Nifedipine (BioDeep_00000001629)

 

Secondary id: BioDeep_00000398974

human metabolite blood metabolite natural product


代谢物信息卡片


3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

化学式: C17H18N2O6 (346.1164808)
中文名称: 硝苯地平
谱图信息: 最多检出来源 Homo sapiens(blood) 31.75%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

描述信息

Nifedipine has been formulated as both a long- and short-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nifedipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Nifedipine is used to treat hypertension and chronic stable angina.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

37 个代谢物同义名

3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester; Adcock ingram brand OF nifedipine; AWD pharma brand OF nifedipine; Monohydrochloride, nifedipine; Nifedipine monohydrochloride; Pfizer brand OF nifedipine; Orion brand OF nifedipine; Bayer brand OF nifedipine; KRKA brand OF nifedipine; Nifedipine pfizer brand; Nifedipine orion brand; Nifedipine bayer brand; Nifedipine krka brand; Nifedipine-gtis; Nifedipine gtis; Procardia XL; Nifedipinum; Afeditab CR; BAY-a-1040; nifedipine; Nifedipres; Nifedipino; BAY a 1040; Fenigidin; Procardia; Cordipine; Korinfar; Coracten; Cordipin; Corinfar; Nifecard; Nifangin; Adapine; Vascard; Nifecor; Adalat



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mariam S El-Semary, F Belal, Ali A El-Emam, Eman M Rabie Shehab El-Din, Amal A El-Masry. Ginseng root extract-mediated synthesis of monodisperse silver nanoparticles as a fluorescent probe for the spectrofluorometric determination of nilvadipine; Evaluation of remarkable anti-bacterial, anti-fungal and in-vitro cytotoxic activities. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Apr; 311(?):124017. doi: 10.1016/j.saa.2024.124017. [PMID: 38354677]
  • Muhammad Imran Qayyum, Sami Ullah, Umer Rashid, Abdul Sadiq, Mater H Mahnashi, Saif Ullah Khan Khalil, Muhammad Masoom Akhtar. N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism. European journal of pharmacology. 2024 Feb; 964(?):176195. doi: 10.1016/j.ejphar.2023.176195. [PMID: 38142849]
  • Fernanda D'Avila da Silva, Maria Eduarda de Andrade Galiciolli, Ana Carolina Irioda, Cláudia Sirlene Oliveira, Bruna Candia Piccoli, Alessandro de Souza Prestes, Bruna Cogo Borin, Andre Passaglia Schuch, Estael Ochoa-Rodríguez, Yanier Nuñez-Figueredo, João Batista Teixeira da Rocha. Investigation of the cytotoxicity, genotoxicity and antioxidant prospects of JM-20 on human blood cells: A multi-target compound with potential therapeutic applications. Blood cells, molecules & diseases. 2024 Jan; 106(?):102827. doi: 10.1016/j.bcmd.2024.102827. [PMID: 38301450]
  • Altaf Al-Romaiyan, Willias Masocha, Sunday Oyedemi, Sulaiman K Marafie, Guo-Cai Huang, Peter M Jones, Shanta J Persaud. Commiphora myrrha stimulates insulin secretion from β-cells through activation of atypical protein kinase C and mitogen-activated protein kinase. Journal of ethnopharmacology. 2023 Feb; 302(Pt B):115937. doi: 10.1016/j.jep.2022.115937. [PMID: 36410575]
  • Hong-Jaan Wang, Elise Chia-Hui Tan, Tzu-Yi Chiang, Wei-Ching Chen, Chien-Chang Shen, Yune-Fang Ueng. Effect of repeated Shengmai-San administration on nifedipine pharmacokinetics and the risk/benefit under co-treatment. Journal of food and drug analysis. 2022 03; 30(1):111-127. doi: 10.38212/2224-6614.3401. [PMID: 35647719]
  • Yongqiang Zhou, Helv Yan, Ting Li, Mei Xie, Xiuya Li, Chunli Zhao. New use of old medicine: Nifedipine acts on the TRP family and inflammatory proteins in the treatment of chilblain. Burns : journal of the International Society for Burn Injuries. 2022 03; 48(2):372-380. doi: 10.1016/j.burns.2021.05.005. [PMID: 34103198]
  • S R Vaibavi, Manoj Sivasubramaniapandian, Rahul Vaippully, Privita Edwina, Basudev Roy, Saumendra Kumar Bajpai. Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells. Cell biochemistry and biophysics. 2022 Mar; 80(1):171-190. doi: 10.1007/s12013-021-01035-3. [PMID: 34643835]
  • Yanbing Yuan, Ning Chen, Luyao Wang, Xuedian Zhang, Hui Chen, Pei Ma. Rapid detection of illegally added nifedipine in Chinese traditional patent medicine by surface-enhanced Raman spectroscopy. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2022 02; 38(2):359-368. doi: 10.2116/analsci.21p148. [PMID: 35314982]
  • Huu-Nghi Nguyen. Visualization of Food Polyphenols. Journal of nutritional science and vitaminology. 2022; 68(Supplement):S116-S118. doi: 10.3177/jnsv.68.s116. [PMID: 36436989]
  • Sheon Mary, Philipp Boder, Giacomo Rossitto, Lesley Graham, Kayley Scott, Arun Flynn, David Kipgen, Delyth Graham, Christian Delles. Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical science (London, England : 1979). 2021 12; 135(24):2749-2761. doi: 10.1042/cs20211017. [PMID: 34870708]
  • Kuruba Manohar, Rishikesh Kumar Gupta, Parth Gupta, Debasmita Saha, Suman Gare, Rahuldeb Sarkar, Ashish Misra, Lopamudra Giri. FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generation. Free radical biology & medicine. 2021 12; 177(?):189-200. doi: 10.1016/j.freeradbiomed.2021.08.245. [PMID: 34666149]
  • Kohkichi Morimoto, Tadashi Yoshida, Naoki Washida, Kiyotaka Uchiyama, Takashin Nakayama, Hiroshi Itoh, Mototsugu Oya. Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey. Renal failure. 2021 Dec; 43(1):651-657. doi: 10.1080/0886022x.2021.1910045. [PMID: 33820495]
  • Rong Lv, Jianghua Chen, Huamin Wang, Jijun Wang, Hong Cheng, Rong Li, Wei Li, Tao Zhang, Lixin Wei, Qinkai Chen, Jian Huang, Feng Yu, Shizhong Shen, Henglan Wu, Cuihong Liu, Fuyuan Hong, Jie Liu, Xiaoru Zhang, Hua Xiao, Wenbin Song. Effectiveness and Tolerability of Nifedipine GITS in Patients with Chronic Kidney Disease and Uncontrolled Hypertension: A Prospective, Multicenter, Observational Study (ADRENAL). Advances in therapy. 2021 09; 38(9):4771-4785. doi: 10.1007/s12325-021-01850-3. [PMID: 34331258]
  • Wanjie Niu, Size Li, Shasha Jin, Xiying Lin, Mengwan Zhang, Weimin Cai, Zheng Jiao, Xiaoqiang Xiang. Investigating the interaction between nifedipine- and ritonavir-containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysis. British journal of clinical pharmacology. 2021 07; 87(7):2790-2806. doi: 10.1111/bcp.14684. [PMID: 33269470]
  • Tahereh Hemati, Mehdi Abbasnejad, Mahtab Mollashahi, Saeed Esmaeili-Mahani, Ali Shahraki. Activation of L-type calcium channels and attenuation of oxidative stress are involved in the improving effect of methyl jasmonate on learning and memory and its anxiolytic property in rats. Behavioural pharmacology. 2021 06; 32(4):286-294. doi: 10.1097/fbp.0000000000000611. [PMID: 33595951]
  • Tzu-Yi Chiang, Hong-Jaan Wang, Yen-Cih Wang, Elise Chia-Hui Tan, I-Jung Lee, Chul-Ho Yun, Yune-Fang Ueng. Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats. Journal of ethnopharmacology. 2021 May; 271(?):113914. doi: 10.1016/j.jep.2021.113914. [PMID: 33571617]
  • Nikita Agrawal, Rutesh Savalia, Sanghamitra Chatterjee. Nanostructured zinc oxide film amalgamated with functionalized carbon nanotubes for facile electrochemical determination of nifedipine. Colloids and surfaces. B, Biointerfaces. 2021 May; 201(?):111635. doi: 10.1016/j.colsurfb.2021.111635. [PMID: 33647712]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ehsan Aali, Habib Ghaznavi, Mohammad Soleiman Soltanpour, Massoud Mahmoudian, Massoumeh Shafiei. Cardioprotective Effects of Mebudipine in a Rat Model of Doxorubicin-Induced Heart Failure. Iranian journal of medical sciences. 2021 03; 46(2):136-143. doi: 10.30476/ijms.2019.82057.0. [PMID: 33753958]
  • Michael Ikechukwu Oraebosi, Temidayo Olutoyin Olurishe, Sherifat Bola Anafi, Mohammed Bisalla. Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats. Chronobiology international. 2021 03; 38(3):443-450. doi: 10.1080/07420528.2020.1866004. [PMID: 33356611]
  • Xuanshuo Liu, Shuli Man, Chen Luo, Yu Liu, Yan Liu, Changxiao Liu, Wenyuan Gao. Shunaoxin pills improve the antihypertensive effect of nifedipine and alleviate its renal lipotoxicity in spontaneous hypertension rats. Environmental toxicology. 2021 Mar; 36(3):386-395. doi: 10.1002/tox.23044. [PMID: 33098358]
  • Eduardo Tozatto, Jhohann Richard de Lima Benzi, Adriana Rocha, Eduardo Barbosa Coelho, Vera Lucia Lanchote. Nifedipine Does Not Alter the Pharmacokinetics of Venlafaxine Enantiomers in Healthy Subjects Phenotyped for CYP2D6, CYP2C19, and CYP3A. Journal of clinical pharmacology. 2021 03; 61(3):319-327. doi: 10.1002/jcph.1745. [PMID: 32974907]
  • Olga Yu Selyutina, Anna V Mastova, Ekaterina A Shelepova, Nikolay E Polyakov. pH-Sensitive Glycyrrhizin Based Vesicles for Nifedipine Delivery. Molecules (Basel, Switzerland). 2021 Feb; 26(5):. doi: 10.3390/molecules26051270. [PMID: 33652843]
  • Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jan; 43(1):49-55. doi: 10.1080/10641963.2020.1797087. [PMID: 32706597]
  • Sabarni Sarker, Md Rajdoula Rafe. Formulation Development of Nifedipine through Nanotechnology: A Comprehensive Review. Pharmaceutical nanotechnology. 2021; 9(4):262-270. doi: 10.2174/2211738509666210707162155. [PMID: 34238180]
  • Ranjeet P Dash, Vijayabhaskar Veeravalli, Jennifer A Thomas, Clint Rosenfeld, Nirali Mehta, Nuggehally R Srinivas. Whole blood or plasma: what is the ideal matrix for pharmacokinetic-driven drug candidate selection?. Future medicinal chemistry. 2021 01; 13(2):157-171. doi: 10.4155/fmc-2020-0187. [PMID: 33275044]
  • Noemi Esteras, Franziska Kundel, Giuseppe F Amodeo, Evgeny V Pavlov, David Klenerman, Andrey Y Abramov. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. The FEBS journal. 2021 01; 288(1):127-141. doi: 10.1111/febs.15340. [PMID: 32338825]
  • Ying-Chang Tung, Tzyy-Jer Hsu, Chia-Pin Lin, Fu-Chih Hsiao, You-Chia Chu, Wen-Jone Chen, Pao-Hsien Chu. Efficacy and safety outcomes of one generic nifedipine versus ADALAT long-acting nifedipine for hypertension management. Journal of clinical hypertension (Greenwich, Conn.). 2020 12; 22(12):2296-2305. doi: 10.1111/jch.14070. [PMID: 33035392]
  • Linfeng Sun, Xiaoding Lin, Sakorn Pornprasert, Xiaomei Lü, Bing Ran, Yan Lin. L-type calcium channel blockers decrease the iron overload-mediated oxidative stress in renal epithelial cells by reducing iron accumulation. European journal of pharmacology. 2020 Nov; 886(?):173513. doi: 10.1016/j.ejphar.2020.173513. [PMID: 32898550]
  • Qian Xu, Nan Yang, Shuang Feng, Jianfei Guo, Qi-Bing Liu, Ming Hu. Cost-effectiveness analysis of combining traditional Chinese medicine in the treatment of hypertension: compound Apocynum tablets combined with Nifedipine sustained-release tablets vs Nifedipine sustained-release tablets alone. BMC complementary medicine and therapies. 2020 Nov; 20(1):330. doi: 10.1186/s12906-020-03091-3. [PMID: 33153455]
  • Eduarda Santa-Helena, Diego da Costa Cabrera, Marcelo G Montes D'Oca, João Luís Rheingantz Scaini, Matheus William Bandeira de Oliveira, Adriano Velasque Werhli, Karina Dos Santos Machado, Carla Amorim Neves Gonçalves, Luiz Eduardo Maia Nery. Long-chain fatty dihydropyridines: Docking calcium channel studies and antihypertensive activity. Life sciences. 2020 Oct; 259(?):118210. doi: 10.1016/j.lfs.2020.118210. [PMID: 32763289]
  • Noriko Uchiyama, Tomoya Yukawa, Yvonne P Dragan, Matthew P Wagoner, Russell T Naven. New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells. Toxicology letters. 2020 Oct; 331(?):227-234. doi: 10.1016/j.toxlet.2020.06.005. [PMID: 32522578]
  • Ikenna Kingsley Uchendu, Chidozie Elochukwu Agu, Ebuka Bitrus Nnedu, Ikechukwu JohnPaul Chukwu. Combination of aqueous extracts of Curcuma longa (turmeric) and some calcium channel blockers synergistically improves CCl4-induced nephrotoxicity in albino rats. Pakistan journal of pharmaceutical sciences. 2020 Sep; 33(5):2059-2065. doi: . [PMID: 33824114]
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  • Didem Yilmaz-Oral, Alev Onder, Serap Gur, Ángel A Carbonell-Barrachina, Ecem Kaya-Sezginer, Cetin Volkan Oztekin, Murat Zor. The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats. Andrologia. 2020 Jul; 52(6):e13606. doi: 10.1111/and.13606. [PMID: 32352181]
  • Teruki Hamada, Yukiko Watanabe, Koichi Iida, Noriyasu Sano, Nobuyuki Amano. Microminipig: A suitable animal model to estimate oral absorption of sustained-release formulation in humans. International journal of pharmaceutics. 2020 Jun; 584(?):119457. doi: 10.1016/j.ijpharm.2020.119457. [PMID: 32464228]
  • Yen-Chung Lin, Jhih-Cheng Wang, Mai-Szu Wu, Yuh-Feng Lin, Chang-Rong Chen, Chang-Yu Chen, Kuan-Chou Chen, Chiung-Chi Peng. Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study. International journal of molecular sciences. 2020 Jun; 21(12):. doi: 10.3390/ijms21124359. [PMID: 32575412]
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  • Chiung-Chi Peng, Chang-Rong Chen, Chang-Yu Chen, Yen-Chung Lin, Kuan-Chou Chen, Robert Y Peng. Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress. International journal of molecular sciences. 2020 Apr; 21(9):. doi: 10.3390/ijms21093147. [PMID: 32365658]
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