Ritonavir (BioDeep_00000001513)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate

化学式: C37H48N6O5S2 (720.3127438)
中文名称: 利托那韦
谱图信息: 最多检出来源 Homo sapiens(blood) 15.19%

分子结构信息

SMILES: CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChI: InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

描述信息

Ritonavir is only found in individuals that have used or taken this drug. It is an HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [PubChem]Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AE - Protease inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065692 - Cytochrome P-450 CYP3A Inhibitors
COVID info from Guide to PHARMACOLOGY, DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D000084762 - Viral Protease Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C97366 - HIV Protease Inhibitor
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

8 个代谢物同义名

1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate; 1,3-thiazol-5-ylmethyl N-[3-hydroxy-5-[[3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate; Abbott 84538; Ritonavir; 538, ABT; ABT 538; ABT-538; Norvir

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:45409
KEGG: C07240
KEGGdrug: D00427
PubChem: 392622
PubChem: 5076
HMDB: HMDB0014646
Metlin: METLIN43377
DrugBank: DB00503
ChEMBL: CHEMBL163
Wikipedia: Ritonavir
MeSH: Ritonavir
chemspider: 347980
CAS: 155213-67-5
PMhub: MS000000682
PubChem: 9449
PDB-CCD: RIT
NIKKAJI: J659.314C
RefMet: Ritonavir

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Chung-Kai Sun, Yen-Ying Kung, Wan-Hsin Lee, Lie-Chwen Lin, Muh-Hwa Yang, Tung-Hu Tsai. Pharmacokinetic analysis of antiviral drug ritonavir across the blood-brain barrier and its interaction with Scutellaria baicalensis using multisite microdialysis in rats. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116162. doi: 10.1016/j.jpba.2024.116162. [PMID: 38678857]
Heta H Desai, Abu T M Serajuddin. Development of lipid-based SEDDS using digestion products of long-chain triglyceride for high drug solubility: Formulation and dispersion testing. International journal of pharmaceutics. 2024 Apr; 654(?):123953. doi: 10.1016/j.ijpharm.2024.123953. [PMID: 38417725]
Hui Yang, Xin Yu, Wenjing Hou, Xiangduan Liu, Jiaojiao Chen, Ying Zhang, Ying Wang, Ying Zhu, Qing Qian, Kuifen Ma, Zhuoling An. Effectiveness and safety of nirmatrelvir-ritonavir in kidney transplant recipients with severe kidney dysfunction infected with COVID-19. Antimicrobial agents and chemotherapy. 2024 Mar; 68(3):e0138423. doi: 10.1128/aac.01384-23. [PMID: 38289075]
Bei Zheng, Qinqin Zhao, Wenjuan Yang, Pinpin Feng, Chuanwei Xin, Yin Ying, Bo Yang, Bing Han, Jun Zhu, Meiling Zhang, Gonghua Li. Small-molecule antiviral treatments for COVID-19: A systematic review and network meta-analysis. International journal of antimicrobial agents. 2024 Mar; 63(3):107096. doi: 10.1016/j.ijantimicag.2024.107096. [PMID: 38244811]
Chloe Orkin, Jean-Michel Molina, Pedro Cahn, Johannes Lombaard, Khuanchai Supparatpinyo, Sushma Kumar, Havilland Campbell, Hong Wan, Valerie Teal, Zhi Jin Xu, Ernest Asante-Appiah, Peter Sklar, Hedy Teppler, Rima Lahoulou. Safety and efficacy of doravirine as first-line therapy in adults with HIV-1: week 192 results from the open-label extensions of the DRIVE-FORWARD and DRIVE-AHEAD phase 3 trials. The lancet. HIV. 2024 Feb; 11(2):e75-e85. doi: 10.1016/s2352-3018(23)00258-8. [PMID: 38141637]
Jianchao Xu, Jinzhong Song, Ziyu Xie, Jie Yang, Di Wu, Fengshuang Liu, Yinuo Zhao, Hongmin Zang, Yubin Zhao. Impact of Paxlovid on in-hospital outcomes and post-COVID-19 condition in adult patients infected with SARS-CoV-2 Omicron variant: A non-randomized controlled clinical trial. Medicine. 2023 Dec; 102(51):e36714. doi: 10.1097/md.0000000000036714. [PMID: 38134107]
Abdurezak Ahmed Abdela, Helen Yifter, Ahmed Reja, Aster Shewaamare, Ighovwerha Ofotokun, Wondwossen Amogne Degu. Prevalence and risk factors of metabolic syndrome in Ethiopia: describing an emerging outbreak in HIV clinics of the sub-Saharan Africa - a cross-sectional study. BMJ open. 2023 12; 13(12):e069637. doi: 10.1136/bmjopen-2022-069637. [PMID: 38070936]
Zhuo Yu, Yanxi Zheng, Bowu Chen, Jia Lv, Xiaojun Zhu, Binyi Shang, Yuping Xv, Ru Tao, Yanbing Yang, Jun Cong, Dan Li, Huan Wu, Wenchao Qv, Xiyi Zhang, Chengbin Xv, Hai Feng, Weian Yuan, Yueqiu Gao. Efficacy and safety of Huashi Baidu granule plus Nirmatrelvir-Ritonavir combination therapy in patients with high-risk factors infected with Omicron (B.1.1.529): A multi-arm single-center, open-label, randomized controlled trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Nov; 120(?):155025. doi: 10.1016/j.phymed.2023.155025. [PMID: 37639813]
Ioannis I Andreadis, Arne Schulzen, Julian Quodbach, Christel A S Bergström. Exploring the use of modified in vitro digestion assays for the evaluation of ritonavir loaded solid lipid-based formulations. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023 Oct; 189(?):106524. doi: 10.1016/j.ejps.2023.106524. [PMID: 37433412]
Srinivas Reddy Jitta, Salwa, Navya Ajitkumar Bhaskaran, Shirleen Miriam Marques, Lalit Kumar, Sri Pragnya Cheruku, Vanishree Rao, Pravesh Sharma, Onkar Prakash Kulkarni. Enhanced tissue distribution of ritonavir-loaded nanostructured lipid carriers-recommending its dose reduction. Drug delivery and translational research. 2023 Jul; ?(?):. doi: 10.1007/s13346-023-01386-9. [PMID: 37402943]
V Krishnaraju, Y Alghazwani, S Durgaramani, Y I Asiri, K Prabahar, K Kalpana, V Rajalakshimi, A K Noohu, P Premalatha, S A Sirajudeen, V Kumar, V Vinoth Prabhu. Beneficial effects of Naringin against lopinavir/ ritonavir-induced hyperlipidemia and reproductive toxicity in male albino rats. European review for medical and pharmacological sciences. 2023 May; 27(9):4221-4231. doi: 10.26355/eurrev_202305_32332. [PMID: 37203848]
Malinda Salim, Gisela Ramirez, Andrew J Clulow, Adrian Hawley, Ben J Boyd. Implications of the Digestion of Milk-Based Formulations for the Solubilization of Lopinavir/Ritonavir in a Combination Therapy. Molecular pharmaceutics. 2023 Apr; 20(4):2256-2265. doi: 10.1021/acs.molpharmaceut.3c00072. [PMID: 36919249]
Zhujun Cao, Weiyi Gao, Hong Bao, Haiyan Feng, Shuya Mei, Peizhan Chen, Yueqiu Gao, Zhilei Cui, Qin Zhang, Xianmin Meng, Honglian Gui, Weijing Wang, Yimei Jiang, Zijia Song, Yiqing Shi, Jing Sun, Yifei Zhang, Qing Xie, Yiping Xu, Guang Ning, Yuan Gao, Ren Zhao. VV116 versus Nirmatrelvir-Ritonavir for Oral Treatment of Covid-19. The New England journal of medicine. 2023 02; 388(5):406-417. doi: 10.1056/nejmoa2208822. [PMID: 36577095]
Wantin Sribenjalux, Tharatorn Nuntawit, Atibordee Meesing, Ploenchan Chetchotisakd. Virological outcomes and metabolic effects after switching from ritonavir-boosted protease inhibitors to a dolutegravir-based regimen in virologically suppressed patients living with HIV. International journal of STD & AIDS. 2023 02; 34(2):98-107. doi: 10.1177/09564624221137972. [PMID: 36378013]
Wen Wen, Chen Chen, Jiake Tang, Chunyi Wang, Mengyun Zhou, Yongran Cheng, Xiang Zhou, Qi Wu, Xingwei Zhang, Zhanhui Feng, Mingwei Wang, Qin Mao. Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19：a meta-analysis. Annals of medicine. 2022 12; 54(1):516-523. doi: 10.1080/07853890.2022.2034936. [PMID: 35118917]
He Xu, Ge Liu, Jixing Gong, Ying Zhang, Shanshan Gu, Zhongjun Wan, Pengcheng Yang, Yage Nie, Yinghan Wang, Zhan-Peng Huang, Guanzheng Luo, Zhongyan Chen, Donghui Zhang, Nan Cao. Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 10; 9(30):e2203388. doi: 10.1002/advs.202203388. [PMID: 36055796]
Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196374. [PMID: 36234910]
Georgia-Ioanna Nora, Ramakrishnan Venkatasubramanian, Sophie Strindberg, Scheyla Daniela Siqueira-Jørgensen, Livia Pagano, Francis S Romanski, Nitin K Swarnakar, Thomas Rades, Anette Müllertz. Combining lipid based drug delivery and amorphous solid dispersions for improved oral drug absorption of a poorly water-soluble drug. Journal of controlled release : official journal of the Controlled Release Society. 2022 09; 349(?):206-212. doi: 10.1016/j.jconrel.2022.06.057. [PMID: 35787914]
Bin Su, Cheng Yao, Qing-Xia Zhao, Wei-Ping Cai, Min Wang, Hong-Zhou Lu, Ting-Ting Mu, Yuan-Yuan Chen, Li Liu, Hui Wang, Yun He, Yu-Huang Zheng, Ling-Hua Li, Jin-Feng Chen, Jian-Hua Yu, Biao Zhu, Min Zhao, Yong-Tao Sun, Wen-Hui Lun, Yi-Hang Zhang, Hu Wang, Wei Xia, Li-Jun Sun, Li-Li Dai, Tai-Yi Jiang, Mei-Xia Wang, Qing-Shan Zheng, Hai-Yan Peng, Yao Wang, Min Hu, Xia Liu, Rong-Jian Lu, Jian-Hua Hu, Cheng-Chen Sun, Hui Xing, Yi-Ming Shao, Dong Xie, Tong Zhang, Fu-Jie Zhang, Hao Wu. Long-acting HIV fusion inhibitor albuvirtide combined with ritonavir-boosted lopinavir for HIV-1-infected patients after failing the first-line antiretroviral therapy: 48-week randomized, controlled, phase 3 non-inferiority TALENT study. The Journal of infection. 2022 09; 85(3):334-363. doi: 10.1016/j.jinf.2022.05.034. [PMID: 35659547]
J R Azanza, J Mensa, J González Del Castillo, M Linares Rufo, J M Molero, N Madero Valle, J Barberán. Interactions listed in the Paxlovid fact sheet, classified according to risks, pharmacological groups, and consequences. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 2022 Aug; 35(4):357-361. doi: 10.37201/req/054.2022. [PMID: 35822605]
Janice Hopkins Tanne. Covid-19: FDA authorises pharmacists to prescribe Paxlovid. BMJ (Clinical research ed.). 2022 07; 378(?):o1695. doi: 10.1136/bmj.o1695. [PMID: 35803606]
Xenia Bacinschi, Gabriel Cristian Popescu, Anca Zgura, Laurentia Gales, Anghel Rodica, Adriana Mercan, Dragos Serban, Bogdan Haineala, Letitia Toma, Laura Iliescu. A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, with or without Ribavirin, in 587 Patients with Chronic Hepatitis C at the Fundeni Clinical Institute, Bucharest, Romania. Medical science monitor : international medical journal of experimental and clinical research. 2022 Jul; 28(?):e936706. doi: 10.12659/msm.936706. [PMID: 35787600]
Sumit Arora, Amita Pansari, Peter J Kilford, Masoud Jamei, David B Turner, Iain Gardner. A Mechanistic Absorption and Disposition Model of Ritonavir to Predict Exposure and Drug-Drug Interaction Potential of CYP3A4/5 and CYP2D6 Substrates. European journal of drug metabolism and pharmacokinetics. 2022 Jul; 47(4):483-495. doi: 10.1007/s13318-022-00765-w. [PMID: 35486324]
Mehdi Hassaniazad, Hossein Farshidi, Abdollah Gharibzadeh, Ali Bazram, Elham Khalili, Afsaneh Noormandi, Mohammad Fathalipour. Efficacy and safety of favipiravir plus interferon-beta versus lopinavir/ritonavir plus interferon-beta in moderately ill patients with COVID-19: A randomized clinical trial. Journal of medical virology. 2022 Jul; 94(7):3184-3191. doi: 10.1002/jmv.27724. [PMID: 35292989]
Maarten van Eijk, Huixin Yu, Emilia Sawicki, Vincent A de Weger, Bastiaan Nuijen, Thomas P C Dorlo, Jos H Beijnen, Alwin D R Huitema. Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies. Cancer chemotherapy and pharmacology. 2022 Jul; 90(1):71-82. doi: 10.1007/s00280-022-04445-z. [PMID: 35799067]
Vishal C Gurumukhi, Sanjaykumar B Bari. Development of ritonavir-loaded nanostructured lipid carriers employing quality by design (QbD) as a tool: characterizations, permeability, and bioavailability studies. Drug delivery and translational research. 2022 07; 12(7):1753-1773. doi: 10.1007/s13346-021-01083-5. [PMID: 34671949]
A Dubois, A Féral, J-B Pain, J Michot, D Fansi Ndengoue, A Benomar, E Clou, I Debrix. [Treatments for SARS-CoV-2 infection: A retrospective study of drug-drug interactions and safety]. Annales pharmaceutiques francaises. 2022 Jul; 80(4):531-542. doi: 10.1016/j.pharma.2021.11.001. [PMID: 34748737]
Talha Burki. The future of Paxlovid for COVID-19. The Lancet. Respiratory medicine. 2022 07; 10(7):e68. doi: 10.1016/s2213-2600(22)00192-8. [PMID: 35623373]
Ravi Shankar P Singh, Sima S Toussi, Frances Hackman, Phylinda L Chan, Rohit Rao, Richard Allen, Lien Van Eyck, Sylvester Pawlak, Eugene P Kadar, Frances Clark, Haihong Shi, Annaliesa S Anderson, Michael Binks, Sandeep Menon, Gianluca Nucci, Arthur Bergman. Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID-19 Trial of Nirmatrelvir. Clinical pharmacology and therapeutics. 2022 Jul; 112(1):101-111. doi: 10.1002/cpt.2603. [PMID: 35388471]
José L Blanco, Jhon Rojas, Elisa de Lazzari, Alexy Inciarte, Mar Subirana, Pilar Callau, María Martinez-Rebollar, Montserrat Laguno, Josep Mallolas, Lorena de la Mora, Berta Torres, Ana Gonzalez-Cordón, Esteban Martinez. Simplification from tenofovir disoproxil fumarate plus lamivudine or emtricitabine plus ritonavir-boosted protease inhibitor to ritonavir-boosted atazanavir plus lamivudine in virologically suppressed HIV-infected adults with osteopenia: a pilot study. The Journal of antimicrobial chemotherapy. 2022 06; 77(7):1974-1979. doi: 10.1093/jac/dkac137. [PMID: 35512339]
Rita Rubin. From Positive to Negative to Positive Again-The Mystery of Why COVID-19 Rebounds in Some Patients Who Take Paxlovid. JAMA. 2022 06; 327(24):2380-2382. doi: 10.1001/jama.2022.9925. [PMID: 35675094]
Rohini Kharwade, Sachin More, Elizabeth Suresh, Amol Warokar, Nilesh Mahajan, Ujwala Mahajan. Improvement in Bioavailability and Pharmacokinetic Characteristics of Efavirenz with Booster Dose of Ritonavir in PEGylated PAMAM G4 Dendrimers. AAPS PharmSciTech. 2022 Jun; 23(6):177. doi: 10.1208/s12249-022-02315-8. [PMID: 35750994]
Deborah E Malden, Vennis Hong, Bruno J Lewin, Bradley K Ackerson, Marc Lipsitch, Joseph A Lewnard, Sara Y Tartof. Hospitalization and Emergency Department Encounters for COVID-19 After Paxlovid Treatment - California, December 2021-May 2022. MMWR. Morbidity and mortality weekly report. 2022 Jun; 71(25):830-833. doi: 10.15585/mmwr.mm7125e2. [PMID: 35737591]
Amedeo De Nicolò, Andrea Calcagno, Ilaria Motta, Elisa De Vivo, Antonio D'Avolio, Giovanni Di Perri, Lubbe Wiesner, Isma-Eel Ebrahim, Gary Maartens, Catherine Orrell, Helen McIlleron. The Effect of Rifampicin on Darunavir, Ritonavir, and Dolutegravir Exposure within Peripheral Blood Mononuclear Cells: a Dose Escalation Study. Antimicrobial agents and chemotherapy. 2022 06; 66(6):e0013622. doi: 10.1128/aac.00136-22. [PMID: 35583344]
NULL. COVID-19 update: NIH recommends against ivermectin. The Medical letter on drugs and therapeutics. 2022 06; 64(1652):95-96. doi: NULL. [PMID: 35657909]
Bożena Czech, Agnieszka Krzyszczak, Anna Boguszewska-Czubara, Grzegorz Opielak, Izabela Jośko, Mirabbos Hojamberdiev. Revealing the toxicity of lopinavir- and ritonavir-containing water and wastewater treated by photo-induced processes to Danio rerio and Allivibrio fischeri. The Science of the total environment. 2022 Jun; 824(?):153967. doi: 10.1016/j.scitotenv.2022.153967. [PMID: 35182634]
David Phizackerley. Three more points about Paxlovid for covid-19. BMJ (Clinical research ed.). 2022 06; 377(?):o1397. doi: 10.1136/bmj.o1397. [PMID: 35672048]
Sibel Ucpinar, Borje Darpo, Ann Neale, Philip Nunn, Jin Shu, Katherine A Chu, Marianne Kavanagh, Hongqi Xue, Pasit Phiasivongsa, Dolca Thomas, Patrick F Smith. A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects. Clinical and translational science. 2022 Jun; 15(6):1507-1518. doi: 10.1111/cts.13271. [PMID: 35301810]
Kristen E Lindauer, Ashlee G Hamel. Case Report: Nirmatrelvir/Ritonavir and Tacrolimus in a Kidney Transplant Recipient With COVID-19. American family physician. 2022 06; 105(6):569-570. doi: NULL. [PMID: 35704835]
J Reina, C Iglesias. [Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 2022 Jun; 35(3):236-240. doi: 10.37201/req/002.2022. [PMID: 35183067]
Nicholas I Paton, Joseph Musaazi, Cissy Kityo, Stephen Walimbwa, Anne Hoppe, Apolo Balyegisawa, Jesca Asienzo, Arvind Kaimal, Grace Mirembe, Abbas Lugemwa, Gilbert Ategeka, Margaret Borok, Henry Mugerwa, Abraham Siika, Eva Laker A Odongpiny, Barbara Castelnuovo, Agnes Kiragga, Andrew Kambugu. Efficacy and safety of dolutegravir or darunavir in combination with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection (NADIA): week 96 results from a prospective, multicentre, open-label, factorial, randomised, non-inferiority trial. The lancet. HIV. 2022 06; 9(6):e381-e393. doi: 10.1016/s2352-3018(22)00092-3. [PMID: 35460601]
Caroline S Foo, Rana Abdelnabi, Suzanne J F Kaptein, Xin Zhang, Sebastiaan Ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K Chatterjee, Pieter P Annaert, Patrick F Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts. HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect. Antiviral research. 2022 06; 202(?):105311. doi: 10.1016/j.antiviral.2022.105311. [PMID: 35390430]
Cihan Yurdaydin, Onur Keskin, Esra Yurdcu, Aysun Çalişkan, Soner Önem, Fatih Karakaya, Çağdaş Kalkan, Ersin Karatayli, Senem Karatayli, Ingrid Choong, David Apelian, Christopher Koh, Theo Heller, Ramazan Idilman, A Mithat Bozdayi, Jeffrey S Glenn. A phase 2 dose-finding study of lonafarnib and ritonavir with or without interferon alpha for chronic delta hepatitis. Hepatology (Baltimore, Md.). 2022 06; 75(6):1551-1565. doi: 10.1002/hep.32259. [PMID: 34860418]
Ruxandra-Cristina Marin, Adrian Streinu-Cercel, Lavinia Cristina Moleriu, Simona Gabriela Bungau. Analysis of virological response to therapy and resistance profile in treatment-experienced and naive HIV-1 infected Romanian patients receiving regimens containing darunavir boosted with ritonavir or cobicistat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113077. doi: 10.1016/j.biopha.2022.113077. [PMID: 35658217]
Athanasios Vassilopoulos, Eleftherios Mylonakis. In patients with COVID-19 at risk for severe disease, nirmatrelvir + ritonavir reduced hospitalization or death. Annals of internal medicine. 2022 06; 175(6):JC63. doi: 10.7326/j22-0038. [PMID: 35667068]
Eunjin Hong, Lisa M Almond, Peter S Chung, Adupa P Rao, Paul M Beringer. Physiologically-Based Pharmacokinetic-Led Guidance for Patients With Cystic Fibrosis Taking Elexacaftor-Tezacaftor-Ivacaftor With Nirmatrelvir-Ritonavir for the Treatment of COVID-19. Clinical pharmacology and therapeutics. 2022 06; 111(6):1324-1333. doi: 10.1002/cpt.2585. [PMID: 35292968]
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