane 1 KCNA3
Cell membrane, sarcolemma 1 CACNA1C
Cell projection, lamellipodium 1 MYLK
Membrane raft 1 KCNA3
collagen-containing extracellular matrix 1 KNG1
lateral plasma membrane 1 ATP2B1
receptor complex 1 ADRB3
chromatin 1 PRL
cell projection 1 ATP2B1
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
blood microparticle 1 KNG1
sperm midpiece 1 ACE
Basolateral cell membrane 1 ATP2B1
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 2 INS, PRL
monoatomic ion channel complex 1 CACNA1C
Cell projection, dendrite 1 CACNA1C
Presynaptic cell membrane 1 ATP2B1
stress fiber 1 MYLK
basal plasma membrane 1 ACE
Cell membrane, sarcolemma, T-tubule 1 CACNA1C
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 GCG, INS, KNG1
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 CACNA1C
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 CACNA1C
immunological synapse 2 ATP2B1, PRKCQ
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
[Isoform 1]: Cell membrane 1 KCNA3
[Glucagon-like peptide 1]: Secreted 1 GCG
photoreceptor ribbon synapse 1 ATP2B1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
L-type voltage-gated calcium channel complex 1 CACNA1C


文献列表

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