sotalol (BioDeep_00000397915)
Main id: BioDeep_00000001570
代谢物信息卡片
sotalol
化学式: C12H20N2O3S (272.119457)
中文名称: 索他洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
InChI: InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3
描述信息
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C93038 - Cation Channel Blocker
CONFIDENCE Reference Standard (Level 1)
同义名列表
1 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:63622
- KEGG: C07309
- KEGGdrug: D08525
- PubChem: 5253
- DrugBank: DB00489
- ChEMBL: CHEMBL471
- MeSH: Sotalol
- CAS: 3930-20-9
- MoNA: WA000654
- MoNA: WA000653
- MoNA: WA000652
- MoNA: WA000651
- MoNA: WA000650
- MoNA: WA000649
- MoNA: FiehnHILIC002989
- MoNA: FiehnHILIC002330
- MoNA: FiehnHILIC001516
- MoNA: FiehnHILIC000767
- MoNA: TUE00653
- MoNA: TUE00652
- MoNA: TUE00651
- PubChem: 9517
- NIKKAJI: J10.583J
- RefMet: Sotalol
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christian Funck-Brentano, Joe-Elie Salem. Influence of baseline QTc on sotalol-induced prolongation of ventricular repolarization in men and women.
British journal of clinical pharmacology.
2022 07; 88(7):3510-3515. doi:
10.1111/bcp.15188. [PMID: 34921433] - Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity.
Journal of hazardous materials.
2022 05; 430(?):128499. doi:
10.1016/j.jhazmat.2022.128499. [PMID: 35739679] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Lei Xu, Weiqi Meng, Jing Lu, Fengjuan Cui, Lidi Gao, Lin Chen, Yang Xin. Hyphenation of field-amplified sample injection and transient isotachophoresis in CE for the determination of sotalol and metoprolol in human urine samples.
Journal of separation science.
2020 Jun; 43(11):2193-2200. doi:
10.1002/jssc.201901165. [PMID: 32068343] - Jessica L Jacobson, John C Somberg, Hoang H Nguyen. Intravenous Sotalol for the Treatment of Ventricular Dysrhythmias in an Infant on Extracorporeal Membrane Oxygenation.
Pediatric cardiology.
2020 Feb; 41(2):418-422. doi:
10.1007/s00246-019-02225-w. [PMID: 31664485] - Yunlu Liu, Lin Wang, Feng Wan, Na Yang. Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs.
Drug design, development and therapy.
2020; 14(?):4263-4276. doi:
10.2147/dddt.s268113. [PMID: 33116414] - Elyes Dahmane, Kathy Tang, Jogarao V S Gobburu, T Joseph Mattingly, Brent N Reed, Vincent Y See, Joshuha Ayres, Vijay Ivaturi. Clinical Pharmacology-Driven Translational Research to Optimize Bedside Therapeutics of Sotalol Therapy.
Clinical and translational science.
2019 11; 12(6):648-656. doi:
10.1111/cts.12670. [PMID: 31328888] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
The Journal of toxicological sciences.
2019; 44(7):441-457. doi:
10.2131/jts.44.441. [PMID: 31270301] - Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women.
JAMA cardiology.
2018 09; 3(9):877-882. doi:
10.1001/jamacardio.2018.2251. [PMID: 30073300] - Saeedeh Ansari, Saeed Masoum. A multi-walled carbon nanotube-based magnetic molecularly imprinted polymer as a highly selective sorbent for ultrasonic-assisted dispersive solid-phase microextraction of sotalol in biological fluids.
The Analyst.
2018 Jun; 143(12):2862-2875. doi:
10.1039/c7an02077e. [PMID: 29790490] - B Broux, D De Clercq, A Decloedt, L Vera, M Devreese, R Gehring, S Croubels, G van Loon. Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses.
Equine veterinary journal.
2018 May; 50(3):377-383. doi:
10.1111/evj.12765. [PMID: 29023952] - Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers.
Journal of pharmacological and toxicological methods.
2018 Mar; 90(?):58-66. doi:
10.1016/j.vascn.2017.12.003. [PMID: 29274391] - Mariusz Stolarczyk, Anna Apola, Anna Malanka, Anna Kwiecien, Edyta Wrona, Wlodzimierz Opoka. DETERMINATION OF SOTALOL, OXPRENOLOL AND LABETALOL IN BINARY MIXTURES AND IN SPIKED HUMAN SERUM BY DERIVATIVE SPECTROPHOTOMETRIC METHOD.
Acta poloniae pharmaceutica.
2017 Jan; 74(1):93-102. doi:
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Analytica chimica acta.
2016 Aug; 934(?):80-7. doi:
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Psychopharmacology.
2016 06; 233(11):2099-2108. doi:
10.1007/s00213-016-4254-5. [PMID: 26935825] - Dingxin Qin, George Leef, Mian Bilal Alam, Rohit Rattan, Mohamad Bilal Munir, Divyang Patel, Furqan Khattak, Evan Adelstein, Sandeep K Jain, Samir Saba. Comparative effectiveness of antiarrhythmic drugs for rhythm control of atrial fibrillation.
Journal of cardiology.
2016 May; 67(5):471-6. doi:
10.1016/j.jjcc.2015.07.001. [PMID: 26233885] - Jun Katagi, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Atsushi Honda, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsushi Sugiyama. Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
Cardiovascular toxicology.
2016 Apr; 16(2):138-46. doi:
10.1007/s12012-015-9322-2. [PMID: 25822712] - B Broux, D De Clercq, A Decloedt, S De Baere, M Devreese, N Van Der Vekens, S Ven, S Croubels, G van Loon. Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function.
Veterinary journal (London, England : 1997).
2016 Feb; 208(?):60-4. doi:
10.1016/j.tvjl.2015.09.021. [PMID: 26670333] - Zhiping Feng, Siyuan Yu, Wei Liu, Li Yang, Yang Liu, Suodi Zhai, Fang Wang, Xianhua Zhang. A simple and sensitive LC-MS/MS method for the determination of sotalol in rat plasma.
Biomedical chromatography : BMC.
2015 Aug; 29(8):1167-72. doi:
10.1002/bmc.3403. [PMID: 25582386] - Ryan M Fryer, Khing Jow Ng, Liguo Chi, Xidong Jin, Glenn A Reinhart. Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment.
Journal of pharmacological and toxicological methods.
2015 Jul; 74(?):26-32. doi:
10.1016/j.vascn.2015.04.007. [PMID: 25946685] - M W Rivolta, L T Mainardi, R Sassi. Quantification of ventricular repolarization heterogeneity during moxifloxacin or sotalol administration using [Formula: see text]-index.
Physiological measurement.
2015 Apr; 36(4):803-11. doi:
10.1088/0967-3334/36/4/803. [PMID: 25798997] - Borje Darpo, Dilip R Karnad, Fabio Badilini, Jeff Florian, Christine E Garnett, Snehal Kothari, Gopi Krishna Panicker, Nenad Sarapa. Are women more susceptible than men to drug-induced QT prolongation? Concentration-QTc modelling in a phase 1 study with oral rac-sotalol.
British journal of clinical pharmacology.
2014 Mar; 77(3):522-31. doi:
10.1111/bcp.12201. [PMID: 23819796] - Feras Khalil, Stephanie Läer. Physiologically based pharmacokinetic models in the prediction of oral drug exposure over the entire pediatric age range-sotalol as a model drug.
The AAPS journal.
2014 Mar; 16(2):226-39. doi:
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Connecticut medicine.
2013 Sep; 77(8):491-3. doi:
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2013 Jun; 44(2):500-4. doi:
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PloS one.
2013; 8(4):e60556. doi:
10.1371/journal.pone.0060556. [PMID: 23593245] - Ali A Ensafi, Ali R Allafchian, B Rezaei, R Mohammadzadeh. Characterization of carbon nanotubes decorated with NiFe2O4 magnetic nanoparticles as a novel electrochemical sensor: application for highly selective determination of sotalol using voltammetry.
Materials science & engineering. C, Materials for biological applications.
2013 Jan; 33(1):202-8. doi:
10.1016/j.msec.2012.08.031. [PMID: 25428063] - Uwe Kunkel, Michael Radke. Fate of pharmaceuticals in rivers: Deriving a benchmark dataset at favorable attenuation conditions.
Water research.
2012 Nov; 46(17):5551-5565. doi:
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Talanta.
2012 Aug; 97(?):462-7. doi:
10.1016/j.talanta.2012.04.063. [PMID: 22841109] - Wei Liu, Hideaki Okochi, Leslie Z Benet, Suo-Di Zhai. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system.
Pharmaceutical research.
2012 Jul; 29(7):1768-74. doi:
10.1007/s11095-012-0699-3. [PMID: 22350803] - Sonia Goineau, Christophe Legrand, Guillaume Froget. Whole-cell configuration of the patch-clamp technique in the hERG channel assay to predict the ability of a compound to prolong QT interval.
Current protocols in pharmacology.
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Basic & clinical pharmacology & toxicology.
2012 Mar; 110(3):207-18. doi:
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Thyroid : official journal of the American Thyroid Association.
2012 Mar; 22(3):325-9. doi:
10.1089/thy.2011.0328. [PMID: 22313427] - John C Somberg, Richard A Preston, Vasant Ranade, Ivana Cvetanovic, Janos Molnar. Gender differences in cardiac repolarization following intravenous sotalol administration.
Journal of cardiovascular pharmacology and therapeutics.
2012 Mar; 17(1):86-92. doi:
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PloS one.
2012; 7(4):e35027. doi:
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Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2011 Oct; 106(2):132-6. doi:
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European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2011 Sep; 40(3):722-9. doi:
10.1016/j.ejcts.2010.09.049. [PMID: 21353585] - Vera H M Deneer, Norbert M van Hemel. Is antiarrhythmic treatment in the elderly different? a review of the specific changes.
Drugs & aging.
2011 Aug; 28(8):617-33. doi:
10.2165/11591680-000000000-00000. [PMID: 21812498] - Irena Baranowska, Sylwia Magiera, Jacek Baranowski. UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Mar; 879(9-10):615-26. doi:
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Archives of toxicology.
2011 Feb; 85(2):79-117. doi:
10.1007/s00204-010-0641-6. [PMID: 21225242] - Mohamed A Alabd, Walid El-Hammady, Ahmed Shawky, Wail Nammas, Mohamed El-Tayeb. QT Interval and QT Dispersion in Patients Undergoing Hemodialysis: Revisiting the Old Theory.
Nephron extra.
2011 Jan; 1(1):1-8. doi:
10.1159/000328930. [PMID: 22470374] - Ramón López-Roldán, Miren López de Alda, Meritxell Gros, Mira Petrovic, Jordi Martín-Alonso, Damià Barceló. Advanced monitoring of pharmaceuticals and estrogens in the Llobregat River basin (Spain) by liquid chromatography-triple quadrupole-tandem mass spectrometry in combination with ultra performance liquid chromatography-time of flight-mass spectrometry.
Chemosphere.
2010 Sep; 80(11):1337-44. doi:
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Talanta.
2010 Aug; 82(3):984-92. doi:
10.1016/j.talanta.2010.06.003. [PMID: 20678656] - Peter Reimer, Rolf Vosshenrich. Detection and characterization of liver lesions using gadoxetic acid as a tissue-specific contrast agent.
Biologics : targets & therapy.
2010 Aug; 4(?):199-212. doi:
10.2147/btt.s6479. [PMID: 20714357] - Anna R M Gelzer, Marc S Kraus, Mark Rishniw, Shari A Hemsley, N Sydney Moïse. Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology.
2010 Aug; 12(2):93-106. doi:
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American journal of therapeutics.
2010 Jul; 17(4):365-72. doi:
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Heart international.
2010 Jun; 5(1):e4. doi:
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Talanta.
2010 Jun; 81(4-5):1288-94. doi:
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Chemosphere.
2010 Jun; 80(3):301-9. doi:
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2010 May; 53(9):3566-84. doi:
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Korean circulation journal.
2010 Apr; 40(4):185-90. doi:
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Stem cell research.
2010 Mar; 4(2):107-16. doi:
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Clinical toxicology (Philadelphia, Pa.).
2010 Mar; 48(3):218-21. doi:
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Cardiology.
2010; 116(3):219-25. doi:
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Cardiovascular therapeutics.
2010; 28(1):59-65. doi:
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Clinical pharmacology : advances and applications.
2010; 2(?):89-93. doi:
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Acta cardiologica.
2009 Dec; 64(6):839-42. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
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Journal of electrocardiology.
2009 Nov; 42(6):534-42. doi:
10.1016/j.jelectrocard.2009.07.010. [PMID: 19700171] - Robert W Bolderman, J J Rob Hermans, Leonard M Rademakers, Tim S Jansen, Sander Verheule, Frederik H van der Veen, Jos G Maessen. Intrapericardial delivery of amiodarone and sotalol: atrial transmural drug distribution and electrophysiological effects.
Journal of cardiovascular pharmacology.
2009 Oct; 54(4):355-63. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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Journal of pharmaceutical sciences.
2009 Jul; 98(7):2529-39. doi:
10.1002/jps.21618. [PMID: 19067419] - Irena Baranowska, Andrzej Wilczek. Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2009 Jun; 25(6):769-72. doi:
10.2116/analsci.25.769. [PMID: 19531885] - Eftychia N Koini, Panagiota Papazafiri, Athanasios Vassilopoulos, Maria Koufaki, Zoltán Horváth, István Koncz, László Virág, Gy J Papp, Andràs Varró, Theodora Calogeropoulou. 5,7,8-Trimethyl-benzopyran and 5,7,8-trimethyl-1,4-benzoxazine aminoamide derivatives as novel antiarrhythmics against ischemia-reperfusion injury.
Journal of medicinal chemistry.
2009 Apr; 52(8):2328-40. doi:
10.1021/jm801228h. [PMID: 19309156] - A Srivastava, M Ahmed Khan, J Watkiss. Post induction arrhythmia in a renal patient: an unexpected risk factor.
Anaesthesia.
2009 Apr; 64(4):439-43. doi:
10.1111/j.1365-2044.2008.05783.x. [PMID: 19317712] - Tomomichi Ishizaka, Yu Yoshimatsu, Minori Ozawa, Tomofumi Kimotsuki, Wataru Takasaki, Sunao Manabe, Mitsuya Yasuda. Evaluation of drug-induced QT prolongation in a halothane-anesthetized monkey model: effects of sotalol.
Journal of pharmacological and toxicological methods.
2009 Mar; 59(2):86-93. doi:
10.1016/j.vascn.2009.01.002. [PMID: 19367688] - M A Alam, M A Awal, N Subhan, M Mostofa. In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.
Journal of health, population, and nutrition.
2009 Feb; 27(1):20-30. doi:
10.3329/jhpn.v27i1.3315. [PMID: 19248645] - N A Mazur, F M Khezheva. [Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension].
Kardiologiia.
2009; 49(2):27-31. doi:
NULL. [PMID: 19254213] - Claus Graff, Mads P Andersen, Joel Q Xue, Thomas B Hardahl, Jørgen K Kanters, Egon Toft, Michael Christiansen, Henrik K Jensen, Johannes J Struijk. Identifying drug-induced repolarization abnormalities from distinct ECG patterns in congenital long QT syndrome: a study of sotalol effects on T-wave morphology.
Drug safety.
2009; 32(7):599-611. doi:
10.2165/00002018-200932070-00006. [PMID: 19530746] - N Walraven, R W P M Laane. Assessing the discharge of pharmaceuticals along the Dutch coast of the North Sea.
Reviews of environmental contamination and toxicology.
2009; 199(?):1-18. doi:
10.1007/978-0-387-09808-1_1. [PMID: 19110938] - Jeremy L Conkle, John R White, Chris D Metcalfe. Reduction of pharmaceutically active compounds by a lagoon wetland wastewater treatment system in Southeast Louisiana.
Chemosphere.
2008 Dec; 73(11):1741-8. doi:
10.1016/j.chemosphere.2008.09.020. [PMID: 18977010] - Jens Mortensen, Uffe Holst, Jørn Skibsted Jakobsen, Frederik Andreasen. Endoluminal norepinephrine inhibits smooth muscle activity of the pig pyeloureter by stimulation of beta-adrenoceptors without side effects.
Basic & clinical pharmacology & toxicology.
2008 Nov; 103(5):455-60. doi:
10.1111/j.1742-7843.2008.00297.x. [PMID: 18713234] - Courtney J Collins, Alfonso Berduque, Damien W M Arrigan. Electrochemically modulated liquid-liquid extraction of ionized drugs under physiological conditions.
Analytical chemistry.
2008 Nov; 80(21):8102-8. doi:
10.1021/ac800646b. [PMID: 18841995] - Fabio Badilini, Martino Vaglio, Rémi Dubois, Pierre Roussel, Nenad Sarapa, Isabelle Denjoy, Fabrice Extramiana, Pierre Maison-Blanche. Automatic analysis of cardiac repolarization morphology using Gaussian mesa function modeling.
Journal of electrocardiology.
2008 Nov; 41(6):588-94. doi:
10.1016/j.jelectrocard.2008.07.020. [PMID: 18954609] - Jean-Philippe Couderc, Meijian Zhou, Nenad Sarapa, Wojciech Zareba. Investigating the effect of sotalol on the repolarization intervals in healthy young individuals.
Journal of electrocardiology.
2008 Nov; 41(6):595-602. doi:
10.1016/j.jelectrocard.2008.06.013. [PMID: 18801493] - Lu Huang, Jin-Ming Lin, Lishuang Yu, Liangjun Xu, Guonan Chen. Field-amplified on-line sample stacking for simultaneous enantioseparation and determination of some beta-blockers using capillary electrophoresis.
Electrophoresis.
2008 Sep; 29(17):3588-94. doi:
10.1002/elps.200700811. [PMID: 18803220] - J J Lynch, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox, S W Mittelstadt. Dose-response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys.
British journal of pharmacology.
2008 Aug; 154(7):1439-45. doi:
10.1038/bjp.2008.206. [PMID: 18516073] - Khalil Kanjwal, Naser Imran, Blair Grubb, Yousuf Kanjwal. Troponin elevation in patients with various tachycardias and normal epicardial coronaries.
Indian pacing and electrophysiology journal.
2008 Aug; 8(3):172-4. doi:
NULL. [PMID: 18679521] - Mitsuyasu Tabo, Toshiko Hara, Sachiko Sone, Nobuyuki Shishido, Shino Kuramoto, Kounosuke Nakano, Hideko Onodera, Kazuya Kimura, Kazuko Kobayashi. Prediction of drug-induced QT interval prolongation in telemetered common marmosets.
The Journal of toxicological sciences.
2008 Aug; 33(3):315-25. doi:
10.2131/jts.33.315. [PMID: 18670163] - Liangmin Shangguan, Wei Liu, Xiangyang Zheng, Lan Zhang. [Screening, quantification and confirmation of beta-blockers in urine using gas chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2008 Jul; 26(4):460-4. doi:
NULL. [PMID: 18959242] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Gui-Rong Li, Hong-Bing Wang, Guo-Wei Qin, Man-Wen Jin, Qiang Tang, Hai-Ying Sun, Xin-Ling Du, Xiu-Ling Deng, Xiao-Hua Zhang, Jing-Bo Chen, Lei Chen, Xiao-Hui Xu, Lik-Cheung Cheng, Shui-Wah Chiu, Hung-Fat Tse, Paul M Vanhoutte, Chu-Pak Lau. Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs.
Circulation.
2008 May; 117(19):2449-57. doi:
10.1161/circulationaha.108.769554. [PMID: 18458165] - Augustin Curticapean, Daniela Muntean, Manuela Curticapean, Maria Dogaru, Camil Vari. Optimized HPLC method for tramadol and O-desmethyl tramadol determination in human plasma.
Journal of biochemical and biophysical methods.
2008 Apr; 70(6):1304-12. doi:
10.1016/j.jprot.2008.01.012. [PMID: 18396334] - Mieko Yorimitsu, Shoshiro Okada, Naoko Yamaguchi-Shima, Takahiro Shimizu, Junichi Arai, Kunihiko Yokotani. Role of brain adrenoceptors in the corticortopin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats.
Life sciences.
2008 Feb; 82(9-10):487-94. doi:
10.1016/j.lfs.2007.12.006. [PMID: 18201726] - Takahiro Ueno, Hironori Tsuchiya, Maki Mizogami, Ko Takakura. Local anesthetic failure associated with inflammation: verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite.
Journal of inflammation research.
2008; 1(?):41-8. doi:
10.2147/jir.s3982. [PMID: 22096346] - M Stockburger, L Gerhardt, S Helms, M Schlegl, C Butter. Bifocal versus unifocal right atrial pacing under plasma level controlled sotalol to prevent atrial fibrillation in patients with symptomatic sinus bradycardia and paroxysmal atrial fibrillation.
Herzschrittmachertherapie & Elektrophysiologie.
2007 Dec; 18(4):250-8. doi:
10.1007/s00399-007-0582-9. [PMID: 18084799] - Anthony A Fossa, Todd Wisialowski, Kimberly Crimin, Eric Wolfgang, Jean-Philippe Couderc, Martin Hinterseer, Stefan Kaab, Wojciech Zareba, Fabio Badilini, Nenad Sarapa. Analyses of dynamic beat-to-beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of torsades de pointes during QT prolongation caused by sotalol.
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.
2007 Oct; 12(4):338-48. doi:
10.1111/j.1542-474x.2007.00183.x. [PMID: 17970959] - Herbert M Himmel. Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential.
Journal of pharmacological and toxicological methods.
2007 Sep; 56(2):145-58. doi:
10.1016/j.vascn.2007.04.004. [PMID: 17590357] - Meritxell Gros, Mira Petrović, Damià Barceló. Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the ebro river basin (northeast Spain).
Environmental toxicology and chemistry.
2007 Aug; 26(8):1553-62. doi:
10.1897/06-495r.1. [PMID: 17702326] - Niina M Vieno, Heli Härkki, Tuula Tuhkanen, Leif Kronberg. Occurrence of pharmaceuticals in river water and their elimination in a pilot-scale drinking water treatment plant.
Environmental science & technology.
2007 Jul; 41(14):5077-84. doi:
10.1021/es062720x. [PMID: 17711226] - James T Limberis, Jeff S McDermott, Heinz J Salmen, Zhi Su, Ann Mikhail, Jonathon R Green, Bryan F Cox, Gary A Gintant, Ruth L Martin. The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.
Journal of pharmacological and toxicological methods.
2007 Jul; 56(1):11-7. doi:
10.1016/j.vascn.2007.01.001. [PMID: 17350293] - N Vieno, T Tuhkanen, L Kronberg. Elimination of pharmaceuticals in sewage treatment plants in Finland.
Water research.
2007 Mar; 41(5):1001-12. doi:
10.1016/j.watres.2006.12.017. [PMID: 17261324] - Shuijun Li, Gangyi Liu, Jingying Jia, Yun Liu, Cheng Pan, Chen Yu, Yongbao Cai, Jianying Ren. Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Mar; 847(2):174-81. doi:
10.1016/j.jchromb.2006.10.013. [PMID: 17113839] - Jelena Radjenovic, Mira Petrovic, Damiá Barceló. Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor.
Analytical and bioanalytical chemistry.
2007 Feb; 387(4):1365-77. doi:
10.1007/s00216-006-0883-6. [PMID: 17115140] - John David Clements, Fakhreddin Jamali. Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol.
Vascular pharmacology.
2007 Jan; 46(1):52-9. doi:
10.1016/j.vph.2006.06.009. [PMID: 16949884]