Sotalol (BioDeep_00000001570)

 

Secondary id: BioDeep_00000397915

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide

化学式: C12H20N2O3S (272.1195)
中文名称: 索他洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 9.06%

Reviewed

Last reviewed on 2024-07-19.

Cite this Page

Sotalol. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/sotalol (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001570). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
InChI: InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3

描述信息

Sotalol is only found in individuals that have used or taken this drug. It is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias (PubChem). Sotalol has both beta-adrenoreceptor blocking (Vaughan Williams Class I) and cardiac action potential duration prolongation (Vaughan Williams Class I) antiarrhythmic properties. Sotalol is a racemic mixture of d- and l-sotalol. Both isomers have similar Class I antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity. Sotalol inhibits response to adrenergic stimuli by competitively blocking β1-adrenergic receptors within the myocardium and β2-adrenergic receptors within bronchial and vascular smooth muscle. The electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells. The class II electrophysiologic effects are caused by an increase in sinus cycle length (slowed heart rate), decreased AV nodal conduction, and increased AV nodal refractoriness, while the class III electrophysiological effects include prolongation of the atrial and ventricular monophasic action potentials, and effective refractory period prolongation of atrial muscle, ventricular muscle, and atrio-ventricular accessory pathways (where present) in both the anterograde and retrograde directions.

同义名列表

16 个代谢物同义名

N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide; 4-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulphonanilide; 4-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide; Knoll pharmaceutical brand OF sotalol; Sotalol monohydrochloride; Sotalol hydrochloride; beta-Cardone; Sotalol HCL; Darob mite; Β-cardone; b-Cardone; Sotalolum; sotalol; Darob; Sotalol; Sotalol



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, ACE, AXIN2, FASN, KCNQ1, NR4A1
Endosome membrane 1 ADRB2
Nucleus 4 ADRB2, AXIN2, MPO, NR4A1
cytosol 4 AXIN2, FASN, KCNN4, NR4A1
centrosome 1 AXIN2
nucleoplasm 4 MPO, NR4A1, SCN5A, SCNN1G
Cell membrane 8 ABCB1, ACE, ADRB2, ADRB3, KCNH2, KCNN4, KCNQ1, SCN5A
ruffle membrane 1 KCNN4
Multi-pass membrane protein 10 ABCB1, ADRB2, ADRB3, CACNA1I, KCNA3, KCNH2, KCNN4, KCNQ1, SCN5A, SCNN1G
cell junction 1 SCN5A
cell surface 3 ABCB1, KCNH2, SCN5A
glutamatergic synapse 1 KCNA3
Golgi apparatus 2 ADRB2, FASN
Golgi membrane 1 INS
neuronal cell body 2 KCNN4, KCNQ1
presynaptic membrane 1 KCNA3
sarcolemma 1 SCN5A
Cytoplasm, cytosol 1 NR4A1
Lysosome 4 ACE, ADRB2, KCNQ1, MPO
Presynapse 1 NR4A1
endosome 2 ACE, ADRB2
plasma membrane 16 ABCB1, ACE, ADRB2, ADRB3, AXIN2, CACNA1I, EDNRA, FASN, GCG, KCNA3, KCNH2, KCNN4, KCNQ1, REN, SCN5A, SCNN1G
Membrane 11 ABCB1, ACE, ADRB2, CACNA1I, FASN, KCNA3, KCNH2, KCNN4, KCNQ1, REN, SCN5A
apical plasma membrane 4 ABCB1, ADRB2, KCNQ1, SCNN1G
axon 1 KCNA3
basolateral plasma membrane 1 KCNQ1
caveola 1 SCN5A
extracellular exosome 5 ABCB1, ACE, FASN, MPO, SCNN1G
endoplasmic reticulum 2 KCNQ1, SCN5A
extracellular space 5 ACE, GCG, INS, MPO, REN
perinuclear region of cytoplasm 3 KCNA3, KCNH2, SCN5A
intercalated disc 1 SCN5A
mitochondrion 1 NR4A1
intracellular membrane-bounded organelle 1 MPO
Single-pass type I membrane protein 1 ACE
Secreted 4 ACE, GCG, INS, REN
extracellular region 5 ACE, GCG, INS, MPO, REN
transcription regulator complex 1 NR4A1
nuclear membrane 1 NR4A1
external side of plasma membrane 2 ACE, SCNN1G
T-tubule 1 SCN5A
Z disc 1 SCN5A
beta-catenin destruction complex 1 AXIN2
nucleolus 1 SCN5A
Early endosome 2 ADRB2, KCNQ1
apical part of cell 1 REN
vesicle 1 KCNN4
postsynaptic membrane 1 KCNA3
Apical cell membrane 3 ABCB1, KCNQ1, SCNN1G
Cell projection, ruffle membrane 1 KCNN4
Cytoplasm, perinuclear region 1 SCN5A
Membrane raft 2 KCNA3, KCNQ1
secretory granule 1 MPO
lateral plasma membrane 2 KCNQ1, SCN5A
Late endosome 1 KCNQ1
receptor complex 2 ADRB2, ADRB3
neuron projection 2 KCNN4, KCNQ1
ciliary base 1 KCNQ1
chromatin 1 NR4A1
brush border membrane 1 ACE
sperm midpiece 1 ACE
Basolateral cell membrane 1 KCNQ1
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 1 INS
monoatomic ion channel complex 2 KCNH2, KCNQ1
Cytoplasmic vesicle membrane 1 KCNQ1
sodium channel complex 1 SCNN1G
Melanosome 1 FASN
basal plasma membrane 1 ACE
azurophil granule 1 MPO
Cell membrane, sarcolemma, T-tubule 1 SCN5A
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 4 KCNA3, KCNH2, KCNN4, KCNQ1
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 INS, KCNQ1
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 ADRB2
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 ADRB2
phagocytic vesicle lumen 1 MPO
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 KCNA3
voltage-gated sodium channel complex 1 SCN5A
[Glucagon-like peptide 1]: Secreted 1 GCG
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
lumenal side of membrane 1 KCNQ1
glycogen granule 1 FASN
basolateral part of cell 1 KCNQ1


文献列表

  • Christian Funck-Brentano, Joe-Elie Salem. Influence of baseline QTc on sotalol-induced prolongation of ventricular repolarization in men and women. British journal of clinical pharmacology. 2022 07; 88(7):3510-3515. doi: 10.1111/bcp.15188. [PMID: 34921433]
  • Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity. Journal of hazardous materials. 2022 05; 430(?):128499. doi: 10.1016/j.jhazmat.2022.128499. [PMID: 35739679]
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  • Lei Xu, Weiqi Meng, Jing Lu, Fengjuan Cui, Lidi Gao, Lin Chen, Yang Xin. Hyphenation of field-amplified sample injection and transient isotachophoresis in CE for the determination of sotalol and metoprolol in human urine samples. Journal of separation science. 2020 Jun; 43(11):2193-2200. doi: 10.1002/jssc.201901165. [PMID: 32068343]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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